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The map label for this gene is adhC2 [H]

Identifier: 17545324

GI number: 17545324

Start: 651399

End: 652505

Strand: Reverse

Name: adhC2 [H]

Synonym: RSc0605

Alternate gene names: 17545324

Gene position: 652505-651399 (Counterclockwise)

Preceding gene: 17545326

Following gene: 17545323

Centisome position: 17.56

GC content: 66.31

Gene sequence:

>1107_bases
ATGAAAACCAAAGCCGCCATCGCCTGGAAATCCGGCGCGCCGCTGACCATCGAAGACGTGGATCTGCAAGGCCCGCGCGC
CGGCGAAGTGCTGGTCGAGATCAAGGCCACCGGCATTTGCCACACCGACTACTACACGCTGTCGGGCGCGGACCCCGAAG
GCATCTTCCCGGCCATCCTCGGCCACGAGGGCGCGGGCGTGGTGCTCGACGTGGGCGCGGGCGTGACCTCGCTGAAGGCC
GGCGACCACGTGATCCCGCTCTATACGCCCGAATGCCGCCAGTGCAAGTTCTGCCTGTCGCGCAAGACCAACCTGTGCCA
GGCGATCCGTGCCACGCAGGGCAAGGGGCTGATGCCGGACGGCACCTCGCGCTTCTCGATCGACGGCAAGCCGATCTTCC
ACTACATGGGCACCTCCACCTTCGCCAACCACATCGTGGTGCCGGAGATCGCACTGGCGAAGATCCGCCCCGACGCGCCG
TTCGACAAGGTCTGCTACATCGGCTGCGGCGTCACCACCGGCGTGGGCGCGGTGGTCTACACGGCCAAGGTTGAGGCCGG
CGCCAACGTGGTGGTGTTCGGCCTGGGCGGCATCGGCCTGAACGTGATCCAGGGCGCGAAAATGGTGGGCGCCGACAAGA
TCATCGGCGTCGACCTGAACCCGGCGCGCGAGGCGATGGCGCGCAAGTTCGGCATGACGCATTTCGTCAACCCGAAGGAA
GTCGGCAACGTGGTCGACCACATCATCCAGCTCACCGACGGCGGCGCTGACTATTCCTTCGAGTGCATCGGCAACACGCA
GGTCATGCGCCAGGCGCTGGAGTGCTGCCACAAGGGCTGGGGCAAGTCGATCATCATCGGCGTGGCCGAGGCCGGCGCGG
AGATCAGCACGCGCCCGTTCCAGCTCGTCACCGGCCGCGAGTGGAAAGGCTCGGCCTTCGGCGGCGCGCGCGGGCGCACC
GACGTGCCGAAGATCGTCGACTGGTACATGGAAGGCAAGCTCAACATCGACGACCTGATCACGCACACGCTGCCGCTCGA
GCGCATCAACGAGGGCTTCGACCTGATGAAGCGCGGCGAGTCGATCCGCTCGGTGGTCCTGTACTGA

Upstream 100 bases:

>100_bases
CCTGGGGGACGCTACCGCCCAGGCCCGGAAAACAGGCCCGGGCGGGCCGTACAATCCCAAACGTTTGCTGTGCCTACCCC
CTCACTGGAGACTGCCCCGC

Downstream 100 bases:

>100_bases
GGAGGGCGCGATGAGCCAATCACCGACACTCGAACTGCTCTCGGAGCACGCCTGCTTCGGCGGCGTGCAGCGCTTTTACC
GGCACGCCTCGGCGGCGATC

Product: bifunctional: glutathione-dependent formaldehyde dehydrogenase/alcohol dehydrogenase class III

Products: NA

Alternate protein names: Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MKTKAAIAWKSGAPLTIEDVDLQGPRAGEVLVEIKATGICHTDYYTLSGADPEGIFPAILGHEGAGVVLDVGAGVTSLKA
GDHVIPLYTPECRQCKFCLSRKTNLCQAIRATQGKGLMPDGTSRFSIDGKPIFHYMGTSTFANHIVVPEIALAKIRPDAP
FDKVCYIGCGVTTGVGAVVYTAKVEAGANVVVFGLGGIGLNVIQGAKMVGADKIIGVDLNPAREAMARKFGMTHFVNPKE
VGNVVDHIIQLTDGGADYSFECIGNTQVMRQALECCHKGWGKSIIIGVAEAGAEISTRPFQLVTGREWKGSAFGGARGRT
DVPKIVDWYMEGKLNIDDLITHTLPLERINEGFDLMKRGESIRSVVLY

Sequences:

>Translated_368_residues
MKTKAAIAWKSGAPLTIEDVDLQGPRAGEVLVEIKATGICHTDYYTLSGADPEGIFPAILGHEGAGVVLDVGAGVTSLKA
GDHVIPLYTPECRQCKFCLSRKTNLCQAIRATQGKGLMPDGTSRFSIDGKPIFHYMGTSTFANHIVVPEIALAKIRPDAP
FDKVCYIGCGVTTGVGAVVYTAKVEAGANVVVFGLGGIGLNVIQGAKMVGADKIIGVDLNPAREAMARKFGMTHFVNPKE
VGNVVDHIIQLTDGGADYSFECIGNTQVMRQALECCHKGWGKSIIIGVAEAGAEISTRPFQLVTGREWKGSAFGGARGRT
DVPKIVDWYMEGKLNIDDLITHTLPLERINEGFDLMKRGESIRSVVLY
>Mature_368_residues
MKTKAAIAWKSGAPLTIEDVDLQGPRAGEVLVEIKATGICHTDYYTLSGADPEGIFPAILGHEGAGVVLDVGAGVTSLKA
GDHVIPLYTPECRQCKFCLSRKTNLCQAIRATQGKGLMPDGTSRFSIDGKPIFHYMGTSTFANHIVVPEIALAKIRPDAP
FDKVCYIGCGVTTGVGAVVYTAKVEAGANVVVFGLGGIGLNVIQGAKMVGADKIIGVDLNPAREAMARKFGMTHFVNPKE
VGNVVDHIIQLTDGGADYSFECIGNTQVMRQALECCHKGWGKSIIIGVAEAGAEISTRPFQLVTGREWKGSAFGGARGRT
DVPKIVDWYMEGKLNIDDLITHTLPLERINEGFDLMKRGESIRSVVLY

Specific function: Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=367, Percent_Identity=60.7629427792915, Blast_Score=460, Evalue=1e-129,
Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=46.070460704607, Blast_Score=354, Evalue=7e-98,
Organism=Homo sapiens, GI71565152, Length=374, Percent_Identity=45.9893048128342, Blast_Score=354, Evalue=7e-98,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=45.2574525745258, Blast_Score=347, Evalue=7e-96,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=44.9864498644986, Blast_Score=342, Evalue=5e-94,
Organism=Homo sapiens, GI262073058, Length=370, Percent_Identity=44.5945945945946, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI71743840, Length=370, Percent_Identity=44.5945945945946, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI156523966, Length=368, Percent_Identity=44.2934782608696, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=44.3213296398892, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI156627571, Length=361, Percent_Identity=26.0387811634349, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=57.9945799457995, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI87082125, Length=382, Percent_Identity=26.4397905759162, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1790045, Length=376, Percent_Identity=28.1914893617021, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1788073, Length=362, Percent_Identity=27.3480662983425, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1786825, Length=400, Percent_Identity=25.25, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787863, Length=356, Percent_Identity=25.8426966292135, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI226510992, Length=373, Percent_Identity=24.1286863270777, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI87081918, Length=342, Percent_Identity=27.7777777777778, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1786518, Length=367, Percent_Identity=24.5231607629428, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=54.4235924932976, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=54.1333333333333, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=54.5189504373178, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562584, Length=366, Percent_Identity=27.8688524590164, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=359, Percent_Identity=27.8551532033426, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17562582, Length=343, Percent_Identity=26.2390670553936, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=372, Percent_Identity=26.6129032258064, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562878, Length=356, Percent_Identity=25.8426966292135, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=54.177897574124, Blast_Score=432, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319621, Length=370, Percent_Identity=27.5675675675676, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=372, Percent_Identity=29.0322580645161, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324486, Length=374, Percent_Identity=27.0053475935829, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323729, Length=366, Percent_Identity=27.0491803278689, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323961, Length=365, Percent_Identity=26.027397260274, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=365, Percent_Identity=28.4931506849315, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=365, Percent_Identity=28.4931506849315, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=361, Percent_Identity=24.0997229916898, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=61.1413043478261, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI17137530, Length=341, Percent_Identity=27.8592375366569, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17737897, Length=341, Percent_Identity=27.5659824046921, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1; =1.1.1.284 [H]

Molecular weight: Translated: 39323; Mature: 39323

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKAAIAWKSGAPLTIEDVDLQGPRAGEVLVEIKATGICHTDYYTLSGADPEGIFPAIL
CCCCEEEEECCCCCEEEEECCCCCCCCCCEEEEEEECEEEECCEEEECCCCCCCCCHHHH
GHEGAGVVLDVGAGVTSLKAGDHVIPLYTPECRQCKFCLSRKTNLCQAIRATQGKGLMPD
CCCCCCEEEECCCCEEEECCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCC
GTSRFSIDGKPIFHYMGTSTFANHIVVPEIALAKIRPDAPFDKVCYIGCGVTTGVGAVVY
CCCEEEECCCEEEEECCCHHHHCCEECCCEEEEEECCCCCCCCEEEEECCCHHCCCEEEE
TAKVEAGANVVVFGLGGIGLNVIQGAKMVGADKIIGVDLNPAREAMARKFGMTHFVNPKE
EEEECCCCCEEEEECCCCCHHHHCCCEEECCCEEEEECCCHHHHHHHHHHCCCCCCCHHH
VGNVVDHIIQLTDGGADYSFECIGNTQVMRQALECCHKGWGKSIIIGVAEAGAEISTRPF
HHHHHHHHHEECCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCE
QLVTGREWKGSAFGGARGRTDVPKIVDWYMEGKLNIDDLITHTLPLERINEGFDLMKRGE
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHCCHHHHHCCC
SIRSVVLY
HHHHEECC
>Mature Secondary Structure
MKTKAAIAWKSGAPLTIEDVDLQGPRAGEVLVEIKATGICHTDYYTLSGADPEGIFPAIL
CCCCEEEEECCCCCEEEEECCCCCCCCCCEEEEEEECEEEECCEEEECCCCCCCCCHHHH
GHEGAGVVLDVGAGVTSLKAGDHVIPLYTPECRQCKFCLSRKTNLCQAIRATQGKGLMPD
CCCCCCEEEECCCCEEEECCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHCCCCCCCCC
GTSRFSIDGKPIFHYMGTSTFANHIVVPEIALAKIRPDAPFDKVCYIGCGVTTGVGAVVY
CCCEEEECCCEEEEECCCHHHHCCEECCCEEEEEECCCCCCCCEEEEECCCHHCCCEEEE
TAKVEAGANVVVFGLGGIGLNVIQGAKMVGADKIIGVDLNPAREAMARKFGMTHFVNPKE
EEEECCCCCEEEEECCCCCHHHHCCCEEECCCEEEEECCCHHHHHHHHHHCCCCCCCHHH
VGNVVDHIIQLTDGGADYSFECIGNTQVMRQALECCHKGWGKSIIIGVAEAGAEISTRPF
HHHHHHHHHEECCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCE
QLVTGREWKGSAFGGARGRTDVPKIVDWYMEGKLNIDDLITHTLPLERINEGFDLMKRGE
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCHHHHHCCHHHHHCCC
SIRSVVLY
HHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631716 [H]