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The map label for this gene is aphA

Identifier: 17230649

GI number: 17230649

Start: 3821607

End: 3823904

Strand: Direct

Name: aphA

Synonym: alr3157

Alternate gene names: 17230649

Gene position: 3821607-3823904 (Clockwise)

Preceding gene: 17230648

Following gene: 17230650

Centisome position: 59.58

GC content: 41.56

Gene sequence:

>2298_bases
ATGAGAATAGACGTAGAATCACAAAATATTAATGTTACTAGTTTAAAGGAAGCGCCAATTCATCTTTCCGGGCAAATTCA
ACCACATGGTGTGCTTTTAGTTTTGGAAGAACCGGGTCTGAAAATATTACAAGTGAGCAATAATACCTGGGGTATTTTGG
GTATCAATGCTGAAAATATATTACAGAAAAAATTAGAAGATTTACTCGATTCCTTTCAAATAGAACGGATTCAATCAGGC
TTATCTTCTGGGAATCTGGAATTTATTAACCCTACAAAAATTTGGATTAGAAAGAAGGGGGATGATTACGCAGTATTTGA
TGCGGTTTTCCATCGCAATACGGAAGGCTTTTTGATTCTGGAGTTAGAACCAGCAATTACTCAAGAAAATATCCCGTTTT
TAAGCTTTTATCATTTGGCGAAAGCTTCAATTAATCAGTTGCAGAAAACAGCAAATTTGCGGGATTTTTGTCAGATAATT
GTCCAAGAAGTCCGAAAAGTCACCGATTTTGATCGGGTAATGTTATATAAATTCGATGATGATGGACATGGTTCAGTCAT
CGCGGAAGAAAAACTAGACAGCCTAGAGCCATACTTAGGACTCCACTATCCAGAATCAGATATTCCTAAACCAGCCAGAA
AATTATTTATTTCTAATTCCATCCGGGTGATTCCCAATGCTCAGGCTCAGGCTATACAGATGATACCCGCTTTGAACCCA
GTGAGCGATCGCCCGGTTGATTTAACTAACTCAATTCTCAGAAGTGCGGCTAACTGTCACCTGGAATATCTACATAATAT
GGGTGTCGGTGCTTCCTTAACTATCTCGTTAATTAAGGACAATAAGCTTTGGGGATTAATTGCTTGTCATCACCTGTCAG
CCAAATATGTTTCCTATGAATTGCGGAAAGCCTGCGAATTTTTGGGACGGGTGATATTTGCGGAAATCTCCGCCAGAGAG
GAAACAGAAGATTACGATTATCGAATGAATCTGACCCATATTCAATCACTCTTGGTTGAATATATGTCCCAAGAAGATAA
CTTTGTTGATGGTTTAATTAAACATCAGCCGAGTCTTCTAGATTTAACCAGCGCTCAAGGTGCGGCTGTATGTTTTGGCG
ACCATTGTACATTAATTGGTGAGACTCCCAAAGCAGAAGATTTAGTTTTCTTAGTCCAGTGGTTGAAGAATAACGTCGAG
GAAGAAGTTTTCTACACGGATTCCTTACCGCAAGTTTATCCAGATGCGGAAAGATATAAAAATGTCGCCAGTGGTTTGTT
AGCGATTCCTATTTCCCAACGTAATTATGTTTTGTGGTTTCGACCGGAAGTAATTCAAACTGTAAACTGGGGTGGTGATC
CTAATCAACCCTTTGAAGTTAATAAGTTAGATGGGAATGTGCGCCTCTGTCCGCGCAAATCCTTTGAACTGTGGAAAGAA
ACAGTCCGCCTCACCTCTCTACCTTGGCGATATGTGGAAATTAGAGCCGCCTTAGAATTGCGGAAAGCAATTGTGAATAT
CGTTCTACGCCAAGCCGATGAACTGGCGCAGTTAGCGCACGATTTAGAACGTTCCAACGCCGAACTGAAAAAATTTGCTT
ATGTTGCATCCCATGACTTACAAGAACCGCTCAATCAAGTAGCGAATTACGTGCAGTTGTTGGAGATGCGCTATCAAGAT
CAACTAGATGCAGATGCCAACGAGTTTATCACCTTTGCCGTCGAGGGTGTGAGCTTGATGCAGACGTTAATCGATGACGT
TTTGGCGTATTCTAAAGTAGATACACAAGCGATCGCTTTTCAACTAACAGAAGTAGAAAAAGCATTAGACAAAGCTTTGG
GTAACTTGCGCCAACGCATCGCCGAAACAGGCGCAAACATTACTCACGACCCCTTACCAACCGTCATGGCTGGTAGTACC
CAACTCATGCAGCTATTCCAGAATTTGATAGCCAACGCCATTAAATTCCGCAGTGAGGAAGCGCCACAAATTCATATAGG
TGCAGAAAGACTAGAAGACGAATGGCTATTCTCAGTTAGAGATAACGGGATTGGGATTGACCCCCAATTTAGTGATCGCA
TTTTCGTAATTTTCCAACGCTTACACACACGGGACGAGTATCATGGTACAGGCATGGGTCTAGCAATCTGTAAGAAAATT
ATCGAATGTCACCGGGGACGAATCTGGGTAGAGTCACAACTTGGTGAAGGTGCTACCTTCTACTTTACGATACCAGTTGG
AGGTCGAGAGCGTGAGCGTAGAAACGGAAGAAAAACACAGAACAATCTTTTTAGTTGA

