Click here to switch to the map view.

The map label for this gene is lhr [C]

Identifier: 17230823

GI number: 17230823

Start: 4025732

End: 4027900

Strand: Direct

Name: lhr [C]

Synonym: alr3331

Alternate gene names: 17230823

Gene position: 4025732-4027900 (Clockwise)

Preceding gene: 17230822

Following gene: 17230828

Centisome position: 62.77

GC content: 38.87

Gene sequence:

>2169_bases
ATGACTAATGCCTTCAACAGACTTGCACCTTTTATTCAAGAATATATTTATCATCATCAGTGGACTGAATTAAGACCTGT
TCAAACGGCAGCTTGTGAGGTGGTATTTGACAGCGATGCTCATCTATTAATTGCCGCCGCTACAGCTGCGGGGAAAACAG
AAGCAGCTTTTTTACCAGTTTTAACTCTGTTACACGACAACCCCGCCAGCACCATAGGCGCACTATATATAGGCCCTATC
AAAGCTTTAATTAATGACCAATTTGCACGGCTCAACGATTTATTAAGATTAGCGGACATCCCCGTTTACCATTGGCATGG
TGATGTGGCGCAAAGTCGCAAAAATAAACTCCTAAAAAATCCCCAAGGGATTCTCCAAATTACACCAGAATCTCTAGAAA
GTTTATTAGTCAATAAACATAAAGAAATATTACGTTTATTTGGCGATTTAAGATTTGTAGTTATTGATGAAATTCATGCC
TTTATGGGTTCGGAACGCGGTTGTCAGATTATTTGTCAATTGCAGCGTTTGACCAACTTAACCAAAACCCAACCCCGCCG
CATTGGTTTATCAGCAACTTTAGGTGATTATTCAATGGCGGAAGAGTGGCTGCGTTTGGGAACTAATAGACAAGTGATTA
CACCAAAAGTGGAAGCTGGAAAACGCCAGATTAAATTAGCTTTAGAACACTTTTATATTGCGAAGGATGTAGATGAATCA
GAAGCCACAGCATACGAACAATATATTTTTAATCTGAGTCAATCTCGTAAATGTTTAATTTTCGCAAACAATCGTACACA
AACTGAATCAATAATTGCTTCTTTGCGACAAATTGCCAGCCAACAAGCACATCCAGATATATATCATGTACATCATGGGA
GTATATCTGCTAGCTTACGACAAGTGGCAGAAAATGCTATGCGCGAACCCCATAACCCGGCGGTGACTGCGGCTACTCTG
ACTTTAGAGTTAGGTATAGATATCGGTCATTTGGAACGAGTAATTCAATTAGAAGCGCCGCTTTCTGTAGCCAGTTTTTT
ACAACGTTTGGGGCGTGCGGGTAGAAGGGGTGAAGCTGCTGATATGCGCTTTATCTGTGCTGAGGATGAAATTTCAGCAG
AAGCACCTTTACCAGAGCAAATTCCTTGGCAACTTTTACAGTGTATAGCGATTATTCAACTTTATTTAGAAGAACGTTGG
ATTGAACCAATTGAACCAATTAAATATCCTTTGAGTTTGTTATATCACCAAACAATGAGTATTTTAGTTGCAGTGGGAGA
AATTTCCCCTGCTGCTTTAGCTAAACAGGTTTTGAGTTTGCCCCCCTTTGCTGCTATTTCTCAGGAAGATTTTAAGTTAC
TGTTGCGTTATTTAATTGATATTGGTCATATTCAACATACTGAACAGAATAAATTAATTCTGGGTTTAGCTGGTGAAAGA
ATAGTTAGTAAGTTTCAGTTTTATGCCGTGTTCGCAGATAACAAAGAATATACTGTTAAGCAAGGGACAAAAGAAATTGG
TAGTATTGCCACACCGCCAGTTGTTGGTAAACAATTTGCTTTAGCAGGGGTGACATGGGAAGTTACAGAAATTGACTTTA
AAAAAAGAGTAGTTATAGTTAAGCAAGTGGAAGGCAAAGCTACAAGTTATTGGCGCGGTGGTAGTGGTACGATTCACACT
AAGGTTTTGCAAAGGATGCGCCGTGTTTTATTAGAAGATGCCGAATATAGCTATTTGCAAAAAAAAGCCCTCCAACGTTT
ACGAAAAGTTCGGGAATTGGTAAAAGAAGTTGGATTAGATAAGCAGTATATTTTGCAGTTAGAAAAAGGTAGATGTTGTA
TCTTTCCGTGGATGGGTACTGTGGCTTACCGCACTTTGGAAAGGTTACTGAATAATTTTTGTCGAGAATCTTTAGAAATT
AGTAGTATTGGTGGGGTAAATCCCTATTATTTGACGATTAAGTTAGGGAAGGGGAAATTTAAATATATTCAGCAAGAGAT
TGTCTCTTTGTGTGAACAAAGAATTAGGAGCGAAGATTTGATAAGTTCGGCGGAAGCGCCAGAGATGCAAAAGTATGACG
AGTTTATTCCTCATCCTCTGTTGCGGAAAGCTTTTGCTGATGATTATTTGGATATGGATGAAATTAGAAGGGTGATTGGT
AATTGGTAA

Upstream 100 bases:

>100_bases
GCCCGGTCAAGCCGGGTTTTTTCATGTCTATATTTGGGACAGACGCGATTAATCGCGTCTCTGACAATTGTACAGACGCG
ATTAATCGCGTCTCCAACTA

Downstream 100 bases:

>100_bases
TTATAGCTGTTGACGGTTGACAGACTTGAAAGCCTTTTATTATCAGGATTTTATCTTAGCTTGATGTCCTAATCTATCTG
GCTACGGCTATATGTAAATG

Product: ATP-dependent helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 722; Mature: 721

Protein sequence:

>722_residues
MTNAFNRLAPFIQEYIYHHQWTELRPVQTAACEVVFDSDAHLLIAAATAAGKTEAAFLPVLTLLHDNPASTIGALYIGPI
KALINDQFARLNDLLRLADIPVYHWHGDVAQSRKNKLLKNPQGILQITPESLESLLVNKHKEILRLFGDLRFVVIDEIHA
FMGSERGCQIICQLQRLTNLTKTQPRRIGLSATLGDYSMAEEWLRLGTNRQVITPKVEAGKRQIKLALEHFYIAKDVDES
EATAYEQYIFNLSQSRKCLIFANNRTQTESIIASLRQIASQQAHPDIYHVHHGSISASLRQVAENAMREPHNPAVTAATL
TLELGIDIGHLERVIQLEAPLSVASFLQRLGRAGRRGEAADMRFICAEDEISAEAPLPEQIPWQLLQCIAIIQLYLEERW
IEPIEPIKYPLSLLYHQTMSILVAVGEISPAALAKQVLSLPPFAAISQEDFKLLLRYLIDIGHIQHTEQNKLILGLAGER
IVSKFQFYAVFADNKEYTVKQGTKEIGSIATPPVVGKQFALAGVTWEVTEIDFKKRVVIVKQVEGKATSYWRGGSGTIHT
KVLQRMRRVLLEDAEYSYLQKKALQRLRKVRELVKEVGLDKQYILQLEKGRCCIFPWMGTVAYRTLERLLNNFCRESLEI
SSIGGVNPYYLTIKLGKGKFKYIQQEIVSLCEQRIRSEDLISSAEAPEMQKYDEFIPHPLLRKAFADDYLDMDEIRRVIG
NW

Sequences:

>Translated_722_residues
MTNAFNRLAPFIQEYIYHHQWTELRPVQTAACEVVFDSDAHLLIAAATAAGKTEAAFLPVLTLLHDNPASTIGALYIGPI
KALINDQFARLNDLLRLADIPVYHWHGDVAQSRKNKLLKNPQGILQITPESLESLLVNKHKEILRLFGDLRFVVIDEIHA
FMGSERGCQIICQLQRLTNLTKTQPRRIGLSATLGDYSMAEEWLRLGTNRQVITPKVEAGKRQIKLALEHFYIAKDVDES
EATAYEQYIFNLSQSRKCLIFANNRTQTESIIASLRQIASQQAHPDIYHVHHGSISASLRQVAENAMREPHNPAVTAATL
TLELGIDIGHLERVIQLEAPLSVASFLQRLGRAGRRGEAADMRFICAEDEISAEAPLPEQIPWQLLQCIAIIQLYLEERW
IEPIEPIKYPLSLLYHQTMSILVAVGEISPAALAKQVLSLPPFAAISQEDFKLLLRYLIDIGHIQHTEQNKLILGLAGER
IVSKFQFYAVFADNKEYTVKQGTKEIGSIATPPVVGKQFALAGVTWEVTEIDFKKRVVIVKQVEGKATSYWRGGSGTIHT
KVLQRMRRVLLEDAEYSYLQKKALQRLRKVRELVKEVGLDKQYILQLEKGRCCIFPWMGTVAYRTLERLLNNFCRESLEI
SSIGGVNPYYLTIKLGKGKFKYIQQEIVSLCEQRIRSEDLISSAEAPEMQKYDEFIPHPLLRKAFADDYLDMDEIRRVIG
NW
>Mature_721_residues
TNAFNRLAPFIQEYIYHHQWTELRPVQTAACEVVFDSDAHLLIAAATAAGKTEAAFLPVLTLLHDNPASTIGALYIGPIK
ALINDQFARLNDLLRLADIPVYHWHGDVAQSRKNKLLKNPQGILQITPESLESLLVNKHKEILRLFGDLRFVVIDEIHAF
MGSERGCQIICQLQRLTNLTKTQPRRIGLSATLGDYSMAEEWLRLGTNRQVITPKVEAGKRQIKLALEHFYIAKDVDESE
ATAYEQYIFNLSQSRKCLIFANNRTQTESIIASLRQIASQQAHPDIYHVHHGSISASLRQVAENAMREPHNPAVTAATLT
LELGIDIGHLERVIQLEAPLSVASFLQRLGRAGRRGEAADMRFICAEDEISAEAPLPEQIPWQLLQCIAIIQLYLEERWI
EPIEPIKYPLSLLYHQTMSILVAVGEISPAALAKQVLSLPPFAAISQEDFKLLLRYLIDIGHIQHTEQNKLILGLAGERI
VSKFQFYAVFADNKEYTVKQGTKEIGSIATPPVVGKQFALAGVTWEVTEIDFKKRVVIVKQVEGKATSYWRGGSGTIHTK
VLQRMRRVLLEDAEYSYLQKKALQRLRKVRELVKEVGLDKQYILQLEKGRCCIFPWMGTVAYRTLERLLNNFCRESLEIS
SIGGVNPYYLTIKLGKGKFKYIQQEIVSLCEQRIRSEDLISSAEAPEMQKYDEFIPHPLLRKAFADDYLDMDEIRRVIGN
W

Specific function: Unknown

COG id: COG1201

COG function: function code R; Lhr-like helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI1787942, Length=610, Percent_Identity=27.3770491803279, Blast_Score=141, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17537127, Length=405, Percent_Identity=24.1975308641975, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17537519, Length=399, Percent_Identity=22.5563909774436, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321020, Length=410, Percent_Identity=25.8536585365854, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574898, Length=395, Percent_Identity=24.0506329113924, Blast_Score=76, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24647182, Length=388, Percent_Identity=21.3917525773196, Blast_Score=69, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR013701
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR017170 [H]

Pfam domain/function: PF00270 DEAD; PF08494 DEAD_assoc; PF00271 Helicase_C [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 81898; Mature: 81767

