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The map label for this gene is ndhH [H]

Identifier: 17230847

GI number: 17230847

Start: 4060270

End: 4061454

Strand: Direct

Name: ndhH [H]

Synonym: alr3355

Alternate gene names: 17230847

Gene position: 4060270-4061454 (Clockwise)

Preceding gene: 17230845

Following gene: 17230848

Centisome position: 63.31

GC content: 47.85

Gene sequence:

>1185_bases
ATGGCAAGAATAGAAACCCGCACTGAACCAATGGTGCTGAATATGGGGCCACACCATCCCTCAATGCACGGGGTTCTGCG
GCTAATTGTCACTTTGGATGGTGAAGATGTCGTTGATTGTGAACCTGTAATCGGCTATCTGCACCGAGGAATGGAGAAAA
TCGCCGAAAACCGTACTACAGTCATGTACGTCCCCTACGTCAGCCGATGGGACTACGCCGCAGGAATGTTCAATGAAGCT
GTCACCGTCAATGCACCGGAAAAGCTGGCTGGTGTTGCTGTTCCTAAACGCGCTAGCTACATCCGCGTCATCATGCTGGA
ACTGAATCGCATTGCTAACCACCTCCTGTGGTTCGGCCCCTTCCTGGCTGACGTAGGCGCACAAACTCCCTTCTTTTACC
AGTTCCGAGAACGGGAGATGATTTACGATTTGTGGGAAGCCGCTACAGGCTACCGCATGGTAAATAACAACTACTTCCGT
GTTGGTGGTGTAGCTGCGGATTTACCCTATGGCTGGGTAGATAAGTGTCTAGAATTTTGTGACTACTTCTTACCCGTAAT
TGATGAATACGAAAAGTTAGTTACCAATAATCCCATTTTCCGCCGTCGGATCGAAGGTATTGGCACAATTAGCCGCGAAG
AAGCAATTAACTGGGGACTTTCCGGCCCGATGTTACGAGCTTCAGGCGTAAAATGGGACTTGCGGAAAGTTGACCATTAC
GAATGTTACGACGATTTCGACTGGGATGTACAGTGGGAGACAGCCGGCGATTGTTTAGCCCGTTACACCGTAAGAATGCG
GGAAATGCGCGAATCTGTGAAGATTATCAAGCAAGCAATCAAAGGATTACCCGGAGGCCCCTACGAAAACCTGGAAGCCA
AGCGTTTAGCAGCTGGGAAGAAATCGGAATGGGATGCTTTTGATTACCAATACATTGGCAAAAAAGTTTCTCCTACCTTC
AAAATGCCCAAAGGTGAAATTTACGCCCGTGTGGAAAGCGGTAAAGGTGAACTAGGCATTTATCTGATTGGCGATGATAA
CGTATTTCCTTGGCGGTGGAAAATTCGCCCAGCCGATTTCAACAACCTGCAAATTCTTCCCCACTTACTACGAGGTATGA
AAGTTGCGGATGTTGTGGTAATTCTCGGCAGTATTGACGTAATTATGGGTTCTGTAGATAGATAG

Upstream 100 bases:

>100_bases
ACGTGAGCGATCACCCACGGTGGGCGGTTACGCCATCGCGTCTGGATGGCATCAACGCGGTTCAACTCAAAATTTTCATA
ATGGGAGAACACGGAAATTT

Downstream 100 bases:

>100_bases
CCATAGCAATACTGTTCCATTTGCAAGTCATGAAAGCTAAAGATTCCCGACACTCAAAGAAGTCGGGATTTTTTTTCGAG
AAAATTAACAGTAACTATAG

Product: NAD(P)H-quinone oxidoreductase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase subunit H; NADH-plastoquinone oxidoreductase subunit H; NDH-1 subunit H; NDH-H [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MARIETRTEPMVLNMGPHHPSMHGVLRLIVTLDGEDVVDCEPVIGYLHRGMEKIAENRTTVMYVPYVSRWDYAAGMFNEA
VTVNAPEKLAGVAVPKRASYIRVIMLELNRIANHLLWFGPFLADVGAQTPFFYQFREREMIYDLWEAATGYRMVNNNYFR
VGGVAADLPYGWVDKCLEFCDYFLPVIDEYEKLVTNNPIFRRRIEGIGTISREEAINWGLSGPMLRASGVKWDLRKVDHY
ECYDDFDWDVQWETAGDCLARYTVRMREMRESVKIIKQAIKGLPGGPYENLEAKRLAAGKKSEWDAFDYQYIGKKVSPTF
KMPKGEIYARVESGKGELGIYLIGDDNVFPWRWKIRPADFNNLQILPHLLRGMKVADVVVILGSIDVIMGSVDR

Sequences:

