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The map label for this gene is gpsA

Identifier: 17545076

GI number: 17545076

Start: 387661

End: 388677

Strand: Direct

Name: gpsA

Synonym: RSc0357

Alternate gene names: 17545076

Gene position: 387661-388677 (Clockwise)

Preceding gene: 17545075

Following gene: 17545079

Centisome position: 10.43

GC content: 71.98

Gene sequence:

>1017_bases
ATGCGGATTTCCGTTCTGGGCGCGGGCGCCTGGGGCACGGCCCTGGCCAGCCACGCCGCGCAATCGCACGATGTCGTGCT
GTGGGGCCGCGACGCGGCACTGGTGGCCCAGATGGCGGCGACACGCGCCAACGAGCGCTACCTGCCGGGCATCCCGCTGC
ACGCATCGCTGCGTTTCGAGGCGGAGATGTCGGCCGCGCTCGATCATGCCACCGGGGAAGACGCGCTGGTCGTGATCGCC
TCGCCGGTCGCGGGGCTGGCCGACCTGACGCGCGGCGTGGCCGCGCATGGCGGCGTGCGCAACGTGATCTGGCTGTGCAA
GGGCTTCGACCCCGAGTCGGGCGCGCTGCCGCACGCCATTGTGGCCGGCGTGCTGGCGCAGACCGGGCGCGCCGATCTGG
CCACCGGTGCACTGTCCGGCCCGAGCTTCGCCAAGGAAGTCGCGCAGGGACTGCCGTGCGCGATGACGGTGGCGTCGGCC
AGCACCGCGCTGTGCACGCGCACTCAGCGCGCTTTCCATCACCATGCGATGCGCGTCTACGCGAGCGACGACCTCGTCGG
CGTGGAAGTGGGCGGCGCGGTGAAGAACGTGCTGGCCATTGCGACCGGCGCGGCGGATGGTCTGGGCCTGGGCCTCAATG
CGCGCGCCGCGCTGGTGACGCGCGGCCTGGCCGAGATGACGCGGTTGGGCACGGCACTGGGCGGCCGGCCGGAGACCTTC
ATGGGCCTGACCGGCATGGGCGATCTGCTGTTGACCGCCACCGGCGATCTCTCCCGCAACCGCACCGTCGGCATGCAGCT
CGCGCAGGGGCGTTCGCTGGATGAGATTCTGGCGCACCTCGGCCATGTCGCCGAGGGTGTGCGCTGCGCACGGGCGGTGG
CGGCTCTTGCGCGCGCCAAGGGCGTCGACATGCCGATCACCTTTGCCGTGTGCGAAGTCCTGTTCGATGGGCTGGCGCCG
TCGCGCGCCGTCGATCGCCTGCTGCAGCGCGACGCCAAGGCCGAATCCGTGCGCTGA

Upstream 100 bases:

>100_bases
GGCCACCCACTGAACACGATGGCGCATTGCGCCTGATGCCCGCGCCGGCCGACCGCTCGCGCGGGCATTTTTTTGCCTGA
CTGACTCACACTTCTAGCTC

Downstream 100 bases:

>100_bases
CCGGCAGGGCCGGCGCGCTCAGGCGCCGCCCGCGAATCCGTTCTGCCGCCACGCCTCGAAGACCACCACGGCCACTGTGT
TCGACAGGTTGAGGCTGCGG

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MRISVLGAGAWGTALASHAAQSHDVVLWGRDAALVAQMAATRANERYLPGIPLHASLRFEAEMSAALDHATGEDALVVIA
SPVAGLADLTRGVAAHGGVRNVIWLCKGFDPESGALPHAIVAGVLAQTGRADLATGALSGPSFAKEVAQGLPCAMTVASA
STALCTRTQRAFHHHAMRVYASDDLVGVEVGGAVKNVLAIATGAADGLGLGLNARAALVTRGLAEMTRLGTALGGRPETF
MGLTGMGDLLLTATGDLSRNRTVGMQLAQGRSLDEILAHLGHVAEGVRCARAVAALARAKGVDMPITFAVCEVLFDGLAP
SRAVDRLLQRDAKAESVR

Sequences:

>Translated_338_residues
MRISVLGAGAWGTALASHAAQSHDVVLWGRDAALVAQMAATRANERYLPGIPLHASLRFEAEMSAALDHATGEDALVVIA
SPVAGLADLTRGVAAHGGVRNVIWLCKGFDPESGALPHAIVAGVLAQTGRADLATGALSGPSFAKEVAQGLPCAMTVASA
STALCTRTQRAFHHHAMRVYASDDLVGVEVGGAVKNVLAIATGAADGLGLGLNARAALVTRGLAEMTRLGTALGGRPETF
MGLTGMGDLLLTATGDLSRNRTVGMQLAQGRSLDEILAHLGHVAEGVRCARAVAALARAKGVDMPITFAVCEVLFDGLAP
SRAVDRLLQRDAKAESVR
>Mature_338_residues
MRISVLGAGAWGTALASHAAQSHDVVLWGRDAALVAQMAATRANERYLPGIPLHASLRFEAEMSAALDHATGEDALVVIA
SPVAGLADLTRGVAAHGGVRNVIWLCKGFDPESGALPHAIVAGVLAQTGRADLATGALSGPSFAKEVAQGLPCAMTVASA
STALCTRTQRAFHHHAMRVYASDDLVGVEVGGAVKNVLAIATGAADGLGLGLNARAALVTRGLAEMTRLGTALGGRPETF
MGLTGMGDLLLTATGDLSRNRTVGMQLAQGRSLDEILAHLGHVAEGVRCARAVAALARAKGVDMPITFAVCEVLFDGLAP
SRAVDRLLQRDAKAESVR

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=338, Percent_Identity=26.6272189349112, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI24307999, Length=354, Percent_Identity=25.4237288135593, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1790037, Length=340, Percent_Identity=41.7647058823529, Blast_Score=239, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI32564399, Length=357, Percent_Identity=26.3305322128852, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI32564403, Length=362, Percent_Identity=26.5193370165746, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI193210136, Length=362, Percent_Identity=25.9668508287293, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17507425, Length=350, Percent_Identity=27.1428571428571, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI193210134, Length=209, Percent_Identity=31.5789473684211, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320181, Length=364, Percent_Identity=27.7472527472527, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324513, Length=351, Percent_Identity=28.2051282051282, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17136202, Length=352, Percent_Identity=25.5681818181818, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136204, Length=352, Percent_Identity=25.5681818181818, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136200, Length=352, Percent_Identity=25.5681818181818, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281362270, Length=301, Percent_Identity=25.5813953488372, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45551945, Length=301, Percent_Identity=25.5813953488372, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_RALSO (Q8Y2H9)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_518478.1
- ProteinModelPortal:   Q8Y2H9
- GeneID:   1219160
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc0357
- NMPDR:   fig|267608.1.peg.357
- HOGENOM:   HBG586392
- OMA:   SQTLRGN
- ProtClustDB:   PRK00094
- BioCyc:   RSOL267608:RSC0357-MONOMER
- BRENDA:   1.1.1.94
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 34668; Mature: 34668

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 195-195 BINDING 107-107 BINDING 107-107 BINDING 144-144 BINDING 259-259 BINDING 285-285

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRISVLGAGAWGTALASHAAQSHDVVLWGRDAALVAQMAATRANERYLPGIPLHASLRFE
CEEEEEECCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEH
AEMSAALDHATGEDALVVIASPVAGLADLTRGVAAHGGVRNVIWLCKGFDPESGALPHAI
HHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCHHEEEEEEECCCCCCCCCHHHH
VAGVLAQTGRADLATGALSGPSFAKEVAQGLPCAMTVASASTALCTRTQRAFHHHAMRVY
HHHHHHHCCCCHHHHCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHEEE
ASDDLVGVEVGGAVKNVLAIATGAADGLGLGLNARAALVTRGLAEMTRLGTALGGRPETF
ECCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCE
MGLTGMGDLLLTATGDLSRNRTVGMQLAQGRSLDEILAHLGHVAEGVRCARAVAALARAK
EECCCCCCEEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVDMPITFAVCEVLFDGLAPSRAVDRLLQRDAKAESVR
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRISVLGAGAWGTALASHAAQSHDVVLWGRDAALVAQMAATRANERYLPGIPLHASLRFE
CEEEEEECCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEH
AEMSAALDHATGEDALVVIASPVAGLADLTRGVAAHGGVRNVIWLCKGFDPESGALPHAI
HHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCHHEEEEEEECCCCCCCCCHHHH
VAGVLAQTGRADLATGALSGPSFAKEVAQGLPCAMTVASASTALCTRTQRAFHHHAMRVY
HHHHHHHCCCCHHHHCCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHEEE
ASDDLVGVEVGGAVKNVLAIATGAADGLGLGLNARAALVTRGLAEMTRLGTALGGRPETF
ECCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCE
MGLTGMGDLLLTATGDLSRNRTVGMQLAQGRSLDEILAHLGHVAEGVRCARAVAALARAK
EECCCCCCEEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVDMPITFAVCEVLFDGLAPSRAVDRLLQRDAKAESVR
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852