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The map label for this gene is fdh [H]

Identifier: 17545343

GI number: 17545343

Start: 671217

End: 672233

Strand: Reverse

Name: fdh [H]

Synonym: RSc0624

Alternate gene names: 17545343

Gene position: 672233-671217 (Counterclockwise)

Preceding gene: 17545350

Following gene: 17545342

Centisome position: 18.09

GC content: 63.23

Gene sequence:

>1017_bases
ATGTACAGTGCCCACGACGTTCGTGTCGAGAACGTCCCGGACGCGACCATCGTGGAGCCTACCGATGCCATCGTCCGCGT
CACCCAAGCTTGTATCTGCGGCAGCGATCTGTGGCCCTATCGAGCCATGGAACCCAGCGAGACCGGCCAGAGCATGGGCC
ACGAGGCCATCGGCGTGGTCGAGGCCATCGGCAGTGGCGTCAACAAGATCAAGGTCGGCGACGTCGTCATCATGCCGTTC
GCCTATTCCGACGGTCGATGCGAGTTCTGTCATGAGGGCCTGCAGACCGCATGCGTTCACGGCGGATTCTTCGGCTACGG
CGGTTTCAACGGCGCCCAAGCAGAAGCCCTTCGGATACCGCAAGCGGATGGCACGCTGTACGCGTTGCCCGGCGGCGTCG
ACAGCGCGTTGATGGCCTCGTTGCTTACGCTGTCTGACGTGATGGGAACGGGCCACCATGCTGCCCGCGTTGCAAGGGTA
CGCCCCGGCACGTCGGCGGCTGTGATCGGCGACGGCGCAGTGGGCCTGTGCGGCGTCATCGCCGCGAAGCGGTTGGGCGC
AGAGCGCATCATCCTCATGGGTCGGCATCCGGACCGCATTGCGCTGGCGCAAGCCTTTGGCGCAACCGATATCGTGAGCG
AGCGCGGCGAAGAAGCGATCGAGCGGGTGCGCGCGCTGACGGGCGGCCATGGTGTGCATTCGGTGCTCGAATGTGTCGGT
ACCGATCAGTCCATGCAAACGGCTGCAAATATCGCACGCCCTGGCGGCGCGGTGGGCCGTGTCGGCGTGCCGCATTACAA
CGCGATACCGGCTGACACAACATTCTTCAAGAATGTCATTGTCGGTGGAGGACCGGCGCCGGTGCGCGCCTACATTGACG
ATCTGTTGCCCGACGTACTGGACGGCAAGATTCAACCTGGCCGTGTGTTCGACCGCGTTATCGGCTTGGACGAAGTCCCA
GATGGCTACCGGGCTATGGACGAACGCCAAGCCATCAAGGTCATGATCAATCTGTGA

Upstream 100 bases:

>100_bases
CCGTGTCGAGCGGTTGGCTATCCACCTGAGCGTGCCGTCATCTGCGCATCGACATGGCATTCCCTCTCAAACTGGAGATC
CATCCATGCGTGCAACTGTT

Downstream 100 bases:

>100_bases
CCGTCTGGTACCGGGAACTCCGCGATAGATTGCTGACCTACACCGGAATTGGTACCGTCCAGAAGTGGAGATTTCCGGCG
TCGTTGAGTCGTCCGTCGAG

Product: zinc-dependent alcohol dehydrogenase oxidoreductase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MYSAHDVRVENVPDATIVEPTDAIVRVTQACICGSDLWPYRAMEPSETGQSMGHEAIGVVEAIGSGVNKIKVGDVVIMPF
AYSDGRCEFCHEGLQTACVHGGFFGYGGFNGAQAEALRIPQADGTLYALPGGVDSALMASLLTLSDVMGTGHHAARVARV
RPGTSAAVIGDGAVGLCGVIAAKRLGAERIILMGRHPDRIALAQAFGATDIVSERGEEAIERVRALTGGHGVHSVLECVG
TDQSMQTAANIARPGGAVGRVGVPHYNAIPADTTFFKNVIVGGGPAPVRAYIDDLLPDVLDGKIQPGRVFDRVIGLDEVP
DGYRAMDERQAIKVMINL

Sequences:

>Translated_338_residues
MYSAHDVRVENVPDATIVEPTDAIVRVTQACICGSDLWPYRAMEPSETGQSMGHEAIGVVEAIGSGVNKIKVGDVVIMPF
AYSDGRCEFCHEGLQTACVHGGFFGYGGFNGAQAEALRIPQADGTLYALPGGVDSALMASLLTLSDVMGTGHHAARVARV
RPGTSAAVIGDGAVGLCGVIAAKRLGAERIILMGRHPDRIALAQAFGATDIVSERGEEAIERVRALTGGHGVHSVLECVG
TDQSMQTAANIARPGGAVGRVGVPHYNAIPADTTFFKNVIVGGGPAPVRAYIDDLLPDVLDGKIQPGRVFDRVIGLDEVP
DGYRAMDERQAIKVMINL
>Mature_338_residues
MYSAHDVRVENVPDATIVEPTDAIVRVTQACICGSDLWPYRAMEPSETGQSMGHEAIGVVEAIGSGVNKIKVGDVVIMPF
AYSDGRCEFCHEGLQTACVHGGFFGYGGFNGAQAEALRIPQADGTLYALPGGVDSALMASLLTLSDVMGTGHHAARVARV
RPGTSAAVIGDGAVGLCGVIAAKRLGAERIILMGRHPDRIALAQAFGATDIVSERGEEAIERVRALTGGHGVHSVLECVG
TDQSMQTAANIARPGGAVGRVGVPHYNAIPADTTFFKNVIVGGGPAPVRAYIDDLLPDVLDGKIQPGRVFDRVIGLDEVP
DGYRAMDERQAIKVMINL

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=326, Percent_Identity=26.9938650306748, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI71565154, Length=339, Percent_Identity=25.0737463126844, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI156627571, Length=267, Percent_Identity=29.9625468164794, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1786825, Length=374, Percent_Identity=30.2139037433155, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1788075, Length=334, Percent_Identity=28.4431137724551, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788073, Length=255, Percent_Identity=31.3725490196078, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082125, Length=350, Percent_Identity=26.2857142857143, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87081918, Length=244, Percent_Identity=30.7377049180328, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788407, Length=286, Percent_Identity=26.5734265734266, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1786552, Length=343, Percent_Identity=26.8221574344023, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790045, Length=326, Percent_Identity=23.9263803680982, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI226510992, Length=264, Percent_Identity=25, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790718, Length=332, Percent_Identity=25.3012048192771, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=274, Percent_Identity=29.5620437956204, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=267, Percent_Identity=28.0898876404494, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=375, Percent_Identity=24.8, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322619, Length=280, Percent_Identity=29.2857142857143, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=280, Percent_Identity=29.2857142857143, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=371, Percent_Identity=23.989218328841, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=265, Percent_Identity=26.0377358490566, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=330, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=341, Percent_Identity=26.099706744868, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323729, Length=322, Percent_Identity=25.1552795031056, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI17737897, Length=356, Percent_Identity=25.2808988764045, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17137530, Length=364, Percent_Identity=25, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45550770, Length=190, Percent_Identity=27.3684210526316, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45551930, Length=190, Percent_Identity=27.3684210526316, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221457811, Length=190, Percent_Identity=27.3684210526316, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 35411; Mature: 35411

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSAHDVRVENVPDATIVEPTDAIVRVTQACICGSDLWPYRAMEPSETGQSMGHEAIGVV
CCCCCCEEECCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCHHHHHHH
EAIGSGVNKIKVGDVVIMPFAYSDGRCEFCHEGLQTACVHGGFFGYGGFNGAQAEALRIP
HHHCCCCCEEEECCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEECC
QADGTLYALPGGVDSALMASLLTLSDVMGTGHHAARVARVRPGTSAAVIGDGAVGLCGVI
CCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHEEEECCCCCEEEECCCHHHHHHHH
AAKRLGAERIILMGRHPDRIALAQAFGATDIVSERGEEAIERVRALTGGHGVHSVLECVG
HHHHCCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
TDQSMQTAANIARPGGAVGRVGVPHYNAIPADTTFFKNVIVGGGPAPVRAYIDDLLPDVL
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
DGKIQPGRVFDRVIGLDEVPDGYRAMDERQAIKVMINL
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHCEEEEEEEC
>Mature Secondary Structure
MYSAHDVRVENVPDATIVEPTDAIVRVTQACICGSDLWPYRAMEPSETGQSMGHEAIGVV
CCCCCCEEECCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCHHHHHHH
EAIGSGVNKIKVGDVVIMPFAYSDGRCEFCHEGLQTACVHGGFFGYGGFNGAQAEALRIP
HHHCCCCCEEEECCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEECC
QADGTLYALPGGVDSALMASLLTLSDVMGTGHHAARVARVRPGTSAAVIGDGAVGLCGVI
CCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHEEEECCCCCEEEECCCHHHHHHHH
AAKRLGAERIILMGRHPDRIALAQAFGATDIVSERGEEAIERVRALTGGHGVHSVLECVG
HHHHCCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHC
TDQSMQTAANIARPGGAVGRVGVPHYNAIPADTTFFKNVIVGGGPAPVRAYIDDLLPDVL
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
DGKIQPGRVFDRVIGLDEVPDGYRAMDERQAIKVMINL
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]