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The map label for this gene is pheA [H]

Identifier: 17231826

GI number: 17231826

Start: 5188157

End: 5189029

Strand: Direct

Name: pheA [H]

Synonym: alr4334

Alternate gene names: 17231826

Gene position: 5188157-5189029 (Clockwise)

Preceding gene: 17231824

Following gene: 17231836

Centisome position: 80.89

GC content: 40.09

Gene sequence:

>873_bases
ATGACATTGTCTGTTGCTCATTTAGGGCCACCTGGCACTTATGCAGAACAAGCTACTATTTTTTATGTAAAATGGCTGAC
TCATAATACTGGACTCGAAGCTGTTTTACATCCCTATTCCAGCATTGCTCAATCCCTCCAAGCTCTAGCTCAAGGAGAAA
CTCAATTAGCTGTTGTGCCTGTAGAAAATTCTATTGAAGGCAGTGTCACCATGACAATGGATACAATGTGGCAGATGGAT
AGTTTGCAAATTCAATCAGCTTTAGTCTTGCCTATTGCTCATGCTTTAATTTCTTGTGCAAATAGTTTAGCTGGGATAAA
AACTGTTTATTCTCATCCCCAGGCCTTAGCCCAGTGTCAAGGGTGGCTGAGAGAATTTCTTCCTGATGTCCAACTGATTC
CTAGTAATTCAACAACTGAGGCGCTGGAAAAACTAGAGCAAGATTTAGCAGTAGGGGCGATCGCTTCTAGTAGATCTGCT
GAACTTTATAATTTGCCCATACTAGCTAGTCGCATTAACGACTATCCAGAAAATTGTACTCGGTTTTGGGCAATCAGTCA
CGCAGAATCTGGTATTACGCACCAATTACCTTTACAAAAACTCACTCACACTTCTATCGCTTTTAGTGTACCTGCCAACG
TACCTGGTGCATTGCTCAAAACACTACAAGTTTTTGCCCACTTGGATATTAACTTGAGTCGAATTGAGTCTCGTCCGACA
AAGCGATCGCTCGGTGAATATTTATTTTTTATTGATTTGGAAGCTGATGTCAATACACCACAGATGAAATCTGCTTTGGT
TGAATTAACTACTTACACAGAAGTCTTAAAAATTTTTGGTAGTTACAGTGTAATTTCGGCTAACAATCAATAG

Upstream 100 bases:

>100_bases
CACTTGATTTTTGGTTCATAGTTAGTTGCTGACAGTCATATTCTATTTGTACTTATGATAAAGTCTATACACCAAATATA
TAACTATAGGTAAAAACATA

Downstream 100 bases:

>100_bases
TAATTATTACTGCATTATTGCTCAACTTCACGACATCAACTTATAGCTTTGGATTAAATGTATCTTTCAAAACAGAACGA
GCTGCCAAGTGATTGCGAGT

Product: prephenate dehydratase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MTLSVAHLGPPGTYAEQATIFYVKWLTHNTGLEAVLHPYSSIAQSLQALAQGETQLAVVPVENSIEGSVTMTMDTMWQMD
SLQIQSALVLPIAHALISCANSLAGIKTVYSHPQALAQCQGWLREFLPDVQLIPSNSTTEALEKLEQDLAVGAIASSRSA
ELYNLPILASRINDYPENCTRFWAISHAESGITHQLPLQKLTHTSIAFSVPANVPGALLKTLQVFAHLDINLSRIESRPT
KRSLGEYLFFIDLEADVNTPQMKSALVELTTYTEVLKIFGSYSVISANNQ

Sequences:

>Translated_290_residues
MTLSVAHLGPPGTYAEQATIFYVKWLTHNTGLEAVLHPYSSIAQSLQALAQGETQLAVVPVENSIEGSVTMTMDTMWQMD
SLQIQSALVLPIAHALISCANSLAGIKTVYSHPQALAQCQGWLREFLPDVQLIPSNSTTEALEKLEQDLAVGAIASSRSA
ELYNLPILASRINDYPENCTRFWAISHAESGITHQLPLQKLTHTSIAFSVPANVPGALLKTLQVFAHLDINLSRIESRPT
KRSLGEYLFFIDLEADVNTPQMKSALVELTTYTEVLKIFGSYSVISANNQ
>Mature_289_residues
TLSVAHLGPPGTYAEQATIFYVKWLTHNTGLEAVLHPYSSIAQSLQALAQGETQLAVVPVENSIEGSVTMTMDTMWQMDS
LQIQSALVLPIAHALISCANSLAGIKTVYSHPQALAQCQGWLREFLPDVQLIPSNSTTEALEKLEQDLAVGAIASSRSAE
LYNLPILASRINDYPENCTRFWAISHAESGITHQLPLQKLTHTSIAFSVPANVPGALLKTLQVFAHLDINLSRIESRPTK
RSLGEYLFFIDLEADVNTPQMKSALVELTTYTEVLKIFGSYSVISANNQ

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=281, Percent_Identity=29.8932384341637, Blast_Score=118, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6324013, Length=314, Percent_Identity=28.343949044586, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010957
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01842 ACT; PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 31708; Mature: 31576

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00857 PREPHENATE_DEHYDR_1 ; PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSVAHLGPPGTYAEQATIFYVKWLTHNTGLEAVLHPYSSIAQSLQALAQGETQLAVVP
CEEEEECCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
VENSIEGSVTMTMDTMWQMDSLQIQSALVLPIAHALISCANSLAGIKTVYSHPQALAQCQ
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
GWLREFLPDVQLIPSNSTTEALEKLEQDLAVGAIASSRSAELYNLPILASRINDYPENCT
HHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHCCCHHHHH
RFWAISHAESGITHQLPLQKLTHTSIAFSVPANVPGALLKTLQVFAHLDINLSRIESRPT
HEEEEECCCCCCCCCCCHHHHHHCEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHCCCC
KRSLGEYLFFIDLEADVNTPQMKSALVELTTYTEVLKIFGSYSVISANNQ
HHHHCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
>Mature Secondary Structure 
TLSVAHLGPPGTYAEQATIFYVKWLTHNTGLEAVLHPYSSIAQSLQALAQGETQLAVVP
EEEEECCCCCCCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
VENSIEGSVTMTMDTMWQMDSLQIQSALVLPIAHALISCANSLAGIKTVYSHPQALAQCQ
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHH
GWLREFLPDVQLIPSNSTTEALEKLEQDLAVGAIASSRSAELYNLPILASRINDYPENCT
HHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHCCCHHHHH
RFWAISHAESGITHQLPLQKLTHTSIAFSVPANVPGALLKTLQVFAHLDINLSRIESRPT
HEEEEECCCCCCCCCCCHHHHHHCEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHCCCC
KRSLGEYLFFIDLEADVNTPQMKSALVELTTYTEVLKIFGSYSVISANNQ
HHHHCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]