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The map label for this gene is pyrC' [H]

Identifier: 17230831

GI number: 17230831

Start: 4035126

End: 4036433

Strand: Direct

Name: pyrC' [H]

Synonym: alr3339

Alternate gene names: 17230831

Gene position: 4035126-4036433 (Clockwise)

Preceding gene: 17230830

Following gene: 17230832

Centisome position: 62.91

GC content: 49.31

Gene sequence:

>1308_bases
ATGACAACTGAACTTCTGCAACAAGTAAGGGTAATCGACCCGGTTTCGGGTATTGACAATATCACAGATGTGTTAATTGC
TGATGGCGTAATTCAAGCCATTGCCCCCAATATTCCTAATACTCGTCCTGATACTCAAATTAGAGATTGTCGAGGATTAG
TTCTTGGCCCTGGTTTAGTGGATTTATACAGCCACTCTGGAGAACCAGGATTTGAAGAACGGGAAACGCTGGCATCTTTC
TTACAAGCGGCGGCGGCTGGTGGTTTTACCAAAGTCAGTATTTTACCCGATACATCTCCGGCTATTGATAACCCCGCACT
GGTGGCACAGTTGCAGAAGAGGGGGCAGGGGGCAGGGGGCAGGGGGCAGGGGGAGAAATCCCCAATCCCCAATCCCCAAT
ACCTAGCACCCCTGCTCTATATCTGGGGTGCTATGACTCTGGATGTGGCTGGGAAGCAGATGACAGAATTGGCTGATTTA
GCGGCGGCTGGGGTGGTTGGTTTTACTGATGGGTTGCCTTTAGACAATTTAAGCTTGGTACGGCGCTTGCTGGAATATGT
CCAACCCTTGGGGAAACCTGTAGCATTTTGTCCATGCGATCGCCAACTCTCCGCTAATGGTGTGATGCGGGAAGGCGCAG
ATGCCCTCCGCTTTGGTTTACCTCCCATACCCCCTAGTGCAGAAACAAGCGCGATCGCGGCTTTATTAGAGTTGGTTGCC
GCTTCAGGTAATACTCAAGTACACATTATGCGGGTTTCCACCGCCCGCAGCGTGGAACTGATCGCCGCCGCCAAAGCCCA
AGGTTTACCCATCACCGCTAGCACCACTTGGCTACATTTGTTACTAGACACCAAAGCGGTTAAAAGTTACAATACCAGCC
TGCATTTAGACCCACCATTGGGTAACGCCAGCGATGTCAAAGCCTTGCGTGAAGGAGTCCGCACAGGGGTAATAGATGCG
ATCGCCATTGATCATGCGCCATACACCTACGAAGAAAAAGTCCAAGCCTTCGCCGAAGCGCCACCAGGGGCGATCGGTTT
TGAGTTAGCATTACCCCTACTTTGGCAAAATCTGGTGGAAACTGGAGAATTTACGGCCTTAGAATTATGGCAAGCTTTGA
GTACTCGCCCAGCCCAATGTATTCAACAAAAAGTGAGTGCGTTTGCTCCTCATCACCAAGCAGAACTAACTTTATTTGAC
CCCCAAAAAATCTGGAAAGTCGAGAAGAAAAATCTGTATACACTTTCTAGTAACACATCTTGGTTAGGGCAAGAATTACA
AGGGCGAGTCATACAAACTTGGGTGTAA

Upstream 100 bases:

>100_bases
ACTACTCATTTGGGTGGTGTATTAGATAAAACCGCAGCTGGAGCATTATAGGCAAAATATATATCACAATAGACAAGCAG
TCCCAGCACTGATAGGTTAC

Downstream 100 bases:

>100_bases
GAATGGGATTTGGATTCAAGATTTTGGTTGAGCAGAGTATCCAATTGTTGACTGTTGCACCAAGACTCGTCCCAGAAGTT
TTGCAACAACCGACAATTCG

Product: dihydroorotase

Products: N-carbamoyl-L-aspartate

Alternate protein names: Aspartate carbamoyltransferase 42 kDa non-catalytic chain [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MTTELLQQVRVIDPVSGIDNITDVLIADGVIQAIAPNIPNTRPDTQIRDCRGLVLGPGLVDLYSHSGEPGFEERETLASF
LQAAAAGGFTKVSILPDTSPAIDNPALVAQLQKRGQGAGGRGQGEKSPIPNPQYLAPLLYIWGAMTLDVAGKQMTELADL
AAAGVVGFTDGLPLDNLSLVRRLLEYVQPLGKPVAFCPCDRQLSANGVMREGADALRFGLPPIPPSAETSAIAALLELVA
ASGNTQVHIMRVSTARSVELIAAAKAQGLPITASTTWLHLLLDTKAVKSYNTSLHLDPPLGNASDVKALREGVRTGVIDA
IAIDHAPYTYEEKVQAFAEAPPGAIGFELALPLLWQNLVETGEFTALELWQALSTRPAQCIQQKVSAFAPHHQAELTLFD
PQKIWKVEKKNLYTLSSNTSWLGQELQGRVIQTWV

Sequences:

