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The map label for this gene is hemE [H]

Identifier: 17231401

GI number: 17231401

Start: 4711861

End: 4712913

Strand: Reverse

Name: hemE [H]

Synonym: all3909

Alternate gene names: 17231401

Gene position: 4712913-4711861 (Counterclockwise)

Preceding gene: 17231405

Following gene: 17231400

Centisome position: 73.48

GC content: 47.29

Gene sequence:

>1053_bases
ATGGGTGTTACTTCAACGGCTCCTCACCTTTTGCGGGCTGCTCGTGGTGAAATTGTAGATCGTCCCCCTGTATGGATGAT
GCGCCAAGCAGGACGATACATGAAAGCTTATCGGGATTTAAGGGAAAAGTATCCTTCATTTCGCGATCGCTCTGAAATTC
CAGAGGTAGCGATTGAAGTTTCCCTGCAACCTTGGAAAGCCTTTCAGCCAGACGGAGTAATTTTATTTTCCGATATTGTC
ACCCCCTTACCCGGCTTAGGGATTGAAATGGACATTGCGGAAGGTAAAGGCCCCATCATTCATGCGCCCATTCGCACTCA
AGCACAAATTGAACAACTGCGCCCCTTAGAACCAGAAGCAGCTTTACCGTTCATTAAAACCATATTGCAGGCTTTACGCC
AAGAAGTAGGTAATCAATCAACGGTATTGGGCTTTGTAGGTGCGCCTTGGACGCTAGCCGCCTATGCTGTGGAGGGTAAA
GGTTCCAAAACCTACTCCATCATCAAAAACATGGCGTTCTCAGACCCTACGATACTGCATCAACTGTTAAGTAAATTAGC
AGATGCGATCGCCATTTATGCTCGTTACCAAATCGACTCCGGCGCACAAGTAGTACAGATGTTCGATTCTTGGGCAGGGC
AACTCAGCCCCCAAGATTATGACACCTTTGCCTTACCCTATCAGCAACGAGTATTCCAGCAAATCAAGCAAACCCATCCT
GATACACCCTTGATTTTGCTAGTTAGTGGTAGCGCCGGCGTACTAGAACGCATGGGACAATCTGGTGCTGATATTGTCAC
TGTAGACTGGACAGTGGACATGGCTGATGCTAGAGCCAGATTAGGCAAACAGATGAAAGTACAGGGCAATCTTGACCCTG
GTGTACTTTATGCCTCTAAACAGTTTATCCGCGATCGCATCATCGATACCGTTCGCAAAGCTGGTAACTGGGGTCATATT
CTCAACCTTGGACACGGTGTACTACCAGACACACCAGAAGAAAACGTCGCCTTCTTCTTTGAAACAGCCAAGCAACTAAA
TGTTTTGGTGTAG

Upstream 100 bases:

>100_bases
GCCTCCTGCCACCTGCGCCCTAACTCCCTTCGATAAAGCGTAATCCCAGAATGATAAGCTAAACAGTGACATAAAAAAGT
GACTTAGGATGAAGTGTTAA

Downstream 100 bases:

>100_bases
TCAGTTGTCAGCTGTCAGTTGTCGGTTGTGAGCCAGTGCGGTCTTGGGGGTTTCCCCCATAAGCAACTGGCGAACCCGAA
GGAACAGTTGACAGTTGACA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MGVTSTAPHLLRAARGEIVDRPPVWMMRQAGRYMKAYRDLREKYPSFRDRSEIPEVAIEVSLQPWKAFQPDGVILFSDIV
TPLPGLGIEMDIAEGKGPIIHAPIRTQAQIEQLRPLEPEAALPFIKTILQALRQEVGNQSTVLGFVGAPWTLAAYAVEGK
GSKTYSIIKNMAFSDPTILHQLLSKLADAIAIYARYQIDSGAQVVQMFDSWAGQLSPQDYDTFALPYQQRVFQQIKQTHP
DTPLILLVSGSAGVLERMGQSGADIVTVDWTVDMADARARLGKQMKVQGNLDPGVLYASKQFIRDRIIDTVRKAGNWGHI
LNLGHGVLPDTPEENVAFFFETAKQLNVLV

Sequences:

