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The map label for this gene is serA1 [H]

Identifier: 17544735

GI number: 17544735

Start: 17482

End: 18543

Strand: Reverse

Name: serA1 [H]

Synonym: RSc0016

Alternate gene names: 17544735

Gene position: 18543-17482 (Counterclockwise)

Preceding gene: 17544739

Following gene: 17544730

Centisome position: 0.5

GC content: 66.01

Gene sequence:

>1062_bases
TTGCTGCGCACCATTGTCCGAAGTGAGATGTCGATGAAGATTGCCGTACTGGACGACTACCAAGACGCCGTTCGCAAGCT
GGATTGCTTCAGCCTGCTGCAAGACCACGAAGTCAAAGTATTCAACAACACCGTCAAAGGCGTGGGGCAATTGGCCGCAC
GGGTGGCCGACGTGGAAGCCATCGTGCTGATCCGCGAGCGCACCCGTGTGACGCGCCAGTTGCTTGACCGGCTGCCCAAG
CTCAAGATCATCAGCCAGACCGGTCGCGTGTCACGCGACGCCGGCGGGCACATCGACCTGGAGGCCTGCACCGACAAGGG
CGTCGTCGTGCTGGAAGGCAAGGGCTCCCCGGTGGCGCCGGCCGAGCTGACCTGGGCGCTGGTGATGGCCGCGCAGCGCC
GCATCCCGCAGTACGTTGCCAGCCTCAAGCATGGCGCGTGGCAGCAGTCGGGGCTGAAATCGACCACGATGCCGCCCAAC
TTCGGCATCGGCCGCGTGCTGAAGGGGCAGACGCTGGGCATCTTCGGCTACGGCAAGATCGGCCAGCTGGTGGCCGGCTA
CGGCCGCGCCTTCGGCATGAACGTCCTGGTGTGGGGGCGCGAGAACTCGAAGGAGCGTGCCCGCGCCGACGGCTTTGCCG
TGGCCGAGTCGAAGGACGCGCTGTTCGAGCAGTCCGACGTGCTGTCCGTCCACCTGCGCCTGAACGACGAGACGCGCGGC
ATCGTCACCGTGGCGGACCTGACCCGCATGAAGCCGACCGCGCTGTTCGTCAACACCAGCCGCGCCGAACTGGTCGAAGA
GAACGGCATGGTGACGGCGCTCAACCGCGGCCGCCCGGGCATGGCGGCCATCGACGTGTTCGAGACCGAGCCCATCCTGC
AGGGCCACACGCTGCTGCGCATGGAGAACTGCATCTGCACGCCGCACATCGGCTACGTGGAGCGCGAAAGCTACGAGATG
TACTTCGGCATCGCCTTCCAGAACATCCTCGACATCCTGCAGGGGAATGTCGACAGCGTGGCCAACCCGACCGCGCTGGC
GCCGGCGCTGATCCGCGCCTGA

Upstream 100 bases:

>100_bases
CTGCGCAATTTGCGTGCCCGCGGCGGGCAATCCGAACGTCGTGCAAGATTGTCATGCGACGAGGGATGGGAAGAATACCA
CCGCAAGGGACCGCTGTTTT

Downstream 100 bases:

>100_bases
GGTCAGCCGTCGCGCGGCCCCGGAGTCAGGCCGCGGCGCGCAGCTGCGGCTGGTTGGCGCCCGCGCCGTCGAAGCGGAAG
CTGTCCATCGCCAGCGCGCC

Product: D-3-phosphoglycerate dehydrogenase oxidoreductase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MLRTIVRSEMSMKIAVLDDYQDAVRKLDCFSLLQDHEVKVFNNTVKGVGQLAARVADVEAIVLIRERTRVTRQLLDRLPK
LKIISQTGRVSRDAGGHIDLEACTDKGVVVLEGKGSPVAPAELTWALVMAAQRRIPQYVASLKHGAWQQSGLKSTTMPPN
FGIGRVLKGQTLGIFGYGKIGQLVAGYGRAFGMNVLVWGRENSKERARADGFAVAESKDALFEQSDVLSVHLRLNDETRG
IVTVADLTRMKPTALFVNTSRAELVEENGMVTALNRGRPGMAAIDVFETEPILQGHTLLRMENCICTPHIGYVERESYEM
YFGIAFQNILDILQGNVDSVANPTALAPALIRA

Sequences:

>Translated_353_residues
MLRTIVRSEMSMKIAVLDDYQDAVRKLDCFSLLQDHEVKVFNNTVKGVGQLAARVADVEAIVLIRERTRVTRQLLDRLPK
LKIISQTGRVSRDAGGHIDLEACTDKGVVVLEGKGSPVAPAELTWALVMAAQRRIPQYVASLKHGAWQQSGLKSTTMPPN
FGIGRVLKGQTLGIFGYGKIGQLVAGYGRAFGMNVLVWGRENSKERARADGFAVAESKDALFEQSDVLSVHLRLNDETRG
IVTVADLTRMKPTALFVNTSRAELVEENGMVTALNRGRPGMAAIDVFETEPILQGHTLLRMENCICTPHIGYVERESYEM
YFGIAFQNILDILQGNVDSVANPTALAPALIRA
>Mature_353_residues
MLRTIVRSEMSMKIAVLDDYQDAVRKLDCFSLLQDHEVKVFNNTVKGVGQLAARVADVEAIVLIRERTRVTRQLLDRLPK
LKIISQTGRVSRDAGGHIDLEACTDKGVVVLEGKGSPVAPAELTWALVMAAQRRIPQYVASLKHGAWQQSGLKSTTMPPN
FGIGRVLKGQTLGIFGYGKIGQLVAGYGRAFGMNVLVWGRENSKERARADGFAVAESKDALFEQSDVLSVHLRLNDETRG
IVTVADLTRMKPTALFVNTSRAELVEENGMVTALNRGRPGMAAIDVFETEPILQGHTLLRMENCICTPHIGYVERESYEM
YFGIAFQNILDILQGNVDSVANPTALAPALIRA

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=325, Percent_Identity=29.5384615384615, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI6912396, Length=216, Percent_Identity=32.8703703703704, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4557497, Length=262, Percent_Identity=32.824427480916, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI61743967, Length=262, Percent_Identity=32.824427480916, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI145580578, Length=254, Percent_Identity=29.9212598425197, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4557499, Length=254, Percent_Identity=29.9212598425197, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI145580575, Length=257, Percent_Identity=29.9610894941634, Blast_Score=95, Evalue=8e-20,
Organism=Escherichia coli, GI87082289, Length=324, Percent_Identity=31.1728395061728, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1789279, Length=275, Percent_Identity=29.0909090909091, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787645, Length=265, Percent_Identity=27.9245283018868, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=305, Percent_Identity=28.8524590163934, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI25147481, Length=297, Percent_Identity=26.2626262626263, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320925, Length=314, Percent_Identity=25.4777070063694, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322116, Length=275, Percent_Identity=25.8181818181818, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=315, Percent_Identity=24.4444444444444, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24646446, Length=274, Percent_Identity=29.5620437956204, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24646448, Length=274, Percent_Identity=29.5620437956204, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24646452, Length=274, Percent_Identity=29.5620437956204, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24646450, Length=274, Percent_Identity=29.5620437956204, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI62472511, Length=274, Percent_Identity=29.5620437956204, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28574286, Length=219, Percent_Identity=29.2237442922374, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=27.906976744186, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28571528, Length=276, Percent_Identity=28.2608695652174, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45552429, Length=218, Percent_Identity=27.9816513761468, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585514, Length=218, Percent_Identity=27.9816513761468, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574282, Length=218, Percent_Identity=27.9816513761468, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45551003, Length=218, Percent_Identity=27.9816513761468, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574284, Length=218, Percent_Identity=27.9816513761468, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24585516, Length=220, Percent_Identity=28.1818181818182, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 38761; Mature: 38761

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRTIVRSEMSMKIAVLDDYQDAVRKLDCFSLLQDHEVKVFNNTVKGVGQLAARVADVEA
CCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCEE
IVLIRERTRVTRQLLDRLPKLKIISQTGRVSRDAGGHIDLEACTDKGVVVLEGKGSPVAP
EEEEHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCH
AELTWALVMAAQRRIPQYVASLKHGAWQQSGLKSTTMPPNFGIGRVLKGQTLGIFGYGKI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCEECCCEEEEEECCHH
GQLVAGYGRAFGMNVLVWGRENSKERARADGFAVAESKDALFEQSDVLSVHLRLNDETRG
HHHHHHHHHHCCCEEEEECCCCCHHHHHCCCEEEECCHHHHHCCCCEEEEEEEECCCCCC
IVTVADLTRMKPTALFVNTSRAELVEENGMVTALNRGRPGMAAIDVFETEPILQGHTLLR
EEEEEHHHCCCCEEEEEECCHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCEEE
MENCICTPHIGYVERESYEMYFGIAFQNILDILQGNVDSVANPTALAPALIRA
ECCCCCCCCCCCEECCCEEEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MLRTIVRSEMSMKIAVLDDYQDAVRKLDCFSLLQDHEVKVFNNTVKGVGQLAARVADVEA
CCHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCEE
IVLIRERTRVTRQLLDRLPKLKIISQTGRVSRDAGGHIDLEACTDKGVVVLEGKGSPVAP
EEEEHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCH
AELTWALVMAAQRRIPQYVASLKHGAWQQSGLKSTTMPPNFGIGRVLKGQTLGIFGYGKI
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCEECCCEEEEEECCHH
GQLVAGYGRAFGMNVLVWGRENSKERARADGFAVAESKDALFEQSDVLSVHLRLNDETRG
HHHHHHHHHHCCCEEEEECCCCCHHHHHCCCEEEECCHHHHHCCCCEEEEEEEECCCCCC
IVTVADLTRMKPTALFVNTSRAELVEENGMVTALNRGRPGMAAIDVFETEPILQGHTLLR
EEEEEHHHCCCCEEEEEECCHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCCEEE
MENCICTPHIGYVERESYEMYFGIAFQNILDILQGNVDSVANPTALAPALIRA
ECCCCCCCCCCCEECCCEEEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]