>Translated_435_residues
MTTELLQQVRVIDPVSGIDNITDVLIADGVIQAIAPNIPNTRPDTQIRDCRGLVLGPGLVDLYSHSGEPGFEERETLASF
LQAAAAGGFTKVSILPDTSPAIDNPALVAQLQKRGQGAGGRGQGEKSPIPNPQYLAPLLYIWGAMTLDVAGKQMTELADL
AAAGVVGFTDGLPLDNLSLVRRLLEYVQPLGKPVAFCPCDRQLSANGVMREGADALRFGLPPIPPSAETSAIAALLELVA
ASGNTQVHIMRVSTARSVELIAAAKAQGLPITASTTWLHLLLDTKAVKSYNTSLHLDPPLGNASDVKALREGVRTGVIDA
IAIDHAPYTYEEKVQAFAEAPPGAIGFELALPLLWQNLVETGEFTALELWQALSTRPAQCIQQKVSAFAPHHQAELTLFD
PQKIWKVEKKNLYTLSSNTSWLGQELQGRVIQTWV
>Mature_434_residues
TTELLQQVRVIDPVSGIDNITDVLIADGVIQAIAPNIPNTRPDTQIRDCRGLVLGPGLVDLYSHSGEPGFEERETLASFL
QAAAAGGFTKVSILPDTSPAIDNPALVAQLQKRGQGAGGRGQGEKSPIPNPQYLAPLLYIWGAMTLDVAGKQMTELADLA
AAGVVGFTDGLPLDNLSLVRRLLEYVQPLGKPVAFCPCDRQLSANGVMREGADALRFGLPPIPPSAETSAIAALLELVAA
SGNTQVHIMRVSTARSVELIAAAKAQGLPITASTTWLHLLLDTKAVKSYNTSLHLDPPLGNASDVKALREGVRTGVIDAI
AIDHAPYTYEEKVQAFAEAPPGAIGFELALPLLWQNLVETGEFTALELWQALSTRPAQCIQQKVSAFAPHHQAELTLFDP
QKIWKVEKKNLYTLSSNTSWLGQELQGRVIQTWV

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=210, Percent_Identity=32.8571428571429, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1786722, Length=434, Percent_Identity=22.8110599078341, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87082175, Length=431, Percent_Identity=24.3619489559165, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI193204318, Length=423, Percent_Identity=27.4231678486998, Blast_Score=101, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6322218, Length=406, Percent_Identity=25.1231527093596, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24642586, Length=416, Percent_Identity=27.1634615384615, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI18859883, Length=438, Percent_Identity=25.3424657534247, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004722 [H]

Pfam domain/function: NA

EC number: 3.5.2.3

Molecular weight: Translated: 46604; Mature: 46473

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTELLQQVRVIDPVSGIDNITDVLIADGVIQAIAPNIPNTRPDTQIRDCRGLVLGPGLV
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCEEECCCHH
DLYSHSGEPGFEERETLASFLQAAAAGGFTKVSILPDTSPAIDNPALVAQLQKRGQGAGG
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCC
RGQGEKSPIPNPQYLAPLLYIWGAMTLDVAGKQMTELADLAAAGVVGFTDGLPLDNLSLV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
RRLLEYVQPLGKPVAFCPCDRQLSANGVMREGADALRFGLPPIPPSAETSAIAALLELVA
HHHHHHHHHHCCCEEECCCCCCCCCCCCHHCCCHHHHHCCCCCCCCCHHHHHHHHHHHHH
ASGNTQVHIMRVSTARSVELIAAAKAQGLPITASTTWLHLLLDTKAVKSYNTSLHLDPPL
CCCCCEEEEEEECCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCEEEECCCC
GNASDVKALREGVRTGVIDAIAIDHAPYTYEEKVQAFAEAPPGAIGFELALPLLWQNLVE
CCHHHHHHHHHHHHHCCHHHEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
TGEFTALELWQALSTRPAQCIQQKVSAFAPHHQAELTLFDPQKIWKVEKKNLYTLSSNTS
CCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHCCCEEEECCCCH
WLGQELQGRVIQTWV
HHHHHHCCCCHHHCC
>Mature Secondary Structure 
TTELLQQVRVIDPVSGIDNITDVLIADGVIQAIAPNIPNTRPDTQIRDCRGLVLGPGLV
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCEEECCCHH
DLYSHSGEPGFEERETLASFLQAAAAGGFTKVSILPDTSPAIDNPALVAQLQKRGQGAGG
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCC
RGQGEKSPIPNPQYLAPLLYIWGAMTLDVAGKQMTELADLAAAGVVGFTDGLPLDNLSLV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
RRLLEYVQPLGKPVAFCPCDRQLSANGVMREGADALRFGLPPIPPSAETSAIAALLELVA
HHHHHHHHHHCCCEEECCCCCCCCCCCCHHCCCHHHHHCCCCCCCCCHHHHHHHHHHHHH
ASGNTQVHIMRVSTARSVELIAAAKAQGLPITASTTWLHLLLDTKAVKSYNTSLHLDPPL
CCCCCEEEEEEECCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCEEEECCCC
GNASDVKALREGVRTGVIDAIAIDHAPYTYEEKVQAFAEAPPGAIGFELALPLLWQNLVE
CCHHHHHHHHHHHHHCCHHHEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
TGEFTALELWQALSTRPAQCIQQKVSAFAPHHQAELTLFDPQKIWKVEKKNLYTLSSNTS
CCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHCCCEEEECCCCH
WLGQELQGRVIQTWV
HHHHHHCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-dihydroorotate; H2O

Specific reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]