Click here to switch to the map view.

The map label for this gene is argJ

Identifier: 17231727

GI number: 17231727

Start: 5071283

End: 5072446

Strand: Direct

Name: argJ

Synonym: alr4235

Alternate gene names: 17231727

Gene position: 5071283-5072446 (Clockwise)

Preceding gene: 17231724

Following gene: 17231730

Centisome position: 79.07

GC content: 41.07

Gene sequence:

>1164_bases
ATGTCACTAACTGCATCTTCCACACCTCAAGGATTTAGTACCTTTATTACTAATTTGGGTATACGTGATACTACTGAAGA
TTTTGTATTCTTACGATCAGATGTACCTTGTGTAGCTGATGGCGTATTTACTCAAAGCCTTTTCGCTGGGCCTAGTGTGA
CTATTAGCCGTCAAAATTTACAAGATGGGCAAGCACAAGGGATTATTATAATTTCCAAAAATGCCAACGTTGCTAATGGT
GCTGTGGGGATTGCTGATGCTCAAGAGATTATACAACTCGTGGCACAGGAAACTGGGATTGCTGCCGAAAATTTGGCGAT
CGCATCCACTGGGGTAATTGGTAGACGTTACCCCATAGAAAAAATTCGCGCTGGCTTGGTGGGAATGGGTCAAAAACTAA
CTGCTGCCGATTTTGACTTAGCTGCACGGGGTATTATGACCACCGACACCGTATCTAAAATCGCTGCACGACAAGTTGGT
AATGCCAAATTGGTGGGTATTGCTAAAGGTGTCGGCATGATTGAGCCGAATATGGCGACAATGTTAGCTTTCTTTTTTAC
TGATGCCGCGATTTCTGCCAATACACTGCGTCAAATTTTTCGCTCTACCATAGATAAAACATTTAATTGTTTAAGCATAG
ATACTGATACTTCTACTAGTGATAGTGCGGTAATTTTGGCGAATGGTTTAGCGGGTGAAGTTCCTGAAGCAGAATTTGCT
AGTGCATTGCAAGAAATTGCCCATGATTTAGTGTTAAAAATTGCCCGTGATGGCGAAGGCGCAACTAAGGTAATTGAGGT
AACCGTAGATTCAGCCGCTAACTATGCTCAAGCTAAACGAGTAGCTAAAGCCATTGTTAATTCACCACTAGTTAAGACTG
CTGTGTATGGTGCAGATCCTAATTGGGGAAGAGTAGCTATGGCAATAGGCAAATGTGAAGATGAACGGGATATTAATCCA
GATCAGGTGGTAATTAGATTTGATGAAGTGCAAGTTTATCCTAATACTTTCCAAGCTGAAAACTTGGAGAAGTTAAAAGA
AATTATGTCCAAAGAAAAAGTCAATATTCATGTAAGTTTGAATATCGGTACAGATGTGGCTACTGTATGGGGTTGCGACT
TGACAGAAGGTTACGTGGAAATTAACGGTAAGTACTCTACTTGA

Upstream 100 bases:

>100_bases
CACCCAGAGAAGGCTAGGGCTGGTATTATTTACCAAGCAAGTTGCTTAACGCCGCGCTACCGCTAATAGTCCTTAGATTC
TTTACTCTCCACAGATCAAA

Downstream 100 bases:

>100_bases
GCAGGGGTGAGGGAGTGCTGAGTTCCCAGCCAATAGTCAACGATTCAGCTTTGCTCATCGTTGACCCTGTTCCAATTAAT
GTAAATAAAGGGCTATAAAT

Product: bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein

Products: NA

Alternate protein names: Glutamate N-acetyltransferase; Ornithine acetyltransferase; OATase; Ornithine transacetylase; Amino-acid acetyltransferase; N-acetylglutamate synthase; AGS

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MSLTASSTPQGFSTFITNLGIRDTTEDFVFLRSDVPCVADGVFTQSLFAGPSVTISRQNLQDGQAQGIIIISKNANVANG
AVGIADAQEIIQLVAQETGIAAENLAIASTGVIGRRYPIEKIRAGLVGMGQKLTAADFDLAARGIMTTDTVSKIAARQVG
NAKLVGIAKGVGMIEPNMATMLAFFFTDAAISANTLRQIFRSTIDKTFNCLSIDTDTSTSDSAVILANGLAGEVPEAEFA
SALQEIAHDLVLKIARDGEGATKVIEVTVDSAANYAQAKRVAKAIVNSPLVKTAVYGADPNWGRVAMAIGKCEDERDINP
DQVVIRFDEVQVYPNTFQAENLEKLKEIMSKEKVNIHVSLNIGTDVATVWGCDLTEGYVEINGKYST

Sequences:

>Translated_387_residues
MSLTASSTPQGFSTFITNLGIRDTTEDFVFLRSDVPCVADGVFTQSLFAGPSVTISRQNLQDGQAQGIIIISKNANVANG
AVGIADAQEIIQLVAQETGIAAENLAIASTGVIGRRYPIEKIRAGLVGMGQKLTAADFDLAARGIMTTDTVSKIAARQVG
NAKLVGIAKGVGMIEPNMATMLAFFFTDAAISANTLRQIFRSTIDKTFNCLSIDTDTSTSDSAVILANGLAGEVPEAEFA
SALQEIAHDLVLKIARDGEGATKVIEVTVDSAANYAQAKRVAKAIVNSPLVKTAVYGADPNWGRVAMAIGKCEDERDINP
DQVVIRFDEVQVYPNTFQAENLEKLKEIMSKEKVNIHVSLNIGTDVATVWGCDLTEGYVEINGKYST
>Mature_386_residues
SLTASSTPQGFSTFITNLGIRDTTEDFVFLRSDVPCVADGVFTQSLFAGPSVTISRQNLQDGQAQGIIIISKNANVANGA
VGIADAQEIIQLVAQETGIAAENLAIASTGVIGRRYPIEKIRAGLVGMGQKLTAADFDLAARGIMTTDTVSKIAARQVGN
AKLVGIAKGVGMIEPNMATMLAFFFTDAAISANTLRQIFRSTIDKTFNCLSIDTDTSTSDSAVILANGLAGEVPEAEFAS
ALQEIAHDLVLKIARDGEGATKVIEVTVDSAANYAQAKRVAKAIVNSPLVKTAVYGADPNWGRVAMAIGKCEDERDINPD
QVVIRFDEVQVYPNTFQAENLEKLKEIMSKEKVNIHVSLNIGTDVATVWGCDLTEGYVEINGKYST

Specific function: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis:the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate

COG id: COG1364

COG function: function code E; N-acetylglutamate synthase (N-acetylornithine aminotransferase)

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArgJ family

Homologues:

Organism=Saccharomyces cerevisiae, GI6323707, Length=416, Percent_Identity=34.1346153846154, Blast_Score=203, Evalue=5e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGJ2_NOSS1 (Q8YPF9)

Other databases:

- EMBL:   BA000019
- PIR:   AD2335
- RefSeq:   NP_488275.1
- ProteinModelPortal:   Q8YPF9
- SMR:   Q8YPF9
- STRING:   Q8YPF9
- MEROPS:   T05.001
- GeneID:   1107837
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr4235
- NMPDR:   fig|103690.1.peg.4542
- eggNOG:   COG1364
- HOGENOM:   HBG284202
- OMA:   AMAIGKC
- PhylomeDB:   Q8YPF9
- ProtClustDB:   PRK05388
- BioCyc:   NSP103690:ALR4235-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01106
- InterPro:   IPR002813
- InterPro:   IPR016117
- PANTHER:   PTHR23100
- TIGRFAMs:   TIGR00120

Pfam domain/function: PF01960 ArgJ; SSF56266 Pept_S58_DmpA/Arg_biosyn_ArgJ

EC number: =2.3.1.35; =2.3.1.1

Molecular weight: Translated: 41146; Mature: 41015

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTASSTPQGFSTFITNLGIRDTTEDFVFLRSDVPCVADGVFTQSLFAGPSVTISRQNL
CCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCC
QDGQAQGIIIISKNANVANGAVGIADAQEIIQLVAQETGIAAENLAIASTGVIGRRYPIE
CCCCCCEEEEEECCCCCCCCCEECCCHHHHHHHHHHHCCCCHHCEEEEECCCCCCCCCHH
KIRAGLVGMGQKLTAADFDLAARGIMTTDTVSKIAARQVGNAKLVGIAKGVGMIEPNMAT
HHHHHHHCCCCCCEECCHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHH
MLAFFFTDAAISANTLRQIFRSTIDKTFNCLSIDTDTSTSDSAVILANGLAGEVPEAEFA
HHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHH
SALQEIAHDLVLKIARDGEGATKVIEVTVDSAANYAQAKRVAKAIVNSPLVKTAVYGADP
HHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCHHEEEECCCC
NWGRVAMAIGKCEDERDINPDQVVIRFDEVQVYPNTFQAENLEKLKEIMSKEKVNIHVSL
CCCEEEEEEECCCCCCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEE
NIGTDVATVWGCDLTEGYVEINGKYST
EECCCEEEEECCCCCCCEEEECCEECC
>Mature Secondary Structure 
SLTASSTPQGFSTFITNLGIRDTTEDFVFLRSDVPCVADGVFTQSLFAGPSVTISRQNL
CCCCCCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCC
QDGQAQGIIIISKNANVANGAVGIADAQEIIQLVAQETGIAAENLAIASTGVIGRRYPIE
CCCCCCEEEEEECCCCCCCCCEECCCHHHHHHHHHHHCCCCHHCEEEEECCCCCCCCCHH
KIRAGLVGMGQKLTAADFDLAARGIMTTDTVSKIAARQVGNAKLVGIAKGVGMIEPNMAT
HHHHHHHCCCCCCEECCHHHHHCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHH
MLAFFFTDAAISANTLRQIFRSTIDKTFNCLSIDTDTSTSDSAVILANGLAGEVPEAEFA
HHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCCCHHHHH
SALQEIAHDLVLKIARDGEGATKVIEVTVDSAANYAQAKRVAKAIVNSPLVKTAVYGADP
HHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCHHEEEECCCC
NWGRVAMAIGKCEDERDINPDQVVIRFDEVQVYPNTFQAENLEKLKEIMSKEKVNIHVSL
CCCEEEEEEECCCCCCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEEE
NIGTDVATVWGCDLTEGYVEINGKYST
EECCCEEEEECCCCCCCEEEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840