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The map label for this gene is luxQ [H]

Identifier: 17231257

GI number: 17231257

Start: 4551273

End: 4552604

Strand: Reverse

Name: luxQ [H]

Synonym: all3765

Alternate gene names: 17231257

Gene position: 4552604-4551273 (Counterclockwise)

Preceding gene: 17231258

Following gene: 17231256

Centisome position: 70.98

GC content: 38.06

Gene sequence:

>1332_bases
ATGGAAGAAACGCTCAAGATTTTGGTTGTAGACGATGATGAAGTAGACCGTATGGCAGTCCGCCGTGCCTTGGTTAAAGC
TGGGGTACGCATGGAAATGTCAGAGGTAAGTGATGGAAGTACGGCACTCTCTATCTTAAGACATAGGTCTTTTGATTGTG
CCTTTATCGACTATCGTTTACCCGACCAAGACGGTTTGAACTTAATCGAAACAATTCGTGGCTTAAATATCAAAATTCCT
TTAGTAGTTTTGACTTCTCAAGGTGATGAACAAATTGCTGTGGAGTTAATGAAAGCTGGTGCAACAGATTACCTATCTAA
ATTTAGAGTCTCATCAGAAACTTTAGCTCAAGTTTTACGCAATGCGATACGGCTTTATCGTGCGGAAATGCAGACTACTA
TTGCCTACCAACAACTGAGAGAAAGTCATGAGCAACTGGTGCGAAAAAATCAAGAATTAGAACGACAACGGCAACAAATC
CAAATTCAAAACTTAAAATTGCTCGAAGCATCGCGGCTGAAATCTCAATTTCTCGCTACCATGTCCCATGAATTAAGGAC
ACCAATGAACGCGATTATCGGTTTTGCTCAGATACTATCACGCCCTAAATTCGGTAATCTCACAGGTCAGCAAGCCGACA
TGGTAGAACGTATTTTGAATAACGGCAAACATTTACTGATGCTATTAAACGAAGTTTTAGACTTCTCCAAATTGGAAGAA
GGAAGATTAGAACTGAAGCCAGAATTATTTGATTTAACTAAAGTCATTAACGCCGTAGTTATGGAAATGCGTTCTCTAGC
TGAGGCAAAAAAGTTGTCTTTGCTAGTGCAGATTGACTTACAAAATTCTTTGCTAGTAAATGATCCAGTACGAATTAAAC
AAATTTTAATAAATTTATTATCTAATGCCATTAAGTTCACAGACTCTGGTAGTATTTGGATCGACGTAAAAGACTTACCA
GGAAGTTGGGTGGAAATTAAAGTAAAAGATACAGGTATTGGTATAGCAGCTAAAGATTTTAAATATATTTTTGAGGCTTT
TCGACAAGTTGATCAAAGCATTACTCGCAAGTATCCAGGGACAGGTTTGGGATTGGCAATTATCGACTCATTAGTGCAAA
TGATGAGTGGTAAAATTTTCCTAGAAAGTCAATTGGGAGTAGGTTCAATTTTTACCATTACATTGCCAAGACAATTGCCA
TTATCAAATTCATCTCTATCTTCATCATCTGTGCAAGATGCGAAAGAAATGATGCAGCCAGATCACAAAGTACACCACCC
TACGGCTAAATCCAACCCAACCGCCAGAAAATATCATAATCTTAAGTTATAA

Upstream 100 bases:

>100_bases
TAACCAAGACTATATTCAAGAGGCTCTAATTTTTAGTTGAACAAGTTGAACCGAGAAATGTTTGAAATCAACCTGTATTT
GGCAGCAAATATAAAAACCG

Downstream 100 bases:

>100_bases
ATTTATATATATAAAACAAATTTATTATCATGTCTGTTGTGGAAAATCATCAAATTGATCGAATTTTGGCTGTTGACGAC
ACTAGAGATAATCTGATTTT

Product: two-component hybrid sensor and regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MEETLKILVVDDDEVDRMAVRRALVKAGVRMEMSEVSDGSTALSILRHRSFDCAFIDYRLPDQDGLNLIETIRGLNIKIP
LVVLTSQGDEQIAVELMKAGATDYLSKFRVSSETLAQVLRNAIRLYRAEMQTTIAYQQLRESHEQLVRKNQELERQRQQI
QIQNLKLLEASRLKSQFLATMSHELRTPMNAIIGFAQILSRPKFGNLTGQQADMVERILNNGKHLLMLLNEVLDFSKLEE
GRLELKPELFDLTKVINAVVMEMRSLAEAKKLSLLVQIDLQNSLLVNDPVRIKQILINLLSNAIKFTDSGSIWIDVKDLP
GSWVEIKVKDTGIGIAAKDFKYIFEAFRQVDQSITRKYPGTGLGLAIIDSLVQMMSGKIFLESQLGVGSIFTITLPRQLP
LSNSSLSSSSVQDAKEMMQPDHKVHHPTAKSNPTARKYHNLKL

Sequences:

>Translated_443_residues
MEETLKILVVDDDEVDRMAVRRALVKAGVRMEMSEVSDGSTALSILRHRSFDCAFIDYRLPDQDGLNLIETIRGLNIKIP
LVVLTSQGDEQIAVELMKAGATDYLSKFRVSSETLAQVLRNAIRLYRAEMQTTIAYQQLRESHEQLVRKNQELERQRQQI
QIQNLKLLEASRLKSQFLATMSHELRTPMNAIIGFAQILSRPKFGNLTGQQADMVERILNNGKHLLMLLNEVLDFSKLEE
GRLELKPELFDLTKVINAVVMEMRSLAEAKKLSLLVQIDLQNSLLVNDPVRIKQILINLLSNAIKFTDSGSIWIDVKDLP
GSWVEIKVKDTGIGIAAKDFKYIFEAFRQVDQSITRKYPGTGLGLAIIDSLVQMMSGKIFLESQLGVGSIFTITLPRQLP
LSNSSLSSSSVQDAKEMMQPDHKVHHPTAKSNPTARKYHNLKL
>Mature_443_residues
MEETLKILVVDDDEVDRMAVRRALVKAGVRMEMSEVSDGSTALSILRHRSFDCAFIDYRLPDQDGLNLIETIRGLNIKIP
LVVLTSQGDEQIAVELMKAGATDYLSKFRVSSETLAQVLRNAIRLYRAEMQTTIAYQQLRESHEQLVRKNQELERQRQQI
QIQNLKLLEASRLKSQFLATMSHELRTPMNAIIGFAQILSRPKFGNLTGQQADMVERILNNGKHLLMLLNEVLDFSKLEE
GRLELKPELFDLTKVINAVVMEMRSLAEAKKLSLLVQIDLQNSLLVNDPVRIKQILINLLSNAIKFTDSGSIWIDVKDLP
GSWVEIKVKDTGIGIAAKDFKYIFEAFRQVDQSITRKYPGTGLGLAIIDSLVQMMSGKIFLESQLGVGSIFTITLPRQLP
LSNSSLSSSSVQDAKEMMQPDHKVHHPTAKSNPTARKYHNLKL

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=274, Percent_Identity=41.970802919708, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI145693157, Length=230, Percent_Identity=40.8695652173913, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1788713, Length=245, Percent_Identity=34.2857142857143, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87081816, Length=231, Percent_Identity=37.2294372294372, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI48994928, Length=248, Percent_Identity=33.8709677419355, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87082128, Length=236, Percent_Identity=30.5084745762712, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=31.063829787234, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786600, Length=239, Percent_Identity=28.8702928870293, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790436, Length=243, Percent_Identity=29.2181069958848, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788549, Length=240, Percent_Identity=29.1666666666667, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786783, Length=227, Percent_Identity=27.7533039647577, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=253, Percent_Identity=30.0395256916996, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788393, Length=229, Percent_Identity=27.5109170305677, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1787894, Length=235, Percent_Identity=28.0851063829787, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790346, Length=227, Percent_Identity=27.7533039647577, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790437, Length=105, Percent_Identity=34.2857142857143, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1790299, Length=125, Percent_Identity=33.6, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787375, Length=114, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788279, Length=227, Percent_Identity=25.5506607929515, Blast_Score=62, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=78, Percent_Identity=51.2820512820513, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49994; Mature: 49994

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEETLKILVVDDDEVDRMAVRRALVKAGVRMEMSEVSDGSTALSILRHRSFDCAFIDYRL
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEHHHCCCCHHHHHHHHHCCCCEEEEEEEC
PDQDGLNLIETIRGLNIKIPLVVLTSQGDEQIAVELMKAGATDYLSKFRVSSETLAQVLR
CCCCCCHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHH
NAIRLYRAEMQTTIAYQQLRESHEQLVRKNQELERQRQQIQIQNLKLLEASRLKSQFLAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MSHELRTPMNAIIGFAQILSRPKFGNLTGQQADMVERILNNGKHLLMLLNEVLDFSKLEE
HHHHHHCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
GRLELKPELFDLTKVINAVVMEMRSLAEAKKLSLLVQIDLQNSLLVNDPVRIKQILINLL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCEEECCCHHHHHHHHHHH
SNAIKFTDSGSIWIDVKDLPGSWVEIKVKDTGIGIAAKDFKYIFEAFRQVDQSITRKYPG
HHHHEECCCCEEEEEEECCCCCEEEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCC
TGLGLAIIDSLVQMMSGKIFLESQLGVGSIFTITLPRQLPLSNSSLSSSSVQDAKEMMQP
CCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCC
DHKVHHPTAKSNPTARKYHNLKL
CCCCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure
MEETLKILVVDDDEVDRMAVRRALVKAGVRMEMSEVSDGSTALSILRHRSFDCAFIDYRL
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEHHHCCCCHHHHHHHHHCCCCEEEEEEEC
PDQDGLNLIETIRGLNIKIPLVVLTSQGDEQIAVELMKAGATDYLSKFRVSSETLAQVLR
CCCCCCHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHH
NAIRLYRAEMQTTIAYQQLRESHEQLVRKNQELERQRQQIQIQNLKLLEASRLKSQFLAT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MSHELRTPMNAIIGFAQILSRPKFGNLTGQQADMVERILNNGKHLLMLLNEVLDFSKLEE
HHHHHHCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
GRLELKPELFDLTKVINAVVMEMRSLAEAKKLSLLVQIDLQNSLLVNDPVRIKQILINLL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCEEECCCHHHHHHHHHHH
SNAIKFTDSGSIWIDVKDLPGSWVEIKVKDTGIGIAAKDFKYIFEAFRQVDQSITRKYPG
HHHHEECCCCEEEEEEECCCCCEEEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCC
TGLGLAIIDSLVQMMSGKIFLESQLGVGSIFTITLPRQLPLSNSSLSSSSVQDAKEMMQP
CCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCC
DHKVHHPTAKSNPTARKYHNLKL
CCCCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]