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The map label for this gene is strD [H]

Identifier: 17545230

GI number: 17545230

Start: 548121

End: 548846

Strand: Reverse

Name: strD [H]

Synonym: RSc0511

Alternate gene names: 17545230

Gene position: 548846-548121 (Counterclockwise)

Preceding gene: 17545231

Following gene: 17545228

Centisome position: 14.77

GC content: 74.1

Gene sequence:

>726_bases
ATGAAAGCGATGATCTTCGCCGCCGGCCGCGGCGACCGCATGCGGCCGCTGACCGACCGCACCCCCAAGCCGCTGCTGCC
CGTGGGCGGCAAGCCGCTGATCGTCTGGCAGATCGAGCGCCTGGCGGCGGCGGGCGTGCGCGATATCGTCATCAACCATG
CATGGCTCGGCGCGCAGATCGAAGCGGCGCTGGGCGACGGCGGCGCCTGGGGCGTGCGCCTGGCGTACTCCCCCGAGAGC
GAAGCGCTGGAGACCGCCGGCGGCGTGGTCCAGGCCCTGCCCCTGCTGCACACGGGCGATGCCCACAGCGTCTTCATCGC
GGTCAGCGGCGACGTGTTCTGCGACTACGACTACGCCGCGCTGCGCGAGCACGCCCAGGCGCTGGCCGCCCGGCCCGCGC
CCGGCATGCACCTGGTGATGGTGCCCAACCCGCCCTACCACCCGCGCGGCGATTTCGCCCTGGCCGCCGACGGCCGCCTG
TACGGCGACGATGCGCCGGCCGGCATCCCGCGCCTGACGTTCGGCAACATCGGGCTATACGACACGCGGCTGTTCGACGG
CATCGCGCCCGGCACGCGGCTGGCGATGACGCCTCTATACCGCCGCGCCATCGCCGCGGGCCAGGCCACCGGCGAACGCT
TCGACGGCCCATGGGAGAACGTCGGCACGCCGGCCCAGCTGGCGGCGCTGGACGCGGCGCTGAGCGCGCCGTCGCGGTCG
GCCTAG

Upstream 100 bases:

>100_bases
CCGGCCTCGTCGCCATCGTCATCGCGCGCATGACCCGCAGCGCGATGTGGACCATCGTCGGCGGCATGGCGGTCCTGCTG
ATCCTGATGAAGGCAATGGC

Downstream 100 bases:

>100_bases
GCCCGCGCTTCGGCCGCCATCGCCTGGAGGCCCTGCGCCTGCGCCAGCCCGGCGGCCTCGAGCACCGCCTGCGCCGTCAT
CGGCCGGCCCAGCAGGTTGC

Product: mannose-1-phosphate guanyltransferase-related protein

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MKAMIFAAGRGDRMRPLTDRTPKPLLPVGGKPLIVWQIERLAAAGVRDIVINHAWLGAQIEAALGDGGAWGVRLAYSPES
EALETAGGVVQALPLLHTGDAHSVFIAVSGDVFCDYDYAALREHAQALAARPAPGMHLVMVPNPPYHPRGDFALAADGRL
YGDDAPAGIPRLTFGNIGLYDTRLFDGIAPGTRLAMTPLYRRAIAAGQATGERFDGPWENVGTPAQLAALDAALSAPSRS
A

Sequences:

>Translated_241_residues
MKAMIFAAGRGDRMRPLTDRTPKPLLPVGGKPLIVWQIERLAAAGVRDIVINHAWLGAQIEAALGDGGAWGVRLAYSPES
EALETAGGVVQALPLLHTGDAHSVFIAVSGDVFCDYDYAALREHAQALAARPAPGMHLVMVPNPPYHPRGDFALAADGRL
YGDDAPAGIPRLTFGNIGLYDTRLFDGIAPGTRLAMTPLYRRAIAAGQATGERFDGPWENVGTPAQLAALDAALSAPSRS
A
>Mature_241_residues
MKAMIFAAGRGDRMRPLTDRTPKPLLPVGGKPLIVWQIERLAAAGVRDIVINHAWLGAQIEAALGDGGAWGVRLAYSPES
EALETAGGVVQALPLLHTGDAHSVFIAVSGDVFCDYDYAALREHAQALAARPAPGMHLVMVPNPPYHPRGDFALAADGRL
YGDDAPAGIPRLTFGNIGLYDTRLFDGIAPGTRLAMTPLYRRAIAAGQATGERFDGPWENVGTPAQLAALDAALSAPSRS
A

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=132, Percent_Identity=37.8787878787879, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI11761619, Length=132, Percent_Identity=37.8787878787879, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI133931050, Length=124, Percent_Identity=37.9032258064516, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=128, Percent_Identity=37.5, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355443, Length=121, Percent_Identity=35.5371900826446, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24644084, Length=121, Percent_Identity=35.5371900826446, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24653912, Length=147, Percent_Identity=34.0136054421769, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 25395; Mature: 25395

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00785 5_NUCLEOTIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMIFAAGRGDRMRPLTDRTPKPLLPVGGKPLIVWQIERLAAAGVRDIVINHAWLGAQI
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHCCHHHHEEECEECCEEE
EAALGDGGAWGVRLAYSPESEALETAGGVVQALPLLHTGDAHSVFIAVSGDVFCDYDYAA
EEEECCCCCEEEEEEECCCHHHHHHHCCHHHHHHEEECCCCCEEEEEEECCEEECCCHHH
LREHAQALAARPAPGMHLVMVPNPPYHPRGDFALAADGRLYGDDAPAGIPRLTFGNIGLY
HHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEECCEEECCCCCCCCCEEEECCCCCC
DTRLFDGIAPGTRLAMTPLYRRAIAAGQATGERFDGPWENVGTPAQLAALDAALSAPSRS
HHHHHHCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCCCC
A
C
>Mature Secondary Structure
MKAMIFAAGRGDRMRPLTDRTPKPLLPVGGKPLIVWQIERLAAAGVRDIVINHAWLGAQI
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHCCHHHHEEECEECCEEE
EAALGDGGAWGVRLAYSPESEALETAGGVVQALPLLHTGDAHSVFIAVSGDVFCDYDYAA
EEEECCCCCEEEEEEECCCHHHHHHHCCHHHHHHEEECCCCCEEEEEEECCEEECCCHHH
LREHAQALAARPAPGMHLVMVPNPPYHPRGDFALAADGRLYGDDAPAGIPRLTFGNIGLY
HHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEECCEEECCCCCCCCCEEEECCCCCC
DTRLFDGIAPGTRLAMTPLYRRAIAAGQATGERFDGPWENVGTPAQLAALDAALSAPSRS
HHHHHHCCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]