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The map label for this gene is degS [H]

Identifier: 17544740

GI number: 17544740

Start: 24619

End: 26082

Strand: Reverse

Name: degS [H]

Synonym: RSc0021

Alternate gene names: 17544740

Gene position: 26082-24619 (Counterclockwise)

Preceding gene: 17544743

Following gene: 17544739

Centisome position: 0.7

GC content: 71.58

Gene sequence:

>1464_bases
ATGAAGCTTCGCCAAAAGATCCTGCTGCTCGCCGTCGCGCCGCTGACCATCGCCATGCTGGCGATCATGCTGACCGTGCG
GCACCAGTCGATCGCCCTGGCGCAGCACGAGCGGCAACTGGTGGAATCGGCCTACCTGCAGGCCAAGGAGGCCGAGCTGC
GCGCCCACGTGAAGCTGGCGCGCAGCGCGATCGCGCCGCTGCTGGCCTCCGGCCGCAGCGACCAGGCCACCCGCGACGAA
GCCATGCGGACGCTGGCCCGCCTGGATTTCGGGCCGGACGGCTACTTCTTCCTCTATGACCTGCGCGGCCGCAACCTGAT
GCATCCGCGCCAGCCCGAACTGGTCGGCCGCGACCTGTGGCGCCTGACCGACGCGCGCGGCCAGCCCACCATCCAGAGAC
TGGTGGCCGCCGCGCAGGCCGGCGGCGGCTTCGTGCGCTACCTGTGGGACAAGCCCTCCAGCCACCAGAGCGTGGCCAAG
CTCGGCTATGTGGAGCCGATTCCCCAATGGGGCTGGATGGTCGGCACCGGCCTGTACCTGGACGATGTCGAGCAGACCCT
GCGCGAGATCGACCGGCGCGCGCAGGCCAATATCGATCAGACCCTGGCGTGGGTCGTCGCCATCGCCGCGGTGTGCATCC
TGCTGGTGGCCGGCAGCGGGCTGGCGCTCAACGTGAGCGACCACCGCGAGGCCGATGCCAAGCTGCGCCAGCTGGCGCAG
CAGGTGGTGCACTCGCAGGAGGACGAGCGCGCGCGCGTGTCGCGCGAGCTGCACGACGGCATCAGCCAGGTGCTGGTCTC
GACCAAGCTGCTGCTCGAAACCGCGCACGGCCACCTGGAGCCGCCGCCCGGCCACGCGACGCCACCGGGCGCGCCCGCGA
CCGACAAGGCCGCCGGCATGCTGCGCCGGGCGCTGGACCGCCTCAACGGGGCGCTGGGCGAGGTGCGGCGCGTATCGCAC
AACCTGCGCCCCGCGCTGCTGGACGATCTCGGCCTGGCCGCCGCGCTGGAGCTGCTGGTGCGCGAGACCCGCGAAGCCCA
CGAAGACCGCCAGCCCGGCTTCGCCATCACCCTGGAGACCGCCGGCCCGCCGGTGCAGTTGCCGGACGCGTGCAACACGG
CCTTCTTCCGCATCGCGCAGGAGGCGGTCTCCAACATCGAGCGCCACGCCACGGGCGCCACGCGCATCGGCCTGCTGCTC
GAGAACGATCTCGATGCGGTGCGCCTGTCGATCCGCGACAACGGCCCGGGCTTCGACGTGGAATCGGTCCAGGTCGACCC
CGAGCACGGCATCGGCCTGCGCAACATGCGCGAGCGCATGGCCGCCCTGGGCGGCACCTGTACCATCGTCTCCGGCCCGC
ACGGCACCGAAGTCGGCGTGGCGTTGCCGCATCTCGTGATCGCCCGGCTGGCCTCGGCCGCCGCGTCCTCATCCGCTTCC
GTTTCCGCTTCCCCGTCCGCATGA

Upstream 100 bases:

>100_bases
CGCAGCACCGCTCCGTAGTACTACGCAGACCCCTTCCCATGCATTGTAGATTGCGCAATCGCGCTGTCGTGCTGCGGTGC
ACGATCCCAGCGCGTCCGTC

Downstream 100 bases:

>100_bases
ACACGCCCGTCAAACTTCTGCTGGTCGACGATCACCCGCTGGTGCGCGATGGCGTACGCGTACGGCTCGAGGCCGTGCCG
CACTTCGCCGTGGTGGGCGA

Product: transmembrane sensor histidine kinase transcription regulator protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MKLRQKILLLAVAPLTIAMLAIMLTVRHQSIALAQHERQLVESAYLQAKEAELRAHVKLARSAIAPLLASGRSDQATRDE
AMRTLARLDFGPDGYFFLYDLRGRNLMHPRQPELVGRDLWRLTDARGQPTIQRLVAAAQAGGGFVRYLWDKPSSHQSVAK
LGYVEPIPQWGWMVGTGLYLDDVEQTLREIDRRAQANIDQTLAWVVAIAAVCILLVAGSGLALNVSDHREADAKLRQLAQ
QVVHSQEDERARVSRELHDGISQVLVSTKLLLETAHGHLEPPPGHATPPGAPATDKAAGMLRRALDRLNGALGEVRRVSH
NLRPALLDDLGLAAALELLVRETREAHEDRQPGFAITLETAGPPVQLPDACNTAFFRIAQEAVSNIERHATGATRIGLLL
ENDLDAVRLSIRDNGPGFDVESVQVDPEHGIGLRNMRERMAALGGTCTIVSGPHGTEVGVALPHLVIARLASAAASSSAS
VSASPSA

Sequences:

>Translated_487_residues
MKLRQKILLLAVAPLTIAMLAIMLTVRHQSIALAQHERQLVESAYLQAKEAELRAHVKLARSAIAPLLASGRSDQATRDE
AMRTLARLDFGPDGYFFLYDLRGRNLMHPRQPELVGRDLWRLTDARGQPTIQRLVAAAQAGGGFVRYLWDKPSSHQSVAK
LGYVEPIPQWGWMVGTGLYLDDVEQTLREIDRRAQANIDQTLAWVVAIAAVCILLVAGSGLALNVSDHREADAKLRQLAQ
QVVHSQEDERARVSRELHDGISQVLVSTKLLLETAHGHLEPPPGHATPPGAPATDKAAGMLRRALDRLNGALGEVRRVSH
NLRPALLDDLGLAAALELLVRETREAHEDRQPGFAITLETAGPPVQLPDACNTAFFRIAQEAVSNIERHATGATRIGLLL
ENDLDAVRLSIRDNGPGFDVESVQVDPEHGIGLRNMRERMAALGGTCTIVSGPHGTEVGVALPHLVIARLASAAASSSAS
VSASPSA
>Mature_487_residues
MKLRQKILLLAVAPLTIAMLAIMLTVRHQSIALAQHERQLVESAYLQAKEAELRAHVKLARSAIAPLLASGRSDQATRDE
AMRTLARLDFGPDGYFFLYDLRGRNLMHPRQPELVGRDLWRLTDARGQPTIQRLVAAAQAGGGFVRYLWDKPSSHQSVAK
LGYVEPIPQWGWMVGTGLYLDDVEQTLREIDRRAQANIDQTLAWVVAIAAVCILLVAGSGLALNVSDHREADAKLRQLAQ
QVVHSQEDERARVSRELHDGISQVLVSTKLLLETAHGHLEPPPGHATPPGAPATDKAAGMLRRALDRLNGALGEVRRVSH
NLRPALLDDLGLAAALELLVRETREAHEDRQPGFAITLETAGPPVQLPDACNTAFFRIAQEAVSNIERHATGATRIGLLL
ENDLDAVRLSIRDNGPGFDVESVQVDPEHGIGLRNMRERMAALGGTCTIVSGPHGTEVGVALPHLVIARLASAAASSSAS
VSASPSA

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4564

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=254, Percent_Identity=33.8582677165354, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1787474, Length=223, Percent_Identity=29.1479820627803, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52715; Mature: 52715

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLRQKILLLAVAPLTIAMLAIMLTVRHQSIALAQHERQLVESAYLQAKEAELRAHVKLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSAIAPLLASGRSDQATRDEAMRTLARLDFGPDGYFFLYDLRGRNLMHPRQPELVGRDLW
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHH
RLTDARGQPTIQRLVAAAQAGGGFVRYLWDKPSSHQSVAKLGYVEPIPQWGWMVGTGLYL
HHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCHHHCCCCHH
DDVEQTLREIDRRAQANIDQTLAWVVAIAAVCILLVAGSGLALNVSDHREADAKLRQLAQ
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHH
QVVHSQEDERARVSRELHDGISQVLVSTKLLLETAHGHLEPPPGHATPPGAPATDKAAGM
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
LRRALDRLNGALGEVRRVSHNLRPALLDDLGLAAALELLVRETREAHEDRQPGFAITLET
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
AGPPVQLPDACNTAFFRIAQEAVSNIERHATGATRIGLLLENDLDAVRLSIRDNGPGFDV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCEEEEEEECCCCCCCC
ESVQVDPEHGIGLRNMRERMAALGGTCTIVSGPHGTEVGVALPHLVIARLASAAASSSAS
CEEEECCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
VSASPSA
CCCCCCC
>Mature Secondary Structure
MKLRQKILLLAVAPLTIAMLAIMLTVRHQSIALAQHERQLVESAYLQAKEAELRAHVKLA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSAIAPLLASGRSDQATRDEAMRTLARLDFGPDGYFFLYDLRGRNLMHPRQPELVGRDLW
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHH
RLTDARGQPTIQRLVAAAQAGGGFVRYLWDKPSSHQSVAKLGYVEPIPQWGWMVGTGLYL
HHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCCHHHCCCCHH
DDVEQTLREIDRRAQANIDQTLAWVVAIAAVCILLVAGSGLALNVSDHREADAKLRQLAQ
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHH
QVVHSQEDERARVSRELHDGISQVLVSTKLLLETAHGHLEPPPGHATPPGAPATDKAAGM
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
LRRALDRLNGALGEVRRVSHNLRPALLDDLGLAAALELLVRETREAHEDRQPGFAITLET
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEC
AGPPVQLPDACNTAFFRIAQEAVSNIERHATGATRIGLLLENDLDAVRLSIRDNGPGFDV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCEEEEEEECCCCCCCC
ESVQVDPEHGIGLRNMRERMAALGGTCTIVSGPHGTEVGVALPHLVIARLASAAASSSAS
CEEEECCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
VSASPSA
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]