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The map label for this gene is iorA [H]

Identifier: 17545345

GI number: 17545345

Start: 673561

End: 674019

Strand: Direct

Name: iorA [H]

Synonym: RSc0626

Alternate gene names: 17545345

Gene position: 673561-674019 (Clockwise)

Preceding gene: 17545344

Following gene: 17545346

Centisome position: 18.12

GC content: 64.27

Gene sequence:

>459_bases
ATGATCACGCTCGACATCAATGGCAAGCCGACGCACGTCGATGCCGCTCCTGACACACCAATCCTCTGGGCGTTGCGCGA
CACGCTTCAACTGACCGGCACCAAATATGGCTGCGGCATGGGGTTGTGCGGTGCGTGCACGGTGCACCTGGATGGCCAGC
CGATCCGTTCCTGCAGCACGCCGCTGTCCGCCGCCGCCGGCAAGAAGATCACCACCATTGAAGGCGTGGATCGTGCCCGC
GTGGGCAAGGCGGTGCAGGAAGCCTGGCGGCACCTCGACGTCGTGCAATGCGGTTACTGCCAATCCGGCCAGATCATGAG
CGCCGTGGCGCTGCTAGAGAGCAACCACCAACCCACCGACGCCGATATTGATGCCGCCATGGCGGGCAACATCTGCCGCT
GCGCCACTTACGTCCGTATCCGCGCCGCCATTCACGATGCGGCGAAGCGCCTGGCCTAA

Upstream 100 bases:

>100_bases
CTGTTGGAGAATCGGGCAAGAAAGCTGGAGGATCGAGCTATCGAGTTTGCCAGGTGGATCCGCAGAATGCGTGACGGCAT
TCCTCTGCCCGGAGAAACGA

Downstream 100 bases:

>100_bases
CTGGAGCGCAGCCATGACGAACAAGACCGCTCATATCGAGAACGCAAGTCGGCGCAACTTCCTGAACGGCGCGATGGGAT
TGACCCTGGCTATTTACCTG

Product: aldehyde dehydrogenase subunit III

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MITLDINGKPTHVDAAPDTPILWALRDTLQLTGTKYGCGMGLCGACTVHLDGQPIRSCSTPLSAAAGKKITTIEGVDRAR
VGKAVQEAWRHLDVVQCGYCQSGQIMSAVALLESNHQPTDADIDAAMAGNICRCATYVRIRAAIHDAAKRLA

Sequences:

>Translated_152_residues
MITLDINGKPTHVDAAPDTPILWALRDTLQLTGTKYGCGMGLCGACTVHLDGQPIRSCSTPLSAAAGKKITTIEGVDRAR
VGKAVQEAWRHLDVVQCGYCQSGQIMSAVALLESNHQPTDADIDAAMAGNICRCATYVRIRAAIHDAAKRLA
>Mature_152_residues
MITLDINGKPTHVDAAPDTPILWALRDTLQLTGTKYGCGMGLCGACTVHLDGQPIRSCSTPLSAAAGKKITTIEGVDRAR
VGKAVQEAWRHLDVVQCGYCQSGQIMSAVALLESNHQPTDADIDAAMAGNICRCATYVRIRAAIHDAAKRLA

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=144, Percent_Identity=36.8055555555556, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786480, Length=165, Percent_Identity=40.6060606060606, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1789232, Length=150, Percent_Identity=40.6666666666667, Blast_Score=99, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17540638, Length=154, Percent_Identity=38.3116883116883, Blast_Score=103, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17539860, Length=155, Percent_Identity=34.1935483870968, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI32566215, Length=155, Percent_Identity=34.1935483870968, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17737937, Length=144, Percent_Identity=38.8888888888889, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24647199, Length=158, Percent_Identity=36.0759493670886, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24647197, Length=166, Percent_Identity=34.3373493975904, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24647195, Length=166, Percent_Identity=34.3373493975904, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24647193, Length=164, Percent_Identity=34.1463414634146, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24647201, Length=159, Percent_Identity=33.9622641509434, Blast_Score=79, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 16102; Mature: 16102

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
5.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITLDINGKPTHVDAAPDTPILWALRDTLQLTGTKYGCGMGLCGACTVHLDGQPIRSCST
CEEEECCCCCCEECCCCCCCEEEHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCC
PLSAAAGKKITTIEGVDRARVGKAVQEAWRHLDVVQCGYCQSGQIMSAVALLESNHQPTD
CCHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHCCCCCCC
ADIDAAMAGNICRCATYVRIRAAIHDAAKRLA
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MITLDINGKPTHVDAAPDTPILWALRDTLQLTGTKYGCGMGLCGACTVHLDGQPIRSCST
CEEEECCCCCCEECCCCCCCEEEHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCC
PLSAAAGKKITTIEGVDRARVGKAVQEAWRHLDVVQCGYCQSGQIMSAVALLESNHQPTD
CCHHHCCCEEEEECCCCHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHCCCCCCC
ADIDAAMAGNICRCATYVRIRAAIHDAAKRLA
CCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]