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The map label for this gene is ndhD [H]

Identifier: 17231649

GI number: 17231649

Start: 5001570

End: 5003072

Strand: Direct

Name: ndhD [H]

Synonym: alr4157

Alternate gene names: 17231649

Gene position: 5001570-5003072 (Clockwise)

Preceding gene: 17231648

Following gene: 17231650

Centisome position: 77.98

GC content: 42.98

Gene sequence:

>1503_bases
ATGCTTAGTGTACTAATTTGGATACCAATTTTAAGCGCTATAGTTATCGGATTTTGGCCTAGTAATCCCAATCAATCTAG
CCGTATCCGTCTAGTAGCATTAACTGTTGCAGCAATAGTATTAATCTGGAATCTGTTTATTCTGTTTAAATTCGATATCA
GCAATCCAGGGATGCAGTTTCAAGAGTATCTGCCTTGGAATGAGACTTTGGGTTTGAGTTATCAATTAGGTGTTGATGGA
TTATCAATTTTGATGTTGGTATTAAATAGCCTCCTCACCTGGATTGCTATTTATAGTAGCAGCAACAAAACAGAACGTCC
TCGACTGTTTTACTCAATGATTCTGTTAGTCAGTGGTGGAGTTGCAGGTGCTTTTCTCTCGGAAAACTTACTGTTATTCT
TCCTATTTTACGAATTAGAATTAATCCCCTTCTATCTATTAATTTCCATTTGGGGAGGAGAAAAAAGAGCTTATGCTGGG
ATCAAATTCCTAATTTACACCGCCGTTTCTGGTGCTTTCATCCTCGCTACATTCTTGGGCATGGTTTGGCTGACTGGTTC
TACCAGTTTCGCCTTTGATGCTATCTCTACCCAAGGCTTATCCGCCGGAATGCAGTTTATTCTCCTGGTGGGCATCATCT
TAGGCTTTGGAATTAAGATTCCCTTGGTTCCCTTCCACACTTGGTTACCTGATGCTTATGTAGAAGCTTCGGCACCAATT
GCGATTCTTTTGGGTGGTGTGTTGGCTAAGTTGGGAACTTACGGACTCCTGCGATTTGGATTGGGGATGTTTCCCCAAAC
TTGGAGTACTGTTGCACCAACCTTGGCAATTTGGGGGGCAGTTAGTGCTATTTATGGGGCGGTGATTGCGATCGCTCAAA
AAGACATCAAGCGCATGGTAGCATACAGTTCCATCGGTCACATGGGTTATGTTCTATTAGCTAGTGCTGCCAGCACATCT
CTAGCCCTTGTTGGTGCTGTATCCCAAATGTTCAGCCACGGTTTGATTTTGGCGATACTCTTCCATTTGGTGGGAATAAT
AGAAGAAAAAGTTGGCACCAGGGAGTTAGATAAACTCAATGGTTTAATGAGTCCAATTCGCGGTTTACCCCTCATTAGTG
CCTTACTAGTTCTCAGTGGCATGGCTAGCGCCGGTATTCCCGGTTTAACAGGATTTATTGCGGAATTTATTGTCTTTCAA
GGCAGTTTTACCGCCTTCCCTTTATCTACTTTGTTGTGTGTGGCATCTAGCGGTTTAACGGCAGTTTATTTCGTTATTCT
CCTCAATCGCACCTGTTTTGGCAGACTCGATAATAACCAAGCCTATTACGCCAAAGTCCTCTGGTCAGAGAAAACACCAG
CCTTAATTCTGGCAGCCCTCATCATCTTTTTAGGGGTACAACCAACTTGGTTAGTGCGTTGGAGTGAACCCACAACTACA
GCAATGGTCGCAGCGATTCCTCCTGTGGAAAAAACCGTAATTTCTCAAGTTGTTTTGAAGTAG

Upstream 100 bases:

>100_bases
ATGTTTTAAGTAATTTAGTCAGTTGTCAGTAGTCAGGTGTTAGGAGCAAGAATTAACACCTGGCTACTAAAAAATAAAAT
ATTCTACTTACCCAAATATT

Downstream 100 bases:

>100_bases
TCAAGTCGCTTCTCTACGAGACGCTACGCGTTAAGCGTTGGCGCAGCCTCTCCGACAGGAGAAGCTATGCCGCAGGCTTT
ACACTCCAATTCAAAATTCA

Product: NAD(P)H-quinone oxidoreductase subunit M

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4; NDH-1, chain 4 [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MLSVLIWIPILSAIVIGFWPSNPNQSSRIRLVALTVAAIVLIWNLFILFKFDISNPGMQFQEYLPWNETLGLSYQLGVDG
LSILMLVLNSLLTWIAIYSSSNKTERPRLFYSMILLVSGGVAGAFLSENLLLFFLFYELELIPFYLLISIWGGEKRAYAG
IKFLIYTAVSGAFILATFLGMVWLTGSTSFAFDAISTQGLSAGMQFILLVGIILGFGIKIPLVPFHTWLPDAYVEASAPI
AILLGGVLAKLGTYGLLRFGLGMFPQTWSTVAPTLAIWGAVSAIYGAVIAIAQKDIKRMVAYSSIGHMGYVLLASAASTS
LALVGAVSQMFSHGLILAILFHLVGIIEEKVGTRELDKLNGLMSPIRGLPLISALLVLSGMASAGIPGLTGFIAEFIVFQ
GSFTAFPLSTLLCVASSGLTAVYFVILLNRTCFGRLDNNQAYYAKVLWSEKTPALILAALIIFLGVQPTWLVRWSEPTTT
AMVAAIPPVEKTVISQVVLK

Sequences:

>Translated_500_residues
MLSVLIWIPILSAIVIGFWPSNPNQSSRIRLVALTVAAIVLIWNLFILFKFDISNPGMQFQEYLPWNETLGLSYQLGVDG
LSILMLVLNSLLTWIAIYSSSNKTERPRLFYSMILLVSGGVAGAFLSENLLLFFLFYELELIPFYLLISIWGGEKRAYAG
IKFLIYTAVSGAFILATFLGMVWLTGSTSFAFDAISTQGLSAGMQFILLVGIILGFGIKIPLVPFHTWLPDAYVEASAPI
AILLGGVLAKLGTYGLLRFGLGMFPQTWSTVAPTLAIWGAVSAIYGAVIAIAQKDIKRMVAYSSIGHMGYVLLASAASTS
LALVGAVSQMFSHGLILAILFHLVGIIEEKVGTRELDKLNGLMSPIRGLPLISALLVLSGMASAGIPGLTGFIAEFIVFQ
GSFTAFPLSTLLCVASSGLTAVYFVILLNRTCFGRLDNNQAYYAKVLWSEKTPALILAALIIFLGVQPTWLVRWSEPTTT
AMVAAIPPVEKTVISQVVLK
>Mature_500_residues
MLSVLIWIPILSAIVIGFWPSNPNQSSRIRLVALTVAAIVLIWNLFILFKFDISNPGMQFQEYLPWNETLGLSYQLGVDG
LSILMLVLNSLLTWIAIYSSSNKTERPRLFYSMILLVSGGVAGAFLSENLLLFFLFYELELIPFYLLISIWGGEKRAYAG
IKFLIYTAVSGAFILATFLGMVWLTGSTSFAFDAISTQGLSAGMQFILLVGIILGFGIKIPLVPFHTWLPDAYVEASAPI
AILLGGVLAKLGTYGLLRFGLGMFPQTWSTVAPTLAIWGAVSAIYGAVIAIAQKDIKRMVAYSSIGHMGYVLLASAASTS
LALVGAVSQMFSHGLILAILFHLVGIIEEKVGTRELDKLNGLMSPIRGLPLISALLVLSGMASAGIPGLTGFIAEFIVFQ
GSFTAFPLSTLLCVASSGLTAVYFVILLNRTCFGRLDNNQAYYAKVLWSEKTPALILAALIIFLGVQPTWLVRWSEPTTT
AMVAAIPPVEKTVISQVVLK

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=373, Percent_Identity=29.4906166219839, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI251831117, Length=405, Percent_Identity=26.4197530864197, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1788613, Length=418, Percent_Identity=37.5598086124402, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI1788827, Length=372, Percent_Identity=27.1505376344086, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788829, Length=346, Percent_Identity=28.6127167630058, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI145693160, Length=342, Percent_Identity=30.9941520467836, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788831, Length=297, Percent_Identity=28.2828282828283, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI2367154, Length=359, Percent_Identity=29.2479108635098, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788614, Length=416, Percent_Identity=25.2403846153846, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: 1.6.5.3

Molecular weight: Translated: 54131; Mature: 54131

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVLIWIPILSAIVIGFWPSNPNQSSRIRLVALTVAAIVLIWNLFILFKFDISNPGMQF
CCHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHEEECCCCCCCCH
QEYLPWNETLGLSYQLGVDGLSILMLVLNSLLTWIAIYSSSNKTERPRLFYSMILLVSGG
HHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
VAGAFLSENLLLFFLFYELELIPFYLLISIWGGEKRAYAGIKFLIYTAVSGAFILATFLG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MVWLTGSTSFAFDAISTQGLSAGMQFILLVGIILGFGIKIPLVPFHTWLPDAYVEASAPI
HHHHCCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEECHHHCCCHHHCCCCCH
AILLGGVLAKLGTYGLLRFGLGMFPQTWSTVAPTLAIWGAVSAIYGAVIAIAQKDIKRMV
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYSSIGHMGYVLLASAASTSLALVGAVSQMFSHGLILAILFHLVGIIEEKVGTRELDKLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHH
GLMSPIRGLPLISALLVLSGMASAGIPGLTGFIAEFIVFQGSFTAFPLSTLLCVASSGLT
HHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHH
AVYFVILLNRTCFGRLDNNQAYYAKVLWSEKTPALILAALIIFLGVQPTWLVRWSEPTTT
HHHHHHHHCCHHCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCC
AMVAAIPPVEKTVISQVVLK
EEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure
MLSVLIWIPILSAIVIGFWPSNPNQSSRIRLVALTVAAIVLIWNLFILFKFDISNPGMQF
CCHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHEEECCCCCCCCH
QEYLPWNETLGLSYQLGVDGLSILMLVLNSLLTWIAIYSSSNKTERPRLFYSMILLVSGG
HHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
VAGAFLSENLLLFFLFYELELIPFYLLISIWGGEKRAYAGIKFLIYTAVSGAFILATFLG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MVWLTGSTSFAFDAISTQGLSAGMQFILLVGIILGFGIKIPLVPFHTWLPDAYVEASAPI
HHHHCCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEECHHHCCCHHHCCCCCH
AILLGGVLAKLGTYGLLRFGLGMFPQTWSTVAPTLAIWGAVSAIYGAVIAIAQKDIKRMV
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AYSSIGHMGYVLLASAASTSLALVGAVSQMFSHGLILAILFHLVGIIEEKVGTRELDKLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHH
GLMSPIRGLPLISALLVLSGMASAGIPGLTGFIAEFIVFQGSFTAFPLSTLLCVASSGLT
HHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHH
AVYFVILLNRTCFGRLDNNQAYYAKVLWSEKTPALILAALIIFLGVQPTWLVRWSEPTTT
HHHHHHHHCCHHCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCC
AMVAAIPPVEKTVISQVVLK
EEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA