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The map label for this gene is mutL [H]

Identifier: 17230547

GI number: 17230547

Start: 3699535

End: 3701226

Strand: Direct

Name: mutL [H]

Synonym: alr3055

Alternate gene names: 17230547

Gene position: 3699535-3701226 (Clockwise)

Preceding gene: 17230545

Following gene: 17230548

Centisome position: 57.68

GC content: 47.1

Gene sequence:

>1692_bases
ATGGCATCTACTATTCAAGCTTTACCTCAAGAAGTCGTGTACCTCATTACAGCAGGGGAGGTAATCGACTCATTTGCTGC
TGTGGTGCGGGAATTGGTAGAAAATTCCTTGGATGCAGGTGCAAACAGAATTGTAGTTTATTTATGGCCGCAGCAATGGC
GGGTTCGTGTGGCAGATAATGGTTGCGGCATGAACTTAGATGATTTGCAACAAGCCGCCTCAGCCCACAGCACCAGTAAA
ATTCGTTCTAGTGCAGATTTGTGGAAAATTCATAGTCTGGGATTTCGGGGTGAAGCACTACATAGTTTAACGACACTAGC
AGATGTAGAAATTATCAGTCGCGCCCCCGAAAATGTGGGGTGGCGAGTAGTTTATGGTGATAGTGGGAAAGCAGTTCACG
TTGAAGCGACAGCGATCGCTCCTGGTACAGTAGTCACAGTCTCGAATTTATTCGCCAGTTGTGCGGCTCGTCGTCAAGGC
TTACCCACAACAGCACAGCAAATGAAAGCTGTGCAAGCCACAATTCAACAAATCGCTCTTTGTCATCCCCAAACCACCTG
GCAAGTTTGGCAAAATGACCGGATTTGGTTCACCATCTCCCCCGCCGCCACAGCCGGACAACTCATACCCCAATTCCTCC
CCCAACTACGCCCAAGTGACTTACAAGAAATCAAGTTAGAGATACCCAACCCAGAAAACCCACAACTCAGCACCAACAAC
AAGCCAAACGCCTCAGCACTTGCCCTAGTTGTAGGATTACCAGACCGTTGTCACCGCCATCGTCCAGATTGGGTGCGGGT
AGCAATTAACGGACGGATGATTAAGTTGCCAGAATTAGAACAAACAATTTTGGCAGCATTCCACAGAACATTACCACGCG
ATCGCTACCCTCTTTGTTTTGTTCATCTTCTGATTTCCCCCGACCAAATCAACTGGAACCGCAACCCCGCAAAAACAGAA
ATTTACCTCCACGATTTGAGTTATTGGCAAGAACAAGTGACTCAAGCCATTAACCAAGCACTACGGATTAGTGCTGCCAA
TATTCCAGAGTCTGTCCAGACAACGCGAGTTAGTCAACTACTCAAAGCCGCCGAAGAGAAAGGGAATTATAACTTTAATC
CTCGAAACGCAAATCCAGCAGACAACACTCAGAACTACCTAAAAGCAGTAGCCCAAGTCAGTAACACTTATATAGTCGCA
GAACATCCTGGGGGAATGTGGCTAGTAGAACAGCACATCGCCCATGAGCGAGTTTTATACGAACAATTGTGTGATAATTG
GCGACTCATTCCCGTTGAACCACCAATTATTCTTTATCAACTATCCCCAGCCCAAGTTGCCCAATTGCAACGCATCGGTT
TAGATATTGACATCTTTGGCGAACAACTTTGGGCAGTCCGTAACTTGCCGGCAATGTTACAACAACGTGAAGACTGTGCC
GAAGCCATTTTAGAACTCAGTTGGGGAGGGGATTTACAAACAGCCCAAGTAGCCGTAGCCTGTCGCAGTGCTATTCGCAA
CGGTACTCCCATGAGTCTGCCAGAAATGCAGAAATTACTAGACGATTGGCAACGTACTCGCAACCCCCGCACCTGTCCCC
ACGGTCGGCCGATTTATTTGTCATTAGATGAATCTTCCTTATCTCGGTTTTTCCGTCGTCATTGGGTGATTGGTAAAAGT
CACGGTATATAA

Upstream 100 bases:

>100_bases
AAAGGGGCAGCTTTGCTGGGAGACGGCGAGAAAGTTTCCCCCTGCTCCCTGCCCCCTGCCTCTTGTTGAATGCTGTACCA
AAAGTTATAAACTATAGTTT

Downstream 100 bases:

>100_bases
ATCAATTCAAAATAAGTCAACAGTCAACAGTCAACAGCCAACAGTCAACAGTCAACAGTCAACAGTCAACATTAAAATCA
TCAGATTGAGTCAGCCTTTG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MASTIQALPQEVVYLITAGEVIDSFAAVVRELVENSLDAGANRIVVYLWPQQWRVRVADNGCGMNLDDLQQAASAHSTSK
IRSSADLWKIHSLGFRGEALHSLTTLADVEIISRAPENVGWRVVYGDSGKAVHVEATAIAPGTVVTVSNLFASCAARRQG
LPTTAQQMKAVQATIQQIALCHPQTTWQVWQNDRIWFTISPAATAGQLIPQFLPQLRPSDLQEIKLEIPNPENPQLSTNN
KPNASALALVVGLPDRCHRHRPDWVRVAINGRMIKLPELEQTILAAFHRTLPRDRYPLCFVHLLISPDQINWNRNPAKTE
IYLHDLSYWQEQVTQAINQALRISAANIPESVQTTRVSQLLKAAEEKGNYNFNPRNANPADNTQNYLKAVAQVSNTYIVA
EHPGGMWLVEQHIAHERVLYEQLCDNWRLIPVEPPIILYQLSPAQVAQLQRIGLDIDIFGEQLWAVRNLPAMLQQREDCA
EAILELSWGGDLQTAQVAVACRSAIRNGTPMSLPEMQKLLDDWQRTRNPRTCPHGRPIYLSLDESSLSRFFRRHWVIGKS
HGI

Sequences:

>Translated_563_residues
MASTIQALPQEVVYLITAGEVIDSFAAVVRELVENSLDAGANRIVVYLWPQQWRVRVADNGCGMNLDDLQQAASAHSTSK
IRSSADLWKIHSLGFRGEALHSLTTLADVEIISRAPENVGWRVVYGDSGKAVHVEATAIAPGTVVTVSNLFASCAARRQG
LPTTAQQMKAVQATIQQIALCHPQTTWQVWQNDRIWFTISPAATAGQLIPQFLPQLRPSDLQEIKLEIPNPENPQLSTNN
KPNASALALVVGLPDRCHRHRPDWVRVAINGRMIKLPELEQTILAAFHRTLPRDRYPLCFVHLLISPDQINWNRNPAKTE
IYLHDLSYWQEQVTQAINQALRISAANIPESVQTTRVSQLLKAAEEKGNYNFNPRNANPADNTQNYLKAVAQVSNTYIVA
EHPGGMWLVEQHIAHERVLYEQLCDNWRLIPVEPPIILYQLSPAQVAQLQRIGLDIDIFGEQLWAVRNLPAMLQQREDCA
EAILELSWGGDLQTAQVAVACRSAIRNGTPMSLPEMQKLLDDWQRTRNPRTCPHGRPIYLSLDESSLSRFFRRHWVIGKS
HGI
>Mature_562_residues
ASTIQALPQEVVYLITAGEVIDSFAAVVRELVENSLDAGANRIVVYLWPQQWRVRVADNGCGMNLDDLQQAASAHSTSKI
RSSADLWKIHSLGFRGEALHSLTTLADVEIISRAPENVGWRVVYGDSGKAVHVEATAIAPGTVVTVSNLFASCAARRQGL
PTTAQQMKAVQATIQQIALCHPQTTWQVWQNDRIWFTISPAATAGQLIPQFLPQLRPSDLQEIKLEIPNPENPQLSTNNK
PNASALALVVGLPDRCHRHRPDWVRVAINGRMIKLPELEQTILAAFHRTLPRDRYPLCFVHLLISPDQINWNRNPAKTEI
YLHDLSYWQEQVTQAINQALRISAANIPESVQTTRVSQLLKAAEEKGNYNFNPRNANPADNTQNYLKAVAQVSNTYIVAE
HPGGMWLVEQHIAHERVLYEQLCDNWRLIPVEPPIILYQLSPAQVAQLQRIGLDIDIFGEQLWAVRNLPAMLQQREDCAE
AILELSWGGDLQTAQVAVACRSAIRNGTPMSLPEMQKLLDDWQRTRNPRTCPHGRPIYLSLDESSLSRFFRRHWVIGKSH
GI

