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The map label for this gene is relA [H]

Identifier: 17232163

GI number: 17232163

Start: 5571643

End: 5572224

Strand: Reverse

Name: relA [H]

Synonym: all4671

Alternate gene names: 17232163

Gene position: 5572224-5571643 (Counterclockwise)

Preceding gene: 17232165

Following gene: 17232160

Centisome position: 86.88

GC content: 46.91

Gene sequence:

>582_bases
ATGCTTTCAGAACGCTTTACCCAAGCTTTGACTTACGCTACTCAACTCCACGCTCACCAAGTCCGTAAAGGTTCGGGTAT
CCCTTATGTGGCTCATTTGTTGGGTGTCGCCAGTATTGCCTTAGAATATGGAGCCAATGAAGATGAAGCCATAGCAGCAC
TTTTACACGACGCGGTGGAAGACCAAGGTGGCGCAGCGACAAGAGAAGAAATTCGTCGCCGCTTTGGCGAAACTGTCACG
GCAATTGTTGATGGTTGTACAGACGCTGATACAATACCAAAGCCTCCTTGGAAACGACGCAAGGAGGCTTATATTGCTCA
TATTTCTACCGCCTCTCCATCAGTGCTACTGGTATCAGCTGCTGATAAACTCCACAATGCTCGGTCAATTCTCCAAGATT
ATCGCCTTGTGGGTGAATCCCTTTGGGAACGCTTCCAAGGTGGTAAAACTGGTACTCTTTGGTATTACCGATCGCTGGTG
GATGCTTATCAAAAGACTGAAACTAGGGCCATTGTTGCAGAACTAGCACGGGTAGTTACCCAAATTGAGGATTTAGCATC
TCAGAAAAAATCTGAAGCATGA

Upstream 100 bases:

>100_bases
TCATACTTAACCAAAACTAAATAACATCAGGGTCAACACTTAACACTTTTAACTTTTCTGCCAATATTTTTCTAGTTCTA
AACACCACCCTCTCTTCCTT

Downstream 100 bases:

>100_bases
AGGCTGAAATATTCCTCACTTCATACTTCATATATTTTTTTGTTTGACTGTAACAGGAAAGACAGTCTTGTTTGGGCTAG
CGGAACATACTACTTATAGA

Product: hypothetical protein

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MLSERFTQALTYATQLHAHQVRKGSGIPYVAHLLGVASIALEYGANEDEAIAALLHDAVEDQGGAATREEIRRRFGETVT
AIVDGCTDADTIPKPPWKRRKEAYIAHISTASPSVLLVSAADKLHNARSILQDYRLVGESLWERFQGGKTGTLWYYRSLV
DAYQKTETRAIVAELARVVTQIEDLASQKKSEA

Sequences:

>Translated_193_residues
MLSERFTQALTYATQLHAHQVRKGSGIPYVAHLLGVASIALEYGANEDEAIAALLHDAVEDQGGAATREEIRRRFGETVT
AIVDGCTDADTIPKPPWKRRKEAYIAHISTASPSVLLVSAADKLHNARSILQDYRLVGESLWERFQGGKTGTLWYYRSLV
DAYQKTETRAIVAELARVVTQIEDLASQKKSEA
>Mature_193_residues
MLSERFTQALTYATQLHAHQVRKGSGIPYVAHLLGVASIALEYGANEDEAIAALLHDAVEDQGGAATREEIRRRFGETVT
AIVDGCTDADTIPKPPWKRRKEAYIAHISTASPSVLLVSAADKLHNARSILQDYRLVGESLWERFQGGKTGTLWYYRSLV
DAYQKTETRAIVAELARVVTQIEDLASQKKSEA

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=129, Percent_Identity=37.2093023255814, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1790082, Length=133, Percent_Identity=32.3308270676692, Blast_Score=62, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25143118, Length=125, Percent_Identity=36.8, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24650996, Length=131, Percent_Identity=35.1145038167939, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 21310; Mature: 21310

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSERFTQALTYATQLHAHQVRKGSGIPYVAHLLGVASIALEYGANEDEAIAALLHDAVE
CCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DQGGAATREEIRRRFGETVTAIVDGCTDADTIPKPPWKRRKEAYIAHISTASPSVLLVSA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEHH
ADKLHNARSILQDYRLVGESLWERFQGGKTGTLWYYRSLVDAYQKTETRAIVAELARVVT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIEDLASQKKSEA
HHHHHHHHHCCCC
>Mature Secondary Structure
MLSERFTQALTYATQLHAHQVRKGSGIPYVAHLLGVASIALEYGANEDEAIAALLHDAVE
CCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DQGGAATREEIRRRFGETVTAIVDGCTDADTIPKPPWKRRKEAYIAHISTASPSVLLVSA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEHH
ADKLHNARSILQDYRLVGESLWERFQGGKTGTLWYYRSLVDAYQKTETRAIVAELARVVT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIEDLASQKKSEA
HHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]