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The map label for this gene is hemB [H]

Identifier: 17231872

GI number: 17231872

Start: 5250505

End: 5251485

Strand: Direct

Name: hemB [H]

Synonym: alr4380

Alternate gene names: 17231872

Gene position: 5250505-5251485 (Clockwise)

Preceding gene: 17231865

Following gene: 17231875

Centisome position: 81.86

GC content: 45.46

Gene sequence:

>981_bases
ATGTTTCCAACACACCGCCCTCGTCGTTTGCGTACCCATCCCCAATTACGCCGCATGGTACGTGAGACTGTATTGACTAC
CAATGATTTGATTTACCCGTTGTTTGCTGTTCCCGGAGAAGGAATTGCTAACGAAGTAAAATCTATGCCTGGTGTCTATC
AACTATCGGTAGATAAGATTGTTGAGGAAGCTAAAGAGGTTCACGATTTAGGCATTCCCGCAATTATTTTGTTTGGTATT
CCCGCAGATAAGGATACAGATGCGACAGGTGCTTGGCATGATTGCGGTATTGTCCAAAAGGCTGCAACGGCTGTAAAAGC
AGCAGTACCCGATTTGATTGTAATTGCGGATACTTGTTTGTGCGAGTACACCAGTCATGGACATTGCGGTTATTTGCAAG
TGGGTGATTTGACAGGACGAGTATTGAATGACCCTACTTTAGAATTGTTGAAGAAAACCGCAGTTTCCCAAGCCAAAGCT
GGTGCGGATATTATCGCCCCTTCCGGGATGATGGATGGCTTTGTGCAGGCAATTCGCGCAGGTTTAGATGAAGCAGGATT
TCAAGACACGCCGATTTTGTCTTATGCTGCTAAGTATGCTTCGGCTTATTATGGCCCATTTAGGGATGCAGCAGATTCTA
CACCACAATTTGGAGATAGAAGAACCTACCAAATGGACCCTGGTAACTCCCGCGAAGCTATCAGAGAAATTGAACTAGAT
ATAGCTGAAGGCGCTGATATGTTGATGGTGAAGCCTGCTTTGGCTTACATGGACATTATTTGGCAGGTAAAGGAAGCCAG
TAATTTACCTGTGGCTGCTTACAATGTGTCTGGTGAATATTCGATGGTGAAAGCTGCGGCGCTGAATGGTTGGATTGATG
AACAGCGCGTAGTGATGGAAACTTTAACTGGGTTTAAGCGTGCTGGTGCTGACCTGATTTTAACCTATCACGCTAAAGAT
GCTGCTCGTTGGTTACCGTAG

Upstream 100 bases:

>100_bases
TAAGCACTTTTTGTAGTCTGTCCGACGACAACGGAGTTTCGCCAGACTTTTGTGACGCTTTGTTTTGTGTCCATACCATT
GTTATTTTTTACAAAACTTT

Downstream 100 bases:

>100_bases
GGTAGGCTATCTCACGCATAGGCGCGGAAATATAGAGTTTTTCGTGTTTAGGCGTGAGATTGATTTTCGTCACAGTTACG
GGAATACTCAAACTCGGCTT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MFPTHRPRRLRTHPQLRRMVRETVLTTNDLIYPLFAVPGEGIANEVKSMPGVYQLSVDKIVEEAKEVHDLGIPAIILFGI
PADKDTDATGAWHDCGIVQKAATAVKAAVPDLIVIADTCLCEYTSHGHCGYLQVGDLTGRVLNDPTLELLKKTAVSQAKA
GADIIAPSGMMDGFVQAIRAGLDEAGFQDTPILSYAAKYASAYYGPFRDAADSTPQFGDRRTYQMDPGNSREAIREIELD
IAEGADMLMVKPALAYMDIIWQVKEASNLPVAAYNVSGEYSMVKAAALNGWIDEQRVVMETLTGFKRAGADLILTYHAKD
AARWLP

Sequences:

>Translated_326_residues
MFPTHRPRRLRTHPQLRRMVRETVLTTNDLIYPLFAVPGEGIANEVKSMPGVYQLSVDKIVEEAKEVHDLGIPAIILFGI
PADKDTDATGAWHDCGIVQKAATAVKAAVPDLIVIADTCLCEYTSHGHCGYLQVGDLTGRVLNDPTLELLKKTAVSQAKA
GADIIAPSGMMDGFVQAIRAGLDEAGFQDTPILSYAAKYASAYYGPFRDAADSTPQFGDRRTYQMDPGNSREAIREIELD
IAEGADMLMVKPALAYMDIIWQVKEASNLPVAAYNVSGEYSMVKAAALNGWIDEQRVVMETLTGFKRAGADLILTYHAKD
AARWLP
>Mature_326_residues
MFPTHRPRRLRTHPQLRRMVRETVLTTNDLIYPLFAVPGEGIANEVKSMPGVYQLSVDKIVEEAKEVHDLGIPAIILFGI
PADKDTDATGAWHDCGIVQKAATAVKAAVPDLIVIADTCLCEYTSHGHCGYLQVGDLTGRVLNDPTLELLKKTAVSQAKA
GADIIAPSGMMDGFVQAIRAGLDEAGFQDTPILSYAAKYASAYYGPFRDAADSTPQFGDRRTYQMDPGNSREAIREIELD
IAEGADMLMVKPALAYMDIIWQVKEASNLPVAAYNVSGEYSMVKAAALNGWIDEQRVVMETLTGFKRAGADLILTYHAKD
AARWLP

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=318, Percent_Identity=40.5660377358491, Blast_Score=245, Evalue=3e-65,
Organism=Escherichia coli, GI87081728, Length=318, Percent_Identity=52.2012578616352, Blast_Score=315, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6321398, Length=319, Percent_Identity=42.0062695924765, Blast_Score=238, Evalue=1e-63,
Organism=Drosophila melanogaster, GI21358291, Length=317, Percent_Identity=39.4321766561514, Blast_Score=234, Evalue=5e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 35587; Mature: 35587

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPTHRPRRLRTHPQLRRMVRETVLTTNDLIYPLFAVPGEGIANEVKSMPGVYQLSVDKI
CCCCCCCCHHCCCHHHHHHHHHHHHHCCCCEEEHEECCCCHHHHHHHHCCCEEEEEHHHH
VEEAKEVHDLGIPAIILFGIPADKDTDATGAWHDCGIVQKAATAVKAAVPDLIVIADTCL
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHH
CEYTSHGHCGYLQVGDLTGRVLNDPTLELLKKTAVSQAKAGADIIAPSGMMDGFVQAIRA
HHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHH
GLDEAGFQDTPILSYAAKYASAYYGPFRDAADSTPQFGDRRTYQMDPGNSREAIREIELD
CHHHCCCCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
IAEGADMLMVKPALAYMDIIWQVKEASNLPVAAYNVSGEYSMVKAAALNGWIDEQRVVME
HHCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHH
TLTGFKRAGADLILTYHAKDAARWLP
HHHHHHHCCCCEEEEEECCCHHCCCC
>Mature Secondary Structure
MFPTHRPRRLRTHPQLRRMVRETVLTTNDLIYPLFAVPGEGIANEVKSMPGVYQLSVDKI
CCCCCCCCHHCCCHHHHHHHHHHHHHCCCCEEEHEECCCCHHHHHHHHCCCEEEEEHHHH
VEEAKEVHDLGIPAIILFGIPADKDTDATGAWHDCGIVQKAATAVKAAVPDLIVIADTCL
HHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEHHHHH
CEYTSHGHCGYLQVGDLTGRVLNDPTLELLKKTAVSQAKAGADIIAPSGMMDGFVQAIRA
HHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHH
GLDEAGFQDTPILSYAAKYASAYYGPFRDAADSTPQFGDRRTYQMDPGNSREAIREIELD
CHHHCCCCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
IAEGADMLMVKPALAYMDIIWQVKEASNLPVAAYNVSGEYSMVKAAALNGWIDEQRVVME
HHCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHH
TLTGFKRAGADLILTYHAKDAARWLP
HHHHHHHCCCCEEEEEECCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]