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The map label for this gene is gcvH [H]

Identifier: 17232100

GI number: 17232100

Start: 5510401

End: 5510793

Strand: Reverse

Name: gcvH [H]

Synonym: all4608

Alternate gene names: 17232100

Gene position: 5510793-5510401 (Counterclockwise)

Preceding gene: 17232101

Following gene: 17232099

Centisome position: 85.92

GC content: 43.26

Gene sequence:

>393_bases
ATGTCGTCGTTTGAATACCCTCAAGATTTAAGATATTTGGATACTCATGAATACGTGAGACTAGATGGCGAAATCGCTAC
TATCGGTATTACAGAATTTGCTGTAGATCAATTGGGTGATGTGGTTTTTCTAGAACTGCCAGACATTGGCGATTTACTAA
CAAAAGGAGACACTTTTGGTTCAATTGAATCAGTCAAAGCCGTCGAAAACTTGAACGCACCAATCACCGGAACAGTTGTA
GAACGCAACGAAATTTTGGTTGAATCGCCCGAAGCGGTTGCAGATGATCCCTACGGTGAAGGTTGGTTCTTGAAGGTGCG
TGTGAATGATCCTGACGAAGTAAATGATGCTTTGACGGCGGATGAATATCGTGCTGAGGTAGAAGGCGAGTAG

Upstream 100 bases:

>100_bases
GAATGTGTTGTAAGATACTCAATCACAGTATGGTTATTAACTAAATATGGTCTTGATTACTTTGGGACACTAATTTTTTG
ATATTTTAAGAGGAAAAGAA

Downstream 100 bases:

>100_bases
CTGGGTTTTGGGGACTGAGTACTGGTGACTAGGAGCAAAGAAGCAGGAGAAAAACTCCTTACTCAACACTAGATAAACAC
CCCGCTATTGCTCTAAGCGT

Product: glycine cleavage system protein H

Products: Proton; NADH; NH3; CO2; 5,10-methylene-THF [C]

Alternate protein names: NA

Number of amino acids: Translated: 130; Mature: 129

Protein sequence:

>130_residues
MSSFEYPQDLRYLDTHEYVRLDGEIATIGITEFAVDQLGDVVFLELPDIGDLLTKGDTFGSIESVKAVENLNAPITGTVV
ERNEILVESPEAVADDPYGEGWFLKVRVNDPDEVNDALTADEYRAEVEGE

Sequences:

>Translated_130_residues
MSSFEYPQDLRYLDTHEYVRLDGEIATIGITEFAVDQLGDVVFLELPDIGDLLTKGDTFGSIESVKAVENLNAPITGTVV
ERNEILVESPEAVADDPYGEGWFLKVRVNDPDEVNDALTADEYRAEVEGE
>Mature_129_residues
SSFEYPQDLRYLDTHEYVRLDGEIATIGITEFAVDQLGDVVFLELPDIGDLLTKGDTFGSIESVKAVENLNAPITGTVVE
RNEILVESPEAVADDPYGEGWFLKVRVNDPDEVNDALTADEYRAEVEGE

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein [H]

COG id: COG0509

COG function: function code E; Glycine cleavage system H protein (lipoate-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI49574537, Length=113, Percent_Identity=39.8230088495575, Blast_Score=101, Evalue=2e-22,
Organism=Homo sapiens, GI89057342, Length=113, Percent_Identity=38.9380530973451, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1789271, Length=125, Percent_Identity=40, Blast_Score=100, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17507493, Length=112, Percent_Identity=43.75, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17551294, Length=112, Percent_Identity=38.3928571428571, Blast_Score=102, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319272, Length=109, Percent_Identity=40.3669724770642, Blast_Score=95, Evalue=4e-21,
Organism=Drosophila melanogaster, GI17865652, Length=119, Percent_Identity=37.8151260504202, Blast_Score=96, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR002930
- InterPro:   IPR017453
- InterPro:   IPR011053 [H]

Pfam domain/function: PF01597 GCV_H [H]

EC number: NA

Molecular weight: Translated: 14398; Mature: 14267

Theoretical pI: Translated: 3.65; Mature: 3.65

Prosite motif: PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSFEYPQDLRYLDTHEYVRLDGEIATIGITEFAVDQLGDVVFLELPDIGDLLTKGDTFG
CCCCCCCCCCEECCCCCEEEECCCEEEEEHHHHHHHHCCCEEEEECCCCHHHHHCCCCCC
SIESVKAVENLNAPITGTVVERNEILVESPEAVADDPYGEGWFLKVRVNDPDEVNDALTA
CHHHHHHHHHCCCCEEEEEEECCEEEEECCCCCCCCCCCCCEEEEEEECCCCHHHCCCCC
DEYRAEVEGE
CCCEEECCCC
>Mature Secondary Structure 
SSFEYPQDLRYLDTHEYVRLDGEIATIGITEFAVDQLGDVVFLELPDIGDLLTKGDTFG
CCCCCCCCCEECCCCCEEEECCCEEEEEHHHHHHHHCCCEEEEECCCCHHHHHCCCCCC
SIESVKAVENLNAPITGTVVERNEILVESPEAVADDPYGEGWFLKVRVNDPDEVNDALTA
CHHHHHHHHHCCCCEEEEEEECCEEEEECCCCCCCCCCCCCEEEEEEECCCCHHHCCCCC
DEYRAEVEGE
CCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Lipoyl Cofactor. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NAD; L-glycine; THF [C]

Specific reaction: NAD + L-glycine + THF = Proton + NADH + NH3 + CO2 + 5,10-methylene-THF [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA