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The map label for this gene is pyrD [H]

Identifier: 17231764

GI number: 17231764

Start: 5122179

End: 5123309

Strand: Reverse

Name: pyrD [H]

Synonym: all4272

Alternate gene names: 17231764

Gene position: 5123309-5122179 (Counterclockwise)

Preceding gene: 17231766

Following gene: 17231758

Centisome position: 79.88

GC content: 44.3

Gene sequence:

>1131_bases
ATGGATATATATAAATTTGCAGTTCGTCCGCTTTTATTTGATTTGGTAAAGGCCGATCCTGAGTGGTTACATCAGCAAAC
AATGAGGAGTTTGAGTTGGCTGTCACACACAAGCGATCGCACAAGTACTAAGTGGGTGCAAAATATCCTACAAAAGTCAC
TTTGTCTAGAAGATTCTCGGCTGGAGCAGAATTTGTTTGGCTTAAGGTTTCCCAATCCTGTGGGTTTGGCTGCTGGTTTT
GATAAGGATGGTGTAGCAGCTAGAATTTGGTCTAGTTTAGGTTTTGGCTTTGCGGAACTGGGAACAGTCACATTTGTCGG
ACAACCTGGTAATCCTCCCCCGCGTCTGTTTCGCTTGCCGTTGGATCAAGCTGCTCTTAACCGCATGGGCTTTAATAATC
ATGGTGCGGCGGTGATGGCTGCACGCTTGGCTGATGAAAAAGGGCAGTTTTCCATCCCTATAGGTATCAATTTGGGTAAA
TCTAAGGTGACACCCTTAGAAGCCGCCGCCGAAGATTATTTAAATAGTTTTCGCTTACTCAAGGAGTTGGGTGACTATTT
TGTAGTTAATGTATCTTCTCCCAATACTCCGGGTTTGCGATCGCTCCAAGATGCCTCAATGCTCAGTTCTATCTTGGATG
TCTTACAAAAGGAAAATAATTCACATAAACCTATATTTGTCAAGATAGCACCGGATTTAGAATGGGAAGCGATCGCTGAC
ATTATTGGATTGGCTAAAACCTACCAGTTAGCAGGTATTATCGCTACTAACACCACAATTCGCCGTGATGGACTGAAAAC
TCAAGTGATTGAGCAAACAGGCAAGGCACCCCAAGAAGAAGCTGGAGGAATTAGCGGTGCGCCAGTGCGCGATCGCTCCA
CGGAAATCATTCGTTTTATTTGGCAGCAAACCCAGGGAGAAATTCCCATCATTGGAGTTGGGGGCATATTTACCCCTGAA
GATGCTTGGGCAAAAATTACTGCTGGAGCCAGCCTGATTCAAGTTTATACGGGCTGGATTTACCAAGGCCCAATGATGGT
GAGCCAGATTTTAACCGGGTTGCTGTCCAAGTTAGAAGAACATGAATTAAATTCCATCAGCGAAGCTATAGGCTTAGAAT
TTAAAAGTTAA

Upstream 100 bases:

>100_bases
ATTACCCACACTAATATCTTTACGGGTATTGATTGATATTTCTGGATGAAAGGGAGCGGTGACTGGGGGTTGGGGAAATT
AAAATTATTGGCTATTGACT

Downstream 100 bases:

>100_bases
TCAGCCAATAGTCAATAGTCCACAGTCAATAGTTTATTAAGCTTCGCGTGTCAGTTGTCAGTTGTCAGTTGTTGAAAGGA
TCTGGTCTAATACCCCAACC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MDIYKFAVRPLLFDLVKADPEWLHQQTMRSLSWLSHTSDRTSTKWVQNILQKSLCLEDSRLEQNLFGLRFPNPVGLAAGF
DKDGVAARIWSSLGFGFAELGTVTFVGQPGNPPPRLFRLPLDQAALNRMGFNNHGAAVMAARLADEKGQFSIPIGINLGK
SKVTPLEAAAEDYLNSFRLLKELGDYFVVNVSSPNTPGLRSLQDASMLSSILDVLQKENNSHKPIFVKIAPDLEWEAIAD
IIGLAKTYQLAGIIATNTTIRRDGLKTQVIEQTGKAPQEEAGGISGAPVRDRSTEIIRFIWQQTQGEIPIIGVGGIFTPE
DAWAKITAGASLIQVYTGWIYQGPMMVSQILTGLLSKLEEHELNSISEAIGLEFKS

Sequences:

>Translated_376_residues
MDIYKFAVRPLLFDLVKADPEWLHQQTMRSLSWLSHTSDRTSTKWVQNILQKSLCLEDSRLEQNLFGLRFPNPVGLAAGF
DKDGVAARIWSSLGFGFAELGTVTFVGQPGNPPPRLFRLPLDQAALNRMGFNNHGAAVMAARLADEKGQFSIPIGINLGK
SKVTPLEAAAEDYLNSFRLLKELGDYFVVNVSSPNTPGLRSLQDASMLSSILDVLQKENNSHKPIFVKIAPDLEWEAIAD
IIGLAKTYQLAGIIATNTTIRRDGLKTQVIEQTGKAPQEEAGGISGAPVRDRSTEIIRFIWQQTQGEIPIIGVGGIFTPE
DAWAKITAGASLIQVYTGWIYQGPMMVSQILTGLLSKLEEHELNSISEAIGLEFKS
>Mature_376_residues
MDIYKFAVRPLLFDLVKADPEWLHQQTMRSLSWLSHTSDRTSTKWVQNILQKSLCLEDSRLEQNLFGLRFPNPVGLAAGF
DKDGVAARIWSSLGFGFAELGTVTFVGQPGNPPPRLFRLPLDQAALNRMGFNNHGAAVMAARLADEKGQFSIPIGINLGK
SKVTPLEAAAEDYLNSFRLLKELGDYFVVNVSSPNTPGLRSLQDASMLSSILDVLQKENNSHKPIFVKIAPDLEWEAIAD
IIGLAKTYQLAGIIATNTTIRRDGLKTQVIEQTGKAPQEEAGGISGAPVRDRSTEIIRFIWQQTQGEIPIIGVGGIFTPE
DAWAKITAGASLIQVYTGWIYQGPMMVSQILTGLLSKLEEHELNSISEAIGLEFKS

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=369, Percent_Identity=42.8184281842818, Blast_Score=260, Evalue=2e-69,
Organism=Escherichia coli, GI1787177, Length=356, Percent_Identity=40.1685393258427, Blast_Score=235, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17509475, Length=387, Percent_Identity=39.7932816537468, Blast_Score=243, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6322633, Length=274, Percent_Identity=25.5474452554745, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281361352, Length=314, Percent_Identity=41.4012738853503, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI17137316, Length=314, Percent_Identity=41.4012738853503, Blast_Score=241, Evalue=5e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 41292; Mature: 41292

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIYKFAVRPLLFDLVKADPEWLHQQTMRSLSWLSHTSDRTSTKWVQNILQKSLCLEDSR
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHH
LEQNLFGLRFPNPVGLAAGFDKDGVAARIWSSLGFGFAELGTVTFVGQPGNPPPRLFRLP
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHCEEEEECCCCCCCCCEEECC
LDQAALNRMGFNNHGAAVMAARLADEKGQFSIPIGINLGKSKVTPLEAAAEDYLNSFRLL
CHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
KELGDYFVVNVSSPNTPGLRSLQDASMLSSILDVLQKENNSHKPIFVKIAPDLEWEAIAD
HHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHH
IIGLAKTYQLAGIIATNTTIRRDGLKTQVIEQTGKAPQEEAGGISGAPVRDRSTEIIRFI
HHHHHHHHHHHEEEEECCEEECCCCHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHH
WQQTQGEIPIIGVGGIFTPEDAWAKITAGASLIQVYTGWIYQGPMMVSQILTGLLSKLEE
HHHCCCCCCEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
HELNSISEAIGLEFKS
HHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDIYKFAVRPLLFDLVKADPEWLHQQTMRSLSWLSHTSDRTSTKWVQNILQKSLCLEDSR
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHH
LEQNLFGLRFPNPVGLAAGFDKDGVAARIWSSLGFGFAELGTVTFVGQPGNPPPRLFRLP
HHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHCEEEEECCCCCCCCCEEECC
LDQAALNRMGFNNHGAAVMAARLADEKGQFSIPIGINLGKSKVTPLEAAAEDYLNSFRLL
CHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHH
KELGDYFVVNVSSPNTPGLRSLQDASMLSSILDVLQKENNSHKPIFVKIAPDLEWEAIAD
HHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHH
IIGLAKTYQLAGIIATNTTIRRDGLKTQVIEQTGKAPQEEAGGISGAPVRDRSTEIIRFI
HHHHHHHHHHHEEEEECCEEECCCCHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHH
WQQTQGEIPIIGVGGIFTPEDAWAKITAGASLIQVYTGWIYQGPMMVSQILTGLLSKLEE
HHHCCCCCCEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
HELNSISEAIGLEFKS
HHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA