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The map label for this gene is tcmR [H]

Identifier: 17545354

GI number: 17545354

Start: 682330

End: 682980

Strand: Reverse

Name: tcmR [H]

Synonym: RSc0635

Alternate gene names: 17545354

Gene position: 682980-682330 (Counterclockwise)

Preceding gene: 17545358

Following gene: 17545352

Centisome position: 18.38

GC content: 60.98

Gene sequence:

>651_bases
ATGTTGCAAGCAGTGCAATGGGGCTGCTACGATGCGGGCATGCCGAACATGAACAGTCAGTCAGAGGATCGTGCGCAGGA
CGGACTGCGCGAAAGGAAGCGTCGCGACACGCTGCAACGCATCGCGCAAACGGGGCTCGATCTCTTTATCGCCAAGGGTT
ACGAAGCCACAACGCTTGATGACGTCGCCGCGGCCGCCGGCATTTCCAGGCGGACCTTCTTCCACTACTTCACATCGAAA
GACGAGATCCTGCTCGCCTGGCAAGTCGGGCTAGTCGACGCCCTGTACGACGCGGTGCTGCAAGCAGCGACAGACCAATC
GCCCCTTGAAGCATTGTGCGGTGCGCTGCAGAAGCTGGCGTCGCACTTTGATGCAGAGAAGGCGATCGACATCGCGAGGG
TTCTCCGCTCGAGCGAGCAGCTGCGCGCAGCCAACCATGCCAAATTCATGAACCTGGAGAACGCCGCGTTCGAGGCGCTG
TGCCGGCTTTGGCCGCAGCGCGGCCGTCGCGGACTCCTGCGAATGGTGGCGATGGCGGGCCTCGGCGCGTTTCGCGTCGC
AATCGATGAATGGGTTGATGAAGGTGGGAAAGAGTCGCTCACCAAGCGGATTGAAAAGACGTTCGAGAATTTGCGCTCGG
CGGTGCAGTGA

Upstream 100 bases:

>100_bases
GACGCGCATGGCATCGGCACTGCCGTAACGATCAAACTGAACCCGTTTCATGCACGCCCCAAAATTTACACTCAGCGCAC
ACAATAATGCACTGAGTGCA

Downstream 100 bases:

>100_bases
CCTTGTACCGAAATCATCGGCGTTGCGGTGCCGCGAGCTCCACAGTCAACAAGGACCGCCGGCCCTGCGAGACGGGCATA
TCTCCTCGCCTTCTGGACTG

Product: transcription regulator protein

Products: NA

Alternate protein names: Tetracenomycin C transcriptional repressor [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MLQAVQWGCYDAGMPNMNSQSEDRAQDGLRERKRRDTLQRIAQTGLDLFIAKGYEATTLDDVAAAAGISRRTFFHYFTSK
DEILLAWQVGLVDALYDAVLQAATDQSPLEALCGALQKLASHFDAEKAIDIARVLRSSEQLRAANHAKFMNLENAAFEAL
CRLWPQRGRRGLLRMVAMAGLGAFRVAIDEWVDEGGKESLTKRIEKTFENLRSAVQ

Sequences:

>Translated_216_residues
MLQAVQWGCYDAGMPNMNSQSEDRAQDGLRERKRRDTLQRIAQTGLDLFIAKGYEATTLDDVAAAAGISRRTFFHYFTSK
DEILLAWQVGLVDALYDAVLQAATDQSPLEALCGALQKLASHFDAEKAIDIARVLRSSEQLRAANHAKFMNLENAAFEAL
CRLWPQRGRRGLLRMVAMAGLGAFRVAIDEWVDEGGKESLTKRIEKTFENLRSAVQ
>Mature_216_residues
MLQAVQWGCYDAGMPNMNSQSEDRAQDGLRERKRRDTLQRIAQTGLDLFIAKGYEATTLDDVAAAAGISRRTFFHYFTSK
DEILLAWQVGLVDALYDAVLQAATDQSPLEALCGALQKLASHFDAEKAIDIARVLRSSEQLRAANHAKFMNLENAAFEAL
CRLWPQRGRRGLLRMVAMAGLGAFRVAIDEWVDEGGKESLTKRIEKTFENLRSAVQ

Specific function: Represses transcription of the divergently oriented tcmR and tcmA (tetracenomycin C resistance and export) genes by binding to an intergenic operator region. This binding is inhibited by tetracenomycin C [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24125; Mature: 24125

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQAVQWGCYDAGMPNMNSQSEDRAQDGLRERKRRDTLQRIAQTGLDLFIAKGYEATTLD
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCHHH
DVAAAAGISRRTFFHYFTSKDEILLAWQVGLVDALYDAVLQAATDQSPLEALCGALQKLA
HHHHHHCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
SHFDAEKAIDIARVLRSSEQLRAANHAKFMNLENAAFEALCRLWPQRGRRGLLRMVAMAG
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LGAFRVAIDEWVDEGGKESLTKRIEKTFENLRSAVQ
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLQAVQWGCYDAGMPNMNSQSEDRAQDGLRERKRRDTLQRIAQTGLDLFIAKGYEATTLD
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCHHH
DVAAAAGISRRTFFHYFTSKDEILLAWQVGLVDALYDAVLQAATDQSPLEALCGALQKLA
HHHHHHCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
SHFDAEKAIDIARVLRSSEQLRAANHAKFMNLENAAFEALCRLWPQRGRRGLLRMVAMAG
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LGAFRVAIDEWVDEGGKESLTKRIEKTFENLRSAVQ
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1592819; 1592820 [H]