>Translated_394_residues
MARIETRTEPMVLNMGPHHPSMHGVLRLIVTLDGEDVVDCEPVIGYLHRGMEKIAENRTTVMYVPYVSRWDYAAGMFNEA
VTVNAPEKLAGVAVPKRASYIRVIMLELNRIANHLLWFGPFLADVGAQTPFFYQFREREMIYDLWEAATGYRMVNNNYFR
VGGVAADLPYGWVDKCLEFCDYFLPVIDEYEKLVTNNPIFRRRIEGIGTISREEAINWGLSGPMLRASGVKWDLRKVDHY
ECYDDFDWDVQWETAGDCLARYTVRMREMRESVKIIKQAIKGLPGGPYENLEAKRLAAGKKSEWDAFDYQYIGKKVSPTF
KMPKGEIYARVESGKGELGIYLIGDDNVFPWRWKIRPADFNNLQILPHLLRGMKVADVVVILGSIDVIMGSVDR
>Mature_393_residues
ARIETRTEPMVLNMGPHHPSMHGVLRLIVTLDGEDVVDCEPVIGYLHRGMEKIAENRTTVMYVPYVSRWDYAAGMFNEAV
TVNAPEKLAGVAVPKRASYIRVIMLELNRIANHLLWFGPFLADVGAQTPFFYQFREREMIYDLWEAATGYRMVNNNYFRV
GGVAADLPYGWVDKCLEFCDYFLPVIDEYEKLVTNNPIFRRRIEGIGTISREEAINWGLSGPMLRASGVKWDLRKVDHYE
CYDDFDWDVQWETAGDCLARYTVRMREMRESVKIIKQAIKGLPGGPYENLEAKRLAAGKKSEWDAFDYQYIGKKVSPTFK
MPKGEIYARVESGKGELGIYLIGDDNVFPWRWKIRPADFNNLQILPHLLRGMKVADVVVILGSIDVIMGSVDR

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=392, Percent_Identity=41.5816326530612, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI260898743, Length=386, Percent_Identity=40.9326424870466, Blast_Score=288, Evalue=6e-78,
Organism=Escherichia coli, GI145693162, Length=401, Percent_Identity=39.4014962593516, Blast_Score=301, Evalue=4e-83,
Organism=Escherichia coli, GI1789076, Length=386, Percent_Identity=29.0155440414508, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1788832, Length=393, Percent_Identity=27.9898218829517, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17555284, Length=393, Percent_Identity=40.4580152671756, Blast_Score=304, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI17568379, Length=393, Percent_Identity=40.4580152671756, Blast_Score=303, Evalue=8e-83,
Organism=Drosophila melanogaster, GI221459469, Length=384, Percent_Identity=44.7916666666667, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI24638644, Length=394, Percent_Identity=41.8781725888325, Blast_Score=321, Evalue=6e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: 1.6.5.3

Molecular weight: Translated: 45217; Mature: 45086

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIETRTEPMVLNMGPHHPSMHGVLRLIVTLDGEDVVDCEPVIGYLHRGMEKIAENRTT
CCCCCCCCCCEEEECCCCCCHHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCE
VMYVPYVSRWDYAAGMFNEAVTVNAPEKLAGVAVPKRASYIRVIMLELNRIANHLLWFGP
EEEECCCCCCCHHHHHCCCCEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FLADVGAQTPFFYQFREREMIYDLWEAATGYRMVNNNYFRVGGVAADLPYGWVDKCLEFC
HHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCEEECCCEEEECCEEECCCHHHHHHHHHHH
DYFLPVIDEYEKLVTNNPIFRRRIEGIGTISREEAINWGLSGPMLRASGVKWDLRKVDHY
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHCCCCCCCEEECCCCEEEHHCCCCC
ECYDDFDWDVQWETAGDCLARYTVRMREMRESVKIIKQAIKGLPGGPYENLEAKRLAAGK
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCC
KSEWDAFDYQYIGKKVSPTFKMPKGEIYARVESGKGELGIYLIGDDNVFPWRWKIRPADF
CCCCCCCCHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCEECEEEEECCCCC
NNLQILPHLLRGMKVADVVVILGSIDVIMGSVDR
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ARIETRTEPMVLNMGPHHPSMHGVLRLIVTLDGEDVVDCEPVIGYLHRGMEKIAENRTT
CCCCCCCCCEEEECCCCCCHHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCE
VMYVPYVSRWDYAAGMFNEAVTVNAPEKLAGVAVPKRASYIRVIMLELNRIANHLLWFGP
EEEECCCCCCCHHHHHCCCCEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FLADVGAQTPFFYQFREREMIYDLWEAATGYRMVNNNYFRVGGVAADLPYGWVDKCLEFC
HHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCEEECCCEEEECCEEECCCHHHHHHHHHHH
DYFLPVIDEYEKLVTNNPIFRRRIEGIGTISREEAINWGLSGPMLRASGVKWDLRKVDHY
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHCCCCCCCEEECCCCEEEHHCCCCC
ECYDDFDWDVQWETAGDCLARYTVRMREMRESVKIIKQAIKGLPGGPYENLEAKRLAAGK
CCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCC
KSEWDAFDYQYIGKKVSPTFKMPKGEIYARVESGKGELGIYLIGDDNVFPWRWKIRPADF
CCCCCCCCHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEECCCEECEEEEECCCCC
NNLQILPHLLRGMKVADVVVILGSIDVIMGSVDR
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA