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The map label for this gene is ubiH [C]

Identifier: 17231766

GI number: 17231766

Start: 5126592

End: 5127851

Strand: Reverse

Name: ubiH [C]

Synonym: all4274

Alternate gene names: 17231766

Gene position: 5127851-5126592 (Counterclockwise)

Preceding gene: 17231768

Following gene: 17231764

Centisome position: 79.95

GC content: 44.6

Gene sequence:

>1260_bases
ATGGCGCTAACGCAGCTTACTCAAACTATTTCTCCTCAACCGACACCGCCAGAACTGCGAAAATACGACTATGATTTAGT
CATCGTCGGCGGTGGAATTGTTGGGTTAACTCTAGCTTCAGCATTAAAAGATTCTGGCTTGAATATACTGCTAATTGAAG
CCAAAGTTGCATCAGCAGCAGTAGCTAAAGGTCAAGCCTACGCAGTTCATCTACTATCAGCCCTAATTTACCAAGGAATT
GGTATTTGGGATAAAATTCTGCCTCAGATTGCCAAGTACCGCCAAGTCCGTCTTTCTGATGCTGATTATCCTGGTGTGGT
GGAGTTTGAAAGCACAGATTTAGGGACACCAGAATTAGGTTATGTAGCGGAACATCAAGCGTTACTGGAACCTCTACAGG
AGTTTGTGCAGAATTGCCCAAATGTGACTTATCTTTGTCCGGCTGAGGTGGTGAGTACCAATTACCAGCCAAATGAAGTA
GTCATCGCTGTTAAAATTGCCGATCAATTAAACACAATTCGTAGCAAATTACTGGTAGCCGCAGATGGATCGCGATCGCC
TATTCGTCAGGCGGCGGGGATTAAAACTCATGGCTGGAAGTATTGGCAATCTTGCATTGTGGCTTTCGTTAAGCCAGAGA
AACCCCATAACGATACAGCTTACGAAAGATTTTGGCCTAGTGGCCCCTTTGCGATTTTACCTCTACCTGAGAACCGTTGC
CGCATCGTTTGGACGGCTCCCCACGATGAAGCAAAAGCCCTTTGTGCCTTAAATGACGAAGAATTTTTACGAGAACTTAG
CCAACGCTTTGGGCAGCAAATGGGTAAGTTGGAATTATTAGGCGATCGCTTCGTTTTTCAAGTACAACTAATGCAAAGCG
ATCGTTATGTCCTTCCCCGTTTAGCTTTAGTTGGCGATGCGGCACATAATTGTCATCCTGTGGGTGGACAAGGATTAAAC
TTGGGTATTCGAGATGTCGCCGCTTTAGCCCAAGTCATTCAAAAAGCACATCAAGCTGGTGAAGATATTGGTAATATTCG
GGTCTTGAAACGTTACGAAAGCTGGCGACAAAAAGAGAACCTAGCCATTTTAGGGTTCACTGATATGTTAGACCGGATGT
TCTCTAACCAATTCCCTCCGTTGGTGTTTCTTCGTCGCTTGGGTTTATGGTTTTTACGCAGTGTCCCTGTGCTGAAAACA
TTTATGCTCAAGTTGATGATTGGGTTGAAGGGAAAAACTCCAGAATTGGCTAAACGTTGA

Upstream 100 bases:

>100_bases
CTATATATCTGTCGCATTCTTTTTTCAAATTGGTATAACTTGCTCAAATAGGGGCGATCGCGTAACAATAATAGTTAAGA
TCGCTTAATCTCTCTTAACA

Downstream 100 bases:

>100_bases
AAGTTTTGTGGGAGTAGTATGCTGTGTTTAAACGTCAGTGATGGCAACTCAGGATGATTCTACTCCTCAAACAATTCCCT
TACCTTTTCTTGGCATTCTC

Product: 2-octaprenyl-6-methoxyphenyl hydroxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MALTQLTQTISPQPTPPELRKYDYDLVIVGGGIVGLTLASALKDSGLNILLIEAKVASAAVAKGQAYAVHLLSALIYQGI
GIWDKILPQIAKYRQVRLSDADYPGVVEFESTDLGTPELGYVAEHQALLEPLQEFVQNCPNVTYLCPAEVVSTNYQPNEV
VIAVKIADQLNTIRSKLLVAADGSRSPIRQAAGIKTHGWKYWQSCIVAFVKPEKPHNDTAYERFWPSGPFAILPLPENRC
RIVWTAPHDEAKALCALNDEEFLRELSQRFGQQMGKLELLGDRFVFQVQLMQSDRYVLPRLALVGDAAHNCHPVGGQGLN
LGIRDVAALAQVIQKAHQAGEDIGNIRVLKRYESWRQKENLAILGFTDMLDRMFSNQFPPLVFLRRLGLWFLRSVPVLKT
FMLKLMIGLKGKTPELAKR

Sequences:

>Translated_419_residues
MALTQLTQTISPQPTPPELRKYDYDLVIVGGGIVGLTLASALKDSGLNILLIEAKVASAAVAKGQAYAVHLLSALIYQGI
GIWDKILPQIAKYRQVRLSDADYPGVVEFESTDLGTPELGYVAEHQALLEPLQEFVQNCPNVTYLCPAEVVSTNYQPNEV
VIAVKIADQLNTIRSKLLVAADGSRSPIRQAAGIKTHGWKYWQSCIVAFVKPEKPHNDTAYERFWPSGPFAILPLPENRC
RIVWTAPHDEAKALCALNDEEFLRELSQRFGQQMGKLELLGDRFVFQVQLMQSDRYVLPRLALVGDAAHNCHPVGGQGLN
LGIRDVAALAQVIQKAHQAGEDIGNIRVLKRYESWRQKENLAILGFTDMLDRMFSNQFPPLVFLRRLGLWFLRSVPVLKT
FMLKLMIGLKGKTPELAKR
>Mature_418_residues
ALTQLTQTISPQPTPPELRKYDYDLVIVGGGIVGLTLASALKDSGLNILLIEAKVASAAVAKGQAYAVHLLSALIYQGIG
IWDKILPQIAKYRQVRLSDADYPGVVEFESTDLGTPELGYVAEHQALLEPLQEFVQNCPNVTYLCPAEVVSTNYQPNEVV
IAVKIADQLNTIRSKLLVAADGSRSPIRQAAGIKTHGWKYWQSCIVAFVKPEKPHNDTAYERFWPSGPFAILPLPENRCR
IVWTAPHDEAKALCALNDEEFLRELSQRFGQQMGKLELLGDRFVFQVQLMQSDRYVLPRLALVGDAAHNCHPVGGQGLNL
GIRDVAALAQVIQKAHQAGEDIGNIRVLKRYESWRQKENLAILGFTDMLDRMFSNQFPPLVFLRRLGLWFLRSVPVLKTF
MLKLMIGLKGKTPELAKR

Specific function: Oxygenase That Introduces The Hydroxyl Group At Carbon Four Of 2-Octaprenyl-6-Methoxyphenol Resulting In The Formation Of 2-Octaprenyl-6-Methoxy-1,4-Benzoquinone. [C]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=369, Percent_Identity=29.810298102981, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI32967307, Length=341, Percent_Identity=30.2052785923754, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1789274, Length=371, Percent_Identity=34.2318059299191, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1786883, Length=390, Percent_Identity=34.6153846153846, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI1789273, Length=392, Percent_Identity=31.6326530612245, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI1786543, Length=399, Percent_Identity=24.5614035087719, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI25146631, Length=434, Percent_Identity=28.5714285714286, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6321694, Length=284, Percent_Identity=30.2816901408451, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI19920760, Length=445, Percent_Identity=27.1910112359551, Blast_Score=147, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.-

Molecular weight: Translated: 46692; Mature: 46561

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTQLTQTISPQPTPPELRKYDYDLVIVGGGIVGLTLASALKDSGLNILLIEAKVASAA
CCHHHHHHHCCCCCCCCHHHHCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEECHHHHHH
VAKGQAYAVHLLSALIYQGIGIWDKILPQIAKYRQVRLSDADYPGVVEFESTDLGTPELG
HHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCCCCCEEEECCCCCCCCCCC
YVAEHQALLEPLQEFVQNCPNVTYLCPAEVVSTNYQPNEVVIAVKIADQLNTIRSKLLVA
HHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHCCCCCCEEEEEEEEHHHHHHHHHHEEEE
ADGSRSPIRQAAGIKTHGWKYWQSCIVAFVKPEKPHNDTAYERFWPSGPFAILPLPENRC
ECCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCE
RIVWTAPHDEAKALCALNDEEFLRELSQRFGQQMGKLELLGDRFVFQVQLMQSDRYVLPR
EEEEECCCCHHHHEEECCHHHHHHHHHHHHHHHHCCEEEECCCEEEEEEEECCCCHHHHH
LALVGDAAHNCHPVGGQGLNLGIRDVAALAQVIQKAHQAGEDIGNIRVLKRYESWRQKEN
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
LAILGFTDMLDRMFSNQFPPLVFLRRLGLWFLRSVPVLKTFMLKLMIGLKGKTPELAKR
EEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHCC
>Mature Secondary Structure 
ALTQLTQTISPQPTPPELRKYDYDLVIVGGGIVGLTLASALKDSGLNILLIEAKVASAA
CHHHHHHHCCCCCCCCHHHHCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEECHHHHHH
VAKGQAYAVHLLSALIYQGIGIWDKILPQIAKYRQVRLSDADYPGVVEFESTDLGTPELG
HHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEECCCCCCCCEEEECCCCCCCCCCC
YVAEHQALLEPLQEFVQNCPNVTYLCPAEVVSTNYQPNEVVIAVKIADQLNTIRSKLLVA
HHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHCCCCCCEEEEEEEEHHHHHHHHHHEEEE
ADGSRSPIRQAAGIKTHGWKYWQSCIVAFVKPEKPHNDTAYERFWPSGPFAILPLPENRC
ECCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCE
RIVWTAPHDEAKALCALNDEEFLRELSQRFGQQMGKLELLGDRFVFQVQLMQSDRYVLPR
EEEEECCCCHHHHEEECCHHHHHHHHHHHHHHHHCCEEEECCCEEEEEEEECCCCHHHHH
LALVGDAAHNCHPVGGQGLNLGIRDVAALAQVIQKAHQAGEDIGNIRVLKRYESWRQKEN
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
LAILGFTDMLDRMFSNQFPPLVFLRRLGLWFLRSVPVLKTFMLKLMIGLKGKTPELAKR
EEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]