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The map label for this gene is ppx [H]

Identifier: 17231044

GI number: 17231044

Start: 4280738

End: 4282390

Strand: Reverse

Name: ppx [H]

Synonym: all3552

Alternate gene names: 17231044

Gene position: 4282390-4280738 (Counterclockwise)

Preceding gene: 17231047

Following gene: 17231043

Centisome position: 66.77

GC content: 45.86

Gene sequence:

>1653_bases
ATGGTGAATTTAGTTTCATCTAGCTGGGAGAGTGTCAGCACTCAACCAGTTCAGCAACACCGGATTATTGCTGCCATTGA
CATGGGAACCAATTCTCTGCACATGGTAGTGGTAAAGATTGACCCGACACTACCAGCTTTTAGCATTGTTTCCAGAGAAA
AAGAAACCGTGCGACTGGGCGATCGCAATATTGCCACTGGGGAGTTAAAACCAGAGGTCATGGCAAAAGCGATCGCTACG
TTGAAGCGCTTTCAAGAAGTTGCCAAAACTGCCAACGCGGAAACATTAATTGCTGTGGCGACTAGTGCGGTGCGGGAAGC
GCCCAATGGTAAAGATTTTTTACACCAGATAGAAACGGAATTGGGTTTAAGCGTTGACTTGATTTCTGGTCAAGAAGAAG
CACGACGCATTTACCTTGGTGTTTTGTCGGGGATGGAATTTCATAACCAACCGCACCTGATTATTGATATTGGTGGTGGT
TCTACGGAGTTGATTTTAGGTGATACTCAAGAACCTCGCACCCTCACCAGCACCAAAGTTGGTGCGGTACGACTCACGAG
CGAGTTAATCACCACAGATCCCATCAGCAATATTGAGTTTCAATACCTGCAAGCCTATGCCAGGGGAATGTTAGAACGTT
CTGTAGAGGAAGTGCTAGCTAACCTGAATTTTGGCGAATCTCCCCGTTTAATTGGCACTTCTGGCACTATTGAAACCATC
GCTATGATTCATGCGCGGGAAAAATCTGGTACAGTCCCTTCTACCCTCAACGGCTATCAATTCACTCTCAAAGACTTGCG
AGAGTGGGTAAATCGCCTGCGGAGAATGACAAATGCCGAAAGAGCCGCTATCCCCGGAATGCCCGAAAAACGCTCTGAAG
TCATACTCGCCGGCGCTGTCATCTTACAAGAAGCCATGACCCTGTTGGGTGTGGAGTCATTAACCGCTTGTGGTCGCGCA
CTACGGGAAGGGGTAATTGTTGACTGGATGTTAAGCCACGGCTTAATTGAAGACAGATTGCGGTTTCAAAGTTCGATTCG
CCAGCGTAGTGTCCTTAAACAAGCAAGTAAGTATCAAGTTAACTTAGAGTATAGCGATCGCGTAGCTACATTTGCCCTGA
GTTTATTTGACCAAACCCAAGGACTACTACACCACTGGGGCAGCAACGAACGGCGATTACTTTGGGCGGCGGCAATTTTA
CACAACTGCGGTCATCATGTCAGCCATTCATCCCACCACAAACATTCCTACTATCTCATTCGCAATAGTGAACTACTCGG
TTACAACGAAACCGAGATCGAAATCATTGCCAATTTAGCCCGGTATCACCGCAAATCACCACCCAAGAAAAAGCATGAAA
ATTTCCGGAACCTGTTGAGTAAAGAGCATCGGCAAGCCGTGAGCCAATTAAGTGCGCTGTTAAGATTGGCAGTAGCATTA
GATCGGCGACAAATTGGAGCGATCGCTCAAATCAAATGTGATTATTATCACCACTTCCAGCAGTTTAATTTGCTCATCTA
TCCATCTCGACCCGATGATAATTGCGCCTTAGAACTCTGGAGTTTAGACTACAAAAAAGCAGTCTTTGAAGCAGAATTTG
GTGTGAAATTACTCACCCATTTGGAAAAAAACTTACTTCCTAATTTCTCCTAA

Upstream 100 bases:

>100_bases
GCTCAACCTGAGAATTAAGTGTGTTGCAACATAATATCAGTGCCAACTACCCCGACACATCATTCATTACCATCCATCCT
GAATACAGAGAGAAGACTAG

Downstream 100 bases:

>100_bases
ACAAGCTACGTTGCTGGTGATCAATTCAGGAAATGGTAATAGGTAATGGGTCATAGGTAATAGCTAAAAATCTTCTCCCA
ATTACTTGTTACCTGTTACC

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MVNLVSSSWESVSTQPVQQHRIIAAIDMGTNSLHMVVVKIDPTLPAFSIVSREKETVRLGDRNIATGELKPEVMAKAIAT
LKRFQEVAKTANAETLIAVATSAVREAPNGKDFLHQIETELGLSVDLISGQEEARRIYLGVLSGMEFHNQPHLIIDIGGG
STELILGDTQEPRTLTSTKVGAVRLTSELITTDPISNIEFQYLQAYARGMLERSVEEVLANLNFGESPRLIGTSGTIETI
AMIHAREKSGTVPSTLNGYQFTLKDLREWVNRLRRMTNAERAAIPGMPEKRSEVILAGAVILQEAMTLLGVESLTACGRA
LREGVIVDWMLSHGLIEDRLRFQSSIRQRSVLKQASKYQVNLEYSDRVATFALSLFDQTQGLLHHWGSNERRLLWAAAIL
HNCGHHVSHSSHHKHSYYLIRNSELLGYNETEIEIIANLARYHRKSPPKKKHENFRNLLSKEHRQAVSQLSALLRLAVAL
DRRQIGAIAQIKCDYYHHFQQFNLLIYPSRPDDNCALELWSLDYKKAVFEAEFGVKLLTHLEKNLLPNFS

Sequences:

>Translated_550_residues
MVNLVSSSWESVSTQPVQQHRIIAAIDMGTNSLHMVVVKIDPTLPAFSIVSREKETVRLGDRNIATGELKPEVMAKAIAT
LKRFQEVAKTANAETLIAVATSAVREAPNGKDFLHQIETELGLSVDLISGQEEARRIYLGVLSGMEFHNQPHLIIDIGGG
STELILGDTQEPRTLTSTKVGAVRLTSELITTDPISNIEFQYLQAYARGMLERSVEEVLANLNFGESPRLIGTSGTIETI
AMIHAREKSGTVPSTLNGYQFTLKDLREWVNRLRRMTNAERAAIPGMPEKRSEVILAGAVILQEAMTLLGVESLTACGRA
LREGVIVDWMLSHGLIEDRLRFQSSIRQRSVLKQASKYQVNLEYSDRVATFALSLFDQTQGLLHHWGSNERRLLWAAAIL
HNCGHHVSHSSHHKHSYYLIRNSELLGYNETEIEIIANLARYHRKSPPKKKHENFRNLLSKEHRQAVSQLSALLRLAVAL
DRRQIGAIAQIKCDYYHHFQQFNLLIYPSRPDDNCALELWSLDYKKAVFEAEFGVKLLTHLEKNLLPNFS
>Mature_550_residues
MVNLVSSSWESVSTQPVQQHRIIAAIDMGTNSLHMVVVKIDPTLPAFSIVSREKETVRLGDRNIATGELKPEVMAKAIAT
LKRFQEVAKTANAETLIAVATSAVREAPNGKDFLHQIETELGLSVDLISGQEEARRIYLGVLSGMEFHNQPHLIIDIGGG
STELILGDTQEPRTLTSTKVGAVRLTSELITTDPISNIEFQYLQAYARGMLERSVEEVLANLNFGESPRLIGTSGTIETI
AMIHAREKSGTVPSTLNGYQFTLKDLREWVNRLRRMTNAERAAIPGMPEKRSEVILAGAVILQEAMTLLGVESLTACGRA
LREGVIVDWMLSHGLIEDRLRFQSSIRQRSVLKQASKYQVNLEYSDRVATFALSLFDQTQGLLHHWGSNERRLLWAAAIL
HNCGHHVSHSSHHKHSYYLIRNSELLGYNETEIEIIANLARYHRKSPPKKKHENFRNLLSKEHRQAVSQLSALLRLAVAL
DRRQIGAIAQIKCDYYHHFQQFNLLIYPSRPDDNCALELWSLDYKKAVFEAEFGVKLLTHLEKNLLPNFS

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=471, Percent_Identity=31.2101910828025, Blast_Score=188, Evalue=7e-49,
Organism=Escherichia coli, GI48994966, Length=469, Percent_Identity=28.5714285714286, Blast_Score=155, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 61804; Mature: 61804

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNLVSSSWESVSTQPVQQHRIIAAIDMGTNSLHMVVVKIDPTLPAFSIVSREKETVRLG
CCCCCCCCCCCCCCCCHHHCEEEEEEECCCCCEEEEEEEECCCCCHHHHHHCCCHHEEEC
DRNIATGELKPEVMAKAIATLKRFQEVAKTANAETLIAVATSAVREAPNGKDFLHQIETE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
LGLSVDLISGQEEARRIYLGVLSGMEFHNQPHLIIDIGGGSTELILGDTQEPRTLTSTKV
HCCEEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCCEECCCCC
GAVRLTSELITTDPISNIEFQYLQAYARGMLERSVEEVLANLNFGESPRLIGTSGTIETI
CCEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHH
AMIHAREKSGTVPSTLNGYQFTLKDLREWVNRLRRMTNAERAAIPGMPEKRSEVILAGAV
HHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCEEHHHHH
ILQEAMTLLGVESLTACGRALREGVIVDWMLSHGLIEDRLRFQSSIRQRSVLKQASKYQV
HHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEE
NLEYSDRVATFALSLFDQTQGLLHHWGSNERRLLWAAAILHNCGHHVSHSSHHKHSYYLI
EEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
RNSELLGYNETEIEIIANLARYHRKSPPKKKHENFRNLLSKEHRQAVSQLSALLRLAVAL
ECCEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRRQIGAIAQIKCDYYHHFQQFNLLIYPSRPDDNCALELWSLDYKKAVFEAEFGVKLLTH
HHHHHCCCEEEEHHHHHHHHHCCEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHH
LEKNLLPNFS
HHHHCCCCCC
>Mature Secondary Structure
MVNLVSSSWESVSTQPVQQHRIIAAIDMGTNSLHMVVVKIDPTLPAFSIVSREKETVRLG
CCCCCCCCCCCCCCCCHHHCEEEEEEECCCCCEEEEEEEECCCCCHHHHHHCCCHHEEEC
DRNIATGELKPEVMAKAIATLKRFQEVAKTANAETLIAVATSAVREAPNGKDFLHQIETE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
LGLSVDLISGQEEARRIYLGVLSGMEFHNQPHLIIDIGGGSTELILGDTQEPRTLTSTKV
HCCEEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCCEECCCCC
GAVRLTSELITTDPISNIEFQYLQAYARGMLERSVEEVLANLNFGESPRLIGTSGTIETI
CCEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHH
AMIHAREKSGTVPSTLNGYQFTLKDLREWVNRLRRMTNAERAAIPGMPEKRSEVILAGAV
HHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCEEHHHHH
ILQEAMTLLGVESLTACGRALREGVIVDWMLSHGLIEDRLRFQSSIRQRSVLKQASKYQV
HHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEEE
NLEYSDRVATFALSLFDQTQGLLHHWGSNERRLLWAAAILHNCGHHVSHSSHHKHSYYLI
EEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
RNSELLGYNETEIEIIANLARYHRKSPPKKKHENFRNLLSKEHRQAVSQLSALLRLAVAL
ECCEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRRQIGAIAQIKCDYYHHFQQFNLLIYPSRPDDNCALELWSLDYKKAVFEAEFGVKLLTH
HHHHHCCCEEEEHHHHHHHHHCCEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHH
LEKNLLPNFS
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]