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The map label for this gene is pepP [H]

Identifier: 17545228

GI number: 17545228

Start: 544431

End: 545807

Strand: Reverse

Name: pepP [H]

Synonym: RSc0509

Alternate gene names: 17545228

Gene position: 545807-544431 (Counterclockwise)

Preceding gene: 17545230

Following gene: 17545227

Centisome position: 14.69

GC content: 72.26

Gene sequence:

>1377_bases
ATGTCCGCCACCGAACTCGCCTTCCTCCAGACCACCCGCCAGCGCCGCGAGCGCATCGCGCAATGGCTGCGCGCGGCGGG
CGGCGGCGTCGCCATCGTCCCGACCGCACCGGAAACCATGCGCAACCGCGACAGCGACTACCCCTACCGGCACGACAGCT
ACTTCTACTACCTGACCGGCTTCACCGAGCCCGAGGCGGTGCTGGCCATCGTGGTGCCGGCCGGCGGCGCGCCGGCGCGC
AGCGTGCTGTTCTGCCGCCCCAAGCACGAGGAGCGCGAAATCTGGGACGGCTTCCGCTTCGGCCCCGAAGCCGCCCGGGA
AGCCTTCGGCCTGGACGAAGCGCATTCGGTCGACGAGATCGACGCGACGCTGCCGGGCCTGCTCGCCAATGCGGCCGCCG
TGGCCTATCCGCTGGCCGAGACCGGCGTCTTCGACCGCCGCATGCGCCGCTGGCTCGACGCCGTGCGCATGCAGGGCCGC
GCCGGCGTGTCGGCGCCGCACCAGGCGCTGGACGTGCGCGCCATCCTCGACGAGATGCGCCTGTTCAAGGACGCGGGCGA
GCTCGACATCATGCGCCGCGCCGCGCGCATCTCCGCCGGGGCGCATGTGCGCGCCATGCGGACCTCGCGCGCCGGCCTGC
GCGAGTACCACCTCGAGGCCGAGCTGCTCTACGAATTCCGCCGCCACGGCGCGCAGAGCGTCGCCTACAACTCCATCGTC
GCCACCGGGCCAAATGCCTGCGTGCTGCACTACCGCGCCGGCAATGCCGAGCTGCGCGACGGCGACCTGTGCCTGATCGA
TGCCGGCTGCGAGCTCGACGGCTATGCCTCCGACATCACCCGCACCTTCCCCGTCAACGGGCGCTTCTCCGGCCCGCAGC
GCGCGCTCTACGACCTCGTGGTGGCCGCGCAGGAGGCCGCCATCGCGCAAACCCGGCCGGGCGTCCCGTACAACGTGCCG
CACGATGCCGCCACGCGCGTGCTGGCGCAGGGCATGCTCGACACCGGCCTGCTGGACGCGAACCGGGTCGGCACGCTCGA
CGACGTGCTCGCCGGCGGCCAGTACCGCCAGTTCTACATGCACCGCACCGGCCACTGGCTGGGCATGGACGTGCACGACG
TGGGCGAATACCGTACGCCCGGCGCGGCGCCCGTCCAGGGCGAGCGCCCGTGGCGCCCGCTCGAGGCCGGCATGGTGCTG
ACCGTCGAGCCCGGCCTCTACGTGCGTCCAGCGCCGGACGTGCCTGAGGCGTTCTGGCACATCGGCATCCGCATCGAGGA
CGATGCCATCGTCACGCCGCAGGGCTGCGAGCTGATCACGCGCGATGTGCCGGTGGCCGCGGACGACATCGAAGCGCTGA
TGCGCAGCCAGGCATGA

Upstream 100 bases:

>100_bases
AAGGAAATGTAAACGCCGGATCGAACGCCGGCGCCACGTGGCCAAGGCCGCCAATCGCAGCGTTACAATCGGCCATCCCC
GTCATCCCTGGGCCCGCGCC

Downstream 100 bases:

>100_bases
CCGATACCGCGGCGGCCACGCCGGACTTCGACATCGCCATCGTCGGCGCCGGGCCGGTCGGTCTGGCGCTGGCCAACTGG
CTGCTGCGCGACACCGACTG

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSATELAFLQTTRQRRERIAQWLRAAGGGVAIVPTAPETMRNRDSDYPYRHDSYFYYLTGFTEPEAVLAIVVPAGGAPAR
SVLFCRPKHEEREIWDGFRFGPEAAREAFGLDEAHSVDEIDATLPGLLANAAAVAYPLAETGVFDRRMRRWLDAVRMQGR
AGVSAPHQALDVRAILDEMRLFKDAGELDIMRRAARISAGAHVRAMRTSRAGLREYHLEAELLYEFRRHGAQSVAYNSIV
ATGPNACVLHYRAGNAELRDGDLCLIDAGCELDGYASDITRTFPVNGRFSGPQRALYDLVVAAQEAAIAQTRPGVPYNVP
HDAATRVLAQGMLDTGLLDANRVGTLDDVLAGGQYRQFYMHRTGHWLGMDVHDVGEYRTPGAAPVQGERPWRPLEAGMVL
TVEPGLYVRPAPDVPEAFWHIGIRIEDDAIVTPQGCELITRDVPVAADDIEALMRSQA

Sequences:

>Translated_458_residues
MSATELAFLQTTRQRRERIAQWLRAAGGGVAIVPTAPETMRNRDSDYPYRHDSYFYYLTGFTEPEAVLAIVVPAGGAPAR
SVLFCRPKHEEREIWDGFRFGPEAAREAFGLDEAHSVDEIDATLPGLLANAAAVAYPLAETGVFDRRMRRWLDAVRMQGR
AGVSAPHQALDVRAILDEMRLFKDAGELDIMRRAARISAGAHVRAMRTSRAGLREYHLEAELLYEFRRHGAQSVAYNSIV
ATGPNACVLHYRAGNAELRDGDLCLIDAGCELDGYASDITRTFPVNGRFSGPQRALYDLVVAAQEAAIAQTRPGVPYNVP
HDAATRVLAQGMLDTGLLDANRVGTLDDVLAGGQYRQFYMHRTGHWLGMDVHDVGEYRTPGAAPVQGERPWRPLEAGMVL
TVEPGLYVRPAPDVPEAFWHIGIRIEDDAIVTPQGCELITRDVPVAADDIEALMRSQA
>Mature_457_residues
SATELAFLQTTRQRRERIAQWLRAAGGGVAIVPTAPETMRNRDSDYPYRHDSYFYYLTGFTEPEAVLAIVVPAGGAPARS
VLFCRPKHEEREIWDGFRFGPEAAREAFGLDEAHSVDEIDATLPGLLANAAAVAYPLAETGVFDRRMRRWLDAVRMQGRA
GVSAPHQALDVRAILDEMRLFKDAGELDIMRRAARISAGAHVRAMRTSRAGLREYHLEAELLYEFRRHGAQSVAYNSIVA
TGPNACVLHYRAGNAELRDGDLCLIDAGCELDGYASDITRTFPVNGRFSGPQRALYDLVVAAQEAAIAQTRPGVPYNVPH
DAATRVLAQGMLDTGLLDANRVGTLDDVLAGGQYRQFYMHRTGHWLGMDVHDVGEYRTPGAAPVQGERPWRPLEAGMVLT
VEPGLYVRPAPDVPEAFWHIGIRIEDDAIVTPQGCELITRDVPVAADDIEALMRSQA

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=455, Percent_Identity=32.0879120879121, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI149589008, Length=484, Percent_Identity=31.404958677686, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI260593665, Length=306, Percent_Identity=35.9477124183007, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI260593663, Length=259, Percent_Identity=35.9073359073359, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI1789275, Length=445, Percent_Identity=43.8202247191011, Blast_Score=367, Evalue=1e-103,
Organism=Escherichia coli, GI1788728, Length=302, Percent_Identity=32.4503311258278, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790282, Length=308, Percent_Identity=30.1948051948052, Blast_Score=99, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17508215, Length=477, Percent_Identity=31.2368972746331, Blast_Score=191, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI71989583, Length=381, Percent_Identity=26.7716535433071, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320922, Length=418, Percent_Identity=28.4688995215311, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6321118, Length=434, Percent_Identity=29.0322580645161, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI19920384, Length=466, Percent_Identity=34.3347639484979, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI21357079, Length=449, Percent_Identity=32.0712694877506, Blast_Score=202, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 50476; Mature: 50344

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATELAFLQTTRQRRERIAQWLRAAGGGVAIVPTAPETMRNRDSDYPYRHDSYFYYLTG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHCCCCCCCCCCCCEEEEEEC
FTEPEAVLAIVVPAGGAPARSVLFCRPKHEEREIWDGFRFGPEAAREAFGLDEAHSVDEI
CCCCCEEEEEEEECCCCCCCCEEEECCCCCHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
DATLPGLLANAAAVAYPLAETGVFDRRMRRWLDAVRMQGRAGVSAPHQALDVRAILDEMR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
LFKDAGELDIMRRAARISAGAHVRAMRTSRAGLREYHLEAELLYEFRRHGAQSVAYNSIV
HHHCCCHHHHHHHHHHHCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHCCEE
ATGPNACVLHYRAGNAELRDGDLCLIDAGCELDGYASDITRTFPVNGRFSGPQRALYDLV
ECCCCEEEEEEECCCCEECCCCEEEEECCCCCCCCHHHCCEECCCCCCCCCHHHHHHHHH
VAAQEAAIAQTRPGVPYNVPHDAATRVLAQGMLDTGLLDANRVGTLDDVLAGGQYRQFYM
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHEE
HRTGHWLGMDVHDVGEYRTPGAAPVQGERPWRPLEAGMVLTVEPGLYVRPAPDVPEAFWH
CCCCCEECCCHHHCCCCCCCCCCCCCCCCCCCCHHCCEEEEECCCEEECCCCCCCHHHEE
IGIRIEDDAIVTPQGCELITRDVPVAADDIEALMRSQA
EEEEECCCEEECCCCCEEEECCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SATELAFLQTTRQRRERIAQWLRAAGGGVAIVPTAPETMRNRDSDYPYRHDSYFYYLTG
CCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHCCCCCCCCCCCCEEEEEEC
FTEPEAVLAIVVPAGGAPARSVLFCRPKHEEREIWDGFRFGPEAAREAFGLDEAHSVDEI
CCCCCEEEEEEEECCCCCCCCEEEECCCCCHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
DATLPGLLANAAAVAYPLAETGVFDRRMRRWLDAVRMQGRAGVSAPHQALDVRAILDEMR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
LFKDAGELDIMRRAARISAGAHVRAMRTSRAGLREYHLEAELLYEFRRHGAQSVAYNSIV
HHHCCCHHHHHHHHHHHCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHCCEE
ATGPNACVLHYRAGNAELRDGDLCLIDAGCELDGYASDITRTFPVNGRFSGPQRALYDLV
ECCCCEEEEEEECCCCEECCCCEEEEECCCCCCCCHHHCCEECCCCCCCCCHHHHHHHHH
VAAQEAAIAQTRPGVPYNVPHDAATRVLAQGMLDTGLLDANRVGTLDDVLAGGQYRQFYM
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHEE
HRTGHWLGMDVHDVGEYRTPGAAPVQGERPWRPLEAGMVLTVEPGLYVRPAPDVPEAFWH
CCCCCEECCCHHHCCCCCCCCCCCCCCCCCCCCHHCCEEEEECCCEEECCCCCCCHHHEE
IGIRIEDDAIVTPQGCELITRDVPVAADDIEALMRSQA
EEEEECCCEEECCCCCEEEECCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]