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The map label for this gene is fus [C]

Identifier: 17231875

GI number: 17231875

Start: 5253354

End: 5255438

Strand: Direct

Name: fus [C]

Synonym: alr4383

Alternate gene names: 17231875

Gene position: 5253354-5255438 (Clockwise)

Preceding gene: 17231872

Following gene: 17231877

Centisome position: 81.91

GC content: 47.77

Gene sequence:

>2085_bases
ATGAGCGAAAAAGTCAGATTAGGTTCGCGGAATGTTGCCATTGTCGGCCCTTATTTAAGTGGAAAAACAACTTTACTAGA
AAGCTTATTATTTGTCACAGGAGCGATTTCTCGCAAAGGCAGCGTTAAGGATACTAACACAGTTGGGGATAGTGCGAATG
AATCACGCGATCGCCACATGAGCGTAGAAATCAGCACTGCCTGCGCTGAGTATAACGACATTCGTTTTACCTTTATAGAC
TGTCCGGGTAGCGTTGAATTTACCCAAGAAACATATAACGCGCTCATGGGCGTTGATGCGGCAATTGTAGTCTGCGAACC
AATACGTGAAAGAGTCCTCACCCTTGCTCCTCTATTTAAATTCCTAGACGATTGGGAAATTCCCCATCTTGTCTTTGTGA
ATAAAATGGATCGAGCAAACATTCATGTCCTCGAAACATTACACGCCCTCAAAGCAGTTTCCAGTCGTCCCTTAGTAGCT
CACCAATACCCCATCATGCAGAGAGAAGTTGGAGCGGCGGCTTCCGCCGATCCAAACTTCGGGGGGGAACAACTCACCGG
CTTTATCGACATGGTGAGTGAACAAGCCTATCAATATCATCCCGGCGCACCAGCTGACCCCATTCCCTTCCCTGAACATC
TCAAACAAGAAGAACATACCGCACGGGCAGAAATGCTCGAAGCCTTAGCAAATTTTGATGACCATTTATTGGAAGAGCTT
TTAGAAGATATTGAACCACCAGCAGAAGAAATCCTCAAAGATTTAAAAATGGAATTAGGGGCAGATTTAGTAGTTCCCGT
CTTCTTTGGTGTCGCGGAACAAGATTATGGTGTCAGACCTTTATTAGAAGCTTTACTCAGGGAAGCCCCCGAACCAGAAA
CCACCGCCGCCCGTCGCCTCAAAGGAAAAGTTAGTCATACACCCATAGCCCAAGTCTTAAAAACCTATTACACTCCCCAA
GGTGGCAAACTTTCCCTCGTGCGAGTATGGCAAGGCAAACTCACCGATGGTATCATCCTCAACGGCGTGCGCGCTGGTGG
GATTTATCGCCTCATGGGACAACAACAGCAATCGGTGAACGAAGTCGGTGCAGGTGAAATTGTCGCCCTCAGCCGTTTAG
AAGGAATTAAAACCGGGGATACCATCTCCACAGAACAGCCGACGCAATTACCCAAAGCCCAACAGTTAGAGCCAGTTTAC
GCCCTCGCCATCACCCCAGAAAAGCGCAACGATGAAGTTAAACTCAGCAACGCTATCACCAAACTCTTAGAAGAAGACCC
CTCTTTAGCTTGGGAACAACACGGCGACACCCACGAAGTGATTTTGTGGGGACAAGGCGAGATTCATTTGCAAGTCGCCC
TGGATAGACTGCGCCGCAAATATAACTTGCCCATGTCTACCCATTTGCCACAAGTGCCTTATAAAGAAACCATCCGTAAA
CCAGTCACCTCAGTACATGGACGCTACAAACACCAAAGCGGTGGTCATGGACAGTTCGGTGATGTGTTCCTGGATATCAA
ACCCCTACCACGGGGTGAAGGCTTCAACTTTAAAGAAAGCATTGTTGGTGGTGTAGTACCTAGACAGTATATTCCTGGGG
TAGAAATGGGTGTGCGGGAATTTCTTGTACATGGGCCTTTAGGCTTCCCAGTGGTTGATGTGGCGGTGACATTAACAAAT
GGTTCCTATCACACCGTTGATAGTTCCGAACAAGCCTTCAAGCAAGCCGCCCGTTTAGCCATGCAAACAGGCATACCCCA
AGCCCAACCCACCTTATTAGAGCCGATTTTGCGGGTGGAAGTGACAACACCCAGTGAGTTTACCTCTAAGGTGCTGCAAT
TATTGAGTGGTAGACGTGGGCAAATTTTGGGCTACGAAGGCAGACAAGATTGGCAAGGCTGGGATAATATTTCTGCTTAC
CTACCACAAGCCGAGATGCAAAACTTTATTGTAGAGCTGCGATCGCTCACTCTCGGCGTTGGTTCATTCCATTGGGCTTA
TGACCACCTGCAAGAAGTCCCAGAAAAGCTTGCTGAACGCGTACTTGCTAGTAACGGTAATGGTAGTAACGGCAATGGCA
AGTAG

Upstream 100 bases:

>100_bases
GGAAGGATAATAACAAGTTAAAGAGAGGGTAATTCTCGGATTATTCATCTTTGACAAAACAGGGCAATGCGGTATTGAGA
CTTACCGCAAGGGAGGTTTT

Downstream 100 bases:

>100_bases
TATCAGTTAACGAATGTCTCCTCTATTCAGAATCTTGGAGTGGTAATATTTATCACTCCAATTTTTTATCACTATTCACC
TTCAGAATATGGACATAATT

Product: elongation factor G

Products: GDP; phosphate

Alternate protein names: NA

Number of amino acids: Translated: 694; Mature: 693

Protein sequence:

>694_residues
MSEKVRLGSRNVAIVGPYLSGKTTLLESLLFVTGAISRKGSVKDTNTVGDSANESRDRHMSVEISTACAEYNDIRFTFID
CPGSVEFTQETYNALMGVDAAIVVCEPIRERVLTLAPLFKFLDDWEIPHLVFVNKMDRANIHVLETLHALKAVSSRPLVA
HQYPIMQREVGAAASADPNFGGEQLTGFIDMVSEQAYQYHPGAPADPIPFPEHLKQEEHTARAEMLEALANFDDHLLEEL
LEDIEPPAEEILKDLKMELGADLVVPVFFGVAEQDYGVRPLLEALLREAPEPETTAARRLKGKVSHTPIAQVLKTYYTPQ
GGKLSLVRVWQGKLTDGIILNGVRAGGIYRLMGQQQQSVNEVGAGEIVALSRLEGIKTGDTISTEQPTQLPKAQQLEPVY
ALAITPEKRNDEVKLSNAITKLLEEDPSLAWEQHGDTHEVILWGQGEIHLQVALDRLRRKYNLPMSTHLPQVPYKETIRK
PVTSVHGRYKHQSGGHGQFGDVFLDIKPLPRGEGFNFKESIVGGVVPRQYIPGVEMGVREFLVHGPLGFPVVDVAVTLTN
GSYHTVDSSEQAFKQAARLAMQTGIPQAQPTLLEPILRVEVTTPSEFTSKVLQLLSGRRGQILGYEGRQDWQGWDNISAY
LPQAEMQNFIVELRSLTLGVGSFHWAYDHLQEVPEKLAERVLASNGNGSNGNGK

Sequences:

>Translated_694_residues
MSEKVRLGSRNVAIVGPYLSGKTTLLESLLFVTGAISRKGSVKDTNTVGDSANESRDRHMSVEISTACAEYNDIRFTFID
CPGSVEFTQETYNALMGVDAAIVVCEPIRERVLTLAPLFKFLDDWEIPHLVFVNKMDRANIHVLETLHALKAVSSRPLVA
HQYPIMQREVGAAASADPNFGGEQLTGFIDMVSEQAYQYHPGAPADPIPFPEHLKQEEHTARAEMLEALANFDDHLLEEL
LEDIEPPAEEILKDLKMELGADLVVPVFFGVAEQDYGVRPLLEALLREAPEPETTAARRLKGKVSHTPIAQVLKTYYTPQ
GGKLSLVRVWQGKLTDGIILNGVRAGGIYRLMGQQQQSVNEVGAGEIVALSRLEGIKTGDTISTEQPTQLPKAQQLEPVY
ALAITPEKRNDEVKLSNAITKLLEEDPSLAWEQHGDTHEVILWGQGEIHLQVALDRLRRKYNLPMSTHLPQVPYKETIRK
PVTSVHGRYKHQSGGHGQFGDVFLDIKPLPRGEGFNFKESIVGGVVPRQYIPGVEMGVREFLVHGPLGFPVVDVAVTLTN
GSYHTVDSSEQAFKQAARLAMQTGIPQAQPTLLEPILRVEVTTPSEFTSKVLQLLSGRRGQILGYEGRQDWQGWDNISAY
LPQAEMQNFIVELRSLTLGVGSFHWAYDHLQEVPEKLAERVLASNGNGSNGNGK
>Mature_693_residues
SEKVRLGSRNVAIVGPYLSGKTTLLESLLFVTGAISRKGSVKDTNTVGDSANESRDRHMSVEISTACAEYNDIRFTFIDC
PGSVEFTQETYNALMGVDAAIVVCEPIRERVLTLAPLFKFLDDWEIPHLVFVNKMDRANIHVLETLHALKAVSSRPLVAH
QYPIMQREVGAAASADPNFGGEQLTGFIDMVSEQAYQYHPGAPADPIPFPEHLKQEEHTARAEMLEALANFDDHLLEELL
EDIEPPAEEILKDLKMELGADLVVPVFFGVAEQDYGVRPLLEALLREAPEPETTAARRLKGKVSHTPIAQVLKTYYTPQG
GKLSLVRVWQGKLTDGIILNGVRAGGIYRLMGQQQQSVNEVGAGEIVALSRLEGIKTGDTISTEQPTQLPKAQQLEPVYA
LAITPEKRNDEVKLSNAITKLLEEDPSLAWEQHGDTHEVILWGQGEIHLQVALDRLRRKYNLPMSTHLPQVPYKETIRKP
VTSVHGRYKHQSGGHGQFGDVFLDIKPLPRGEGFNFKESIVGGVVPRQYIPGVEMGVREFLVHGPLGFPVVDVAVTLTNG
SYHTVDSSEQAFKQAARLAMQTGIPQAQPTLLEPILRVEVTTPSEFTSKVLQLLSGRRGQILGYEGRQDWQGWDNISAYL
PQAEMQNFIVELRSLTLGVGSFHWAYDHLQEVPEKLAERVLASNGNGSNGNGK

Specific function: This Protein Promotes The GTP-Dependent Translocation Of The Nascent Protein Chain From The A-Site To The P-Site Of The Ribosome. [C]

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=695, Percent_Identity=29.6402877697842, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI19923640, Length=709, Percent_Identity=25.9520451339915, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI25306287, Length=703, Percent_Identity=25.1778093883357, Blast_Score=173, Evalue=4e-43,
Organism=Homo sapiens, GI25306283, Length=397, Percent_Identity=24.9370277078086, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI1789738, Length=712, Percent_Identity=32.1629213483146, Blast_Score=342, Evalue=6e-95,
Organism=Escherichia coli, GI1790835, Length=475, Percent_Identity=22.9473684210526, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17533571, Length=706, Percent_Identity=28.328611898017, Blast_Score=273, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17556745, Length=725, Percent_Identity=22.2068965517241, Blast_Score=125, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6323098, Length=693, Percent_Identity=31.1688311688312, Blast_Score=294, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6322359, Length=802, Percent_Identity=23.6907730673317, Blast_Score=167, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24582462, Length=691, Percent_Identity=31.8379160636758, Blast_Score=292, Evalue=5e-79,
Organism=Drosophila melanogaster, GI221458488, Length=723, Percent_Identity=25.7261410788382, Blast_Score=172, Evalue=1e-42,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 76725; Mature: 76594

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKVRLGSRNVAIVGPYLSGKTTLLESLLFVTGAISRKGSVKDTNTVGDSANESRDRHM
CCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEE
SVEISTACAEYNDIRFTFIDCPGSVEFTQETYNALMGVDAAIVVCEPIRERVLTLAPLFK
EEEEHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHHHH
FLDDWEIPHLVFVNKMDRANIHVLETLHALKAVSSRPLVAHQYPIMQREVGAAASADPNF
HHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEECCCCHHHHHHCCCCCCCCCC
GGEQLTGFIDMVSEQAYQYHPGAPADPIPFPEHLKQEEHTARAEMLEALANFDDHLLEEL
CHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LEDIEPPAEEILKDLKMELGADLVVPVFFGVAEQDYGVRPLLEALLREAPEPETTAARRL
HHHCCCCHHHHHHHHHHHHCCCEEHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
KGKVSHTPIAQVLKTYYTPQGGKLSLVRVWQGKLTDGIILNGVRAGGIYRLMGQQQQSVN
HCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEECCCCCCHHHHHCCHHHHHH
EVGAGEIVALSRLEGIKTGDTISTEQPTQLPKAQQLEPVYALAITPEKRNDEVKLSNAIT
HCCCCCEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHH
KLLEEDPSLAWEQHGDTHEVILWGQGEIHLQVALDRLRRKYNLPMSTHLPQVPYKETIRK
HHHHCCCCCHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHH
PVTSVHGRYKHQSGGHGQFGDVFLDIKPLPRGEGFNFKESIVGGVVPRQYIPGVEMGVRE
HHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCHHHCCCHHHHHHH
FLVHGPLGFPVVDVAVTLTNGSYHTVDSSEQAFKQAARLAMQTGIPQAQPTLLEPILRVE
HHHHCCCCCCEEEEEEEEECCCEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHEEE
VTTPSEFTSKVLQLLSGRRGQILGYEGRQDWQGWDNISAYLPQAEMQNFIVELRSLTLGV
ECCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCC
GSFHWAYDHLQEVPEKLAERVLASNGNGSNGNGK
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SEKVRLGSRNVAIVGPYLSGKTTLLESLLFVTGAISRKGSVKDTNTVGDSANESRDRHM
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEE
SVEISTACAEYNDIRFTFIDCPGSVEFTQETYNALMGVDAAIVVCEPIRERVLTLAPLFK
EEEEHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHHHH
FLDDWEIPHLVFVNKMDRANIHVLETLHALKAVSSRPLVAHQYPIMQREVGAAASADPNF
HHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEECCCCHHHHHHCCCCCCCCCC
GGEQLTGFIDMVSEQAYQYHPGAPADPIPFPEHLKQEEHTARAEMLEALANFDDHLLEEL
CHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
LEDIEPPAEEILKDLKMELGADLVVPVFFGVAEQDYGVRPLLEALLREAPEPETTAARRL
HHHCCCCHHHHHHHHHHHHCCCEEHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
KGKVSHTPIAQVLKTYYTPQGGKLSLVRVWQGKLTDGIILNGVRAGGIYRLMGQQQQSVN
HCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEECCCCCCHHHHHCCHHHHHH
EVGAGEIVALSRLEGIKTGDTISTEQPTQLPKAQQLEPVYALAITPEKRNDEVKLSNAIT
HCCCCCEEEHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHH
KLLEEDPSLAWEQHGDTHEVILWGQGEIHLQVALDRLRRKYNLPMSTHLPQVPYKETIRK
HHHHCCCCCHHHCCCCCEEEEEECCCCEEHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHH
PVTSVHGRYKHQSGGHGQFGDVFLDIKPLPRGEGFNFKESIVGGVVPRQYIPGVEMGVRE
HHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCHHHCCCHHHHHHH
FLVHGPLGFPVVDVAVTLTNGSYHTVDSSEQAFKQAARLAMQTGIPQAQPTLLEPILRVE
HHHHCCCCCCEEEEEEEEECCCEEECCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHEEE
VTTPSEFTSKVLQLLSGRRGQILGYEGRQDWQGWDNISAYLPQAEMQNFIVELRSLTLGV
ECCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHCC
GSFHWAYDHLQEVPEKLAERVLASNGNGSNGNGK
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]