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The map label for this gene is adhA [H]

Identifier: 17545351

GI number: 17545351

Start: 679031

End: 680089

Strand: Reverse

Name: adhA [H]

Synonym: RSc0632

Alternate gene names: 17545351

Gene position: 680089-679031 (Counterclockwise)

Preceding gene: 17545352

Following gene: 17545350

Centisome position: 18.3

GC content: 61.57

Gene sequence:

>1059_bases
ATGCAGGCCCTGGGATACGCTGCTGCGTCTTCAACCGATGCGCTCGTACCATTGCGCTTCGAGCGGCGGGAGCCACGTCC
GGACGATGTCGTTCTGGACGTGCTCTACTGCGGCGTCTGCCACACAGACCTCCACATCGCAAAGAACCATGGCGGGTATA
CGAACTACCCTGTCGTGCCGGGTCACGAAATCATCGGACGCGTCACGCGGGTCGGTAGCGAAGTCACCCGCTTTAAGGTG
GGGGACACGGTTGGCGTCGGATGCATGGTCGATTCGTGCCAGCACTGCAACCCTTGCCTCGCGGGCTATGAACAGCACTG
CCAGGCGGGACCGGTCTTCACCTACAACGGAACGGACCGGCATGACCACACGAGAACCTTCGGCGGTTACTCGAACACGC
TGGTCGTATCGGACAAGTTTGTCTTGAGCATTCCCAATGGGCTTGACCCGGCCGGTGCCGCACCTCTGCTCTGCGCCGGA
ATCACGACGTGGGAGCCGCTGCATCAGTGGAAAGTCGGCCCGGGCAGCCAGGTCGCCGTTGTGGGCTTGGGCGGCCTGGG
TCACATGGCCCTGAAGCTGGCCAAAGCGCTCGGGGCAGAGGTCACCCTGTTGACCCGTTCGCCCAATAAGGAGCTCGATG
CACGGCGTCTCGGCGCCAATCACGTCGTGCTGTCGACCGATGCTAGCCAGATGGCGTCCGTGGCCGGGCGCTTCGACTTG
ATCGTGGACACCGTTCCCTACGAACACGACGTCAATCCGTACCTGCCTACCCTAGCGCTTAACGGTACCTTGGTCTTGGT
CGGCTACATGGGACCGCTGAACGAGCCGGTTTCAGCAAGAGCACTCGTGTTCGGCCGCAAGGCCATCGCGGGATCGTTCA
TCGGCGGCATTGCCGCAACGCAGGCGATGCTCGACTTTTGCGGGGCGCACAACGTCGTGTCGGATGTCGAGATCATCCCG
ATCCAGCAGATCAACGCAGCGTATGAACGGCTGCTCAAGAGCGACGTGAAATATCGCTTCGTCATTGATATGTCATCACT
GGCGGCGGACAAGCCCTGA

Upstream 100 bases:

>100_bases
TTGCAAGCGATCTGAGCACCGCGCGACATCTCGGCCGGCGCGTTGCCGAGATCACCCGACAATTCAGCGCCGCAGCGGTT
GTCCCCGAGGGAGCCTAACC

Downstream 100 bases:

>100_bases
CACCATCGACTCCGCAAGGGCACACGCCCTTGCGAGTCCACCACAACACTGACAACATGAACACAAGCGCATCATCAAGC
ACCGATCCGCTGTTTCAGAT

Product: NADP-dependent alcohol dehydrogenase oxidoreductase

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MQALGYAAASSTDALVPLRFERREPRPDDVVLDVLYCGVCHTDLHIAKNHGGYTNYPVVPGHEIIGRVTRVGSEVTRFKV
GDTVGVGCMVDSCQHCNPCLAGYEQHCQAGPVFTYNGTDRHDHTRTFGGYSNTLVVSDKFVLSIPNGLDPAGAAPLLCAG
ITTWEPLHQWKVGPGSQVAVVGLGGLGHMALKLAKALGAEVTLLTRSPNKELDARRLGANHVVLSTDASQMASVAGRFDL
IVDTVPYEHDVNPYLPTLALNGTLVLVGYMGPLNEPVSARALVFGRKAIAGSFIGGIAATQAMLDFCGAHNVVSDVEIIP
IQQINAAYERLLKSDVKYRFVIDMSSLAADKP

Sequences:

>Translated_352_residues
MQALGYAAASSTDALVPLRFERREPRPDDVVLDVLYCGVCHTDLHIAKNHGGYTNYPVVPGHEIIGRVTRVGSEVTRFKV
GDTVGVGCMVDSCQHCNPCLAGYEQHCQAGPVFTYNGTDRHDHTRTFGGYSNTLVVSDKFVLSIPNGLDPAGAAPLLCAG
ITTWEPLHQWKVGPGSQVAVVGLGGLGHMALKLAKALGAEVTLLTRSPNKELDARRLGANHVVLSTDASQMASVAGRFDL
IVDTVPYEHDVNPYLPTLALNGTLVLVGYMGPLNEPVSARALVFGRKAIAGSFIGGIAATQAMLDFCGAHNVVSDVEIIP
IQQINAAYERLLKSDVKYRFVIDMSSLAADKP
>Mature_352_residues
MQALGYAAASSTDALVPLRFERREPRPDDVVLDVLYCGVCHTDLHIAKNHGGYTNYPVVPGHEIIGRVTRVGSEVTRFKV
GDTVGVGCMVDSCQHCNPCLAGYEQHCQAGPVFTYNGTDRHDHTRTFGGYSNTLVVSDKFVLSIPNGLDPAGAAPLLCAG
ITTWEPLHQWKVGPGSQVAVVGLGGLGHMALKLAKALGAEVTLLTRSPNKELDARRLGANHVVLSTDASQMASVAGRFDL
IVDTVPYEHDVNPYLPTLALNGTLVLVGYMGPLNEPVSARALVFGRKAIAGSFIGGIAATQAMLDFCGAHNVVSDVEIIP
IQQINAAYERLLKSDVKYRFVIDMSSLAADKP

Specific function: Functions in the protection against aldehyde-stress [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=247, Percent_Identity=29.9595141700405, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI71743840, Length=365, Percent_Identity=25.7534246575342, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI262073058, Length=365, Percent_Identity=25.7534246575342, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI34577061, Length=367, Percent_Identity=26.158038147139, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI4501933, Length=367, Percent_Identity=25.8855585831063, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786518, Length=348, Percent_Identity=47.7011494252874, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI87082401, Length=340, Percent_Identity=35.8823529411765, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI87081918, Length=343, Percent_Identity=29.4460641399417, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1788073, Length=210, Percent_Identity=29.0476190476191, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788407, Length=256, Percent_Identity=30.078125, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI226510992, Length=266, Percent_Identity=29.6992481203008, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082125, Length=284, Percent_Identity=27.4647887323944, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787863, Length=130, Percent_Identity=33.8461538461538, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=324, Percent_Identity=26.8518518518519, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17562584, Length=329, Percent_Identity=27.355623100304, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17562582, Length=332, Percent_Identity=27.4096385542169, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI25146526, Length=371, Percent_Identity=28.3018867924528, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=373, Percent_Identity=28.1501340482574, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17565904, Length=345, Percent_Identity=28.695652173913, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562878, Length=217, Percent_Identity=29.4930875576037, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=271, Percent_Identity=27.6752767527675, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=349, Percent_Identity=33.5243553008596, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319949, Length=333, Percent_Identity=33.033033033033, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6323961, Length=333, Percent_Identity=31.5315315315315, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323729, Length=334, Percent_Identity=30.2395209580838, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324486, Length=332, Percent_Identity=29.8192771084337, Blast_Score=132, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6319621, Length=334, Percent_Identity=28.7425149700599, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6319258, Length=324, Percent_Identity=25.3086419753086, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=28.6103542234332, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737895, Length=377, Percent_Identity=29.1777188328912, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17737897, Length=220, Percent_Identity=30.4545454545455, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 37574; Mature: 37574

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQALGYAAASSTDALVPLRFERREPRPDDVVLDVLYCGVCHTDLHIAKNHGGYTNYPVVP
CCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
GHEIIGRVTRVGSEVTRFKVGDTVGVGCMVDSCQHCNPCLAGYEQHCQAGPVFTYNGTDR
CHHHHHHHHHHCCHHHEEECCCCCCCHHHHHCHHCCCHHHHCHHHHCCCCCEEEECCCCC
HDHTRTFGGYSNTLVVSDKFVLSIPNGLDPAGAAPLLCAGITTWEPLHQWKVGPGSQVAV
CCCCCCCCCCCCEEEEECEEEEECCCCCCCCCCCCEEEECCCCCCHHHHCCCCCCCEEEE
VGLGGLGHMALKLAKALGAEVTLLTRSPNKELDARRLGANHVVLSTDASQMASVAGRFDL
EEECCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCEEEEECCHHHHHHHHCCEEE
IVDTVPYEHDVNPYLPTLALNGTLVLVGYMGPLNEPVSARALVFGRKAIAGSFIGGIAAT
EEECCCCCCCCCCCCCEEEECCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QAMLDFCGAHNVVSDVEIIPIQQINAAYERLLKSDVKYRFVIDMSSLAADKP
HHHHHHHCCCCHHCCCEEEEHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCC
>Mature Secondary Structure
MQALGYAAASSTDALVPLRFERREPRPDDVVLDVLYCGVCHTDLHIAKNHGGYTNYPVVP
CCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
GHEIIGRVTRVGSEVTRFKVGDTVGVGCMVDSCQHCNPCLAGYEQHCQAGPVFTYNGTDR
CHHHHHHHHHHCCHHHEEECCCCCCCHHHHHCHHCCCHHHHCHHHHCCCCCEEEECCCCC
HDHTRTFGGYSNTLVVSDKFVLSIPNGLDPAGAAPLLCAGITTWEPLHQWKVGPGSQVAV
CCCCCCCCCCCCEEEEECEEEEECCCCCCCCCCCCEEEECCCCCCHHHHCCCCCCCEEEE
VGLGGLGHMALKLAKALGAEVTLLTRSPNKELDARRLGANHVVLSTDASQMASVAGRFDL
EEECCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCEEEEECCHHHHHHHHCCEEE
IVDTVPYEHDVNPYLPTLALNGTLVLVGYMGPLNEPVSARALVFGRKAIAGSFIGGIAAT
EEECCCCCCCCCCCCCEEEECCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QAMLDFCGAHNVVSDVEIIPIQQINAAYERLLKSDVKYRFVIDMSSLAADKP
HHHHHHHCCCCHHCCCEEEEHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]