Upstream 100 bases:

>100_bases
AGTAATGCCTTCAATTAAGGAATGTAAATAATTAATTCCTGAGGTTAAAAAATATATCAACTCTAATTTTGATTATTCTA
GGGAATCAAAGAGGCTTTTT

Downstream 100 bases:

>100_bases
GGATAATAAAGCCGATATCCGCCTTATCCAAGAAGCCTTTAAAAATAGCCAATTGCCACACGAAGTGGTAACAGTTAGAG
ATGGTATGGACGCAATGGCC

Product: phytochrome A, two-component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MRIDVESQNINVTSLKEAPIHLSGQIQPHGVLLVLEEPGLKILQVSNNTWGILGINAENILQKKLEDLLDSFQIERIQSG
LSSGNLEFINPTKIWIRKKGDDYAVFDAVFHRNTEGFLILELEPAITQENIPFLSFYHLAKASINQLQKTANLRDFCQII
VQEVRKVTDFDRVMLYKFDDDGHGSVIAEEKLDSLEPYLGLHYPESDIPKPARKLFISNSIRVIPNAQAQAIQMIPALNP
VSDRPVDLTNSILRSAANCHLEYLHNMGVGASLTISLIKDNKLWGLIACHHLSAKYVSYELRKACEFLGRVIFAEISARE
ETEDYDYRMNLTHIQSLLVEYMSQEDNFVDGLIKHQPSLLDLTSAQGAAVCFGDHCTLIGETPKAEDLVFLVQWLKNNVE
EEVFYTDSLPQVYPDAERYKNVASGLLAIPISQRNYVLWFRPEVIQTVNWGGDPNQPFEVNKLDGNVRLCPRKSFELWKE
TVRLTSLPWRYVEIRAALELRKAIVNIVLRQADELAQLAHDLERSNAELKKFAYVASHDLQEPLNQVANYVQLLEMRYQD
QLDADANEFITFAVEGVSLMQTLIDDVLAYSKVDTQAIAFQLTEVEKALDKALGNLRQRIAETGANITHDPLPTVMAGST
QLMQLFQNLIANAIKFRSEEAPQIHIGAERLEDEWLFSVRDNGIGIDPQFSDRIFVIFQRLHTRDEYHGTGMGLAICKKI
IECHRGRIWVESQLGEGATFYFTIPVGGRERERRNGRKTQNNLFS

Sequences:

>Translated_765_residues
MRIDVESQNINVTSLKEAPIHLSGQIQPHGVLLVLEEPGLKILQVSNNTWGILGINAENILQKKLEDLLDSFQIERIQSG
LSSGNLEFINPTKIWIRKKGDDYAVFDAVFHRNTEGFLILELEPAITQENIPFLSFYHLAKASINQLQKTANLRDFCQII
VQEVRKVTDFDRVMLYKFDDDGHGSVIAEEKLDSLEPYLGLHYPESDIPKPARKLFISNSIRVIPNAQAQAIQMIPALNP
VSDRPVDLTNSILRSAANCHLEYLHNMGVGASLTISLIKDNKLWGLIACHHLSAKYVSYELRKACEFLGRVIFAEISARE
ETEDYDYRMNLTHIQSLLVEYMSQEDNFVDGLIKHQPSLLDLTSAQGAAVCFGDHCTLIGETPKAEDLVFLVQWLKNNVE
EEVFYTDSLPQVYPDAERYKNVASGLLAIPISQRNYVLWFRPEVIQTVNWGGDPNQPFEVNKLDGNVRLCPRKSFELWKE
TVRLTSLPWRYVEIRAALELRKAIVNIVLRQADELAQLAHDLERSNAELKKFAYVASHDLQEPLNQVANYVQLLEMRYQD
QLDADANEFITFAVEGVSLMQTLIDDVLAYSKVDTQAIAFQLTEVEKALDKALGNLRQRIAETGANITHDPLPTVMAGST
QLMQLFQNLIANAIKFRSEEAPQIHIGAERLEDEWLFSVRDNGIGIDPQFSDRIFVIFQRLHTRDEYHGTGMGLAICKKI
IECHRGRIWVESQLGEGATFYFTIPVGGRERERRNGRKTQNNLFS
>Mature_765_residues
MRIDVESQNINVTSLKEAPIHLSGQIQPHGVLLVLEEPGLKILQVSNNTWGILGINAENILQKKLEDLLDSFQIERIQSG
LSSGNLEFINPTKIWIRKKGDDYAVFDAVFHRNTEGFLILELEPAITQENIPFLSFYHLAKASINQLQKTANLRDFCQII
VQEVRKVTDFDRVMLYKFDDDGHGSVIAEEKLDSLEPYLGLHYPESDIPKPARKLFISNSIRVIPNAQAQAIQMIPALNP
VSDRPVDLTNSILRSAANCHLEYLHNMGVGASLTISLIKDNKLWGLIACHHLSAKYVSYELRKACEFLGRVIFAEISARE
ETEDYDYRMNLTHIQSLLVEYMSQEDNFVDGLIKHQPSLLDLTSAQGAAVCFGDHCTLIGETPKAEDLVFLVQWLKNNVE
EEVFYTDSLPQVYPDAERYKNVASGLLAIPISQRNYVLWFRPEVIQTVNWGGDPNQPFEVNKLDGNVRLCPRKSFELWKE
TVRLTSLPWRYVEIRAALELRKAIVNIVLRQADELAQLAHDLERSNAELKKFAYVASHDLQEPLNQVANYVQLLEMRYQD
QLDADANEFITFAVEGVSLMQTLIDDVLAYSKVDTQAIAFQLTEVEKALDKALGNLRQRIAETGANITHDPLPTVMAGST
QLMQLFQNLIANAIKFRSEEAPQIHIGAERLEDEWLFSVRDNGIGIDPQFSDRIFVIFQRLHTRDEYHGTGMGLAICKKI
IECHRGRIWVESQLGEGATFYFTIPVGGRERERRNGRKTQNNLFS

Specific function: Photoreceptor which exists in two forms that are reversibly interconvertible by light:the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region

COG id: COG4251

COG function: function code T; Bacteriophytochrome (light-regulated signal transduction histidine kinase)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI145693157, Length=256, Percent_Identity=26.953125, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI48994928, Length=240, Percent_Identity=30.4166666666667, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788393, Length=242, Percent_Identity=27.6859504132231, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786600, Length=264, Percent_Identity=28.030303030303, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789149, Length=266, Percent_Identity=27.4436090225564, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI87081816, Length=234, Percent_Identity=25.6410256410256, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788549, Length=224, Percent_Identity=25, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786912, Length=248, Percent_Identity=25.8064516129032, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=23.9316239316239, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=26.0089686098655, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1790436, Length=119, Percent_Identity=36.9747899159664, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PHYA_NOSS1 (Q9LCC2)

Other databases:

- EMBL:   AB028873
- EMBL:   BA000019
- PIR:   AF2200
- RefSeq:   NP_487197.1
- ProteinModelPortal:   Q9LCC2
- SMR:   Q9LCC2
- STRING:   Q9LCC2
- GeneID:   1106755
- GenomeReviews:   BA000019_GR
- KEGG:   ana:alr3157
- NMPDR:   fig|103690.1.peg.3464
- eggNOG:   COG4251
- HOGENOM:   HBG639461
- OMA:   PVHLQYM
- ProtClustDB:   CLSK893476
- BioCyc:   NSP103690:ALR3157-MONOMER
- BRENDA:   2.7.13.3
- GO:   GO:0016020
- GO:   GO:0006350
- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR013654
- InterPro:   IPR016132
- InterPro:   IPR001294
- InterPro:   IPR013515
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR01033
- SMART:   SM00065
- SMART:   SM00387
- SMART:   SM00388

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF00512 HisKA; PF08446 PAS_2; PF00360 Phytochrome; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 86931; Mature: 86931

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS50109 HIS_KIN; PS00245 PHYTOCHROME_1; PS50046 PHYTOCHROME_2

Important sites: BINDING 259-259

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIDVESQNINVTSLKEAPIHLSGQIQPHGVLLVLEEPGLKILQVSNNTWGILGINAENI
CEEECCCCCCCEEEECCCCEEEECEECCCEEEEEEECCCCEEEEECCCCEEEEEECHHHH
LQKKLEDLLDSFQIERIQSGLSSGNLEFINPTKIWIRKKGDDYAVFDAVFHRNTEGFLIL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEEECCCCEEHHHHHHHCCCCCEEEE
ELEPAITQENIPFLSFYHLAKASINQLQKTANLRDFCQIIVQEVRKVTDFDRVMLYKFDD
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECC
DGHGSVIAEEKLDSLEPYLGLHYPESDIPKPARKLFISNSIRVIPNAQAQAIQMIPALNP
CCCCCEEEHHHHHHCCCHHCCCCCCCCCCCHHHHHHHCCCEEEECCCHHHHHHHCCCCCC
VSDRPVDLTNSILRSAANCHLEYLHNMGVGASLTISLIKDNKLWGLIACHHLSAKYVSYE
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEEHHHHHHHHHHHH
LRKACEFLGRVIFAEISAREETEDYDYRMNLTHIQSLLVEYMSQEDNFVDGLIKHQPSLL
HHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHCCCCCHHHHHHHCCCCEE
DLTSAQGAAVCFGDHCTLIGETPKAEDLVFLVQWLKNNVEEEVFYTDSLPQVYPDAERYK
EECCCCCCEEEECCCEEEECCCCCHHHHHHHHHHHHCCCCHHEEEECCCCCCCCCHHHHH
NVASGLLAIPISQRNYVLWFRPEVIQTVNWGGDPNQPFEVNKLDGNVRLCPRKSFELWKE
HHHCCEEEEEECCCCEEEEECHHHHHEECCCCCCCCCEEEEECCCCEEECCCCHHHHHHH
TVRLTSLPWRYVEIRAALELRKAIVNIVLRQADELAQLAHDLERSNAELKKFAYVASHDL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
QEPLNQVANYVQLLEMRYQDQLDADANEFITFAVEGVSLMQTLIDDVLAYSKVDTQAIAF
HHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHH
QLTEVEKALDKALGNLRQRIAETGANITHDPLPTVMAGSTQLMQLFQNLIANAIKFRSEE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCC
APQIHIGAERLEDEWLFSVRDNGIGIDPQFSDRIFVIFQRLHTRDEYHGTGMGLAICKKI
CCEEEECHHHHCCHHEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
IECHRGRIWVESQLGEGATFYFTIPVGGRERERRNGRKTQNNLFS
HHHHCCCEEEEECCCCCEEEEEEECCCCCHHHHHCCCCCHHCCCC
>Mature Secondary Structure
MRIDVESQNINVTSLKEAPIHLSGQIQPHGVLLVLEEPGLKILQVSNNTWGILGINAENI
CEEECCCCCCCEEEECCCCEEEECEECCCEEEEEEECCCCEEEEECCCCEEEEEECHHHH
LQKKLEDLLDSFQIERIQSGLSSGNLEFINPTKIWIRKKGDDYAVFDAVFHRNTEGFLIL
HHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEEECCCCEEHHHHHHHCCCCCEEEE
ELEPAITQENIPFLSFYHLAKASINQLQKTANLRDFCQIIVQEVRKVTDFDRVMLYKFDD
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECC
DGHGSVIAEEKLDSLEPYLGLHYPESDIPKPARKLFISNSIRVIPNAQAQAIQMIPALNP
CCCCCEEEHHHHHHCCCHHCCCCCCCCCCCHHHHHHHCCCEEEECCCHHHHHHHCCCCCC
VSDRPVDLTNSILRSAANCHLEYLHNMGVGASLTISLIKDNKLWGLIACHHLSAKYVSYE
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEEHHHHHHHHHHHH
LRKACEFLGRVIFAEISAREETEDYDYRMNLTHIQSLLVEYMSQEDNFVDGLIKHQPSLL
HHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHCCCCCHHHHHHHCCCCEE
DLTSAQGAAVCFGDHCTLIGETPKAEDLVFLVQWLKNNVEEEVFYTDSLPQVYPDAERYK
EECCCCCCEEEECCCEEEECCCCCHHHHHHHHHHHHCCCCHHEEEECCCCCCCCCHHHHH
NVASGLLAIPISQRNYVLWFRPEVIQTVNWGGDPNQPFEVNKLDGNVRLCPRKSFELWKE
HHHCCEEEEEECCCCEEEEECHHHHHEECCCCCCCCCEEEEECCCCEEECCCCHHHHHHH
TVRLTSLPWRYVEIRAALELRKAIVNIVLRQADELAQLAHDLERSNAELKKFAYVASHDL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
QEPLNQVANYVQLLEMRYQDQLDADANEFITFAVEGVSLMQTLIDDVLAYSKVDTQAIAF
HHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHH
QLTEVEKALDKALGNLRQRIAETGANITHDPLPTVMAGSTQLMQLFQNLIANAIKFRSEE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCC
APQIHIGAERLEDEWLFSVRDNGIGIDPQFSDRIFVIFQRLHTRDEYHGTGMGLAICKKI
CCEEEECHHHHCCHHEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHH
IECHRGRIWVESQLGEGATFYFTIPVGGRERERRNGRKTQNNLFS
HHHHCCCEEEEECCCCCEEEEEEECCCCCHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840