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The map label for this gene is thrS [H]

Identifier: 17232215

GI number: 17232215

Start: 5629260

End: 5631098

Strand: Reverse

Name: thrS [H]

Synonym: all4723

Alternate gene names: 17232215

Gene position: 5631098-5629260 (Counterclockwise)

Preceding gene: 17232216

Following gene: 17232214

Centisome position: 87.8

GC content: 40.95

Gene sequence:

>1839_bases
ATGGTCAGTTCCTTAACCCAGTCCCAGAGAGACTTAGACCAGCACAACAGCGAGCAACTTGTGCGGATTCGTCACACCTG
CGCCCACATCATGGCGATGGCAGTACAGAAGTTATTTCTAGGGACAAAAGTAGCAACTGGCCCAGTGACAGACAACGGAT
TTTACTACGACTTCGATTGTCCAATCAGCATCACTCCCGATGACTTGGGCAAAATTGCAGCAGAAATGCGGCGCATCATC
AAAGCCAACCTGCCAATAATCCGCGAAGAGGTGCAACGAGAAGAAATCCGCACCGAAATCGCTCAGTTAAACGAACCTTA
CAAGTTAGAAATCTTAGACCGTATCCCCCCAGAAGAAACCATCACCCGCTACTTTATTGGTAGCCCTGACACCAGCACAC
CAGAATCTTCCTTGTTTGTTGCAGATGTCAAACCAGCCAGTAACTATTGGTGGGACTTGTGCGCTGGGCCGCATATTAAT
TTTACTGGTGAAATTGACCCCAATAGTTTCCAACTATTAAACATTGCCGGTGCATATTGGCAAGGCGATGAAAGCAAGCC
CCAACTACAACGCATTTATGGCACAGCTTGGAAAACAAAGGCAGAACTAGAGGCTTACCTCAAACAAAGAGAAGAAGCTT
TACGCCGCGACCATAGAAAGTTGGGTCAAGAGCTAAACTTATTTAGTATTCAAGAGGAAGCTGGCGGTGGTTTAGTTTTT
TGGCATCCCAAAGGCGCGAGTATTCGTTACATCATTGAAGATTATTGGCGAAAATGTCATCTAGAATCTGGCTATCAATT
ACTCTACACACCTCATGTAGCCAACCTCGATTTATGGAAGACATCTGGTCATTTTGACTTCTATCAAGAGAATATGTTTG
ACTCAATGGAAGTGGAAAATCAGGCTTATCAAATTAAGCCTATGAATTGTCCCTTTCATGTCCTCACTTATAAACATCAA
TTACATTCTTATCGAGAATTACCCTTAAGATGGGCTGAATTAGGCACTGTTTATCGTTATGAACGTTCAGGGGCGCTACA
TGGTTTGATGAGGGTCAGAGGATTTACCCAAGATGATGCTCATATTTTTTGTTTACCTCATCAAATCGCTGATGAAATTT
TAGGAGTTTTAAATCTCACTGAACATATTTTGTCAGATTTTGGTTTTAAAAATTATGAGGTTAATCTTTCAACCCGTCCC
GATAAATCAGTAGGAAATAATGAAGTTTGGGAACTAGCCACATCAGCCTTAAGACAAGCCTTGGATGCTAAAGGCTGGAA
TTATATTGTTGATGAAGGTGGTGGTGCTTTTTATGGCCCTAAAATTGATATCAAAATTCAAGATGCTATTGGTCGTCTCT
GGCAATGTTCCACTATTCAGGTAGATTTTAATTTACCTGAACGTTTCGATATGGAATATATTGCTACTGATGGTAGTCGC
CAAAGACCAATTATGATTCATCGCGCGATTTTTGGTTCTTTGGAACGATTTTTCGGCATCTTAATTGAGAATTATGCAGG
TGATTTTCCTTTATGGTTAGCACCAGTACAGATAAGATTATTACCTGTGAGCGACGATGTGAGAGGATATACAGAATCTG
TTGCCATAGCTTTGCAAAAAGATGGATTTAGAGTCGAAATAGATATCAGTGGCGAGCGTTTAGGAAAGCAGATTCGTACA
GCAGAGTTAGAAAAGATTCCCGTGGTTGGTGTCGTAGGTAAAAAAGAAGTGGAAAATCAAAATTTAAGTGTAAGAACTAG
AGCAAATGGTGATTTGGGAGCGATTAATTTAAATGATCTGACAAATCACTTACGAGAAACTATAATTGCCAAGAAGTAA

Upstream 100 bases:

>100_bases
GTGTAGGGGTCAAAGAAATCATAACTTTGACGTTTTTATAGTCATTCCCAATCCGCCCCTTTTTGCGCTAACATGATAAC
GATTCTCATTATTTATTAAT

Downstream 100 bases:

>100_bases
TTTACAAATACAAAATCCTTAAGCAGATTGCTGAAGTTGAATATACGTACATAGCCACAATTATTCAACAGCGTCATTGA
TTTCATAGTTCACAAACATC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MVSSLTQSQRDLDQHNSEQLVRIRHTCAHIMAMAVQKLFLGTKVATGPVTDNGFYYDFDCPISITPDDLGKIAAEMRRII
KANLPIIREEVQREEIRTEIAQLNEPYKLEILDRIPPEETITRYFIGSPDTSTPESSLFVADVKPASNYWWDLCAGPHIN
FTGEIDPNSFQLLNIAGAYWQGDESKPQLQRIYGTAWKTKAELEAYLKQREEALRRDHRKLGQELNLFSIQEEAGGGLVF
WHPKGASIRYIIEDYWRKCHLESGYQLLYTPHVANLDLWKTSGHFDFYQENMFDSMEVENQAYQIKPMNCPFHVLTYKHQ
LHSYRELPLRWAELGTVYRYERSGALHGLMRVRGFTQDDAHIFCLPHQIADEILGVLNLTEHILSDFGFKNYEVNLSTRP
DKSVGNNEVWELATSALRQALDAKGWNYIVDEGGGAFYGPKIDIKIQDAIGRLWQCSTIQVDFNLPERFDMEYIATDGSR
QRPIMIHRAIFGSLERFFGILIENYAGDFPLWLAPVQIRLLPVSDDVRGYTESVAIALQKDGFRVEIDISGERLGKQIRT
AELEKIPVVGVVGKKEVENQNLSVRTRANGDLGAINLNDLTNHLRETIIAKK

Sequences:

>Translated_612_residues
MVSSLTQSQRDLDQHNSEQLVRIRHTCAHIMAMAVQKLFLGTKVATGPVTDNGFYYDFDCPISITPDDLGKIAAEMRRII
KANLPIIREEVQREEIRTEIAQLNEPYKLEILDRIPPEETITRYFIGSPDTSTPESSLFVADVKPASNYWWDLCAGPHIN
FTGEIDPNSFQLLNIAGAYWQGDESKPQLQRIYGTAWKTKAELEAYLKQREEALRRDHRKLGQELNLFSIQEEAGGGLVF
WHPKGASIRYIIEDYWRKCHLESGYQLLYTPHVANLDLWKTSGHFDFYQENMFDSMEVENQAYQIKPMNCPFHVLTYKHQ
LHSYRELPLRWAELGTVYRYERSGALHGLMRVRGFTQDDAHIFCLPHQIADEILGVLNLTEHILSDFGFKNYEVNLSTRP
DKSVGNNEVWELATSALRQALDAKGWNYIVDEGGGAFYGPKIDIKIQDAIGRLWQCSTIQVDFNLPERFDMEYIATDGSR
QRPIMIHRAIFGSLERFFGILIENYAGDFPLWLAPVQIRLLPVSDDVRGYTESVAIALQKDGFRVEIDISGERLGKQIRT
AELEKIPVVGVVGKKEVENQNLSVRTRANGDLGAINLNDLTNHLRETIIAKK
>Mature_612_residues
MVSSLTQSQRDLDQHNSEQLVRIRHTCAHIMAMAVQKLFLGTKVATGPVTDNGFYYDFDCPISITPDDLGKIAAEMRRII
KANLPIIREEVQREEIRTEIAQLNEPYKLEILDRIPPEETITRYFIGSPDTSTPESSLFVADVKPASNYWWDLCAGPHIN
FTGEIDPNSFQLLNIAGAYWQGDESKPQLQRIYGTAWKTKAELEAYLKQREEALRRDHRKLGQELNLFSIQEEAGGGLVF
WHPKGASIRYIIEDYWRKCHLESGYQLLYTPHVANLDLWKTSGHFDFYQENMFDSMEVENQAYQIKPMNCPFHVLTYKHQ
LHSYRELPLRWAELGTVYRYERSGALHGLMRVRGFTQDDAHIFCLPHQIADEILGVLNLTEHILSDFGFKNYEVNLSTRP
DKSVGNNEVWELATSALRQALDAKGWNYIVDEGGGAFYGPKIDIKIQDAIGRLWQCSTIQVDFNLPERFDMEYIATDGSR
QRPIMIHRAIFGSLERFFGILIENYAGDFPLWLAPVQIRLLPVSDDVRGYTESVAIALQKDGFRVEIDISGERLGKQIRT
AELEKIPVVGVVGKKEVENQNLSVRTRANGDLGAINLNDLTNHLRETIIAKK

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=585, Percent_Identity=39.6581196581197, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI38570111, Length=589, Percent_Identity=38.7096774193548, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI20070344, Length=601, Percent_Identity=34.6089850249584, Blast_Score=354, Evalue=2e-97,
Organism=Escherichia coli, GI1788013, Length=604, Percent_Identity=42.8807947019868, Blast_Score=499, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI71984184, Length=584, Percent_Identity=39.554794520548, Blast_Score=430, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71984192, Length=584, Percent_Identity=39.554794520548, Blast_Score=430, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322112, Length=595, Percent_Identity=38.8235294117647, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6322654, Length=398, Percent_Identity=37.4371859296482, Blast_Score=268, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24583839, Length=584, Percent_Identity=39.2123287671233, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24583842, Length=584, Percent_Identity=39.2123287671233, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI28574141, Length=584, Percent_Identity=39.2123287671233, Blast_Score=421, Evalue=1e-118,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 70054; Mature: 70054

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSSLTQSQRDLDQHNSEQLVRIRHTCAHIMAMAVQKLFLGTKVATGPVTDNGFYYDFDC
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEECC
PISITPDDLGKIAAEMRRIIKANLPIIREEVQREEIRTEIAQLNEPYKLEILDRIPPEET
CEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
ITRYFIGSPDTSTPESSLFVADVKPASNYWWDLCAGPHINFTGEIDPNSFQLLNIAGAYW
HHEEEECCCCCCCCCCCEEEEECCCCCCCEEEECCCCCCCEEECCCCCCEEEEEEECCEE
QGDESKPQLQRIYGTAWKTKAELEAYLKQREEALRRDHRKLGQELNLFSIQEEAGGGLVF
CCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEE
WHPKGASIRYIIEDYWRKCHLESGYQLLYTPHVANLDLWKTSGHFDFYQENMFDSMEVEN
ECCCCCCEEHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCCCCHHHHHCCCCCEECC
QAYQIKPMNCPFHVLTYKHQLHSYRELPLRWAELGTVYRYERSGALHGLMRVRGFTQDDA
CEEEEEECCCCEEEEHHHHHHHHHHHCCCCHHHHCCEEEEECCCHHHHHHHHCCCCCCCC
HIFCLPHQIADEILGVLNLTEHILSDFGFKNYEVNLSTRPDKSVGNNEVWELATSALRQA
EEEEECHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
LDAKGWNYIVDEGGGAFYGPKIDIKIQDAIGRLWQCSTIQVDFNLPERFDMEYIATDGSR
HHCCCCEEEEECCCCEEECCEEEEEEHHHHHCCEECEEEEEECCCCCCCCCEEEECCCCC
QRPIMIHRAIFGSLERFFGILIENYAGDFPLWLAPVQIRLLPVSDDVRGYTESVAIALQK
CCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEECEEEEEEECCCCCCCCCCEEEEEEEC
DGFRVEIDISGERLGKQIRTAELEKIPVVGVVGKKEVENQNLSVRTRANGDLGAINLNDL
CCEEEEEEECHHHHHHHHHHHHHHCCCEEEECCCHHCCCCCEEEEEECCCCEEEEEHHHH
TNHLRETIIAKK
HHHHHHHHHCCC
>Mature Secondary Structure
MVSSLTQSQRDLDQHNSEQLVRIRHTCAHIMAMAVQKLFLGTKVATGPVTDNGFYYDFDC
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEECC
PISITPDDLGKIAAEMRRIIKANLPIIREEVQREEIRTEIAQLNEPYKLEILDRIPPEET
CEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
ITRYFIGSPDTSTPESSLFVADVKPASNYWWDLCAGPHINFTGEIDPNSFQLLNIAGAYW
HHEEEECCCCCCCCCCCEEEEECCCCCCCEEEECCCCCCCEEECCCCCCEEEEEEECCEE
QGDESKPQLQRIYGTAWKTKAELEAYLKQREEALRRDHRKLGQELNLFSIQEEAGGGLVF
CCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEE
WHPKGASIRYIIEDYWRKCHLESGYQLLYTPHVANLDLWKTSGHFDFYQENMFDSMEVEN
ECCCCCCEEHHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCCCCCHHHHHCCCCCEECC
QAYQIKPMNCPFHVLTYKHQLHSYRELPLRWAELGTVYRYERSGALHGLMRVRGFTQDDA
CEEEEEECCCCEEEEHHHHHHHHHHHCCCCHHHHCCEEEEECCCHHHHHHHHCCCCCCCC
HIFCLPHQIADEILGVLNLTEHILSDFGFKNYEVNLSTRPDKSVGNNEVWELATSALRQA
EEEEECHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHH
LDAKGWNYIVDEGGGAFYGPKIDIKIQDAIGRLWQCSTIQVDFNLPERFDMEYIATDGSR
HHCCCCEEEEECCCCEEECCEEEEEEHHHHHCCEECEEEEEECCCCCCCCCEEEECCCCC
QRPIMIHRAIFGSLERFFGILIENYAGDFPLWLAPVQIRLLPVSDDVRGYTESVAIALQK
CCCEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEECEEEEEEECCCCCCCCCCEEEEEEEC
DGFRVEIDISGERLGKQIRTAELEKIPVVGVVGKKEVENQNLSVRTRANGDLGAINLNDL
CCEEEEEEECHHHHHHHHHHHHHHCCCEEEECCCHHCCCCCEEEEEECCCCEEEEEHHHH
TNHLRETIIAKK
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA