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The map label for this gene is csd [H]

Identifier: 17230702

GI number: 17230702

Start: 3879025

End: 3880230

Strand: Direct

Name: csd [H]

Synonym: alr3210

Alternate gene names: 17230702

Gene position: 3879025-3880230 (Clockwise)

Preceding gene: 17230696

Following gene: 17230705

Centisome position: 60.48

GC content: 45.44

Gene sequence:

>1206_bases
ATGACTATTTTGAATTCTAATTTGTCTATGACTTCTATTTCTACTTTACAGACTAGGTTGCACAGCCATCGGGAACAGTT
CCCGGCTTTAGCTAATAAGACCTATTTTAACTATGGTGGACAGGGGCCGATGCCTCAAGGGGCAATGGATATTATTACCC
AATCTCTCACTTATATCCAACAAATCGGCCCTTTTGGGACTGAGGCGGGTAATTGGATAACCAGACAAACTCAAGCTGTG
AGGGAAGCGATCGCCTCGGAATTAAACGCCTCTTCTGATACGATTACTTTTACAGATAATGTCACTGTTGGCTGTAATAT
CGCTCTTTGGGGCATCCCTTGGCAAGCCGGCGACCATATTTTACTATCGGACTGCGAACACCCAGGGGTAATTGCTGCTA
CCCAAGAAATTAGTCGCCGCTTTGGGGTGGAAGTTACTACTTGTCCCCTCAAATCTACGTTAAATGAGGGCGAACCGACA
ACAATTATCGCCCAGCACCTCCGCAAAAATACTCGCTTGGTAGTACTTAGTCATGTCTTTTGGAATACTGGACAGGTACT
ACCTTTGGATAAAATTGTTGAGGTATGCAGAAATAATAACTCTTTACTATTAGTCGATGCTGCCCAGTCTGTTGGGGCGT
TACCTCTGAATTTAACCGAGTTGGGGGTAGATTTTTATGCTTTTACTGGTCACAAATGGTTATGCGGCCCTGAGGGTGTG
GGCGGTTTGTATGTGCGACCAGAGGTGAGAGAAAGCCTCAACCCGACATTCATCGGTTTGTATGGAATTATTGTGGATAA
CCAAGCCCAACCTGTAAGCTGGAAGCCAGACGGGCGCAGGTATGAAGTATCTACCCTAGCTTATCCATTATACCTGGGGT
TAAAGGAAGCGATCGCCACTCATCAGCGATGGGGAACACCACAGGAACGTTACGCGCAAATTTGTCACAACAGCGAATAC
CTGTGGCGCAGTTTGGCGGCGATACCCAATGTCAAATGTTTACGTGATACACCACCGGAAACTGGTATTGTTTCTTTCCA
ACTCCACCAAACCCCATCCCTCAAGCTGGTGCAATTTCTCGATTCCCAAAAGATATTAACCCGAACCATTGCCGACCCAA
GTTGTATCCGGGTAACTGTTCATTATTTAACACTGGAATCAGAAATAGACCAATTAGTTGAAGCTATAGCTAGGTTTTCA
GTCTAG

Upstream 100 bases:

>100_bases
AAGTGTTCAGCATTAATTAGCATTCATTTGGGGATTGGGGATTGGGGATTGGGGATTGGGGATTGGGGATTGGGGACTAT
TGACTATAGACTATGGACTA

Downstream 100 bases:

>100_bases
TCATTAGTTATTGGTCAAGAAAGTAGACAGTAAAAAACACAGTAGAATGCTTTCTTGCTATTTGGATTAACACAATTGTT
TTTTCTATAAAATTAATGTT

Product: L-cysteine/cystine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTILNSNLSMTSISTLQTRLHSHREQFPALANKTYFNYGGQGPMPQGAMDIITQSLTYIQQIGPFGTEAGNWITRQTQAV
REAIASELNASSDTITFTDNVTVGCNIALWGIPWQAGDHILLSDCEHPGVIAATQEISRRFGVEVTTCPLKSTLNEGEPT
TIIAQHLRKNTRLVVLSHVFWNTGQVLPLDKIVEVCRNNNSLLLVDAAQSVGALPLNLTELGVDFYAFTGHKWLCGPEGV
GGLYVRPEVRESLNPTFIGLYGIIVDNQAQPVSWKPDGRRYEVSTLAYPLYLGLKEAIATHQRWGTPQERYAQICHNSEY
LWRSLAAIPNVKCLRDTPPETGIVSFQLHQTPSLKLVQFLDSQKILTRTIADPSCIRVTVHYLTLESEIDQLVEAIARFS
V

Sequences:

>Translated_401_residues
MTILNSNLSMTSISTLQTRLHSHREQFPALANKTYFNYGGQGPMPQGAMDIITQSLTYIQQIGPFGTEAGNWITRQTQAV
REAIASELNASSDTITFTDNVTVGCNIALWGIPWQAGDHILLSDCEHPGVIAATQEISRRFGVEVTTCPLKSTLNEGEPT
TIIAQHLRKNTRLVVLSHVFWNTGQVLPLDKIVEVCRNNNSLLLVDAAQSVGALPLNLTELGVDFYAFTGHKWLCGPEGV
GGLYVRPEVRESLNPTFIGLYGIIVDNQAQPVSWKPDGRRYEVSTLAYPLYLGLKEAIATHQRWGTPQERYAQICHNSEY
LWRSLAAIPNVKCLRDTPPETGIVSFQLHQTPSLKLVQFLDSQKILTRTIADPSCIRVTVHYLTLESEIDQLVEAIARFS
V
>Mature_400_residues
TILNSNLSMTSISTLQTRLHSHREQFPALANKTYFNYGGQGPMPQGAMDIITQSLTYIQQIGPFGTEAGNWITRQTQAVR
EAIASELNASSDTITFTDNVTVGCNIALWGIPWQAGDHILLSDCEHPGVIAATQEISRRFGVEVTTCPLKSTLNEGEPTT
IIAQHLRKNTRLVVLSHVFWNTGQVLPLDKIVEVCRNNNSLLLVDAAQSVGALPLNLTELGVDFYAFTGHKWLCGPEGVG
GLYVRPEVRESLNPTFIGLYGIIVDNQAQPVSWKPDGRRYEVSTLAYPLYLGLKEAIATHQRWGTPQERYAQICHNSEYL
WRSLAAIPNVKCLRDTPPETGIVSFQLHQTPSLKLVQFLDSQKILTRTIADPSCIRVTVHYLTLESEIDQLVEAIARFSV

Specific function: Cysteine Desulfurases Mobilize The Sulfur From L- Cysteine To Yield L-Alanine, An Essential Step In Sulfur Metabolism For Biosynthesis Of A Variety Of Sulfur-Containing Biomolecules. Component Of The Suf Operon, Which Is Activated And Required Under Speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=355, Percent_Identity=25.3521126760563, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1787970, Length=346, Percent_Identity=27.4566473988439, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI48994898, Length=228, Percent_Identity=32.8947368421053, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789175, Length=247, Percent_Identity=27.1255060728745, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25143064, Length=281, Percent_Identity=28.4697508896797, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319831, Length=403, Percent_Identity=24.317617866005, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20129463, Length=229, Percent_Identity=29.6943231441048, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44513; Mature: 44382

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILNSNLSMTSISTLQTRLHSHREQFPALANKTYFNYGGQGPMPQGAMDIITQSLTYIQ
CEEECCCCCHHHHHHHHHHHHHHHHHCCHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHH
QIGPFGTEAGNWITRQTQAVREAIASELNASSDTITFTDNVTVGCNIALWGIPWQAGDHI
HHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEEEEEEEEECCCCCCCEE
LLSDCEHPGVIAATQEISRRFGVEVTTCPLKSTLNEGEPTTIIAQHLRKNTRLVVLSHVF
EEECCCCCCEEEHHHHHHHHHCCEEEECCCHHHCCCCCCHHHHHHHHCCCCEEEEEEEEC
WNTGQVLPLDKIVEVCRNNNSLLLVDAAQSVGALPLNLTELGVDFYAFTGHKWLCGPEGV
CCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHCCEEEEECCCEEEECCCCC
GGLYVRPEVRESLNPTFIGLYGIIVDNQAQPVSWKPDGRRYEVSTLAYPLYLGLKEAIAT
CCEEECCHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
HQRWGTPQERYAQICHNSEYLWRSLAAIPNVKCLRDTPPETGIVSFQLHQTPSLKLVQFL
HHHCCCCHHHHHHHHCCCHHHHHHHHHCCCCEEECCCCCCCCEEEEEECCCCCHHHHHHH
DSQKILTRTIADPSCIRVTVHYLTLESEIDQLVEAIARFSV
CCHHHHHHHCCCCCEEEEEEEEEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TILNSNLSMTSISTLQTRLHSHREQFPALANKTYFNYGGQGPMPQGAMDIITQSLTYIQ
EEECCCCCHHHHHHHHHHHHHHHHHCCHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHH
QIGPFGTEAGNWITRQTQAVREAIASELNASSDTITFTDNVTVGCNIALWGIPWQAGDHI
HHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEEEEEEEEECCCCCCCEE
LLSDCEHPGVIAATQEISRRFGVEVTTCPLKSTLNEGEPTTIIAQHLRKNTRLVVLSHVF
EEECCCCCCEEEHHHHHHHHHCCEEEECCCHHHCCCCCCHHHHHHHHCCCCEEEEEEEEC
WNTGQVLPLDKIVEVCRNNNSLLLVDAAQSVGALPLNLTELGVDFYAFTGHKWLCGPEGV
CCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHCCEEEEECCCEEEECCCCC
GGLYVRPEVRESLNPTFIGLYGIIVDNQAQPVSWKPDGRRYEVSTLAYPLYLGLKEAIAT
CCEEECCHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
HQRWGTPQERYAQICHNSEYLWRSLAAIPNVKCLRDTPPETGIVSFQLHQTPSLKLVQFL
HHHCCCCHHHHHHHHCCCHHHHHHHHHCCCCEEECCCCCCCCEEEEEECCCCCHHHHHHH
DSQKILTRTIADPSCIRVTVHYLTLESEIDQLVEAIARFSV
CCHHHHHHHCCCCCEEEEEEEEEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]