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The map label for this gene is acrA [H]

Identifier: 17544730

GI number: 17544730

Start: 11621

End: 12817

Strand: Reverse

Name: acrA [H]

Synonym: RSc0011

Alternate gene names: 17544730

Gene position: 12817-11621 (Counterclockwise)

Preceding gene: 17544735

Following gene: 17544729

Centisome position: 0.34

GC content: 70.68

Gene sequence:

>1197_bases
ATGTCGAACACCCGCCGTTATCACCAACTCGCTGCTGCCGGGCTCACGGTCGTGGCGCTTGCAGCCTGCGGCAACAAGCA
GGCACAAGGGCCGGGCGGCGGCATGCCGCCGACGGAGGTCGGTGTCGTGACCGTGCAGCCGCACTCGGTGGGCCTGACCA
CCGAGTTGCCGGGCCGCCTGGAAGCCACGCGCGTGGCGCAGGTGCGTGCACGGGTGGCCGGCATCGTGCTCAAGCGCACG
TACCAGGAAGGCAGCGATGTGAAGGCGAACGACGTGCTCTTCCGCATCGATCCGGCGCAATACCAGGCTTCGCTCGATAG
CGCCAAGGCTCAGCTGGCCCGCGCCGAAGCCACGCAGACCCAGGCGCAGCTCAAGGCCGAGCGCTACAAGCCGCTGGTCG
CCACCAATGCCATCAGCAAGCAGGACTACGACGACGCCGTCGCCGCCGCCAAGCAGGCCACCGCCGACGTCGGCGCGGCG
CGCGCGGCCGTGGAGACCGCCAAGCTCAACCTCGGCTACGCCACCGTCACTTCACCCATTTCGGGCCGCGCAGGCCTGGC
GCAGGTCACCGAAGGCGCGCTGGTCGGCCAGGGCAGCGACGCCACGCTGCTGGCGACCGTGCAGCAGATCGACCCGATCT
ACCTGACCTTCACCCAGTCGAGCACCGAAGTGATGCGCCTGCAGGAAGCGCTCAAGGCCGGCAAGCTGGCGGCCGCGGGC
GACACCGCCGCCAAGGTCACGCTGGTGACCGAGGACGGCCGCGTCTACGCGCAGACGGGCAAGCTGTACTTCTCCGACCT
GACGGTGGACCAGACCACCGGCTCGATCACGCTGCGCGCGATCTTCCCGAACGCCGAGCGCACCCTGCTGCCGGGCATGT
ACGTGCGCGCGCGGCTGGAGCAGGCGGTCGACCAGCAGGCCATCACGGTGCCGCAGCAGGCCGTGTCGCGCGGCGCGGAC
GGCGCCTCGGTGATGATCGTCGACGCGGAAGGCAAGGTCGCCCCACGCCCGGTCCAGGCCGATCGCGCCGTCGGCACGGA
TTGGATCGTCTCCAGCGGCCTGAAAGCCGGTGACAAGGTGATCGTCGACGGCCTGCAGAAAGTCCGGCCGGGCGCGCCGG
TCAAGCCGGTGGCGTGGCAGGCCGGCGGCGCGCAGGGTCAGGGTGCTGCCGCCAGCGCCCCCGCAGCCAAGCAGTAA

Upstream 100 bases:

>100_bases
ACGTTTTCGGATCGTGTTTTCAGGTCGCCCGGACCCTACCCGCGGTGCATTTGTTAGTGCGCCGCCCGGGCACACCGCTT
ATCGCCACATGGGGTCATCT

Downstream 100 bases:

>100_bases
GCCGCAGTAAACAAGGAGCCATCGCATGGCAAAGTTTTTTATCGATCGCCCGGTCTTTGCCTGGGTGCTCGCGCTGTTCA
TCATCGTGGCTGGGGCCATC

Product: acriflavin resistance lipoprotein A precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSNTRRYHQLAAAGLTVVALAACGNKQAQGPGGGMPPTEVGVVTVQPHSVGLTTELPGRLEATRVAQVRARVAGIVLKRT
YQEGSDVKANDVLFRIDPAQYQASLDSAKAQLARAEATQTQAQLKAERYKPLVATNAISKQDYDDAVAAAKQATADVGAA
RAAVETAKLNLGYATVTSPISGRAGLAQVTEGALVGQGSDATLLATVQQIDPIYLTFTQSSTEVMRLQEALKAGKLAAAG
DTAAKVTLVTEDGRVYAQTGKLYFSDLTVDQTTGSITLRAIFPNAERTLLPGMYVRARLEQAVDQQAITVPQQAVSRGAD
GASVMIVDAEGKVAPRPVQADRAVGTDWIVSSGLKAGDKVIVDGLQKVRPGAPVKPVAWQAGGAQGQGAAASAPAAKQ

Sequences:

>Translated_398_residues
MSNTRRYHQLAAAGLTVVALAACGNKQAQGPGGGMPPTEVGVVTVQPHSVGLTTELPGRLEATRVAQVRARVAGIVLKRT
YQEGSDVKANDVLFRIDPAQYQASLDSAKAQLARAEATQTQAQLKAERYKPLVATNAISKQDYDDAVAAAKQATADVGAA
RAAVETAKLNLGYATVTSPISGRAGLAQVTEGALVGQGSDATLLATVQQIDPIYLTFTQSSTEVMRLQEALKAGKLAAAG
DTAAKVTLVTEDGRVYAQTGKLYFSDLTVDQTTGSITLRAIFPNAERTLLPGMYVRARLEQAVDQQAITVPQQAVSRGAD
GASVMIVDAEGKVAPRPVQADRAVGTDWIVSSGLKAGDKVIVDGLQKVRPGAPVKPVAWQAGGAQGQGAAASAPAAKQ
>Mature_397_residues
SNTRRYHQLAAAGLTVVALAACGNKQAQGPGGGMPPTEVGVVTVQPHSVGLTTELPGRLEATRVAQVRARVAGIVLKRTY
QEGSDVKANDVLFRIDPAQYQASLDSAKAQLARAEATQTQAQLKAERYKPLVATNAISKQDYDDAVAAAKQATADVGAAR
AAVETAKLNLGYATVTSPISGRAGLAQVTEGALVGQGSDATLLATVQQIDPIYLTFTQSSTEVMRLQEALKAGKLAAAGD
TAAKVTLVTEDGRVYAQTGKLYFSDLTVDQTTGSITLRAIFPNAERTLLPGMYVRARLEQAVDQQAITVPQQAVSRGADG
ASVMIVDAEGKVAPRPVQADRAVGTDWIVSSGLKAGDKVIVDGLQKVRPGAPVKPVAWQAGGAQGQGAAASAPAAKQ

Specific function: AcrAB is a drug efflux protein with a broad substrate specificity [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786668, Length=378, Percent_Identity=55.2910052910053, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1789665, Length=377, Percent_Identity=51.7241379310345, Blast_Score=347, Evalue=7e-97,
Organism=Escherichia coli, GI1789929, Length=377, Percent_Identity=45.0928381962865, Blast_Score=311, Evalue=7e-86,
Organism=Escherichia coli, GI87082036, Length=322, Percent_Identity=32.9192546583851, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI87081796, Length=333, Percent_Identity=25.8258258258258, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41235; Mature: 41104

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTRRYHQLAAAGLTVVALAACGNKQAQGPGGGMPPTEVGVVTVQPHSVGLTTELPGRL
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEECCCCCH
EATRVAQVRARVAGIVLKRTYQEGSDVKANDVLFRIDPAQYQASLDSAKAQLARAEATQT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHH
QAQLKAERYKPLVATNAISKQDYDDAVAAAKQATADVGAARAAVETAKLNLGYATVTSPI
HHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEECCCC
SGRAGLAQVTEGALVGQGSDATLLATVQQIDPIYLTFTQSSTEVMRLQEALKAGKLAAAG
CCCCCHHHHHCCEEEECCCCCEEEEEHHHCCCEEEEEECCCHHHHHHHHHHHHCCEEECC
DTAAKVTLVTEDGRVYAQTGKLYFSDLTVDQTTGSITLRAIFPNAERTLLPGMYVRARLE
CCCEEEEEEECCCEEEEEECCEEEEEEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHH
QAVDQQAITVPQQAVSRGADGASVMIVDAEGKVAPRPVQADRAVGTDWIVSSGLKAGDKV
HHHHHHHHCCCHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCCHH
IVDGLQKVRPGAPVKPVAWQAGGAQGQGAAASAPAAKQ
HHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SNTRRYHQLAAAGLTVVALAACGNKQAQGPGGGMPPTEVGVVTVQPHSVGLTTELPGRL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEECCCCCH
EATRVAQVRARVAGIVLKRTYQEGSDVKANDVLFRIDPAQYQASLDSAKAQLARAEATQT
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHH
QAQLKAERYKPLVATNAISKQDYDDAVAAAKQATADVGAARAAVETAKLNLGYATVTSPI
HHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEECCCC
SGRAGLAQVTEGALVGQGSDATLLATVQQIDPIYLTFTQSSTEVMRLQEALKAGKLAAAG
CCCCCHHHHHCCEEEECCCCCEEEEEHHHCCCEEEEEECCCHHHHHHHHHHHHCCEEECC
DTAAKVTLVTEDGRVYAQTGKLYFSDLTVDQTTGSITLRAIFPNAERTLLPGMYVRARLE
CCCEEEEEEECCCEEEEEECCEEEEEEEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHH
QAVDQQAITVPQQAVSRGADGASVMIVDAEGKVAPRPVQADRAVGTDWIVSSGLKAGDKV
HHHHHHHHCCCHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCCCHH
IVDGLQKVRPGAPVKPVAWQAGGAQGQGAAASAPAAKQ
HHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]