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=349, Percent_Identity=27.2206303724928, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI4505913, Length=160, Percent_Identity=38.125, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI310128478, Length=160, Percent_Identity=38.125, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI4505911, Length=203, Percent_Identity=32.512315270936, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI189458896, Length=199, Percent_Identity=32.6633165829146, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI189458898, Length=203, Percent_Identity=32.512315270936, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI91992160, Length=193, Percent_Identity=34.1968911917098, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI91992162, Length=193, Percent_Identity=34.1968911917098, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI310128480, Length=106, Percent_Identity=37.7358490566038, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790612, Length=354, Percent_Identity=31.0734463276836, Blast_Score=136, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=29.5031055900621, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17562796, Length=411, Percent_Identity=23.3576642335766, Blast_Score=112, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6323819, Length=372, Percent_Identity=23.1182795698925, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6324247, Length=340, Percent_Identity=26.4705882352941, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325093, Length=213, Percent_Identity=27.6995305164319, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17136968, Length=341, Percent_Identity=26.3929618768328, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17136970, Length=359, Percent_Identity=26.7409470752089, Blast_Score=109, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 63156; Mature: 63025

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTIQALPQEVVYLITAGEVIDSFAAVVRELVENSLDAGANRIVVYLWPQQWRVRVADN
CCCHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECC
GCGMNLDDLQQAASAHSTSKIRSSADLWKIHSLGFRGEALHSLTTLADVEIISRAPENVG
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
WRVVYGDSGKAVHVEATAIAPGTVVTVSNLFASCAARRQGLPTTAQQMKAVQATIQQIAL
EEEEECCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
CHPQTTWQVWQNDRIWFTISPAATAGQLIPQFLPQLRPSDLQEIKLEIPNPENPQLSTNN
CCCCCCCEEECCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHEEEECCCCCCCCCCCCC
KPNASALALVVGLPDRCHRHRPDWVRVAINGRMIKLPELEQTILAAFHRTLPRDRYPLCF
CCCCCEEEEEECCCHHHHCCCCCEEEEEECCEEEECCCHHHHHHHHHHHHCCCCCCCEEE
VHLLISPDQINWNRNPAKTEIYLHDLSYWQEQVTQAINQALRISAANIPESVQTTRVSQL
EEEEECCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LKAAEEKGNYNFNPRNANPADNTQNYLKAVAQVSNTYIVAEHPGGMWLVEQHIAHERVLY
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCEEHHHHHHHHHHHHH
EQLCDNWRLIPVEPPIILYQLSPAQVAQLQRIGLDIDIFGEQLWAVRNLPAMLQQREDCA
HHHHCCCEEEECCCCEEEEECCHHHHHHHHHHCCCCEEHHHHHHHHHCCHHHHHHHHHHH
EAILELSWGGDLQTAQVAVACRSAIRNGTPMSLPEMQKLLDDWQRTRNPRTCPHGRPIYL
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEE
SLDESSLSRFFRRHWVIGKSHGI
EECHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ASTIQALPQEVVYLITAGEVIDSFAAVVRELVENSLDAGANRIVVYLWPQQWRVRVADN
CCHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECC
GCGMNLDDLQQAASAHSTSKIRSSADLWKIHSLGFRGEALHSLTTLADVEIISRAPENVG
CCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
WRVVYGDSGKAVHVEATAIAPGTVVTVSNLFASCAARRQGLPTTAQQMKAVQATIQQIAL
EEEEECCCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
CHPQTTWQVWQNDRIWFTISPAATAGQLIPQFLPQLRPSDLQEIKLEIPNPENPQLSTNN
CCCCCCCEEECCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHEEEECCCCCCCCCCCCC
KPNASALALVVGLPDRCHRHRPDWVRVAINGRMIKLPELEQTILAAFHRTLPRDRYPLCF
CCCCCEEEEEECCCHHHHCCCCCEEEEEECCEEEECCCHHHHHHHHHHHHCCCCCCCEEE
VHLLISPDQINWNRNPAKTEIYLHDLSYWQEQVTQAINQALRISAANIPESVQTTRVSQL
EEEEECCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LKAAEEKGNYNFNPRNANPADNTQNYLKAVAQVSNTYIVAEHPGGMWLVEQHIAHERVLY
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCEEHHHHHHHHHHHHH
EQLCDNWRLIPVEPPIILYQLSPAQVAQLQRIGLDIDIFGEQLWAVRNLPAMLQQREDCA
HHHHCCCEEEECCCCEEEEECCHHHHHHHHHHCCCCEEHHHHHHHHHCCHHHHHHHHHHH
EAILELSWGGDLQTAQVAVACRSAIRNGTPMSLPEMQKLLDDWQRTRNPRTCPHGRPIYL
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEE
SLDESSLSRFFRRHWVIGKSHGI
EECHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA