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The map label for this gene is hisD [H]

Identifier: 17230548

GI number: 17230548

Start: 3701406

End: 3702701

Strand: Direct

Name: hisD [H]

Synonym: alr3056

Alternate gene names: 17230548

Gene position: 3701406-3702701 (Clockwise)

Preceding gene: 17230547

Following gene: 17230549

Centisome position: 57.71

GC content: 46.91

Gene sequence:

>1296_bases
ATGCTAGTCTTGAAAACAACCGACAAAGAATTTTCTCCCAGATTCCAAAGCTTGGTGAGCGATCGCCGAGAAGCAACGGT
TGATGTTAGTGGTACAGTACGCGATATACTCGCTCATGTAAAAGCGCGTGGTGATGCCGCAGTCCAGGAATATACCAGTC
GTTTTGATCACTATAGACCCCATTCTCATCATTTAAGTGCGGCTTTCATTGCCGAACAAGCAGCGAAATGTTCAGATGAG
GTAAAAGCAGCCTTAGAACTAGCGGCTGAACGTATTAGTTCTTTTCATCAAAAACAATTACCCCAAGATATTGGTTACAC
CGATACCGCAGGCGTAAAACTGGGCTTAAATTGGGTAGCTTTATCGCAAGTGGGAATTTATGTCCCTGGCGGACGCGCCA
GTTACCCCAGTTCGGTCTTGATGAATGCCCTACCCGCCAAAATTGCAGGTGTAGAACGCATCGTTATGACTGTGCCTATG
CCTCATGGGGAAATCAATCCCGCCGTTCTGGCTGCTGCCCAAGTCGCCGGCGTAACAGAAATATATAGTATAGGTGGAGC
GCAAGCAGTCGGGGCGTTAGCCTACGGTACAGAAACTATCACCCCCGTAGATAAAATTGTCGGGCCTGGTAATGCCTACG
TTGCTGAAGCCAAACGCCAAGTATTTGGGACTGTGGGTATTGACAGCATCGCCGGGCCTTCGGAAATTTTAGTTGTCGCC
GATCGCCAAAACAATCCAGAATGGATCGCCTGGGATTTATTATCCCAAGCTGAACACGATCCCAGCGCTCAATCAATTTT
AATTACTGACTCTGAATCCTTTGCCCAACAAGTGATTGCGGCGGTAGAGCAAATCCTCACTACCTTACCCAGTCAAAAAG
TAGCCAGTAGTAGTTGGCAAAATCATGGGGCAGTGATTATTGTTAGGGATTTAGCCGAAAGTATCCCTTTACTCAATCAA
CTAGCTCCAGAACACGTAGAACTGTGTGTAGATAACCCTCAATTGCTAGCTAGTCAAATTAAGTGTGCTGGTAGTTTATT
TTTAGGTCGTTATACTCCAGAGGCGATCGGTGATTATTTAGGTGGCCCCAATCACGTATTACCTACTTCCCGTTCTGCCC
GCTTTGCTTCCGGCTTAAGTGTCTACGATTTTCTCAAGCGCATTACCTATTTAGAATGCAATCAAGCGGCATTGCAGAAA
ATAGGCCAGTCCGCCGTCACTCTTGCAGAAACTGAGGGTTTACCAGCTCATGCAGGTAGTGTAGCGGTGCGTTTGCAAGG
GCTGAAAGATATGTAG

Upstream 100 bases:

>100_bases
ATCAGATTGAGTCAGCCTTTGACTTCCACTCAGGGTTAATATCGCTCTACACTAAATATTGTCCTTACTGCAAACCGGCA
TTAGCCCAGAGATACTGTCC

Downstream 100 bases:

>100_bases
GGGTGTTGGGGTATAGGGGTTTAGGGGTATAGGGGTTCAAATATATTTAAAGAATGAAATGTACTAATCCCCAATCCCCA
GTCCCCAATCCCCAATCCCC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 1 [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLVLKTTDKEFSPRFQSLVSDRREATVDVSGTVRDILAHVKARGDAAVQEYTSRFDHYRPHSHHLSAAFIAEQAAKCSDE
VKAALELAAERISSFHQKQLPQDIGYTDTAGVKLGLNWVALSQVGIYVPGGRASYPSSVLMNALPAKIAGVERIVMTVPM
PHGEINPAVLAAAQVAGVTEIYSIGGAQAVGALAYGTETITPVDKIVGPGNAYVAEAKRQVFGTVGIDSIAGPSEILVVA
DRQNNPEWIAWDLLSQAEHDPSAQSILITDSESFAQQVIAAVEQILTTLPSQKVASSSWQNHGAVIIVRDLAESIPLLNQ
LAPEHVELCVDNPQLLASQIKCAGSLFLGRYTPEAIGDYLGGPNHVLPTSRSARFASGLSVYDFLKRITYLECNQAALQK
IGQSAVTLAETEGLPAHAGSVAVRLQGLKDM

Sequences:

>Translated_431_residues
MLVLKTTDKEFSPRFQSLVSDRREATVDVSGTVRDILAHVKARGDAAVQEYTSRFDHYRPHSHHLSAAFIAEQAAKCSDE
VKAALELAAERISSFHQKQLPQDIGYTDTAGVKLGLNWVALSQVGIYVPGGRASYPSSVLMNALPAKIAGVERIVMTVPM
PHGEINPAVLAAAQVAGVTEIYSIGGAQAVGALAYGTETITPVDKIVGPGNAYVAEAKRQVFGTVGIDSIAGPSEILVVA
DRQNNPEWIAWDLLSQAEHDPSAQSILITDSESFAQQVIAAVEQILTTLPSQKVASSSWQNHGAVIIVRDLAESIPLLNQ
LAPEHVELCVDNPQLLASQIKCAGSLFLGRYTPEAIGDYLGGPNHVLPTSRSARFASGLSVYDFLKRITYLECNQAALQK
IGQSAVTLAETEGLPAHAGSVAVRLQGLKDM
>Mature_431_residues
MLVLKTTDKEFSPRFQSLVSDRREATVDVSGTVRDILAHVKARGDAAVQEYTSRFDHYRPHSHHLSAAFIAEQAAKCSDE
VKAALELAAERISSFHQKQLPQDIGYTDTAGVKLGLNWVALSQVGIYVPGGRASYPSSVLMNALPAKIAGVERIVMTVPM
PHGEINPAVLAAAQVAGVTEIYSIGGAQAVGALAYGTETITPVDKIVGPGNAYVAEAKRQVFGTVGIDSIAGPSEILVVA
DRQNNPEWIAWDLLSQAEHDPSAQSILITDSESFAQQVIAAVEQILTTLPSQKVASSSWQNHGAVIIVRDLAESIPLLNQ
LAPEHVELCVDNPQLLASQIKCAGSLFLGRYTPEAIGDYLGGPNHVLPTSRSARFASGLSVYDFLKRITYLECNQAALQK
IGQSAVTLAETEGLPAHAGSVAVRLQGLKDM

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=409, Percent_Identity=42.0537897310513, Blast_Score=309, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6319819, Length=414, Percent_Identity=37.43961352657, Blast_Score=254, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46005; Mature: 46005

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLKTTDKEFSPRFQSLVSDRREATVDVSGTVRDILAHVKARGDAAVQEYTSRFDHYRP
CEEEECCCCCCCHHHHHHHHHHHHCEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
HSHHLSAAFIAEQAAKCSDEVKAALELAAERISSFHQKQLPQDIGYTDTAGVKLGLNWVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCEEECCCEEE
LSQVGIYVPGGRASYPSSVLMNALPAKIAGVERIVMTVPMPHGEINPAVLAAAQVAGVTE
EECCEEEECCCCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHHHHH
IYSIGGAQAVGALAYGTETITPVDKIVGPGNAYVAEAKRQVFGTVGIDSIAGPSEILVVA
HHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
DRQNNPEWIAWDLLSQAEHDPSAQSILITDSESFAQQVIAAVEQILTTLPSQKVASSSWQ
ECCCCCCEEHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHCCCC
NHGAVIIVRDLAESIPLLNQLAPEHVELCVDNPQLLASQIKCAGSLFLGRYTPEAIGDYL
CCCCEEEEHHHHHHCCHHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHC
GGPNHVLPTSRSARFASGLSVYDFLKRITYLECNQAALQKIGQSAVTLAETEGLPAHAGS
CCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCHHHHHHHCHHHEEEHHCCCCCCCCCC
VAVRLQGLKDM
EEEEECCCCCC
>Mature Secondary Structure
MLVLKTTDKEFSPRFQSLVSDRREATVDVSGTVRDILAHVKARGDAAVQEYTSRFDHYRP
CEEEECCCCCCCHHHHHHHHHHHHCEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
HSHHLSAAFIAEQAAKCSDEVKAALELAAERISSFHQKQLPQDIGYTDTAGVKLGLNWVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCEEECCCEEE
LSQVGIYVPGGRASYPSSVLMNALPAKIAGVERIVMTVPMPHGEINPAVLAAAQVAGVTE
EECCEEEECCCCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHHHHH
IYSIGGAQAVGALAYGTETITPVDKIVGPGNAYVAEAKRQVFGTVGIDSIAGPSEILVVA
HHHCCCHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEE
DRQNNPEWIAWDLLSQAEHDPSAQSILITDSESFAQQVIAAVEQILTTLPSQKVASSSWQ
ECCCCCCEEHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHCCCC
NHGAVIIVRDLAESIPLLNQLAPEHVELCVDNPQLLASQIKCAGSLFLGRYTPEAIGDYL
CCCCEEEEHHHHHHCCHHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHC
GGPNHVLPTSRSARFASGLSVYDFLKRITYLECNQAALQKIGQSAVTLAETEGLPAHAGS
CCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCHHHHHHHCHHHEEEHHCCCCCCCCCC
VAVRLQGLKDM
EEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA