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The map label for this gene is ispD [H]

Identifier: 17232659

GI number: 17232659

Start: 6164816

End: 6165502

Strand: Reverse

Name: ispD [H]

Synonym: all5167

Alternate gene names: 17232659

Gene position: 6165502-6164816 (Counterclockwise)

Preceding gene: 17232661

Following gene: 17232658

Centisome position: 96.13

GC content: 44.69

Gene sequence:

>687_bases
GTGTATTTACTAATTCCCGCCGCCGGCGTTGGCAAAAGAATGGGATGTGACCGCAATAAGCTGCTGCTAGAAGTGCGATC
GCAACCTATTATTGCTTGGACTCTTTTAGCTGCACAAGCAGCCAGTGAAATTAGTTGGATTGGCATTATTTCCCAACCCA
CTGACTGGCCAGATTTTAAATCTATTCTTGCTAACTTGCAGCTGACTAAACCAGTGGAATTTATCTTAGGAGGCTCCACT
AGACAAGAATCGGTTTACAACGGCTTACAGGCGCTACCAACAGCCGCAGAGCAAGTTTTAATTCATGATGGTGCTAGATG
TCTGGCGACACCGAATTTACTCAACTCCTGCGCTCAAGCAATTCGTCACTGTTCCGGCTTGATTGCGGCTGTCCCTGTAA
AAGACACGATTAAAGTTGTGGATGAAGATGGCATAATTCAAAATACACCAGACCGACGCAATCTTTGGGCTGCACAAACC
CCCCAAGGCTTTAATGTTGAATTGTTGAAACAGTGCCACGCTGAAGGTGTTCGTCAAGGTTGGGAAGTGACTGACGATGC
GGCTTTATTTGAAAAGTGCGGTATCGAAGTGCAAATTGTGGAAGGTGAGGAAACAAATTTGAAAGTAACAACTCCCCAAG
ATTTAGCGATCGCTGAATTTATTCTTAACAGTCGAGATAATTCGTAA

Upstream 100 bases:

>100_bases
GCCAACAAAATTCAAAACTAAGTCATTTTCAATTCATAATTTTGAATTGGAGGTAGCCAAGTTTCCCTGTATTCATTCCC
TAGTTTGGCATTAAAAGACA

Downstream 100 bases:

>100_bases
TTTAGGCTGCTAAAAGTCTTGTGTTTTGCTGCTTTGACGAACTTGGGTAAGCATCTTGACTGAAAATCAAAAAATATGTA
TAATCCCCCACATTTATTGG

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MYLLIPAAGVGKRMGCDRNKLLLEVRSQPIIAWTLLAAQAASEISWIGIISQPTDWPDFKSILANLQLTKPVEFILGGST
RQESVYNGLQALPTAAEQVLIHDGARCLATPNLLNSCAQAIRHCSGLIAAVPVKDTIKVVDEDGIIQNTPDRRNLWAAQT
PQGFNVELLKQCHAEGVRQGWEVTDDAALFEKCGIEVQIVEGEETNLKVTTPQDLAIAEFILNSRDNS

Sequences:

>Translated_228_residues
MYLLIPAAGVGKRMGCDRNKLLLEVRSQPIIAWTLLAAQAASEISWIGIISQPTDWPDFKSILANLQLTKPVEFILGGST
RQESVYNGLQALPTAAEQVLIHDGARCLATPNLLNSCAQAIRHCSGLIAAVPVKDTIKVVDEDGIIQNTPDRRNLWAAQT
PQGFNVELLKQCHAEGVRQGWEVTDDAALFEKCGIEVQIVEGEETNLKVTTPQDLAIAEFILNSRDNS
>Mature_228_residues
MYLLIPAAGVGKRMGCDRNKLLLEVRSQPIIAWTLLAAQAASEISWIGIISQPTDWPDFKSILANLQLTKPVEFILGGST
RQESVYNGLQALPTAAEQVLIHDGARCLATPNLLNSCAQAIRHCSGLIAAVPVKDTIKVVDEDGIIQNTPDRRNLWAAQT
PQGFNVELLKQCHAEGVRQGWEVTDDAALFEKCGIEVQIVEGEETNLKVTTPQDLAIAEFILNSRDNS

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=237, Percent_Identity=28.2700421940928, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1789104, Length=222, Percent_Identity=37.8378378378378, Blast_Score=126, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 24883; Mature: 24883

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLLIPAAGVGKRMGCDRNKLLLEVRSQPIIAWTLLAAQAASEISWIGIISQPTDWPDFK
CEEEEECCCCCHHCCCCCHHEEEEECCCCEEHHHHHHHHHHCCEEEEEEECCCCCCHHHH
SILANLQLTKPVEFILGGSTRQESVYNGLQALPTAAEQVLIHDGARCLATPNLLNSCAQA
HHHHCCCCCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEECHHHHHHHHHH
IRHCSGLIAAVPVKDTIKVVDEDGIIQNTPDRRNLWAAQTPQGFNVELLKQCHAEGVRQG
HHHHCCCEEEECCCHHHEEECCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCC
WEVTDDAALFEKCGIEVQIVEGEETNLKVTTPQDLAIAEFILNSRDNS
CCCCCHHHHHHHCCCEEEEEECCCCCEEEECCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MYLLIPAAGVGKRMGCDRNKLLLEVRSQPIIAWTLLAAQAASEISWIGIISQPTDWPDFK
CEEEEECCCCCHHCCCCCHHEEEEECCCCEEHHHHHHHHHHCCEEEEEEECCCCCCHHHH
SILANLQLTKPVEFILGGSTRQESVYNGLQALPTAAEQVLIHDGARCLATPNLLNSCAQA
HHHHCCCCCCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEECHHHHHHHHHH
IRHCSGLIAAVPVKDTIKVVDEDGIIQNTPDRRNLWAAQTPQGFNVELLKQCHAEGVRQG
HHHHCCCEEEECCCHHHEEECCCCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCC
WEVTDDAALFEKCGIEVQIVEGEETNLKVTTPQDLAIAEFILNSRDNS
CCCCCHHHHHHHCCCEEEEEECCCCCEEEECCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA