Click here to switch to the map view.

The map label for this gene is dtd

Identifier: 17545216

GI number: 17545216

Start: 532855

End: 533355

Strand: Direct

Name: dtd

Synonym: RSc0497

Alternate gene names: 17545216

Gene position: 532855-533355 (Clockwise)

Preceding gene: 17545215

Following gene: 17545217

Centisome position: 14.34

GC content: 70.86

Gene sequence:

>501_bases
GTGATCGGTCTGATCCAGCGCGTCTCGCAGGCGGCGGTGCGGGTCGATGGCCGCGTGGTCGGCGAGATCGGGCCGGGCCT
GCTGGCGCTGGTGTGCGCCGAGCGTGGCGATACCGTCGCCGAGGCCGACCGCCTGCTGGAGAAGCTGCTGAACTACCGTG
TGTTCTCCGATGCGCAGGGCAAGATGAACCTGCCGGTGCGCAACATCGACGGCAACGGGCTGGCAGGCGGCTTGCTGGTG
GTATCGCAGTTCACGCTGGCGGCCGATACCAAGTCCGGCACGCGGCCGAGCTTCACGCCGGCGGCGGCGCCCGAGGCGGG
CCGCCGCCTGTATGAGCATTTCGTGGCGCGGGCACGGCAGCAGCATCCCATCGTCGCGACCGGCGAGTTCGGCGCGATGA
TGCAGGTGTCGCTGGTCAACGACGGCCCGGTCACGTTCTGGCTGCAGGTGGCGCCGCAGGCCGTGCGCGCCGGCGAGGCC
GAGACCGCGAAATCCGCCTGA

Upstream 100 bases:

>100_bases
AGATCGACGGCACCGTCATCAGCGACAAGGGGCTGAAGGTCGAGGCCGGCACCTTTGTGATGCAGGTGGGCAAGCGGCGC
TTTGCGCGCGTGGTGCTGTC

Downstream 100 bases:

>100_bases
TCACCAGGAGGGGCACGATGAAGCTGACTTCCGACGTCATTCACCGCGACGCGCCGATTCCCGTCGAATGTGTCGAAGGC
CACGCGCTGGCCGAGGCGTC

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MIGLIQRVSQAAVRVDGRVVGEIGPGLLALVCAERGDTVAEADRLLEKLLNYRVFSDAQGKMNLPVRNIDGNGLAGGLLV
VSQFTLAADTKSGTRPSFTPAAAPEAGRRLYEHFVARARQQHPIVATGEFGAMMQVSLVNDGPVTFWLQVAPQAVRAGEA
ETAKSA

Sequences:

>Translated_166_residues
MIGLIQRVSQAAVRVDGRVVGEIGPGLLALVCAERGDTVAEADRLLEKLLNYRVFSDAQGKMNLPVRNIDGNGLAGGLLV
VSQFTLAADTKSGTRPSFTPAAAPEAGRRLYEHFVARARQQHPIVATGEFGAMMQVSLVNDGPVTFWLQVAPQAVRAGEA
ETAKSA
>Mature_166_residues
MIGLIQRVSQAAVRVDGRVVGEIGPGLLALVCAERGDTVAEADRLLEKLLNYRVFSDAQGKMNLPVRNIDGNGLAGGLLV
VSQFTLAADTKSGTRPSFTPAAAPEAGRRLYEHFVARARQQHPIVATGEFGAMMQVSLVNDGPVTFWLQVAPQAVRAGEA
ETAKSA

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=151, Percent_Identity=36.4238410596026, Blast_Score=87, Evalue=7e-18,
Organism=Escherichia coli, GI1790320, Length=150, Percent_Identity=58.6666666666667, Blast_Score=175, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI115533292, Length=145, Percent_Identity=38.6206896551724, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319982, Length=148, Percent_Identity=43.9189189189189, Blast_Score=112, Evalue=4e-26,
Organism=Drosophila melanogaster, GI281361569, Length=155, Percent_Identity=37.4193548387097, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_RALSO (Q8Y239)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_518618.1
- ProteinModelPortal:   Q8Y239
- SMR:   Q8Y239
- GeneID:   1219301
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc0497
- NMPDR:   fig|267608.1.peg.497
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- ProtClustDB:   PRK05273
- BioCyc:   RSOL267608:RSC0497-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 17582; Mature: 17582

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: NA

Important sites: ACT_SITE 85-85

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGLIQRVSQAAVRVDGRVVGEIGPGLLALVCAERGDTVAEADRLLEKLLNYRVFSDAQG
CCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCCCCC
KMNLPVRNIDGNGLAGGLLVVSQFTLAADTKSGTRPSFTPAAAPEAGRRLYEHFVARARQ
CCCCCEEECCCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QHPIVATGEFGAMMQVSLVNDGPVTFWLQVAPQAVRAGEAETAKSA
CCCEEEECCCCCEEEEEEECCCCEEEEEEECHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIGLIQRVSQAAVRVDGRVVGEIGPGLLALVCAERGDTVAEADRLLEKLLNYRVFSDAQG
CCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCCCCC
KMNLPVRNIDGNGLAGGLLVVSQFTLAADTKSGTRPSFTPAAAPEAGRRLYEHFVARARQ
CCCCCEEECCCCCCHHHHHHHHHHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QHPIVATGEFGAMMQVSLVNDGPVTFWLQVAPQAVRAGEAETAKSA
CCCEEEECCCCCEEEEEEECCCCEEEEEEECHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852