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The map label for this gene is pyrFE [H]

Identifier: 17230437

GI number: 17230437

Start: 3582106

End: 3583608

Strand: Direct

Name: pyrFE [H]

Synonym: alr2945

Alternate gene names: 17230437

Gene position: 3582106-3583608 (Clockwise)

Preceding gene: 17230436

Following gene: 17230438

Centisome position: 55.85

GC content: 37.59

Gene sequence:

>1503_bases
ATGGTTTTGGTGGGCAATGCCCACCCTACAGATACTGAGAATTTTATACCTAATTACCTAACAAATAAAATGATTTTTTT
CGATAAACTACATCAAAATATATCGCAAAATCAGAGTTTACTTTTTGTTGGACTTGACCCAAACCCTGAAATGATGCCCG
GACGCTATAGCTCTCAGGATATCATAGATGGATTGTGGGATTGGTTGCAATTTATTATTGCTGAAACTGCTGATTTTGTT
TGTGCATATAAGCCAACATTAGGTTTTTATGAAGCCTTGGGTGTTCCTGGTTTAGAACTGTTACAAAAAACTTTAGCTGC
TATTCCTAGCCATATTCCCATCATTTTAGATGCTAAACATAGCGATTTAAATACAAGTACTATTTTTGCCAAGACTGTAT
TCACACAATGGGGGGTAGATGCAATTACTCTCAGCCCATATACAGGACAAGATCATGTGGCTCCATTTTTAGTTTATCCT
GATAAAGCTGTGTTTATTCTATGTTCTACATCTAACCCTGGTGCAGAGGCTTTACAGCAATATCCAACAAGAGAATCACC
CCTTTATTTACAAGTTGTACAAGAGTCCAAAAATTGGGGTACTCCAGAACAATTAGGTCTAGAAGTTGGCACTACAAATG
CTGAAGTTTTGGCAAGAATTCGCCAAGTTGCGCCGGAAAGAATGATTATGGTACGCAGTATTTGGGCTGAAGGAGGCAAT
TTAAACCGCATTTTAGAAGTTGGTTTAAATACTGATGGTAATGGTTTGTTAATTCCTGTTCCCCAAGATATGTTAGCAAG
TGCAAATTTATCTAAGGAAATTCAATCTCTACGTGCAGAAATTAATCAGGTGAGGGATATAACTGTTCGTGATGTTGCTA
GCTGTTCTGTATGGCTACCTGATGTTTTTACTGTTAAGCAACACCCTCTACATGATTTAATTTTGCAGCTATACGATATT
GATTGCATTATGTTTGGTAATTTTGTCCAAGCATCCGGTGCGGTGTTTCCTTACTATATAGACTTACGTAAAATTATTTC
TAATCCTCAGGTATTTAATCAAGTACTTAGTGGCTATGAAAATATTGTTAAAAATCTCACTTTCGATAGGTTGGCAGGTA
TTCCTTATGGTTCTTTACCAACAGCAACTGGTTTAGCTTTGCGTCTCAATTGTCCGATGATTTTTCCGCGTAAAGAAGTG
AAAGCCCACGGAACTCGGAGGTTAATAGAAGGTAATTTTCGTACTGGTGAAGTAGTGGTAGTAGTTGATGATATTCTCAT
CAGTGGTAAGAGTGTGATGGAAGGGGCAGATAAGTTAAAATCAGCAGGGTTAAACGTTCATGATATTGTAGTATTTATTG
ACCACGAGCAAGGTGTGAAAGATAAGTTACAAGCAAATGGGTATCGGGGTCATGCAGTTTTAACTATTTCGGAAATTACT
AGTGTTTTACACCAAGCAGGGCGGATAAATGATGAGCAGTTTTTGGCTCTAACTGCTGAATAA

Upstream 100 bases:

>100_bases
TTGGGAAGACAAGGGTTATGAATGGTTTGCAGGAATTTAAATTTTATATCGGACTCATACTTGATTTTTGAAATTTAGGT
AGGGCAATGCTTACCTTATC

Downstream 100 bases:

>100_bases
ATCTGAATTTGTCAGTTGTTAGTAGTCAGTAGTCAGTGGTCAATAATTTTTAATGCTGCTTCTGTAAGAATAAGGATTTA
AAGTAAGTAGAAAAACAACT

Product: bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein

Products: NA

Alternate protein names: Orotidine 5'-phosphate decarboxylase; OMP decarboxylase; OMPDCase; OMPdecase; Orotate phosphoribosyltransferase; OPRT; OPRTase [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MVLVGNAHPTDTENFIPNYLTNKMIFFDKLHQNISQNQSLLFVGLDPNPEMMPGRYSSQDIIDGLWDWLQFIIAETADFV
CAYKPTLGFYEALGVPGLELLQKTLAAIPSHIPIILDAKHSDLNTSTIFAKTVFTQWGVDAITLSPYTGQDHVAPFLVYP
DKAVFILCSTSNPGAEALQQYPTRESPLYLQVVQESKNWGTPEQLGLEVGTTNAEVLARIRQVAPERMIMVRSIWAEGGN
LNRILEVGLNTDGNGLLIPVPQDMLASANLSKEIQSLRAEINQVRDITVRDVASCSVWLPDVFTVKQHPLHDLILQLYDI
DCIMFGNFVQASGAVFPYYIDLRKIISNPQVFNQVLSGYENIVKNLTFDRLAGIPYGSLPTATGLALRLNCPMIFPRKEV
KAHGTRRLIEGNFRTGEVVVVVDDILISGKSVMEGADKLKSAGLNVHDIVVFIDHEQGVKDKLQANGYRGHAVLTISEIT
SVLHQAGRINDEQFLALTAE

Sequences:

>Translated_500_residues
MVLVGNAHPTDTENFIPNYLTNKMIFFDKLHQNISQNQSLLFVGLDPNPEMMPGRYSSQDIIDGLWDWLQFIIAETADFV
CAYKPTLGFYEALGVPGLELLQKTLAAIPSHIPIILDAKHSDLNTSTIFAKTVFTQWGVDAITLSPYTGQDHVAPFLVYP
DKAVFILCSTSNPGAEALQQYPTRESPLYLQVVQESKNWGTPEQLGLEVGTTNAEVLARIRQVAPERMIMVRSIWAEGGN
LNRILEVGLNTDGNGLLIPVPQDMLASANLSKEIQSLRAEINQVRDITVRDVASCSVWLPDVFTVKQHPLHDLILQLYDI
DCIMFGNFVQASGAVFPYYIDLRKIISNPQVFNQVLSGYENIVKNLTFDRLAGIPYGSLPTATGLALRLNCPMIFPRKEV
KAHGTRRLIEGNFRTGEVVVVVDDILISGKSVMEGADKLKSAGLNVHDIVVFIDHEQGVKDKLQANGYRGHAVLTISEIT
SVLHQAGRINDEQFLALTAE
>Mature_500_residues
MVLVGNAHPTDTENFIPNYLTNKMIFFDKLHQNISQNQSLLFVGLDPNPEMMPGRYSSQDIIDGLWDWLQFIIAETADFV
CAYKPTLGFYEALGVPGLELLQKTLAAIPSHIPIILDAKHSDLNTSTIFAKTVFTQWGVDAITLSPYTGQDHVAPFLVYP
DKAVFILCSTSNPGAEALQQYPTRESPLYLQVVQESKNWGTPEQLGLEVGTTNAEVLARIRQVAPERMIMVRSIWAEGGN
LNRILEVGLNTDGNGLLIPVPQDMLASANLSKEIQSLRAEINQVRDITVRDVASCSVWLPDVFTVKQHPLHDLILQLYDI
DCIMFGNFVQASGAVFPYYIDLRKIISNPQVFNQVLSGYENIVKNLTFDRLAGIPYGSLPTATGLALRLNCPMIFPRKEV
KAHGTRRLIEGNFRTGEVVVVVDDILISGKSVMEGADKLKSAGLNVHDIVVFIDHEQGVKDKLQANGYRGHAVLTISEIT
SVLHQAGRINDEQFLALTAE

Specific function: Catalyzes the decarboxylation of orotidine monophosphate (OMP) to uridine monophosphate (UMP) [H]

COG id: COG0284

COG function: function code F; Orotidine-5'-phosphate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=192, Percent_Identity=40.625, Blast_Score=156, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17508631, Length=184, Percent_Identity=36.9565217391304, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17554964, Length=187, Percent_Identity=30.4812834224599, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17933654, Length=183, Percent_Identity=36.6120218579235, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011995
- InterPro:   IPR001754
- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase; PF00156 Pribosyltran [H]

EC number: =4.1.1.23; =2.4.2.10 [H]

Molecular weight: Translated: 55397; Mature: 55397

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLVGNAHPTDTENFIPNYLTNKMIFFDKLHQNISQNQSLLFVGLDPNPEMMPGRYSSQD
CEEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHH
IIDGLWDWLQFIIAETADFVCAYKPTLGFYEALGVPGLELLQKTLAAIPSHIPIILDAKH
HHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCC
SDLNTSTIFAKTVFTQWGVDAITLSPYTGQDHVAPFLVYPDKAVFILCSTSNPGAEALQQ
CCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCEEEEEEECCCCCHHHHHH
YPTRESPLYLQVVQESKNWGTPEQLGLEVGTTNAEVLARIRQVAPERMIMVRSIWAEGGN
CCCCCCCEEEEEEECCCCCCCHHHHCEEECCCCHHHHHHHHHHCHHHHHHHHHHHHCCCC
LNRILEVGLNTDGNGLLIPVPQDMLASANLSKEIQSLRAEINQVRDITVRDVASCSVWLP
CCEEEEECCCCCCCEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHCCCEEECC
DVFTVKQHPLHDLILQLYDIDCIMFGNFVQASGAVFPYYIDLRKIISNPQVFNQVLSGYE
CEEECCCCCHHHHHHHHHCCCEEEECCCHHHCCCEEEHHHHHHHHHCCHHHHHHHHHHHH
NIVKNLTFDRLAGIPYGSLPTATGLALRLNCPMIFPRKEVKAHGTRRLIEGNFRTGEVVV
HHHHCCCHHHHCCCCCCCCCCCCCEEEEECCCEECCCHHHHHCCCHHEEECCCCCCEEEE
VVDDILISGKSVMEGADKLKSAGLNVHDIVVFIDHEQGVKDKLQANGYRGHAVLTISEIT
EEECCHHCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHCCCCCCEEEEEHHHHH
SVLHQAGRINDEQFLALTAE
HHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MVLVGNAHPTDTENFIPNYLTNKMIFFDKLHQNISQNQSLLFVGLDPNPEMMPGRYSSQD
CEEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHH
IIDGLWDWLQFIIAETADFVCAYKPTLGFYEALGVPGLELLQKTLAAIPSHIPIILDAKH
HHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHCCCHHHHHHHHHHHCCCCCCEEEECCC
SDLNTSTIFAKTVFTQWGVDAITLSPYTGQDHVAPFLVYPDKAVFILCSTSNPGAEALQQ
CCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCEEEEEEECCCCCHHHHHH
YPTRESPLYLQVVQESKNWGTPEQLGLEVGTTNAEVLARIRQVAPERMIMVRSIWAEGGN
CCCCCCCEEEEEEECCCCCCCHHHHCEEECCCCHHHHHHHHHHCHHHHHHHHHHHHCCCC
LNRILEVGLNTDGNGLLIPVPQDMLASANLSKEIQSLRAEINQVRDITVRDVASCSVWLP
CCEEEEECCCCCCCEEEEECCHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHCCCEEECC
DVFTVKQHPLHDLILQLYDIDCIMFGNFVQASGAVFPYYIDLRKIISNPQVFNQVLSGYE
CEEECCCCCHHHHHHHHHCCCEEEECCCHHHCCCEEEHHHHHHHHHCCHHHHHHHHHHHH
NIVKNLTFDRLAGIPYGSLPTATGLALRLNCPMIFPRKEVKAHGTRRLIEGNFRTGEVVV
HHHHCCCHHHHCCCCCCCCCCCCCEEEEECCCEECCCHHHHHCCCHHEEECCCCCCEEEE
VVDDILISGKSVMEGADKLKSAGLNVHDIVVFIDHEQGVKDKLQANGYRGHAVLTISEIT
EEECCHHCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHCCCCCCEEEEEHHHHH
SVLHQAGRINDEQFLALTAE
HHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]