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The map label for this gene is lon2 [H]

Identifier: 17231827

GI number: 17231827

Start: 5189070

End: 5189720

Strand: Reverse

Name: lon2 [H]

Synonym: all4335

Alternate gene names: 17231827

Gene position: 5189720-5189070 (Counterclockwise)

Preceding gene: 17231828

Following gene: 17231825

Centisome position: 80.92

GC content: 43.78

Gene sequence:

>651_bases
ATGACATCTTCTTCTAGAATTGCCGTCCGCGAACTACCTCTGTTCCCGTTACCCGAAGTAGTTCTGTTTCCTACCAGACC
ATTGCCCCTGCATATATTTGAATTCCGCTACCGAATCATGATGAACACGATTTTGGAAAGCGATCGCAGGTTTGGTGTCT
TGATGGTTGACCCAGTAAAAGGCACAATTGCAAATGTAGGTTGCTGTGCAGAAATTATTCACTATCAGCGTCTACCAGAT
GACCGCATGAAAATGTTGACTTTGGGACAACAAAGATTCCGTGTCTTAGAATATGTGCGGGAAAAACCCTACCGTGTCGG
TTTAGTGGAATGGTTAGAAGACCATCCACCAGCAAAGGATTTGCGCCCTTTGGCAACAGATGTAGAGCAACTGCTGCGTG
ATGTTGTTCGTCTTTCAGCCAAAATTACAGAACAAAATATAGAGATTCCTGAAGAACTGCCAGATTTACCCACAGAATTA
TCTTACTGGGTCGCCAGCAACTTATATGGGGTAGCTGGAGAGCAGCAATCATTACTGGAAATGCAAGATACTGCTGCTCG
CCTAGAACGAGAAGCGGAAATTTTAACAACCACTCGCAATCACTTGGCAGCTCGTTCTGTTTTGAAAGATACATTTAATC
CAAAGCTATAA

Upstream 100 bases:

>100_bases
GCATTTTATTTAGCCAGAAAACAAATGATAGAATGTAAAGAAAATACGGGAAAAGCAGAGAAAGAGAAATTTTAAAGATT
AAATTTATACTCAGGTAAAA

Downstream 100 bases:

>100_bases
GTTGATGTCGTGAAGTTGAGCAATAATGCAGTAATAATTACTATTGATTGTTAGCCGAAATTACACTGTAACTACCAAAA
ATTTTTAAGACTTCTGTGTA

Product: hypothetical protein

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTSSSRIAVRELPLFPLPEVVLFPTRPLPLHIFEFRYRIMMNTILESDRRFGVLMVDPVKGTIANVGCCAEIIHYQRLPD
DRMKMLTLGQQRFRVLEYVREKPYRVGLVEWLEDHPPAKDLRPLATDVEQLLRDVVRLSAKITEQNIEIPEELPDLPTEL
SYWVASNLYGVAGEQQSLLEMQDTAARLEREAEILTTTRNHLAARSVLKDTFNPKL

Sequences:

>Translated_216_residues
MTSSSRIAVRELPLFPLPEVVLFPTRPLPLHIFEFRYRIMMNTILESDRRFGVLMVDPVKGTIANVGCCAEIIHYQRLPD
DRMKMLTLGQQRFRVLEYVREKPYRVGLVEWLEDHPPAKDLRPLATDVEQLLRDVVRLSAKITEQNIEIPEELPDLPTEL
SYWVASNLYGVAGEQQSLLEMQDTAARLEREAEILTTTRNHLAARSVLKDTFNPKL
>Mature_215_residues
TSSSRIAVRELPLFPLPEVVLFPTRPLPLHIFEFRYRIMMNTILESDRRFGVLMVDPVKGTIANVGCCAEIIHYQRLPDD
RMKMLTLGQQRFRVLEYVREKPYRVGLVEWLEDHPPAKDLRPLATDVEQLLRDVVRLSAKITEQNIEIPEELPDLPTELS
YWVASNLYGVAGEQQSLLEMQDTAARLEREAEILTTTRNHLAARSVLKDTFNPKL

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG2802

COG function: function code R; Uncharacterized protein, similar to the N-terminal domain of Lon protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI73747840, Length=107, Percent_Identity=38.3177570093458, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI37622896, Length=107, Percent_Identity=38.3177570093458, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI87080813, Length=207, Percent_Identity=30.9178743961353, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI148528975, Length=127, Percent_Identity=33.8582677165354, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 24952; Mature: 24821

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSSRIAVRELPLFPLPEVVLFPTRPLPLHIFEFRYRIMMNTILESDRRFGVLMVDPVK
CCCCCCEEHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
GTIANVGCCAEIIHYQRLPDDRMKMLTLGQQRFRVLEYVREKPYRVGLVEWLEDHPPAKD
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHCCCCHHH
LRPLATDVEQLLRDVVRLSAKITEQNIEIPEELPDLPTELSYWVASNLYGVAGEQQSLLE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHCCCCCCCCHHHHHH
MQDTAARLEREAEILTTTRNHLAARSVLKDTFNPKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TSSSRIAVRELPLFPLPEVVLFPTRPLPLHIFEFRYRIMMNTILESDRRFGVLMVDPVK
CCCCCEEHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
GTIANVGCCAEIIHYQRLPDDRMKMLTLGQQRFRVLEYVREKPYRVGLVEWLEDHPPAKD
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHCCCCHHH
LRPLATDVEQLLRDVVRLSAKITEQNIEIPEELPDLPTELSYWVASNLYGVAGEQQSLLE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHCCCCCCCCHHHHHH
MQDTAARLEREAEILTTTRNHLAARSVLKDTFNPKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8331083; 8331082 [H]