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The map label for this gene is bioC [H]

Identifier: 17545079

GI number: 17545079

Start: 389941

End: 391044

Strand: Direct

Name: bioC [H]

Synonym: RSc0360

Alternate gene names: 17545079

Gene position: 389941-391044 (Clockwise)

Preceding gene: 17545076

Following gene: 17545080

Centisome position: 10.49

GC content: 69.93

Gene sequence:

>1104_bases
ATGGCGGAGGCCGGCGGCGAGCCGGTGCAGCAGGAGCGGGACGGGCATGGCAAAAAGCCCCATCGAAACCGATCGGCGCG
CGCCGCGCCATCGGACAGCGCCCCGAAATGGCCCGCCGGTATACTGAGCGGCCGCAGCACATTGCCTCGTGTTTCCTGTC
CGATGTCCGATCCCGTTCTTGCCCGTCCCGCCGCGCTGCGGCGCGCCTTCGACCGCCGCGCCGCGCGCTTTGCCGAGGCG
GATTTCCTGCTGCGCGAGGTGGGGCAGCGGATGCAGGACAGGCTGTCATACATCAAGCTCACGCCCGCCCGTGCACTGGA
CCTGGGCTGCGGCCTCGGTCAGGGCCTGGCGGTGCTGCGCGCGCAGTACCCCGACGCGCAGATCTGCGGGCTGGACTGGT
CGGCCGCCATGCTGGCCCGCGCGCGCCAGCTCGATCCGCAGCACAGCGATGGCGGCTGGCTGGGCCGGCTGCTGAAGAAG
CGGCCGGTGTTCGATTTCGCCCAGGCGGATTTCCGTGCGCTGCCGTTTGCCGATGCGTCGTTCGATCTGCTGTGGTCCAA
CCTGGCGCTGCACTGGGATCCGTCGCCGCACGCGATCTTTCCCGAATGGCACCGCGTGACGGCCGAGGGCGGCCTGCTGA
TGTTCAGCCTGTTCGGCCCCGACACCTTGCGCGAACTGCGCAGCGCGCTGGCCGGCATCGACGCCTCCGTGCATACGCTG
CGGTTTGTCGACATGCACGATATCGGCGACATGCTGGTGCACGGCCGCTGGTCCACGCCGGTCATGGACATGGAGCAGAT
CACCATCACCTACGAATCGCCCCAGGCCCTGCTGGCCGATGTGCACCTGCTGGGCGGCATGGCAGGCCTGGCGGATGGGG
ATGGCCGCGCGCTGTCGGGCCCGGGCCTGTACACGCCGCGCTGGCGCCAGCACCTGTTCGACGCGCTCGATGCCCAGCGC
AATCCCGACGGCCTGATTCCGCTCACGTTCGAAGTCGTCTATGGCCACGCATGGAAGCTGGCGCCCAACCCGAGGCAGGC
GCTGGACGAGCAGGGCCGGGCCATGATCCCGGTCGACCGGATCGGCCGCAGGCCGCGCGCCTGA

Upstream 100 bases:

>100_bases
AGCGGCGCCGATCCAGCAGCGGTGACATGTCCGCCATGCAGCCTGCGCAGACGAGGTCATGCTGGACGGCGCCGCACAGC
GCGCAGGCGCAGGGCAGCAG

Downstream 100 bases:

>100_bases
GGCCTGCGGGGCCGCCGCGTCGGCATCGGCGGCCCTTGTCAATCCGGGACTTGCATCAGCCGGCTTGCCTTGTTCGGGGT
CCGTTACGGCCATATAATGC

Product: biotin synthesis protein (methyltransferase)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MAEAGGEPVQQERDGHGKKPHRNRSARAAPSDSAPKWPAGILSGRSTLPRVSCPMSDPVLARPAALRRAFDRRAARFAEA
DFLLREVGQRMQDRLSYIKLTPARALDLGCGLGQGLAVLRAQYPDAQICGLDWSAAMLARARQLDPQHSDGGWLGRLLKK
RPVFDFAQADFRALPFADASFDLLWSNLALHWDPSPHAIFPEWHRVTAEGGLLMFSLFGPDTLRELRSALAGIDASVHTL
RFVDMHDIGDMLVHGRWSTPVMDMEQITITYESPQALLADVHLLGGMAGLADGDGRALSGPGLYTPRWRQHLFDALDAQR
NPDGLIPLTFEVVYGHAWKLAPNPRQALDEQGRAMIPVDRIGRRPRA

Sequences:

>Translated_367_residues
MAEAGGEPVQQERDGHGKKPHRNRSARAAPSDSAPKWPAGILSGRSTLPRVSCPMSDPVLARPAALRRAFDRRAARFAEA
DFLLREVGQRMQDRLSYIKLTPARALDLGCGLGQGLAVLRAQYPDAQICGLDWSAAMLARARQLDPQHSDGGWLGRLLKK
RPVFDFAQADFRALPFADASFDLLWSNLALHWDPSPHAIFPEWHRVTAEGGLLMFSLFGPDTLRELRSALAGIDASVHTL
RFVDMHDIGDMLVHGRWSTPVMDMEQITITYESPQALLADVHLLGGMAGLADGDGRALSGPGLYTPRWRQHLFDALDAQR
NPDGLIPLTFEVVYGHAWKLAPNPRQALDEQGRAMIPVDRIGRRPRA
>Mature_366_residues
AEAGGEPVQQERDGHGKKPHRNRSARAAPSDSAPKWPAGILSGRSTLPRVSCPMSDPVLARPAALRRAFDRRAARFAEAD
FLLREVGQRMQDRLSYIKLTPARALDLGCGLGQGLAVLRAQYPDAQICGLDWSAAMLARARQLDPQHSDGGWLGRLLKKR
PVFDFAQADFRALPFADASFDLLWSNLALHWDPSPHAIFPEWHRVTAEGGLLMFSLFGPDTLRELRSALAGIDASVHTLR
FVDMHDIGDMLVHGRWSTPVMDMEQITITYESPQALLADVHLLGGMAGLADGDGRALSGPGLYTPRWRQHLFDALDAQRN
PDGLIPLTFEVVYGHAWKLAPNPRQALDEQGRAMIPVDRIGRRPRA

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=313, Percent_Identity=26.8370607028754, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1786994, Length=235, Percent_Identity=28.5106382978723, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17535003, Length=322, Percent_Identity=25.1552795031056, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19922210, Length=343, Percent_Identity=29.1545189504373, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 40529; Mature: 40398

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAGGEPVQQERDGHGKKPHRNRSARAAPSDSAPKWPAGILSGRSTLPRVSCPMSDPVL
CCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCC
ARPAALRRAFDRRAARFAEADFLLREVGQRMQDRLSYIKLTPARALDLGCGLGQGLAVLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHCCCCCCCCHHHHH
AQYPDAQICGLDWSAAMLARARQLDPQHSDGGWLGRLLKKRPVFDFAQADFRALPFADAS
HCCCCCEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCCH
FDLLWSNLALHWDPSPHAIFPEWHRVTAEGGLLMFSLFGPDTLRELRSALAGIDASVHTL
HHHHHHCEEEEECCCCCCCCCHHHEEECCCCEEEEEECCCHHHHHHHHHHHCCCCCHHEE
RFVDMHDIGDMLVHGRWSTPVMDMEQITITYESPQALLADVHLLGGMAGLADGDGRALSG
EEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEECC
PGLYTPRWRQHLFDALDAQRNPDGLIPLTFEVVYGHAWKLAPNPRQALDEQGRAMIPVDR
CCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCEEECCCCHHHHHHHCCCEECCHHH
IGRRPRA
CCCCCCC
>Mature Secondary Structure 
AEAGGEPVQQERDGHGKKPHRNRSARAAPSDSAPKWPAGILSGRSTLPRVSCPMSDPVL
CCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCC
ARPAALRRAFDRRAARFAEADFLLREVGQRMQDRLSYIKLTPARALDLGCGLGQGLAVLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHCCCCCCCCHHHHH
AQYPDAQICGLDWSAAMLARARQLDPQHSDGGWLGRLLKKRPVFDFAQADFRALPFADAS
HCCCCCEEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHCCCCCCCCCCCH
FDLLWSNLALHWDPSPHAIFPEWHRVTAEGGLLMFSLFGPDTLRELRSALAGIDASVHTL
HHHHHHCEEEEECCCCCCCCCHHHEEECCCCEEEEEECCCHHHHHHHHHHHCCCCCHHEE
RFVDMHDIGDMLVHGRWSTPVMDMEQITITYESPQALLADVHLLGGMAGLADGDGRALSG
EEEEHHHHHHHHCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEECC
PGLYTPRWRQHLFDALDAQRNPDGLIPLTFEVVYGHAWKLAPNPRQALDEQGRAMIPVDR
CCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCEEECCCCHHHHHHHCCCEECCHHH
IGRRPRA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9063571 [H]