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNAFNRLAPFIQEYIYHHQWTELRPVQTAACEVVFDSDAHLLIAAATAAGKTEAAFLPV
CCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEEEECCCCCEEEEEECCCCCCHHHHHHH
LTLLHDNPASTIGALYIGPIKALINDQFARLNDLLRLADIPVYHWHGDVAQSRKNKLLKN
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCC
PQGILQITPESLESLLVNKHKEILRLFGDLRFVVIDEIHAFMGSERGCQIICQLQRLTNL
CCCEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCH
TKTQPRRIGLSATLGDYSMAEEWLRLGTNRQVITPKVEAGKRQIKLALEHFYIAKDVDES
HCCCCCCCCCEEECCCHHHHHHHHHCCCCCEEECCCHHCCHHHHHHHHHHHHHHCCCCCH
EATAYEQYIFNLSQSRKCLIFANNRTQTESIIASLRQIASQQAHPDIYHVHHGSISASLR
HHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
QVAENAMREPHNPAVTAATLTLELGIDIGHLERVIQLEAPLSVASFLQRLGRAGRRGEAA
HHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
DMRFICAEDEISAEAPLPEQIPWQLLQCIAIIQLYLEERWIEPIEPIKYPLSLLYHQTMS
CEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
ILVAVGEISPAALAKQVLSLPPFAAISQEDFKLLLRYLIDIGHIQHTEQNKLILGLAGER
HHHHHCCCCHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHH
IVSKFQFYAVFADNKEYTVKQGTKEIGSIATPPVVGKQFALAGVTWEVTEIDFKKRVVIV
HHHHEEEEEEEECCCCEEHHHCHHHHCCCCCCCCCCCCCEEECCEEEEEEECCCCEEEEE
KQVEGKATSYWRGGSGTIHTKVLQRMRRVLLEDAEYSYLQKKALQRLRKVRELVKEVGLD
EECCCCCCCEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
KQYILQLEKGRCCIFPWMGTVAYRTLERLLNNFCRESLEISSIGGVNPYYLTIKLGKGKF
HHHHHEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCHH
KYIQQEIVSLCEQRIRSEDLISSAEAPEMQKYDEFIPHPLLRKAFADDYLDMDEIRRVIG
HHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHC
NW
CC
>Mature Secondary Structure 
TNAFNRLAPFIQEYIYHHQWTELRPVQTAACEVVFDSDAHLLIAAATAAGKTEAAFLPV
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEEEECCCCCEEEEEECCCCCCHHHHHHH
LTLLHDNPASTIGALYIGPIKALINDQFARLNDLLRLADIPVYHWHGDVAQSRKNKLLKN
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCC
PQGILQITPESLESLLVNKHKEILRLFGDLRFVVIDEIHAFMGSERGCQIICQLQRLTNL
CCCEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCH
TKTQPRRIGLSATLGDYSMAEEWLRLGTNRQVITPKVEAGKRQIKLALEHFYIAKDVDES
HCCCCCCCCCEEECCCHHHHHHHHHCCCCCEEECCCHHCCHHHHHHHHHHHHHHCCCCCH
EATAYEQYIFNLSQSRKCLIFANNRTQTESIIASLRQIASQQAHPDIYHVHHGSISASLR
HHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHH
QVAENAMREPHNPAVTAATLTLELGIDIGHLERVIQLEAPLSVASFLQRLGRAGRRGEAA
HHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCC
DMRFICAEDEISAEAPLPEQIPWQLLQCIAIIQLYLEERWIEPIEPIKYPLSLLYHQTMS
CEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
ILVAVGEISPAALAKQVLSLPPFAAISQEDFKLLLRYLIDIGHIQHTEQNKLILGLAGER
HHHHHCCCCHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHH
IVSKFQFYAVFADNKEYTVKQGTKEIGSIATPPVVGKQFALAGVTWEVTEIDFKKRVVIV
HHHHEEEEEEEECCCCEEHHHCHHHHCCCCCCCCCCCCCEEECCEEEEEEECCCCEEEEE
KQVEGKATSYWRGGSGTIHTKVLQRMRRVLLEDAEYSYLQKKALQRLRKVRELVKEVGLD
EECCCCCCCEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
KQYILQLEKGRCCIFPWMGTVAYRTLERLLNNFCRESLEISSIGGVNPYYLTIKLGKGKF
HHHHHEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCHH
KYIQQEIVSLCEQRIRSEDLISSAEAPEMQKYDEFIPHPLLRKAFADDYLDMDEIRRVIG
HHHHHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHC
NW
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726 [H]