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The map label for this gene is tmk [H]

Identifier: 17232200

GI number: 17232200

Start: 5612944

End: 5613579

Strand: Reverse

Name: tmk [H]

Synonym: all4708

Alternate gene names: 17232200

Gene position: 5613579-5612944 (Counterclockwise)

Preceding gene: 17232201

Following gene: 17232197

Centisome position: 87.52

GC content: 45.13

Gene sequence:

>636_bases
ATGGGTGGCAGATTCATTGTATTTGAAGGGGTTGAAGGTTGCGGCAAAACTAGCCAAATGCAGCTTTGTGCAGAGTGGTT
GCAAAGTTTGGGGATTTCTGTGGTTCTCACCCGTGAACCAGGAGGAACAGAATTAGGTTTAGATTTGCGGCGCTTGTTGT
TACAGAAGGCGGAAGATAAGCCAATCGCTGAGGTGACGGAGTTATTATTATATGCTGCCGATCGCGCACAACACGTTGCC
CAAGAACTCAAACCTAAGTTAGCTCAGGGTAAGTATATATTATGCGATCGCTATGTTGACTCTACCATTGCCTACCAAGG
TTACGGTCGCAATTTGGATATGAATCTCATCCATCAGTTAAATGACATCGCCACTGGTGGATTAACCAGTGACATCACCA
TCTGGCTAGATGTGGATGTTGAAGTCGGATTAGCTCGTAAACGGGGGGACAATGTAGGACTAGACCGAATTGAACAAGAA
ACCATCGCTTTCCATCGTCGTGTACAGCAAGGCTATGCAGACTTAGCCGCATCCTCTCCGAAGCGAATTATCAGAGTTGA
TGGTCAATTGAGTAAAGAAACTGTACATAAAACCATTCAGGAAATTCTTAGCGTACATCTCAAGCAATGGCTGTAG

Upstream 100 bases:

>100_bases
TAAGAGTATAAGTGTTCACAACTCTTACTCCCCTACACCCTTGCACAGCTAAAAATCTTGTTGAGCCAGTCCTCAAAACA
TCGGCGAACATAAAAACAGC

Downstream 100 bases:

>100_bases
TCAGTCGTTTGATAATTTTGTCATCGAAAAATCATTAGATTATTTATATCCAGCCCCAGCAAAACTTTATTTACTGGGGA
ATTTTTATTCTCAACAAAAG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MGGRFIVFEGVEGCGKTSQMQLCAEWLQSLGISVVLTREPGGTELGLDLRRLLLQKAEDKPIAEVTELLLYAADRAQHVA
QELKPKLAQGKYILCDRYVDSTIAYQGYGRNLDMNLIHQLNDIATGGLTSDITIWLDVDVEVGLARKRGDNVGLDRIEQE
TIAFHRRVQQGYADLAASSPKRIIRVDGQLSKETVHKTIQEILSVHLKQWL

Sequences:

>Translated_211_residues
MGGRFIVFEGVEGCGKTSQMQLCAEWLQSLGISVVLTREPGGTELGLDLRRLLLQKAEDKPIAEVTELLLYAADRAQHVA
QELKPKLAQGKYILCDRYVDSTIAYQGYGRNLDMNLIHQLNDIATGGLTSDITIWLDVDVEVGLARKRGDNVGLDRIEQE
TIAFHRRVQQGYADLAASSPKRIIRVDGQLSKETVHKTIQEILSVHLKQWL
>Mature_210_residues
GGRFIVFEGVEGCGKTSQMQLCAEWLQSLGISVVLTREPGGTELGLDLRRLLLQKAEDKPIAEVTELLLYAADRAQHVAQ
ELKPKLAQGKYILCDRYVDSTIAYQGYGRNLDMNLIHQLNDIATGGLTSDITIWLDVDVEVGLARKRGDNVGLDRIEQET
IAFHRRVQQGYADLAASSPKRIIRVDGQLSKETVHKTIQEILSVHLKQWL

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=214, Percent_Identity=41.1214953271028, Blast_Score=139, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23567; Mature: 23436

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGRFIVFEGVEGCGKTSQMQLCAEWLQSLGISVVLTREPGGTELGLDLRRLLLQKAEDK
CCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCC
PIAEVTELLLYAADRAQHVAQELKPKLAQGKYILCDRYVDSTIAYQGYGRNLDMNLIHQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHCHHHEECCCCCCCCHHHHHHH
NDIATGGLTSDITIWLDVDVEVGLARKRGDNVGLDRIEQETIAFHRRVQQGYADLAASSP
HHHHCCCCCCCEEEEEEECEEECHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
KRIIRVDGQLSKETVHKTIQEILSVHLKQWL
CEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GGRFIVFEGVEGCGKTSQMQLCAEWLQSLGISVVLTREPGGTELGLDLRRLLLQKAEDK
CCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCCC
PIAEVTELLLYAADRAQHVAQELKPKLAQGKYILCDRYVDSTIAYQGYGRNLDMNLIHQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHCHHHEECCCCCCCCHHHHHHH
NDIATGGLTSDITIWLDVDVEVGLARKRGDNVGLDRIEQETIAFHRRVQQGYADLAASSP
HHHHCCCCCCCEEEEEEECEEECHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
KRIIRVDGQLSKETVHKTIQEILSVHLKQWL
CEEEEECCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA