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The map label for this gene is ilvA [H]

Identifier: 17231724

GI number: 17231724

Start: 5067906

End: 5069417

Strand: Direct

Name: ilvA [H]

Synonym: alr4232

Alternate gene names: 17231724

Gene position: 5067906-5069417 (Clockwise)

Preceding gene: 17231722

Following gene: 17231727

Centisome position: 79.02

GC content: 46.36

Gene sequence:

>1512_bases
ATGTTTTGCGACTACCTGGTACAAATTCTGACTGCCCGTGTGTATGATGTTGCCCAGGAATCACCTCTGGAATATGCCCC
CAATCTTTCAGCCAGACTGAATAATAAACTGTTGCTGAAGCGTGAGGATATGCAGTCTGTGTTTTCCTTTAAGCTGCGGG
GTGCTTACAACAAGATGGTGAATCTACCGCCGGATTTACTGGCACAGGGTGTAATTGCGGCTTCTGCGGGGAATCATGCC
CAAGGTGTGGCTCTAGGCGCAAAACAGCTAGGAACGAGAGCGATTATTGTCATGCCGGTTACTACACCCCAGGTGAAGGT
AGATGCAGTTAAAGCACGAGGAGGAGAGGTGGTATTGCATGGGGATACCTATGATGATGCCTATGCCTACGCGCGCCAAT
TGGAAGCAGAGAAAGGTTTAACATTTATTCACCCCTTTGATGATCCTCATGTAATTGCGGGACAGGGAACTATTGGGATG
GAAATTCTCAGACAATATCAGCAACCTATTCATGCAATTTTTGTTGCTATTGGCGGCGGCGGTTTGATTTCGGGGATTGC
TGCTTATGTAAAACGCTTACGTCCAGAAATTAAAATTATTGGGGTTGAACCGGTTGACGCTGATGCCATGAACCAATCCT
TGCAAGCTGGTAAACGGGTGCGATTGTCACAGGTGGGTTTATTTGCCGATGGGGTAGCAGTGCGGGAAGTGGGAGAAGAA
ACCTTCCGGCTGTGTCAGGAATATGTGGACGAGATTATTTTGGTCGATACAGATGACACCTGTGCAGCGATTAAGGATGT
ATTTGAAGATACCAGATCTATTTTAGAACCGGCGGGGGCATTGGCGATCGCCGGCGCTAAAGCTTATGTAGAACGAGAAC
AAATCCAAGGACAAACTTTAGTTGCTGTCGCCTGCGGCGCAAATATGAATTTTGACCGTCTGCGCTTTGTTGCAGAACGG
GCAGAATTTGGTGAACGCCGCGAAGCTATCTTTGCAGTGACAATTCCTGAAACACCTGGGAGTTTGCGGAAGTTTTGCGA
ATGTATTGGTAGACGCAATTTGACAGAGTTTAACTATCGCATTGCTGATGAAAAAATTGCCCATATTTTTATTGGGATGC
AGATTCAAAACCGTGCTGATAAAATTCACATGGTAGAGACTTTTGCAGAATGTGGTTTTGAAATCCTCGATTTAACAGAT
GATGAACTGACAAAACTGCACTTGCGCCACATGGTGGGTGGACATTCTCCCCTAGCCCATAATGAATTACTCTACCGTTT
TGAATTTCCGGAACGCCCTGGCGCATTGATGAAATTTGTTGCCTCCATGAGTCCTAATTGGAATATCAGTATGTTTCACT
ACCGCAACAATGGCTCAGACTACGGGCGCATTGTGGTAGGAATGCAAGTCCCACCGCAGGAAATGGAAGAATGGCAAGCA
TTTCTCGATTCCCTCGGCTACCAGTATTGGGATGAAAGCCAGAACCCAGCCTATAAGCTATTTTTGGGTTAG

Upstream 100 bases:

>100_bases
CTGAATCTGATTATTAGCGATCGCTAATAATCGTCAAAGCATAAGGACAAACTTAACGTAAAATTATCTTTTATCTACCC
CTCCTCACTCCATCTACCCC

Downstream 100 bases:

>100_bases
AGATGACAGCCCACTATTTGAATTCTATAAAAGACAAATCTTCAGCAAGAATCAAGTTAATTTCGTAATCATCTAACTCT
TGTAAATGTGTAACGATGCG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MFCDYLVQILTARVYDVAQESPLEYAPNLSARLNNKLLLKREDMQSVFSFKLRGAYNKMVNLPPDLLAQGVIAASAGNHA
QGVALGAKQLGTRAIIVMPVTTPQVKVDAVKARGGEVVLHGDTYDDAYAYARQLEAEKGLTFIHPFDDPHVIAGQGTIGM
EILRQYQQPIHAIFVAIGGGGLISGIAAYVKRLRPEIKIIGVEPVDADAMNQSLQAGKRVRLSQVGLFADGVAVREVGEE
TFRLCQEYVDEIILVDTDDTCAAIKDVFEDTRSILEPAGALAIAGAKAYVEREQIQGQTLVAVACGANMNFDRLRFVAER
AEFGERREAIFAVTIPETPGSLRKFCECIGRRNLTEFNYRIADEKIAHIFIGMQIQNRADKIHMVETFAECGFEILDLTD
DELTKLHLRHMVGGHSPLAHNELLYRFEFPERPGALMKFVASMSPNWNISMFHYRNNGSDYGRIVVGMQVPPQEMEEWQA
FLDSLGYQYWDESQNPAYKLFLG

Sequences:

>Translated_503_residues
MFCDYLVQILTARVYDVAQESPLEYAPNLSARLNNKLLLKREDMQSVFSFKLRGAYNKMVNLPPDLLAQGVIAASAGNHA
QGVALGAKQLGTRAIIVMPVTTPQVKVDAVKARGGEVVLHGDTYDDAYAYARQLEAEKGLTFIHPFDDPHVIAGQGTIGM
EILRQYQQPIHAIFVAIGGGGLISGIAAYVKRLRPEIKIIGVEPVDADAMNQSLQAGKRVRLSQVGLFADGVAVREVGEE
TFRLCQEYVDEIILVDTDDTCAAIKDVFEDTRSILEPAGALAIAGAKAYVEREQIQGQTLVAVACGANMNFDRLRFVAER
AEFGERREAIFAVTIPETPGSLRKFCECIGRRNLTEFNYRIADEKIAHIFIGMQIQNRADKIHMVETFAECGFEILDLTD
DELTKLHLRHMVGGHSPLAHNELLYRFEFPERPGALMKFVASMSPNWNISMFHYRNNGSDYGRIVVGMQVPPQEMEEWQA
FLDSLGYQYWDESQNPAYKLFLG
>Mature_503_residues
MFCDYLVQILTARVYDVAQESPLEYAPNLSARLNNKLLLKREDMQSVFSFKLRGAYNKMVNLPPDLLAQGVIAASAGNHA
QGVALGAKQLGTRAIIVMPVTTPQVKVDAVKARGGEVVLHGDTYDDAYAYARQLEAEKGLTFIHPFDDPHVIAGQGTIGM
EILRQYQQPIHAIFVAIGGGGLISGIAAYVKRLRPEIKIIGVEPVDADAMNQSLQAGKRVRLSQVGLFADGVAVREVGEE
TFRLCQEYVDEIILVDTDDTCAAIKDVFEDTRSILEPAGALAIAGAKAYVEREQIQGQTLVAVACGANMNFDRLRFVAER
AEFGERREAIFAVTIPETPGSLRKFCECIGRRNLTEFNYRIADEKIAHIFIGMQIQNRADKIHMVETFAECGFEILDLTD
DELTKLHLRHMVGGHSPLAHNELLYRFEFPERPGALMKFVASMSPNWNISMFHYRNNGSDYGRIVVGMQVPPQEMEEWQA
FLDSLGYQYWDESQNPAYKLFLG

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=277, Percent_Identity=33.9350180505415, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI33469958, Length=317, Percent_Identity=28.391167192429, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI19923959, Length=319, Percent_Identity=26.9592476489028, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1790207, Length=500, Percent_Identity=50.4, Blast_Score=500, Evalue=1e-142,
Organism=Escherichia coli, GI1789505, Length=307, Percent_Identity=37.785016286645, Blast_Score=169, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71991565, Length=333, Percent_Identity=31.5315315315315, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17537387, Length=322, Percent_Identity=35.0931677018634, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17508781, Length=292, Percent_Identity=28.4246575342466, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320930, Length=514, Percent_Identity=50.3891050583658, Blast_Score=492, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6322631, Length=301, Percent_Identity=36.2126245847176, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6319788, Length=300, Percent_Identity=24, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322024, Length=188, Percent_Identity=25.531914893617, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355833, Length=316, Percent_Identity=31.3291139240506, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24645328, Length=254, Percent_Identity=29.9212598425197, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 56027; Mature: 56027

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFCDYLVQILTARVYDVAQESPLEYAPNLSARLNNKLLLKREDMQSVFSFKLRGAYNKMV
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHC
NLPPDLLAQGVIAASAGNHAQGVALGAKQLGTRAIIVMPVTTPQVKVDAVKARGGEVVLH
CCCHHHHHCCCEEECCCCCCCCEEECHHHCCCEEEEEEECCCCCEEEEEEECCCCEEEEE
GDTYDDAYAYARQLEAEKGLTFIHPFDDPHVIAGQGTIGMEILRQYQQPIHAIFVAIGGG
CCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCHHHHHHHHHHCHHEEEEEEECCC
GLISGIAAYVKRLRPEIKIIGVEPVDADAMNQSLQAGKRVRLSQVGLFADGVAVREVGEE
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCEEHHHCCEECCCHHHHHHHHH
TFRLCQEYVDEIILVDTDDTCAAIKDVFEDTRSILEPAGALAIAGAKAYVEREQIQGQTL
HHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCCEE
VAVACGANMNFDRLRFVAERAEFGERREAIFAVTIPETPGSLRKFCECIGRRNLTEFNYR
EEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCEE
IADEKIAHIFIGMQIQNRADKIHMVETFAECGFEILDLTDDELTKLHLRHMVGGHSPLAH
ECCCCEEEEEEEEEECCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCCC
NELLYRFEFPERPGALMKFVASMSPNWNISMFHYRNNGSDYGRIVVGMQVPPQEMEEWQA
CCEEEEEECCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEECCCHHHHHHHHH
FLDSLGYQYWDESQNPAYKLFLG
HHHHCCCHHCCCCCCCCEEEEEC
>Mature Secondary Structure
MFCDYLVQILTARVYDVAQESPLEYAPNLSARLNNKLLLKREDMQSVFSFKLRGAYNKMV
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHC
NLPPDLLAQGVIAASAGNHAQGVALGAKQLGTRAIIVMPVTTPQVKVDAVKARGGEVVLH
CCCHHHHHCCCEEECCCCCCCCEEECHHHCCCEEEEEEECCCCCEEEEEEECCCCEEEEE
GDTYDDAYAYARQLEAEKGLTFIHPFDDPHVIAGQGTIGMEILRQYQQPIHAIFVAIGGG
CCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCHHHHHHHHHHCHHEEEEEEECCC
GLISGIAAYVKRLRPEIKIIGVEPVDADAMNQSLQAGKRVRLSQVGLFADGVAVREVGEE
HHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCEEHHHCCEECCCHHHHHHHHH
TFRLCQEYVDEIILVDTDDTCAAIKDVFEDTRSILEPAGALAIAGAKAYVEREQIQGQTL
HHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCCEE
VAVACGANMNFDRLRFVAERAEFGERREAIFAVTIPETPGSLRKFCECIGRRNLTEFNYR
EEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCEE
IADEKIAHIFIGMQIQNRADKIHMVETFAECGFEILDLTDDELTKLHLRHMVGGHSPLAH
ECCCCEEEEEEEEEECCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCCCCC
NELLYRFEFPERPGALMKFVASMSPNWNISMFHYRNNGSDYGRIVVGMQVPPQEMEEWQA
CCEEEEEECCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEECCCHHHHHHHHH
FLDSLGYQYWDESQNPAYKLFLG
HHHHCCCHHCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA