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The map label for this gene is yvrG [H]

Identifier: 17230651

GI number: 17230651

Start: 3824423

End: 3825580

Strand: Direct

Name: yvrG [H]

Synonym: alr3159

Alternate gene names: 17230651

Gene position: 3824423-3825580 (Clockwise)

Preceding gene: 17230650

Following gene: 17230654

Centisome position: 59.63

GC content: 39.46

Gene sequence:

>1158_bases
ATGGTTGGACACTCAGTCAGGATTTTATTAATTGAGGATAGCCTCGCAGAAGCCAGGTTATTACAGGAATATTTGCATCA
AGCTGAGTCCAAACAATTTGTTCTGGTTCATGTGAAGCGATTACAGGAAGCACTCAATGAACTAAAACAGACCAGCTACG
ATGTGATTTTGTTAGACCTCACCCTACCGGATAGCCAAGGGTTATCATCTTTACCTATATTGATAGGACGGGTTCCTAGT
GTACCAATAGTTGTCTTGACAAATACTAACGATGAAGACTTAGCAATTGAAGCAGTCAGACAAGGAGCGCAAGATTATTT
AGTCAAGCGACAGGTAAATGTTAATGTATTGGTTCGTGCTGTATTTTATGCAATTGAGCGTAAGCAAGCATTAGAAACAT
TACGCACCATGAATACAACCCTAGAAAACCGGGTGGAAGAACGCACGGCTGAATTGGTGAAAGCGCAAGAAATCAACCAG
TTTAAATCTGAGTTTGTTTCCATGCTCTCCCATGACATCCGTAATCCCCTAAATACTATTTTGTTAGCGGCTGGGTTGTT
GCAAAATAACGAAGACAAATTAACTAAGGAGAAAAAACGTTCTCATTTACAAATGATTCGTTCCGCCATTAAAAATATGG
CACAACTATTAGATGAAGTGTCATTAATAGGCAAAGCTGAATCAGGTAAACTCCAGTGTGAACTTATCTCTATAGATTTG
GAAGCATTCTGTCGCCAATTAGTAGCAGAAGCGCAATTAACTATAGGCGAGAAGCATTTGACTGTAATTTTTACCTGCAA
TAAATCATTTGACGAAGCTTTATTAGATGAAACCTTGCTGCGTCACATTTTAGGTAATGTACTAGGCAACGCCATTAAGT
ATTCCCTTCCCGGCGGTATAATCCACTTTGAATTAACTGCCCAAAATAACGCAGTTATGTTTAAGATTCAAGATTGCGGA
ATTGGTATTTCCCAGGAAGACCAGAAACAACTATTTCAATCATTCCATCGTGGAGAAAATGTAGGAGGAATTGCAGGTAC
TGGCTTAGGACTAGCTATAGTCAAAAAATGTGTTGATGCTCACGGCGGCGAAATTATCGTCAATAGTGAGGTTGGGGTTG
GTACAACGTTTACTATCATCCTGCCATTAATCAACTAA

Upstream 100 bases:

>100_bases
GGAGCAGGGGAGAAAATTATTAAATTTTGAATTTTGAATTTTGAATTTTGAATTGATTACTCCCCAATCACCAATTACAA
GGGGGTAAAACCAGAAAATT

Downstream 100 bases:

>100_bases
TCAACATTTAAATGGGAGAGTTCATTTAATTTTCAATTGATTTAAAAAATTGCCAAATCTGTTCACTTGAGCATAGGTGA
TAAATGCTCTTGGTGTTTTT

Product: two-component hybrid sensor and regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MVGHSVRILLIEDSLAEARLLQEYLHQAESKQFVLVHVKRLQEALNELKQTSYDVILLDLTLPDSQGLSSLPILIGRVPS
VPIVVLTNTNDEDLAIEAVRQGAQDYLVKRQVNVNVLVRAVFYAIERKQALETLRTMNTTLENRVEERTAELVKAQEINQ
FKSEFVSMLSHDIRNPLNTILLAAGLLQNNEDKLTKEKKRSHLQMIRSAIKNMAQLLDEVSLIGKAESGKLQCELISIDL
EAFCRQLVAEAQLTIGEKHLTVIFTCNKSFDEALLDETLLRHILGNVLGNAIKYSLPGGIIHFELTAQNNAVMFKIQDCG
IGISQEDQKQLFQSFHRGENVGGIAGTGLGLAIVKKCVDAHGGEIIVNSEVGVGTTFTIILPLIN

Sequences:

>Translated_385_residues
MVGHSVRILLIEDSLAEARLLQEYLHQAESKQFVLVHVKRLQEALNELKQTSYDVILLDLTLPDSQGLSSLPILIGRVPS
VPIVVLTNTNDEDLAIEAVRQGAQDYLVKRQVNVNVLVRAVFYAIERKQALETLRTMNTTLENRVEERTAELVKAQEINQ
FKSEFVSMLSHDIRNPLNTILLAAGLLQNNEDKLTKEKKRSHLQMIRSAIKNMAQLLDEVSLIGKAESGKLQCELISIDL
EAFCRQLVAEAQLTIGEKHLTVIFTCNKSFDEALLDETLLRHILGNVLGNAIKYSLPGGIIHFELTAQNNAVMFKIQDCG
IGISQEDQKQLFQSFHRGENVGGIAGTGLGLAIVKKCVDAHGGEIIVNSEVGVGTTFTIILPLIN
>Mature_385_residues
MVGHSVRILLIEDSLAEARLLQEYLHQAESKQFVLVHVKRLQEALNELKQTSYDVILLDLTLPDSQGLSSLPILIGRVPS
VPIVVLTNTNDEDLAIEAVRQGAQDYLVKRQVNVNVLVRAVFYAIERKQALETLRTMNTTLENRVEERTAELVKAQEINQ
FKSEFVSMLSHDIRNPLNTILLAAGLLQNNEDKLTKEKKRSHLQMIRSAIKNMAQLLDEVSLIGKAESGKLQCELISIDL
EAFCRQLVAEAQLTIGEKHLTVIFTCNKSFDEALLDETLLRHILGNVLGNAIKYSLPGGIIHFELTAQNNAVMFKIQDCG
IGISQEDQKQLFQSFHRGENVGGIAGTGLGLAIVKKCVDAHGGEIIVNSEVGVGTTFTIILPLIN

Specific function: Member of the two-component regulatory system YvrG/YvrH that positively regulates 7 transcriptional units (wprA, wapA- yxxG, dltABCDE, sunA, sunT-bdbA-yolJ-bdbB, sigO-rsoA, and sigX- rsiX), and negatively regulates the lytABC operon. Probably activates yv

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=315, Percent_Identity=30.4761904761905, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788713, Length=232, Percent_Identity=28.8793103448276, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI48994928, Length=226, Percent_Identity=28.7610619469027, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=31.1740890688259, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI87081816, Length=260, Percent_Identity=29.6153846153846, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=27.3542600896861, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788393, Length=226, Percent_Identity=25.2212389380531, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=234, Percent_Identity=28.2051282051282, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788279, Length=224, Percent_Identity=25.8928571428571, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=28.3783783783784, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789808, Length=215, Percent_Identity=26.9767441860465, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI87082128, Length=226, Percent_Identity=25.2212389380531, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790436, Length=216, Percent_Identity=26.8518518518519, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786783, Length=241, Percent_Identity=24.4813278008299, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=213, Percent_Identity=24.4131455399061, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 42674; Mature: 42674

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGHSVRILLIEDSLAEARLLQEYLHQAESKQFVLVHVKRLQEALNELKQTSYDVILLDL
CCCCEEEEEEEECCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEE
TLPDSQGLSSLPILIGRVPSVPIVVLTNTNDEDLAIEAVRQGAQDYLVKRQVNVNVLVRA
ECCCCCCCCCCCHHHCCCCCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHCCCHHHHHHH
VFYAIERKQALETLRTMNTTLENRVEERTAELVKAQEINQFKSEFVSMLSHDIRNPLNTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAAGLLQNNEDKLTKEKKRSHLQMIRSAIKNMAQLLDEVSLIGKAESGKLQCELISIDL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECH
EAFCRQLVAEAQLTIGEKHLTVIFTCNKSFDEALLDETLLRHILGNVLGNAIKYSLPGGI
HHHHHHHHHHHHHEECCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCE
IHFELTAQNNAVMFKIQDCGIGISQEDQKQLFQSFHRGENVGGIAGTGLGLAIVKKCVDA
EEEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHC
HGGEIIVNSEVGVGTTFTIILPLIN
CCCEEEEECCCCCCEEEEEEEECCC
>Mature Secondary Structure
MVGHSVRILLIEDSLAEARLLQEYLHQAESKQFVLVHVKRLQEALNELKQTSYDVILLDL
CCCCEEEEEEEECCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEE
TLPDSQGLSSLPILIGRVPSVPIVVLTNTNDEDLAIEAVRQGAQDYLVKRQVNVNVLVRA
ECCCCCCCCCCCHHHCCCCCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHCCCHHHHHHH
VFYAIERKQALETLRTMNTTLENRVEERTAELVKAQEINQFKSEFVSMLSHDIRNPLNTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAAGLLQNNEDKLTKEKKRSHLQMIRSAIKNMAQLLDEVSLIGKAESGKLQCELISIDL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECH
EAFCRQLVAEAQLTIGEKHLTVIFTCNKSFDEALLDETLLRHILGNVLGNAIKYSLPGGI
HHHHHHHHHHHHHEECCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCE
IHFELTAQNNAVMFKIQDCGIGISQEDQKQLFQSFHRGENVGGIAGTGLGLAIVKKCVDA
EEEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHC
HGGEIIVNSEVGVGTTFTIILPLIN
CCCEEEEECCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]