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The map label for this gene is iclR [H]

Identifier: 17545019

GI number: 17545019

Start: 332763

End: 333635

Strand: Reverse

Name: iclR [H]

Synonym: RSc0300

Alternate gene names: 17545019

Gene position: 333635-332763 (Counterclockwise)

Preceding gene: 17545021

Following gene: 17545018

Centisome position: 8.98

GC content: 71.59

Gene sequence:

>873_bases
ATGCCCCGCCCCACGCCGCCCGCCGACGCCGATCCGGACCTGGATCCCGAAGCCGACTCCGCAGCGGACGCGCCCGCGCG
CACGGGCATCCAGTCCATTGAAGTCGGCTTCCGCCTGCTCGATGTGCTCGCGCGCAGCAACGGCCCGATGATGCTGCGCG
ATCTCGCGCGCGCCGCGCCGATGAACCCGGCCAAGGCGCACCGCTACCTGGTCAGCTTCGCGCGCCTGGGACTGGTCGCG
CAGACGCCCGAGGGCCGCTACGACCTCGGCCCCTTCGCCAGCGAAATGGGGCTGGTGAGCCTGAACCGGCAGGACCCGAT
GCGCCGCGCCCGCCCCGCCGCCGCCGCGCTGCGCGACGAGATCGACCACACCATCGGCCTGGCCGTATGGGGCAACCAGG
GGCCGGCCATCGTCCACTGGGAAGAGGCCAGCCAACCGATCACCGTCAGCCTGCGCCTGGGCGACATCATGCCCATGCTC
AACTCGGCCACCGGCCGCGTGTTTGGCGCCTACCTGCCGCGCGCGCAGACGCTGCCTTTCATCCAGCGCGAACTGGACGC
GCTGGCCGCCGCCGGTGCCACGGCGGGCAACCCCGAGCACCCGCGCACGCTGCAAGCGTACGATGCCCTCTGCGCCGAAG
TGCGCGCGTGCGGCGTGTCGCGCATCCATGGCGGCGTGCTGCCGGGCATCAATGCGATGTCCCTGCCGGTGTTCGACGCC
AACGGCCAGCTGTGCCTGGCGCTGCTCGCCCTGGGTGCCCAGAGCACATTCGATACCACGGCCGACGGCCCGCTGGAGCG
GCGCTTGCGGCAGGCCGTACAACAGCTTTCCGCCGATCTTGGATACGTTCCGCTCCACCACCCGCAATCCTGA

Upstream 100 bases:

>100_bases
GGGTGGCGAGTTTCATATCGGTACAAGGGCGGGAACAGGCTGCGCGGATGCTACACCATGCATCGGCTACACTGACCCGA
ACCGACCGTCCCGCACCGCC

Downstream 100 bases:

>100_bases
CGCGCCGGGCACCGGCACGCGCACACGCCGCTGGCGGCGCTGGGGCGTGGTGGCGCTGGCCGCGCTGCTGGCGCACGGCA
TCGCGGTGATCTGGGTCGCG

Product: transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MPRPTPPADADPDLDPEADSAADAPARTGIQSIEVGFRLLDVLARSNGPMMLRDLARAAPMNPAKAHRYLVSFARLGLVA
QTPEGRYDLGPFASEMGLVSLNRQDPMRRARPAAAALRDEIDHTIGLAVWGNQGPAIVHWEEASQPITVSLRLGDIMPML
NSATGRVFGAYLPRAQTLPFIQRELDALAAAGATAGNPEHPRTLQAYDALCAEVRACGVSRIHGGVLPGINAMSLPVFDA
NGQLCLALLALGAQSTFDTTADGPLERRLRQAVQQLSADLGYVPLHHPQS

Sequences:

>Translated_290_residues
MPRPTPPADADPDLDPEADSAADAPARTGIQSIEVGFRLLDVLARSNGPMMLRDLARAAPMNPAKAHRYLVSFARLGLVA
QTPEGRYDLGPFASEMGLVSLNRQDPMRRARPAAAALRDEIDHTIGLAVWGNQGPAIVHWEEASQPITVSLRLGDIMPML
NSATGRVFGAYLPRAQTLPFIQRELDALAAAGATAGNPEHPRTLQAYDALCAEVRACGVSRIHGGVLPGINAMSLPVFDA
NGQLCLALLALGAQSTFDTTADGPLERRLRQAVQQLSADLGYVPLHHPQS
>Mature_289_residues
PRPTPPADADPDLDPEADSAADAPARTGIQSIEVGFRLLDVLARSNGPMMLRDLARAAPMNPAKAHRYLVSFARLGLVAQ
TPEGRYDLGPFASEMGLVSLNRQDPMRRARPAAAALRDEIDHTIGLAVWGNQGPAIVHWEEASQPITVSLRLGDIMPMLN
SATGRVFGAYLPRAQTLPFIQRELDALAAAGATAGNPEHPRTLQAYDALCAEVRACGVSRIHGGVLPGINAMSLPVFDAN
GQLCLALLALGAQSTFDTTADGPLERRLRQAVQQLSADLGYVPLHHPQS

Specific function: Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyr

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=168, Percent_Identity=27.9761904761905, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30925; Mature: 30793

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPTPPADADPDLDPEADSAADAPARTGIQSIEVGFRLLDVLARSNGPMMLRDLARAAP
CCCCCCCCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
MNPAKAHRYLVSFARLGLVAQTPEGRYDLGPFASEMGLVSLNRQDPMRRARPAAAALRDE
CCHHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHCCEEEECCCCHHHHHHHHHHHHHHH
IDHTIGLAVWGNQGPAIVHWEEASQPITVSLRLGDIMPMLNSATGRVFGAYLPRAQTLPF
HHHHEEEEEECCCCCEEEEECCCCCCEEEEEEHHHHHHHHHHHCHHHHHHHCCCCCCCHH
IQRELDALAAAGATAGNPEHPRTLQAYDALCAEVRACGVSRIHGGVLPGINAMSLPVFDA
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCEEEEECC
NGQLCLALLALGAQSTFDTTADGPLERRLRQAVQQLSADLGYVPLHHPQS
CCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PRPTPPADADPDLDPEADSAADAPARTGIQSIEVGFRLLDVLARSNGPMMLRDLARAAP
CCCCCCCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
MNPAKAHRYLVSFARLGLVAQTPEGRYDLGPFASEMGLVSLNRQDPMRRARPAAAALRDE
CCHHHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHCCEEEECCCCHHHHHHHHHHHHHHH
IDHTIGLAVWGNQGPAIVHWEEASQPITVSLRLGDIMPMLNSATGRVFGAYLPRAQTLPF
HHHHEEEEEECCCCCEEEEECCCCCCEEEEEEHHHHHHHHHHHCHHHHHHHCCCCCCCHH
IQRELDALAAAGATAGNPEHPRTLQAYDALCAEVRACGVSRIHGGVLPGINAMSLPVFDA
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCEEEEECC
NGQLCLALLALGAQSTFDTTADGPLERRLRQAVQQLSADLGYVPLHHPQS
CCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185227; 1995431; 8265357; 9278503; 1995429 [H]