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The map label for this gene is ntrC [H]

Identifier: 17544797

GI number: 17544797

Start: 89947

End: 90666

Strand: Direct

Name: ntrC [H]

Synonym: RSc0078

Alternate gene names: 17544797

Gene position: 89947-90666 (Clockwise)

Preceding gene: 17544796

Following gene: 17544798

Centisome position: 2.42

GC content: 67.22

Gene sequence:

>720_bases
ATGGCCACCATCCTCGTTGTCGACGACGAAATGGGTATCCGGGAGTTGCTCTCCGAAATTCTCGGAGACGAAGGACACGT
TGTCGAAGTCGCCGAGAACGCGCAGCAGGCGCGCGAACACCGCAACGGCGCCACGCCTGACCTGGTGCTGCTCGATATCT
GGATGCCGGACACCGACGGCGTGACGCTGCTCAAGGAGTGGGCCTCGCAGGGGCTGCTGACGATGCCGGTCATCATGATG
TCCGGCCACGCCACCATCGACACGGCGGTGGAAGCCACCAAGATCGGTGCGCTCAACTTCCTGGAAAAACCGATCGCCTT
GCAGAAGCTGCTGGCTGCAGTGGAGCAGGGCCTGGCGCGCGGCAAGGAAAGGCCGCGCGTCTCGCCGGCGGCACCGCTGG
CGGTCGCGGCCGTCGGTGGGGGCAGCGCACCGCTTGCGGCTGCTGCGCAGGGGGCGGTCCTGGCGACGGATCGCGCCGAC
GTGAACGGTGCGCCGGTGCGCGCGGCCGAGGGCGGCGGCATGCAGTTCTCGTTCGACATGCCGCTGCGCGAGGCGCGCGA
TCTGTTCGAGCGCGCCTACTTCGAATACCACTTGCAGCGCGAAGGCGGCAGCATGACCCGCGTGGCGGAGAAGACCGGAC
TGGAGCGTACCCACCTGTACCGCAAGCTCAAGCAACTGGGCGTGGAGCTGTCGCGCAACAAGGGTGAACCGTCGGCCTGA

Upstream 100 bases:

>100_bases
CCGCCAGTCGGGCACCGACACCGTCGGCGCCCAGGTTTCCATTCTGTTCGTAAAACTTGCCTAGCGCGGTAGGCGATCCC
GCCGCACATAGAGGAAAAGC

Downstream 100 bases:

>100_bases
TTGGATGATTCGGTGGTGCTTGACGACAAGGGACAAGTGCTGTCATACTTGCGTTTCTTTGCTTGGCCCGGTAGCTCAGT
TGGTAGAGCAGCGGATTGAA

Product: two component response regulator transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MATILVVDDEMGIRELLSEILGDEGHVVEVAENAQQAREHRNGATPDLVLLDIWMPDTDGVTLLKEWASQGLLTMPVIMM
SGHATIDTAVEATKIGALNFLEKPIALQKLLAAVEQGLARGKERPRVSPAAPLAVAAVGGGSAPLAAAAQGAVLATDRAD
VNGAPVRAAEGGGMQFSFDMPLREARDLFERAYFEYHLQREGGSMTRVAEKTGLERTHLYRKLKQLGVELSRNKGEPSA

Sequences:

>Translated_239_residues
MATILVVDDEMGIRELLSEILGDEGHVVEVAENAQQAREHRNGATPDLVLLDIWMPDTDGVTLLKEWASQGLLTMPVIMM
SGHATIDTAVEATKIGALNFLEKPIALQKLLAAVEQGLARGKERPRVSPAAPLAVAAVGGGSAPLAAAAQGAVLATDRAD
VNGAPVRAAEGGGMQFSFDMPLREARDLFERAYFEYHLQREGGSMTRVAEKTGLERTHLYRKLKQLGVELSRNKGEPSA
>Mature_238_residues
ATILVVDDEMGIRELLSEILGDEGHVVEVAENAQQAREHRNGATPDLVLLDIWMPDTDGVTLLKEWASQGLLTMPVIMMS
GHATIDTAVEATKIGALNFLEKPIALQKLLAAVEQGLARGKERPRVSPAAPLAVAAVGGGSAPLAAAAQGAVLATDRADV
NGAPVRAAEGGGMQFSFDMPLREARDLFERAYFEYHLQREGGSMTRVAEKTGLERTHLYRKLKQLGVELSRNKGEPSA

Specific function: Member of the two-component regulatory system ntrB/ntrC involved in the activation of nitrogen assimilatory genes such as glnA. NtrC is phosphorylated by ntrB and interacts with sigma-54 [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=115, Percent_Identity=40, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1790437, Length=127, Percent_Identity=37.007874015748, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790299, Length=125, Percent_Identity=36.8, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1787375, Length=118, Percent_Identity=28.8135593220339, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786784, Length=120, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789809, Length=136, Percent_Identity=31.6176470588235, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1786911, Length=123, Percent_Identity=31.7073170731707, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786599, Length=140, Percent_Identity=29.2857142857143, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR010114
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 25604; Mature: 25472

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATILVVDDEMGIRELLSEILGDEGHVVEVAENAQQAREHRNGATPDLVLLDIWMPDTDG
CEEEEEEECCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCC
VTLLKEWASQGLLTMPVIMMSGHATIDTAVEATKIGALNFLEKPIALQKLLAAVEQGLAR
HHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKERPRVSPAAPLAVAAVGGGSAPLAAAAQGAVLATDRADVNGAPVRAAEGGGMQFSFDM
CCCCCCCCCCCCEEEEEECCCCCCHHHHCCCCEEEECCCCCCCCCEEECCCCCEEEEECC
PLREARDLFERAYFEYHLQREGGSMTRVAEKTGLERTHLYRKLKQLGVELSRNKGEPSA
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCHHHHCCCCCCCC
>Mature Secondary Structure 
ATILVVDDEMGIRELLSEILGDEGHVVEVAENAQQAREHRNGATPDLVLLDIWMPDTDG
EEEEEEECCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCC
VTLLKEWASQGLLTMPVIMMSGHATIDTAVEATKIGALNFLEKPIALQKLLAAVEQGLAR
HHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKERPRVSPAAPLAVAAVGGGSAPLAAAAQGAVLATDRADVNGAPVRAAEGGGMQFSFDM
CCCCCCCCCCCCEEEEEECCCCCCHHHHCCCCEEEECCCCCCCCCEEECCCCCEEEEECC
PLREARDLFERAYFEYHLQREGGSMTRVAEKTGLERTHLYRKLKQLGVELSRNKGEPSA
CHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8095910 [H]