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The map label for this gene is ptrB [C]

Identifier: 17230025

GI number: 17230025

Start: 3037915

End: 3039984

Strand: Reverse

Name: ptrB [C]

Synonym: all2533

Alternate gene names: 17230025

Gene position: 3039984-3037915 (Counterclockwise)

Preceding gene: 17230026

Following gene: 17230023

Centisome position: 47.4

GC content: 39.08

Gene sequence:

>2070_bases
ATGCCCTACTCTGAAAAATCCCTTAACTATCCACTCAGCCACAAAATTGATCACGTTGATGATTACCACGGTACTTTAGT
AGCAGATCCTTATCGTTGGTTAGAAGATCCTGACTCTGAAAAAACTAGGGTTTGGATCGAGGCACAAAATCAAATTACTT
TTGCGTATTTGGGCGAAGTTTCGATTAGAGAGAAAATTCAACAACGTCTTAACAAACTTTGGGATTATGAAAAGTATGGA
ATCCCATTTAAAGAAGGAGAAAATTATTTTTATTTCAAAAATGATGGCTTGCAAAATCAAAGTGTTTTGTATACATTGAA
ATCACTGGATTCTGAACCAAGAGTTTTACTAGACCCTAACAAACTTTCAGATGATGGGACTGTTGCTCTTTCGGGTTTAG
CTATCAGCAATAATGGCAAGCTTTTGGCATATGGTATATCTACTTCTGGTTCTGATTGGCAAGAATGGAAGGTTGTTGAT
GTAGAAACTGGTGCAGATTTTCCAGATCATCTAAATTGGATTAAATTTTCCGGTGCATCTTGGACGAATGATAATCAAGG
CTTTTTCTATAGTCGTTATGACGAACCAAAGGAAAAAACCAAATTGGAAGATGTTAACTATTACCAAAAGCTTTACTACC
ATCGATTAGGTACACCCCAATCTGAAGACGTACTAATTTACCAACGCCTTGATCAAAAAGAATGGGGTTTTAATGGAGTT
GTCTCAGAAGATGGTTGCTATCTGATAATTTCGGTTTGGCTGGGTACTGATTCCAGAAATCTAGTTTTTTATAAGGACTT
AACTAACCTCCATGCCGAAGTTGTAGAACTAATTAATCAATTTGAAGCAGATTATAGTTTCATTGATAATGATGAGAGCG
TTTTCTACTTCCGTACTGACTGGGATGCACCACGGGGTAGAGTAATTGCTATTGATACAGCTAATCCGTCTCAAGAAATA
TGGCGAGAAATTATTCCTCAAGCTGAAGCAACTTTAGAAAGTGTCAATATCTTAAATAATCAGTTTATTGCTGATTATTT
AGAAGATGCCCGATCGCAAGTTAAAATTTTCGACCTCAACGGTACATTAATTCGGGATGTAGAATTACCAGGATTGGGTG
CTGTAGGTGGCTTTGGTGGTAAGCGTGACGATACAGAAACTTTTTACAAATTCACTAGTTTTACTACACCAGGAACTATT
TACCGCTATAACTTAGTAACAGGAAAAAGTGAGGTTTTTAGAGAAACAATTGTAGATTTTAATCCTGATAATTACGAAAC
TAAACAAGTTTTTTATCAAAGTAAAGATGGTACACAAGTACCCATGTTTATTACACATAAGAAAGGCATTCAATTGAATG
GGAATAACCCCACTTATCTTTATGCCTACGGTGGTTTTAATGTCTCACTCACGCCCAGTTTTTCTGTAAGTATGTTGGTA
TGGATGGAAATGGGTGGTGTTTATGCCATGCCAAATATACGCGGTGGCGGAGAATACGGCGAAGAATGGCATCAAGCAGG
AATGAAGGATAAAAAGCAAAATGTTTTTGATGATTTTATTGCTGCTGCTGAGTGGTTGATTGCCAATAATTATACAAAAC
CGGAAAAACTAGCGATCGCTGGTGGTAGTAACGGTGGTTTATTAGTGGGTGCTTGCATGACTCAGCGTCCTGAATTATTC
GGCGCAGCTTTACCAGCAGTTGGTGTGATGGATATGTTACGGTTTCACAAATTTACCATTGGTTGGGCTTGGACTGCTGA
ATATGGTTCCCCAGATAACCCACAAGAGTTTCCTGCACTCTACGCTTATTCACCACTGCATAATCTCAAACCAGGTACAG
CATACCCCGCAACCTTGATTACCACCGCCGATCACGATGATCGCGTTGTCCCCGCCCACAGCTTCAAATTTGCCGCAGCT
TTGCAAACTGCACACAACGGCAATGCACCTGTATTAATTAGAATTGAAACTAAAGCTGGACATGGTGCAGGGAAACCCAC
GGCGAAGATTATCGAAGAAGCCGCAGATAAATGGGCTTTTTTAGTCCGGACTTTAGCTGTTGAAGTTTAA

Upstream 100 bases:

>100_bases
CAGATAAACCGTAACCATGCCAATTCTGCGTCAATAGTACCTACATCAAGACTGGGGTTTATGTTTGTAGTATATGAAAA
GATACTTTTAATCCAAAACT

Downstream 100 bases:

>100_bases
CCGCAGAGAATATTAGGACTTACGCATGAAAGGGTACAGGGGTGTAGGGGTGTAAATCTTTAAAATCCTTACACCTTTGT
GTCCTTAACCCCTTATATCT

Product: prolyl endopeptidase

Products: NA

Alternate protein names: PE; Post-proline cleaving enzyme [H]

Number of amino acids: Translated: 689; Mature: 688

Protein sequence:

>689_residues
MPYSEKSLNYPLSHKIDHVDDYHGTLVADPYRWLEDPDSEKTRVWIEAQNQITFAYLGEVSIREKIQQRLNKLWDYEKYG
IPFKEGENYFYFKNDGLQNQSVLYTLKSLDSEPRVLLDPNKLSDDGTVALSGLAISNNGKLLAYGISTSGSDWQEWKVVD
VETGADFPDHLNWIKFSGASWTNDNQGFFYSRYDEPKEKTKLEDVNYYQKLYYHRLGTPQSEDVLIYQRLDQKEWGFNGV
VSEDGCYLIISVWLGTDSRNLVFYKDLTNLHAEVVELINQFEADYSFIDNDESVFYFRTDWDAPRGRVIAIDTANPSQEI
WREIIPQAEATLESVNILNNQFIADYLEDARSQVKIFDLNGTLIRDVELPGLGAVGGFGGKRDDTETFYKFTSFTTPGTI
YRYNLVTGKSEVFRETIVDFNPDNYETKQVFYQSKDGTQVPMFITHKKGIQLNGNNPTYLYAYGGFNVSLTPSFSVSMLV
WMEMGGVYAMPNIRGGGEYGEEWHQAGMKDKKQNVFDDFIAAAEWLIANNYTKPEKLAIAGGSNGGLLVGACMTQRPELF
GAALPAVGVMDMLRFHKFTIGWAWTAEYGSPDNPQEFPALYAYSPLHNLKPGTAYPATLITTADHDDRVVPAHSFKFAAA
LQTAHNGNAPVLIRIETKAGHGAGKPTAKIIEEAADKWAFLVRTLAVEV

Sequences:

>Translated_689_residues
MPYSEKSLNYPLSHKIDHVDDYHGTLVADPYRWLEDPDSEKTRVWIEAQNQITFAYLGEVSIREKIQQRLNKLWDYEKYG
IPFKEGENYFYFKNDGLQNQSVLYTLKSLDSEPRVLLDPNKLSDDGTVALSGLAISNNGKLLAYGISTSGSDWQEWKVVD
VETGADFPDHLNWIKFSGASWTNDNQGFFYSRYDEPKEKTKLEDVNYYQKLYYHRLGTPQSEDVLIYQRLDQKEWGFNGV
VSEDGCYLIISVWLGTDSRNLVFYKDLTNLHAEVVELINQFEADYSFIDNDESVFYFRTDWDAPRGRVIAIDTANPSQEI
WREIIPQAEATLESVNILNNQFIADYLEDARSQVKIFDLNGTLIRDVELPGLGAVGGFGGKRDDTETFYKFTSFTTPGTI
YRYNLVTGKSEVFRETIVDFNPDNYETKQVFYQSKDGTQVPMFITHKKGIQLNGNNPTYLYAYGGFNVSLTPSFSVSMLV
WMEMGGVYAMPNIRGGGEYGEEWHQAGMKDKKQNVFDDFIAAAEWLIANNYTKPEKLAIAGGSNGGLLVGACMTQRPELF
GAALPAVGVMDMLRFHKFTIGWAWTAEYGSPDNPQEFPALYAYSPLHNLKPGTAYPATLITTADHDDRVVPAHSFKFAAA
LQTAHNGNAPVLIRIETKAGHGAGKPTAKIIEEAADKWAFLVRTLAVEV
>Mature_688_residues
PYSEKSLNYPLSHKIDHVDDYHGTLVADPYRWLEDPDSEKTRVWIEAQNQITFAYLGEVSIREKIQQRLNKLWDYEKYGI
PFKEGENYFYFKNDGLQNQSVLYTLKSLDSEPRVLLDPNKLSDDGTVALSGLAISNNGKLLAYGISTSGSDWQEWKVVDV
ETGADFPDHLNWIKFSGASWTNDNQGFFYSRYDEPKEKTKLEDVNYYQKLYYHRLGTPQSEDVLIYQRLDQKEWGFNGVV
SEDGCYLIISVWLGTDSRNLVFYKDLTNLHAEVVELINQFEADYSFIDNDESVFYFRTDWDAPRGRVIAIDTANPSQEIW
REIIPQAEATLESVNILNNQFIADYLEDARSQVKIFDLNGTLIRDVELPGLGAVGGFGGKRDDTETFYKFTSFTTPGTIY
RYNLVTGKSEVFRETIVDFNPDNYETKQVFYQSKDGTQVPMFITHKKGIQLNGNNPTYLYAYGGFNVSLTPSFSVSMLVW
MEMGGVYAMPNIRGGGEYGEEWHQAGMKDKKQNVFDDFIAAAEWLIANNYTKPEKLAIAGGSNGGLLVGACMTQRPELFG
AALPAVGVMDMLRFHKFTIGWAWTAEYGSPDNPQEFPALYAYSPLHNLKPGTAYPATLITTADHDDRVVPAHSFKFAAAL
QTAHNGNAPVLIRIETKAGHGAGKPTAKIIEEAADKWAFLVRTLAVEV

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=706, Percent_Identity=48.7252124645892, Blast_Score=673, Evalue=0.0,
Organism=Homo sapiens, GI284172420, Length=282, Percent_Identity=26.9503546099291, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI284172413, Length=282, Percent_Identity=26.9503546099291, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI70778815, Length=282, Percent_Identity=26.9503546099291, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI284172438, Length=282, Percent_Identity=26.9503546099291, Blast_Score=100, Evalue=9e-21,
Organism=Homo sapiens, GI284172431, Length=282, Percent_Identity=26.9503546099291, Blast_Score=100, Evalue=9e-21,
Organism=Homo sapiens, GI108860686, Length=247, Percent_Identity=28.3400809716599, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI108860692, Length=199, Percent_Identity=29.6482412060301, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1788150, Length=690, Percent_Identity=25.6521739130435, Blast_Score=217, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24583414, Length=710, Percent_Identity=48.4507042253521, Blast_Score=638, Evalue=0.0,
Organism=Drosophila melanogaster, GI221510989, Length=710, Percent_Identity=45.9154929577465, Blast_Score=602, Evalue=1e-172,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 77918; Mature: 77787

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYSEKSLNYPLSHKIDHVDDYHGTLVADPYRWLEDPDSEKTRVWIEAQNQITFAYLGEV
CCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCCCEEEEEEECCEEEEEEECCH
SIREKIQQRLNKLWDYEKYGIPFKEGENYFYFKNDGLQNQSVLYTLKSLDSEPRVLLDPN
HHHHHHHHHHHHHCCHHHCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCEEECCC
KLSDDGTVALSGLAISNNGKLLAYGISTSGSDWQEWKVVDVETGADFPDHLNWIKFSGAS
CCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCEEEECCCC
WTNDNQGFFYSRYDEPKEKTKLEDVNYYQKLYYHRLGTPQSEDVLIYQRLDQKEWGFNGV
CCCCCCCEEEECCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCE
VSEDGCYLIISVWLGTDSRNLVFYKDLTNLHAEVVELINQFEADYSFIDNDESVFYFRTD
ECCCCCEEEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEEC
WDAPRGRVIAIDTANPSQEIWREIIPQAEATLESVNILNNQFIADYLEDARSQVKIFDLN
CCCCCCEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECC
GTLIRDVELPGLGAVGGFGGKRDDTETFYKFTSFTTPGTIYRYNLVTGKSEVFRETIVDF
CCEEEEECCCCCCCCCCCCCCCCCCHHEEEEEEECCCCEEEEEEEECCCHHHHHHHHHCC
NPDNYETKQVFYQSKDGTQVPMFITHKKGIQLNGNNPTYLYAYGGFNVSLTPSFSVSMLV
CCCCCCCEEEEEECCCCCCCCEEEEECCCEEECCCCCEEEEEECCEEEEECCCCCEEEEE
WMEMGGVYAMPNIRGGGEYGEEWHQAGMKDKKQNVFDDFIAAAEWLIANNYTKPEKLAIA
EEECCCEEECCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCCCCCEEEEE
GGSNGGLLVGACMTQRPELFGAALPAVGVMDMLRFHKFTIGWAWTAEYGSPDNPQEFPAL
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCHHCCEE
YAYSPLHNLKPGTAYPATLITTADHDDRVVPAHSFKFAAALQTAHNGNAPVLIRIETKAG
EEECCHHCCCCCCCCCEEEEEECCCCCCEECCCCCHHHHHHHHCCCCCCCEEEEEEECCC
HGAGKPTAKIIEEAADKWAFLVRTLAVEV
CCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PYSEKSLNYPLSHKIDHVDDYHGTLVADPYRWLEDPDSEKTRVWIEAQNQITFAYLGEV
CCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCCCEEEEEEECCEEEEEEECCH
SIREKIQQRLNKLWDYEKYGIPFKEGENYFYFKNDGLQNQSVLYTLKSLDSEPRVLLDPN
HHHHHHHHHHHHHCCHHHCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCEEECCC
KLSDDGTVALSGLAISNNGKLLAYGISTSGSDWQEWKVVDVETGADFPDHLNWIKFSGAS
CCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCEEEEEEEECCCCCCCCCCEEEECCCC
WTNDNQGFFYSRYDEPKEKTKLEDVNYYQKLYYHRLGTPQSEDVLIYQRLDQKEWGFNGV
CCCCCCCEEEECCCCCHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCE
VSEDGCYLIISVWLGTDSRNLVFYKDLTNLHAEVVELINQFEADYSFIDNDESVFYFRTD
ECCCCCEEEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEEEC
WDAPRGRVIAIDTANPSQEIWREIIPQAEATLESVNILNNQFIADYLEDARSQVKIFDLN
CCCCCCEEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECC
GTLIRDVELPGLGAVGGFGGKRDDTETFYKFTSFTTPGTIYRYNLVTGKSEVFRETIVDF
CCEEEEECCCCCCCCCCCCCCCCCCHHEEEEEEECCCCEEEEEEEECCCHHHHHHHHHCC
NPDNYETKQVFYQSKDGTQVPMFITHKKGIQLNGNNPTYLYAYGGFNVSLTPSFSVSMLV
CCCCCCCEEEEEECCCCCCCCEEEEECCCEEECCCCCEEEEEECCEEEEECCCCCEEEEE
WMEMGGVYAMPNIRGGGEYGEEWHQAGMKDKKQNVFDDFIAAAEWLIANNYTKPEKLAIA
EEECCCEEECCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCCCCCEEEEE
GGSNGGLLVGACMTQRPELFGAALPAVGVMDMLRFHKFTIGWAWTAEYGSPDNPQEFPAL
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCHHCCEE
YAYSPLHNLKPGTAYPATLITTADHDDRVVPAHSFKFAAALQTAHNGNAPVLIRIETKAG
EEECCHHCCCCCCCCCEEEEEECCCCCCEECCCCCHHHHHHHHCCCCCCCEEEEEEECCC
HGAGKPTAKIIEEAADKWAFLVRTLAVEV
CCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8370677 [H]