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The map label for this gene is fcl [C]

Identifier: 17232318

GI number: 17232318

Start: 5745455

End: 5746399

Strand: Reverse

Name: fcl [C]

Synonym: all4826

Alternate gene names: 17232318

Gene position: 5746399-5745455 (Counterclockwise)

Preceding gene: 17232319

Following gene: 17232317

Centisome position: 89.59

GC content: 43.6

Gene sequence:

>945_bases
ATGACCGCCTTAGAACTAAAAAATAAACGGATTCTTGTCACTGGTGGGGCAGGGTTTCTAGGTCGTCAGGTAATAGATCA
GCTGTGTCAAGCTGGAGCTGATACGGCGAAAATTAGTGTACCGCGATCGCGTGACTTGGATTTACGTGTTTGGGAAAATT
GCCAACGTGCAGTAGATCAACAAGATATTATTATCCACTTAGCTGCTCATGTGGGTGGTATTGGACTCAACCGGGAAAAA
CCCGCAGAGTTGTTCTACGATAACTTGATCATGGGTACTCAATTAATCCATGCTGCCCATCAAGCTGGAGTAGAAAAATT
TGTGTGTGTGGGTACAATCTGTGCTTATCCCAAATTTACCCCAGTACCATTTAAAGAAGACGACCTGTGGAACGGTTATC
CAGAAGAAACGAATGCTCCATACGGAGTTGCTAAAAAAGCTCTTTTAGTTCAATTGCAATCTTATCGTCAGCAGTATGGC
TTTAATGGCGTTTACTTGCTGCCAGTAAATTTATATGGGCCAGAGGATAACTTTGATCCCGGTAGTTCTCATGTCATCCC
AGCGTTAATTCGCAAAGTCTACGAAGCTCAAGTTAGGGGTGATAAAGAGTTTCCAGTTTGGGGGGATGGTAGTCCTACCC
GCGAGTTTCTCTATTCTGAAGATGCAGCGCGGGGTATTGTGATGGGAACTCAATTCTACAATGACTCCGAACCAATCAAC
TTGGGAACTGGTTACGAAATCTCCATCCGCGATTTAGTCACACTCATCTGTGAATTGATGGAATTTAAAGGTGAAATTAT
TTGGGAAACCGATAAACCCAATGGTCAACCCCGCCGTTGTTTGGATACCGAACGAGCGAAGCAAGCTTTTAATTTCACAG
CCCAAGTAGACTTTAAACAGGGATTGAAAAATACCATTGACTGGTATCGGCAAAATGCTGCTTAG

Upstream 100 bases:

>100_bases
TCCCAATGGTAATACTTCAATCCTACCCCAGGATATTGCTACTATTCGTCAACAACTGGGTGTACTCCACTTCTGATTAA
TTCTTGCCAAGGATGAAAGT

Downstream 100 bases:

>100_bases
GTAATGGGTAATGGGTAATGGGTAATGGGATGAATAATATTTTTGTAACCTCTTCCCAATCCTCAGTACCCTATTTCCTA
TACCCCATCTTTGAATATGA

Product: dTDP-glucose dehydratase

Products: GDP-4-dehydro-6-deoxy-D-mannose; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MTALELKNKRILVTGGAGFLGRQVIDQLCQAGADTAKISVPRSRDLDLRVWENCQRAVDQQDIIIHLAAHVGGIGLNREK
PAELFYDNLIMGTQLIHAAHQAGVEKFVCVGTICAYPKFTPVPFKEDDLWNGYPEETNAPYGVAKKALLVQLQSYRQQYG
FNGVYLLPVNLYGPEDNFDPGSSHVIPALIRKVYEAQVRGDKEFPVWGDGSPTREFLYSEDAARGIVMGTQFYNDSEPIN
LGTGYEISIRDLVTLICELMEFKGEIIWETDKPNGQPRRCLDTERAKQAFNFTAQVDFKQGLKNTIDWYRQNAA

Sequences:

>Translated_314_residues
MTALELKNKRILVTGGAGFLGRQVIDQLCQAGADTAKISVPRSRDLDLRVWENCQRAVDQQDIIIHLAAHVGGIGLNREK
PAELFYDNLIMGTQLIHAAHQAGVEKFVCVGTICAYPKFTPVPFKEDDLWNGYPEETNAPYGVAKKALLVQLQSYRQQYG
FNGVYLLPVNLYGPEDNFDPGSSHVIPALIRKVYEAQVRGDKEFPVWGDGSPTREFLYSEDAARGIVMGTQFYNDSEPIN
LGTGYEISIRDLVTLICELMEFKGEIIWETDKPNGQPRRCLDTERAKQAFNFTAQVDFKQGLKNTIDWYRQNAA
>Mature_313_residues
TALELKNKRILVTGGAGFLGRQVIDQLCQAGADTAKISVPRSRDLDLRVWENCQRAVDQQDIIIHLAAHVGGIGLNREKP
AELFYDNLIMGTQLIHAAHQAGVEKFVCVGTICAYPKFTPVPFKEDDLWNGYPEETNAPYGVAKKALLVQLQSYRQQYGF
NGVYLLPVNLYGPEDNFDPGSSHVIPALIRKVYEAQVRGDKEFPVWGDGSPTREFLYSEDAARGIVMGTQFYNDSEPINL
GTGYEISIRDLVTLICELMEFKGEIIWETDKPNGQPRRCLDTERAKQAFNFTAQVDFKQGLKNTIDWYRQNAA

Specific function: Putative nucleotide sugar epimerase/dehydrogenase [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fucose synthase family [H]

Homologues:

Organism=Homo sapiens, GI4507709, Length=314, Percent_Identity=35.031847133758, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI7657641, Length=333, Percent_Identity=27.6276276276276, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI42516563, Length=322, Percent_Identity=24.5341614906832, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1788365, Length=320, Percent_Identity=35.9375, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI48994969, Length=346, Percent_Identity=24.2774566473988, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788353, Length=350, Percent_Identity=25.1428571428571, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17554428, Length=310, Percent_Identity=32.258064516129, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17568069, Length=333, Percent_Identity=24.9249249249249, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115532424, Length=329, Percent_Identity=23.7082066869301, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19922778, Length=314, Percent_Identity=28.9808917197452, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI21356223, Length=324, Percent_Identity=25.3086419753086, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 1.1.1.271

Molecular weight: Translated: 35268; Mature: 35137

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALELKNKRILVTGGAGFLGRQVIDQLCQAGADTAKISVPRSRDLDLRVWENCQRAVDQ
CCCEEECCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHCCC
QDIIIHLAAHVGGIGLNREKPAELFYDNLIMGTQLIHAAHQAGVEKFVCVGTICAYPKFT
HHHEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PVPFKEDDLWNGYPEETNAPYGVAKKALLVQLQSYRQQYGFNGVYLLPVNLYGPEDNFDP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCC
GSSHVIPALIRKVYEAQVRGDKEFPVWGDGSPTREFLYSEDAARGIVMGTQFYNDSEPIN
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEEEECCCCCCEE
LGTGYEISIRDLVTLICELMEFKGEIIWETDKPNGQPRRCLDTERAKQAFNFTAQVDFKQ
CCCCCEEEHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHCCEEEECHHH
GLKNTIDWYRQNAA
HHHHHHHHHHHCCC
>Mature Secondary Structure 
TALELKNKRILVTGGAGFLGRQVIDQLCQAGADTAKISVPRSRDLDLRVWENCQRAVDQ
CCEEECCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHCCC
QDIIIHLAAHVGGIGLNREKPAELFYDNLIMGTQLIHAAHQAGVEKFVCVGTICAYPKFT
HHHEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PVPFKEDDLWNGYPEETNAPYGVAKKALLVQLQSYRQQYGFNGVYLLPVNLYGPEDNFDP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCC
GSSHVIPALIRKVYEAQVRGDKEFPVWGDGSPTREFLYSEDAARGIVMGTQFYNDSEPIN
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCEEEEEEEECCCCCCEE
LGTGYEISIRDLVTLICELMEFKGEIIWETDKPNGQPRRCLDTERAKQAFNFTAQVDFKQ
CCCCCEEEHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHCCEEEECHHH
GLKNTIDWYRQNAA
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDP-L-fucose; NADP+

Specific reaction: GDP-L-fucose + NADP+ = GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]