>Translated_350_residues
MGVTSTAPHLLRAARGEIVDRPPVWMMRQAGRYMKAYRDLREKYPSFRDRSEIPEVAIEVSLQPWKAFQPDGVILFSDIV
TPLPGLGIEMDIAEGKGPIIHAPIRTQAQIEQLRPLEPEAALPFIKTILQALRQEVGNQSTVLGFVGAPWTLAAYAVEGK
GSKTYSIIKNMAFSDPTILHQLLSKLADAIAIYARYQIDSGAQVVQMFDSWAGQLSPQDYDTFALPYQQRVFQQIKQTHP
DTPLILLVSGSAGVLERMGQSGADIVTVDWTVDMADARARLGKQMKVQGNLDPGVLYASKQFIRDRIIDTVRKAGNWGHI
LNLGHGVLPDTPEENVAFFFETAKQLNVLV
>Mature_349_residues
GVTSTAPHLLRAARGEIVDRPPVWMMRQAGRYMKAYRDLREKYPSFRDRSEIPEVAIEVSLQPWKAFQPDGVILFSDIVT
PLPGLGIEMDIAEGKGPIIHAPIRTQAQIEQLRPLEPEAALPFIKTILQALRQEVGNQSTVLGFVGAPWTLAAYAVEGKG
SKTYSIIKNMAFSDPTILHQLLSKLADAIAIYARYQIDSGAQVVQMFDSWAGQLSPQDYDTFALPYQQRVFQQIKQTHPD
TPLILLVSGSAGVLERMGQSGADIVTVDWTVDMADARARLGKQMKVQGNLDPGVLYASKQFIRDRIIDTVRKAGNWGHIL
NLGHGVLPDTPEENVAFFFETAKQLNVLV

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=349, Percent_Identity=38.6819484240688, Blast_Score=237, Evalue=1e-62,
Organism=Escherichia coli, GI2367337, Length=340, Percent_Identity=38.2352941176471, Blast_Score=263, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6320252, Length=349, Percent_Identity=32.0916905444126, Blast_Score=213, Evalue=5e-56,
Organism=Drosophila melanogaster, GI221330099, Length=342, Percent_Identity=36.2573099415205, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI19921920, Length=342, Percent_Identity=36.2573099415205, Blast_Score=233, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 38820; Mature: 38689

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVTSTAPHLLRAARGEIVDRPPVWMMRQAGRYMKAYRDLREKYPSFRDRSEIPEVAIEV
CCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEE
SLQPWKAFQPDGVILFSDIVTPLPGLGIEMDIAEGKGPIIHAPIRTQAQIEQLRPLEPEA
EECCCCCCCCCCEEEEHHHHCCCCCCCEEEEECCCCCCEEECCCCCHHHHHHCCCCCCHH
ALPFIKTILQALRQEVGNQSTVLGFVGAPWTLAAYAVEGKGSKTYSIIKNMAFSDPTILH
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHCCCCHHHHH
QLLSKLADAIAIYARYQIDSGAQVVQMFDSWAGQLSPQDYDTFALPYQQRVFQQIKQTHP
HHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHHHCCC
DTPLILLVSGSAGVLERMGQSGADIVTVDWTVDMADARARLGKQMKVQGNLDPGVLYASK
CCCEEEEECCCCHHHHHCCCCCCCEEEEEEEECHHHHHHHCCCCEEEECCCCCCHHHHHH
QFIRDRIIDTVRKAGNWGHILNLGHGVLPDTPEENVAFFFETAKQLNVLV
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GVTSTAPHLLRAARGEIVDRPPVWMMRQAGRYMKAYRDLREKYPSFRDRSEIPEVAIEV
CCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEE
SLQPWKAFQPDGVILFSDIVTPLPGLGIEMDIAEGKGPIIHAPIRTQAQIEQLRPLEPEA
EECCCCCCCCCCEEEEHHHHCCCCCCCEEEEECCCCCCEEECCCCCHHHHHHCCCCCCHH
ALPFIKTILQALRQEVGNQSTVLGFVGAPWTLAAYAVEGKGSKTYSIIKNMAFSDPTILH
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCHHHHHHHHHCCCCHHHHH
QLLSKLADAIAIYARYQIDSGAQVVQMFDSWAGQLSPQDYDTFALPYQQRVFQQIKQTHP
HHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHHHCCC
DTPLILLVSGSAGVLERMGQSGADIVTVDWTVDMADARARLGKQMKVQGNLDPGVLYASK
CCCEEEEECCCCHHHHHCCCCCCCEEEEEEEECHHHHHHHCCCCEEEECCCCCCHHHHHH
QFIRDRIIDTVRKAGNWGHILNLGHGVLPDTPEENVAFFFETAKQLNVLV
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA