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The map label for this gene is ilvB [H]

Identifier: 17231047

GI number: 17231047

Start: 4285425

End: 4287068

Strand: Reverse

Name: ilvB [H]

Synonym: all3555

Alternate gene names: 17231047

Gene position: 4287068-4285425 (Counterclockwise)

Preceding gene: 17231048

Following gene: 17231044

Centisome position: 66.84

GC content: 42.03

Gene sequence:

>1644_bases
ATGAATACAGCAGAACTGTTAGTACAGTGTTTAGAAAATGAAGGGGTACAATATGTTTTTGGACTTCCAGGCGAAGAAAA
CTTACACGTTTTAGAAGCGCTTAAACATTCCTCTATTCAATTTATTACAACCCGTCATGAACAAGGTGCAGCTTTCATGG
CAGATGTTTACGGACGGTTGACAGGAAAAGCCGGCGTATGTCTTTCCACCTTGGGGCCGGGGGCGACAAATCTCATGACT
GGGGTGGCTGATGCCAACCTGGATGGTGCGCCTTTGGTGGCGATTACTGGACAAGTGGGAACCGATAGAATGCACATCGA
ATCCCATCAATATCTAGATTTAGTGGCGATGTTTGCTCCTGTAACTAAGTGGAATAAACAGATTGTCCGACCGAGTATTA
CACCCGAAGTAGTGCGTAAAGCCTTCAAGCGATCGCAAAGCGAAAAACCAGGGGCAGTTCACATAGATTTACCAGAAAAT
ATTGCCGCTATGCCCGTAGAGGGCAAACCTTTGCAGAAAGACAATATCGAGAAAACATACGCATCTTTCGCCAGTATTCG
TGCCGCCGCCGCCGCTATTTCTCAAGCTGTTAATCCCTTAATCTTAGTGGGAAATGGTGCAATTAGGGCTAAAGCTAGTG
ATGCCGTCACCCAATTTGCTACCCAAATGAATATCCCTGTTGCTAATACTTTCATGGGTAAAGGTGTGATTCCTTACACT
CATCCCTTAGCCTTATGGTCAGTAGGATTGCAACAAAGAGATTTCATTACCTGCGGTTTTGATAATACAGATTTAGTAAT
TGCTATTGGTTATGATTTGATCGAATTTTCACCCAAAAAATGGAACCCAGAAGGCAAAATTCCTATTGTCCATATTGGTG
CAGATTCGGCGGAAATTGACAGTAGCTATATCCCTAATGTATCCGTTATTGGTGATATTTCTGATTCTCTAGTAGAAATA
TTAAAAGTAGCAGATAGACAAGGCAAACCTAATCCTTATGCTATCAGCTTAAGAGGCAATATTCGGGAAGATTACGAACA
ATATGCCAATGATGATGGTTATCCGATTAAGCCACAAAAGTTGATCTATGACTTACGGCAAGTAATGGGGCCCGATGATA
TCGTAATTTCCGATGTCGGCGCTCATAAAATGTGGATAGCCCGTCATTATCATTGCCACAGCCCTAATACCTGTATTATT
TCTAATGGCTTTGCCGCAATGGGTATTGCTATTCCTGGTGCTTTGGCTGCAAAACTCGTTTATCCTAACCGTAAAGTTGT
CGCCGCTACTGGTGACGGTGGCTTTATGATGAATTGCCAAGAATTAGAAACAGCCCTACGAGTTGGTACACCATTCGTCA
CCTTAATTTTCAATGATGGCGGCTACGGTTTAATTGAATGGAAACAAGAAAATCAATTTGGTAAAGGACAATCATCTTTT
GTACATTTCGGCAATCCAGATTTTGTCAAATTAGCCGAAAGTATGGGCTTAAAAGGTTACAGAGTTGAATCAGCTTTAGA
TTTAATTCCCGTACTCAAAGAAGCCTTAGCGCAAGATGTACCAGCTGTGATTGATTGTCCTGTAGATTACCGAGAAAATC
GCCGCTTTACACAAAAAGCTGGTGAGTTAAGTTGTTCTGTTTAG

Upstream 100 bases:

>100_bases
GTTTGGGTTAAGTAAGTTGTTTTTGTCAGTTGTTAGTTGTTTATTCTTTGCTACTGACAACTGACTATTGACTCTTTCGC
AAATAAGGAATTAATTCAAA

Downstream 100 bases:

>100_bases
TAATATTCTAGAAGTATTTTAGTTTGTGGTCGGCACTTTATTTCTAATTTATCTCAGCACTCAAGTGCTGACTACAAACA
CTATTTTCTTGGCTTTTGCT

Product: acetolactate synthase

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MNTAELLVQCLENEGVQYVFGLPGEENLHVLEALKHSSIQFITTRHEQGAAFMADVYGRLTGKAGVCLSTLGPGATNLMT
GVADANLDGAPLVAITGQVGTDRMHIESHQYLDLVAMFAPVTKWNKQIVRPSITPEVVRKAFKRSQSEKPGAVHIDLPEN
IAAMPVEGKPLQKDNIEKTYASFASIRAAAAAISQAVNPLILVGNGAIRAKASDAVTQFATQMNIPVANTFMGKGVIPYT
HPLALWSVGLQQRDFITCGFDNTDLVIAIGYDLIEFSPKKWNPEGKIPIVHIGADSAEIDSSYIPNVSVIGDISDSLVEI
LKVADRQGKPNPYAISLRGNIREDYEQYANDDGYPIKPQKLIYDLRQVMGPDDIVISDVGAHKMWIARHYHCHSPNTCII
SNGFAAMGIAIPGALAAKLVYPNRKVVAATGDGGFMMNCQELETALRVGTPFVTLIFNDGGYGLIEWKQENQFGKGQSSF
VHFGNPDFVKLAESMGLKGYRVESALDLIPVLKEALAQDVPAVIDCPVDYRENRRFTQKAGELSCSV

Sequences:

>Translated_547_residues
MNTAELLVQCLENEGVQYVFGLPGEENLHVLEALKHSSIQFITTRHEQGAAFMADVYGRLTGKAGVCLSTLGPGATNLMT
GVADANLDGAPLVAITGQVGTDRMHIESHQYLDLVAMFAPVTKWNKQIVRPSITPEVVRKAFKRSQSEKPGAVHIDLPEN
IAAMPVEGKPLQKDNIEKTYASFASIRAAAAAISQAVNPLILVGNGAIRAKASDAVTQFATQMNIPVANTFMGKGVIPYT
HPLALWSVGLQQRDFITCGFDNTDLVIAIGYDLIEFSPKKWNPEGKIPIVHIGADSAEIDSSYIPNVSVIGDISDSLVEI
LKVADRQGKPNPYAISLRGNIREDYEQYANDDGYPIKPQKLIYDLRQVMGPDDIVISDVGAHKMWIARHYHCHSPNTCII
SNGFAAMGIAIPGALAAKLVYPNRKVVAATGDGGFMMNCQELETALRVGTPFVTLIFNDGGYGLIEWKQENQFGKGQSSF
VHFGNPDFVKLAESMGLKGYRVESALDLIPVLKEALAQDVPAVIDCPVDYRENRRFTQKAGELSCSV
>Mature_547_residues
MNTAELLVQCLENEGVQYVFGLPGEENLHVLEALKHSSIQFITTRHEQGAAFMADVYGRLTGKAGVCLSTLGPGATNLMT
GVADANLDGAPLVAITGQVGTDRMHIESHQYLDLVAMFAPVTKWNKQIVRPSITPEVVRKAFKRSQSEKPGAVHIDLPEN
IAAMPVEGKPLQKDNIEKTYASFASIRAAAAAISQAVNPLILVGNGAIRAKASDAVTQFATQMNIPVANTFMGKGVIPYT
HPLALWSVGLQQRDFITCGFDNTDLVIAIGYDLIEFSPKKWNPEGKIPIVHIGADSAEIDSSYIPNVSVIGDISDSLVEI
LKVADRQGKPNPYAISLRGNIREDYEQYANDDGYPIKPQKLIYDLRQVMGPDDIVISDVGAHKMWIARHYHCHSPNTCII
SNGFAAMGIAIPGALAAKLVYPNRKVVAATGDGGFMMNCQELETALRVGTPFVTLIFNDGGYGLIEWKQENQFGKGQSSF
VHFGNPDFVKLAESMGLKGYRVESALDLIPVLKEALAQDVPAVIDCPVDYRENRRFTQKAGELSCSV

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=561, Percent_Identity=25.668449197861, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI21361361, Length=556, Percent_Identity=23.7410071942446, Blast_Score=135, Evalue=7e-32,
Organism=Escherichia coli, GI1790104, Length=536, Percent_Identity=31.7164179104478, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI87081685, Length=559, Percent_Identity=31.8425760286225, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1786717, Length=561, Percent_Identity=30.1247771836007, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI1787096, Length=540, Percent_Identity=24.2592592592593, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1788716, Length=551, Percent_Identity=26.3157894736842, Blast_Score=142, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17531299, Length=480, Percent_Identity=27.2916666666667, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17531301, Length=480, Percent_Identity=27.2916666666667, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17542570, Length=571, Percent_Identity=24.8686514886165, Blast_Score=122, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323755, Length=559, Percent_Identity=31.8425760286225, Blast_Score=254, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6320816, Length=482, Percent_Identity=25.9336099585062, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323163, Length=484, Percent_Identity=23.3471074380165, Blast_Score=95, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323073, Length=521, Percent_Identity=22.8406909788868, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6321524, Length=481, Percent_Identity=22.4532224532225, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320588, Length=617, Percent_Identity=22.3662884927066, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320123, Length=506, Percent_Identity=22.5296442687747, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19922626, Length=559, Percent_Identity=25.2236135957066, Blast_Score=168, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 59413; Mature: 59413

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTAELLVQCLENEGVQYVFGLPGEENLHVLEALKHSSIQFITTRHEQGAAFMADVYGRL
CCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHH
TGKAGVCLSTLGPGATNLMTGVADANLDGAPLVAITGQVGTDRMHIESHQYLDLVAMFAP
CCCCCEEEECCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEECCHHHHHHHHHHHH
VTKWNKQIVRPSITPEVVRKAFKRSQSEKPGAVHIDLPENIAAMPVEGKPLQKDNIEKTY
HHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCEECCCCCCCCCCCCHHHHH
ASFASIRAAAAAISQAVNPLILVGNGAIRAKASDAVTQFATQMNIPVANTFMGKGVIPYT
HHHHHHHHHHHHHHHCCCCEEEECCCCEEECHHHHHHHHHHHCCCCCHHHHCCCCCCCCC
HPLALWSVGLQQRDFITCGFDNTDLVIAIGYDLIEFSPKKWNPEGKIPIVHIGADSAEID
CHHHHHHHCCCCCCEEEECCCCCCEEEEECCHHEECCCCCCCCCCCEEEEEECCCCCCCC
SSYIPNVSVIGDISDSLVEILKVADRQGKPNPYAISLRGNIREDYEQYANDDGYPIKPQK
CCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCCCCHHH
LIYDLRQVMGPDDIVISDVGAHKMWIARHYHCHSPNTCIISNGFAAMGIAIPGALAAKLV
HHHHHHHHCCCCCEEEECCCCCEEEEEEEEECCCCCEEEEECCCEEEHHHCCCHHHEEEE
YPNRKVVAATGDGGFMMNCQELETALRVGTPFVTLIFNDGGYGLIEWKQENQFGKGQSSF
CCCCEEEEEECCCCEEEEHHHHHHHHHCCCCEEEEEEECCCEEEEEEECCCCCCCCCCCE
VHFGNPDFVKLAESMGLKGYRVESALDLIPVLKEALAQDVPAVIDCPVDYRENRRFTQKA
EECCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHC
GELSCSV
CCCCCCC
>Mature Secondary Structure
MNTAELLVQCLENEGVQYVFGLPGEENLHVLEALKHSSIQFITTRHEQGAAFMADVYGRL
CCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHH
TGKAGVCLSTLGPGATNLMTGVADANLDGAPLVAITGQVGTDRMHIESHQYLDLVAMFAP
CCCCCEEEECCCCCHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEECCHHHHHHHHHHHH
VTKWNKQIVRPSITPEVVRKAFKRSQSEKPGAVHIDLPENIAAMPVEGKPLQKDNIEKTY
HHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCEECCCCCCCCCCCCHHHHH
ASFASIRAAAAAISQAVNPLILVGNGAIRAKASDAVTQFATQMNIPVANTFMGKGVIPYT
HHHHHHHHHHHHHHHCCCCEEEECCCCEEECHHHHHHHHHHHCCCCCHHHHCCCCCCCCC
HPLALWSVGLQQRDFITCGFDNTDLVIAIGYDLIEFSPKKWNPEGKIPIVHIGADSAEID
CHHHHHHHCCCCCCEEEECCCCCCEEEEECCHHEECCCCCCCCCCCEEEEEECCCCCCCC
SSYIPNVSVIGDISDSLVEILKVADRQGKPNPYAISLRGNIREDYEQYANDDGYPIKPQK
CCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHCCCCCCCCCHHH
LIYDLRQVMGPDDIVISDVGAHKMWIARHYHCHSPNTCIISNGFAAMGIAIPGALAAKLV
HHHHHHHHCCCCCEEEECCCCCEEEEEEEEECCCCCEEEEECCCEEEHHHCCCHHHEEEE
YPNRKVVAATGDGGFMMNCQELETALRVGTPFVTLIFNDGGYGLIEWKQENQFGKGQSSF
CCCCEEEEEECCCCEEEEHHHHHHHHHCCCCEEEEEEECCCEEEEEEECCCCCCCCCCCE
VHFGNPDFVKLAESMGLKGYRVESALDLIPVLKEALAQDVPAVIDCPVDYRENRRFTQKA
EECCCCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHC
GELSCSV
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9099862 [H]