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The map label for this gene is dapA

Identifier: 17231171

GI number: 17231171

Start: 4436671

End: 4437555

Strand: Reverse

Name: dapA

Synonym: all3679

Alternate gene names: 17231171

Gene position: 4437555-4436671 (Counterclockwise)

Preceding gene: 161353742

Following gene: 17231170

Centisome position: 69.19

GC content: 43.5

Gene sequence:

>885_bases
GTGGGAGATTTTGGCACAGTTTTAACCGCTATGATTACACCGTTCAAAGCGGACGGGAGCGTTAACTATGCTGTAGCGGC
AGAACTAGCAGCGAATTTAGTTGACAATGGTACAGATACATTGGTTGTGTGTGGTACAACTGGAGAGTCACCCACCTTGA
GTTGGGATGAAGAATACAATTTATTTGTAGAAGTTTTGCAGACAGTAGCAGGCAAAGCCAAGGTAATAGCTGGATGTGGT
TCCAATTCCACCAAAGAAGCGATCGCAGCTACGCAAAAAGCAGCTAAAATAGGAGTACATGGTACTTTACAAGTTGTACC
TTACTACAACAAACCGCCACAAGCCGGACTATACCAGCACTTTCAGGCGATAGCGCAAGCCTGTCCAGAGCTACCGCTAT
TGTTATATAACGTTCCTGGTCGTACTGGTCAAAATCTCAGTCCAGAGACAGTTGTGCGGTTAGCTGAAATCGACAATATT
GTTGGTGTTAAAGAAGCTAGTGGCAATCTTGACCAAGCGGGTGAAATCCGTCGCTTGACACCAAAAGAATTCCAGATTTA
CGCTGGAGATGATTCGTTAACTTTACCCTTGTTAGCTATAGGGGCAAAAGGCGTAGTCAGTGTGGCTTCCCATCTGGTAG
GGAACCAACTACAACAGATGATTCAAGCTTTTAATTCTGGGCAAGTGACAGTTGCCAGTGATATTCATCTTCGACTTTTG
CCGTTGTTTAAGACTTTATTTATCACTACAAATCCGATTCCCATTAAACAAGCACTAAAACTTCAAGGTTGGGAAGTTGG
CTCAACCCGTCCACCGCTAAGTGATGCTGATGCAGAAGTCAGTCAAAAACTAGAAGCAGTAATGAAACATCTCGATTTAA
TTTAA

Upstream 100 bases:

>100_bases
ACCGACTACTTTCGACTAATGACAGTGAACAGTTAACTGTCATCTGACACCTAAATAACTGATCAACATAATTAAAAGGA
AATTGAGGAGTAACAAGAGG

Downstream 100 bases:

>100_bases
TCACCATTATCTAAGGACTAGTTAAATTCTATTTCCCAAAACTGTATATCAATAACTAATGGGGTTTATTAGAAAAATCT
GATGATTAAAGTTTTATTCC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MGDFGTVLTAMITPFKADGSVNYAVAAELAANLVDNGTDTLVVCGTTGESPTLSWDEEYNLFVEVLQTVAGKAKVIAGCG
SNSTKEAIAATQKAAKIGVHGTLQVVPYYNKPPQAGLYQHFQAIAQACPELPLLLYNVPGRTGQNLSPETVVRLAEIDNI
VGVKEASGNLDQAGEIRRLTPKEFQIYAGDDSLTLPLLAIGAKGVVSVASHLVGNQLQQMIQAFNSGQVTVASDIHLRLL
PLFKTLFITTNPIPIKQALKLQGWEVGSTRPPLSDADAEVSQKLEAVMKHLDLI

Sequences:

>Translated_294_residues
MGDFGTVLTAMITPFKADGSVNYAVAAELAANLVDNGTDTLVVCGTTGESPTLSWDEEYNLFVEVLQTVAGKAKVIAGCG
SNSTKEAIAATQKAAKIGVHGTLQVVPYYNKPPQAGLYQHFQAIAQACPELPLLLYNVPGRTGQNLSPETVVRLAEIDNI
VGVKEASGNLDQAGEIRRLTPKEFQIYAGDDSLTLPLLAIGAKGVVSVASHLVGNQLQQMIQAFNSGQVTVASDIHLRLL
PLFKTLFITTNPIPIKQALKLQGWEVGSTRPPLSDADAEVSQKLEAVMKHLDLI
>Mature_293_residues
GDFGTVLTAMITPFKADGSVNYAVAAELAANLVDNGTDTLVVCGTTGESPTLSWDEEYNLFVEVLQTVAGKAKVIAGCGS
NSTKEAIAATQKAAKIGVHGTLQVVPYYNKPPQAGLYQHFQAIAQACPELPLLLYNVPGRTGQNLSPETVVRLAEIDNIV
GVKEASGNLDQAGEIRRLTPKEFQIYAGDDSLTLPLLAIGAKGVVSVASHLVGNQLQQMIQAFNSGQVTVASDIHLRLLP
LFKTLFITTNPIPIKQALKLQGWEVGSTRPPLSDADAEVSQKLEAVMKHLDLI

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=279, Percent_Identity=29.3906810035842, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI13540533, Length=299, Percent_Identity=28.4280936454849, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=41.0958904109589, Blast_Score=221, Evalue=4e-59,
Organism=Escherichia coli, GI87082415, Length=301, Percent_Identity=28.9036544850498, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1786463, Length=287, Percent_Identity=28.2229965156794, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789620, Length=286, Percent_Identity=26.2237762237762, Blast_Score=98, Evalue=5e-22,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_NOSS1 (Q8YQY1)

Other databases:

- EMBL:   BA000019
- PIR:   AH2265
- RefSeq:   NP_487719.1
- ProteinModelPortal:   Q8YQY1
- SMR:   Q8YQY1
- STRING:   Q8YQY1
- GeneID:   1107277
- GenomeReviews:   BA000019_GR
- KEGG:   ana:all3679
- NMPDR:   fig|103690.1.peg.3986
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   LFITTNP
- PhylomeDB:   Q8YQY1
- ProtClustDB:   PRK03170
- BioCyc:   NSP103690:ALL3679-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31274; Mature: 31143

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2; PS00430 TONB_DEPENDENT_REC_1

Important sites: ACT_SITE 164-164 BINDING 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDFGTVLTAMITPFKADGSVNYAVAAELAANLVDNGTDTLVVCGTTGESPTLSWDEEYN
CCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHH
LFVEVLQTVAGKAKVIAGCGSNSTKEAIAATQKAAKIGVHGTLQVVPYYNKPPQAGLYQH
HHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHH
FQAIAQACPELPLLLYNVPGRTGQNLSPETVVRLAEIDNIVGVKEASGNLDQAGEIRRLT
HHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCC
PKEFQIYAGDDSLTLPLLAIGAKGVVSVASHLVGNQLQQMIQAFNSGQVTVASDIHLRLL
CCCEEEEECCCCCEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHH
PLFKTLFITTNPIPIKQALKLQGWEVGSTRPPLSDADAEVSQKLEAVMKHLDLI
HHHHHHHHCCCCCCHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GDFGTVLTAMITPFKADGSVNYAVAAELAANLVDNGTDTLVVCGTTGESPTLSWDEEYN
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHH
LFVEVLQTVAGKAKVIAGCGSNSTKEAIAATQKAAKIGVHGTLQVVPYYNKPPQAGLYQH
HHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHH
FQAIAQACPELPLLLYNVPGRTGQNLSPETVVRLAEIDNIVGVKEASGNLDQAGEIRRLT
HHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCC
PKEFQIYAGDDSLTLPLLAIGAKGVVSVASHLVGNQLQQMIQAFNSGQVTVASDIHLRLL
CCCEEEEECCCCCEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHH
PLFKTLFITTNPIPIKQALKLQGWEVGSTRPPLSDADAEVSQKLEAVMKHLDLI
HHHHHHHHCCCCCCHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840