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The map label for this gene is hisC

Identifier: 17232458

GI number: 17232458

Start: 5928126

End: 5929280

Strand: Reverse

Name: hisC

Synonym: all4966

Alternate gene names: 17232458

Gene position: 5929280-5928126 (Counterclockwise)

Preceding gene: 17232459

Following gene: 17232455

Centisome position: 92.45

GC content: 42.86

Gene sequence:

>1155_bases
ATGCTTCCTTTTATCCGCTCAGATTTAGCCCAATTTAACGCCTACAAACCTCATCCCAGCAGCGATACAGCCTCAGCCGT
CCCGCCCCAATTGGATCGGTTGGATACTAACGAAAGCCCCTATGATTTGCCTCCTGAGTTAAAACAAAAGCTCGCCTGGA
CTTTTCAGCAAGTAATTGAAAGTAATCGTTATCCTGATGGCGGACATGAGACACTTAAAAGTGCGATCGCCGAATATGTC
AACGAATCCGCTAATATTTCATCATTACGGTTTACCGCCGCTAATATATCTGTCGGTAATGGTTCGGATGAATTAATCCG
TTCTTTATTAATTGCTACGTGTTTAAGCGGAGAAGGGTCTATTCTCGTTGCTAATCCCACCTTTTCCATGTATGGGATTT
TGGCACAAACTTTGGGTATTCCTGTCGTGTCGGTATCAAGGAATCCTGATAATTTTGCCATCGACTTAACAGCAGCTCAA
TCTGCAATTGAACAAACTCTAAATCCTCCCATTCGGGTGGTGTTCGTCGTTCATCCCAATTCCCCCACAGCTAATCCTTT
AACTGCAAATGAGTTGAGATGGTTGAAAAGTCTCAGCGAACGAATTTTAGTAGTAGTTGACGAAGCTTATTTTGAGTTTA
GCCAAAATACCCTAGTCAGCGAATTGGCACAGCGTCCTAATTGGATAATTCTACGCACATTTTCTAAAGCTTTTCGATTA
GCAGCCATGCGCGTTGGCTATTGTGTCGCTCATCCAGAAGCGATCGCTATTTTAGAAAAAGTCCGCTTACCTTACAATCT
ACCTAGTTTCTCCATTGCATCTGCTTTAGTTGCCTTACAAAATCGCGCCATCTTACTAGAATCCATTCCTCAAACTCTAG
ATGAACGCACCAAGCTGATTAATGCCTTCTCTCAGCATCCTGCACTAGCCGTTGCAGAAAGTGCCGCCAACTTTATTTTC
TTGCGTCTGAAAGCAGATAGTGACAATTCATCAGACACTACTTTACTAAATCTTCATCAACAACTCAAGAATTCTGGCAC
ATTAGTACGGCAAATAAGCGGCGGATTGAGAATTACCATAGGTACACCTGAAGAAAACATCCGCACGCTTAACCATATAC
AAACAGCCTTAATAAAGCCAGAGCTTGTAGGCTAG

Upstream 100 bases:

>100_bases
AGCGGTAGAATATGAACTCTCCTGATAAATGTTTTGTGTCAGTTGTTAGTTGTAATTTGCTATTGACCACTGACAACTGA
CCACTGACAACTGATTAATT

Downstream 100 bases:

>100_bases
AGGAGACACAAATTACCGATTACCAATCCCCAAATATCAATCTATTCCGTTTCACTACCCCAACGACGTACCATTCCCGC
AGTTTGTGGTAGCACTCCTA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MLPFIRSDLAQFNAYKPHPSSDTASAVPPQLDRLDTNESPYDLPPELKQKLAWTFQQVIESNRYPDGGHETLKSAIAEYV
NESANISSLRFTAANISVGNGSDELIRSLLIATCLSGEGSILVANPTFSMYGILAQTLGIPVVSVSRNPDNFAIDLTAAQ
SAIEQTLNPPIRVVFVVHPNSPTANPLTANELRWLKSLSERILVVVDEAYFEFSQNTLVSELAQRPNWIILRTFSKAFRL
AAMRVGYCVAHPEAIAILEKVRLPYNLPSFSIASALVALQNRAILLESIPQTLDERTKLINAFSQHPALAVAESAANFIF
LRLKADSDNSSDTTLLNLHQQLKNSGTLVRQISGGLRITIGTPEENIRTLNHIQTALIKPELVG

Sequences:

>Translated_384_residues
MLPFIRSDLAQFNAYKPHPSSDTASAVPPQLDRLDTNESPYDLPPELKQKLAWTFQQVIESNRYPDGGHETLKSAIAEYV
NESANISSLRFTAANISVGNGSDELIRSLLIATCLSGEGSILVANPTFSMYGILAQTLGIPVVSVSRNPDNFAIDLTAAQ
SAIEQTLNPPIRVVFVVHPNSPTANPLTANELRWLKSLSERILVVVDEAYFEFSQNTLVSELAQRPNWIILRTFSKAFRL
AAMRVGYCVAHPEAIAILEKVRLPYNLPSFSIASALVALQNRAILLESIPQTLDERTKLINAFSQHPALAVAESAANFIF
LRLKADSDNSSDTTLLNLHQQLKNSGTLVRQISGGLRITIGTPEENIRTLNHIQTALIKPELVG
>Mature_384_residues
MLPFIRSDLAQFNAYKPHPSSDTASAVPPQLDRLDTNESPYDLPPELKQKLAWTFQQVIESNRYPDGGHETLKSAIAEYV
NESANISSLRFTAANISVGNGSDELIRSLLIATCLSGEGSILVANPTFSMYGILAQTLGIPVVSVSRNPDNFAIDLTAAQ
SAIEQTLNPPIRVVFVVHPNSPTANPLTANELRWLKSLSERILVVVDEAYFEFSQNTLVSELAQRPNWIILRTFSKAFRL
AAMRVGYCVAHPEAIAILEKVRLPYNLPSFSIASALVALQNRAILLESIPQTLDERTKLINAFSQHPALAVAESAANFIF
LRLKADSDNSSDTTLLNLHQQLKNSGTLVRQISGGLRITIGTPEENIRTLNHIQTALIKPELVG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=352, Percent_Identity=32.1022727272727, Blast_Score=152, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6322075, Length=337, Percent_Identity=31.7507418397626, Blast_Score=143, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS82_NOSS1 (Q8YMG7)

Other databases:

- EMBL:   BA000019
- PIR:   AF2426
- RefSeq:   NP_489006.1
- ProteinModelPortal:   Q8YMG7
- SMR:   Q8YMG7
- STRING:   Q8YMG7
- GeneID:   1108567
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all4966
- NMPDR:   fig|103690.1.peg.5273
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   QNPTYLE
- PhylomeDB:   Q8YMG7
- ProtClustDB:   PRK02610
- BioCyc:   NSP103690:ALL4966-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 42119; Mature: 42119

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPFIRSDLAQFNAYKPHPSSDTASAVPPQLDRLDTNESPYDLPPELKQKLAWTFQQVIE
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
SNRYPDGGHETLKSAIAEYVNESANISSLRFTAANISVGNGSDELIRSLLIATCLSGEGS
CCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHCCCCCC
ILVANPTFSMYGILAQTLGIPVVSVSRNPDNFAIDLTAAQSAIEQTLNPPIRVVFVVHPN
EEEECCCHHHHHHHHHHHCCCEEEECCCCCCEEEEEHHHHHHHHHHCCCCEEEEEEEECC
SPTANPLTANELRWLKSLSERILVVVDEAYFEFSQNTLVSELAQRPNWIILRTFSKAFRL
CCCCCCCCHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHH
AAMRVGYCVAHPEAIAILEKVRLPYNLPSFSIASALVALQNRAILLESIPQTLDERTKLI
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
NAFSQHPALAVAESAANFIFLRLKADSDNSSDTTLLNLHQQLKNSGTLVRQISGGLRITI
HHHHCCCCHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEE
GTPEENIRTLNHIQTALIKPELVG
CCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLPFIRSDLAQFNAYKPHPSSDTASAVPPQLDRLDTNESPYDLPPELKQKLAWTFQQVIE
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
SNRYPDGGHETLKSAIAEYVNESANISSLRFTAANISVGNGSDELIRSLLIATCLSGEGS
CCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHCCCCCC
ILVANPTFSMYGILAQTLGIPVVSVSRNPDNFAIDLTAAQSAIEQTLNPPIRVVFVVHPN
EEEECCCHHHHHHHHHHHCCCEEEECCCCCCEEEEEHHHHHHHHHHCCCCEEEEEEEECC
SPTANPLTANELRWLKSLSERILVVVDEAYFEFSQNTLVSELAQRPNWIILRTFSKAFRL
CCCCCCCCHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHH
AAMRVGYCVAHPEAIAILEKVRLPYNLPSFSIASALVALQNRAILLESIPQTLDERTKLI
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
NAFSQHPALAVAESAANFIFLRLKADSDNSSDTTLLNLHQQLKNSGTLVRQISGGLRITI
HHHHCCCCHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEE
GTPEENIRTLNHIQTALIKPELVG
CCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840