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The map label for this gene is aspS [H]

Identifier: 17229928

GI number: 17229928

Start: 2929156

End: 2930943

Strand: Reverse

Name: aspS [H]

Synonym: all2436

Alternate gene names: 17229928

Gene position: 2930943-2929156 (Counterclockwise)

Preceding gene: 17229929

Following gene: 17229927

Centisome position: 45.7

GC content: 45.86

Gene sequence:

>1788_bases
ATGCGAACTCACTATTGCGGCGAACTCCGACAAAAGGATATTGGAGAAACTGTTACCTTATATGGATGGGTAGACCGTCG
CCGCGATCATGGGGGCGTGATATTCTTGGATTTACGCGATCGCTCTGGCATTGTCCAAGTTGTCAGCGATCCGCAACGCA
CCCCAGATTCCTACGAACTGGCTAACTCTCTACGTAATGAATACGTTGTGGAAATTACTGGTAGGGTAACACAACGTCCA
GAAGAATCACTGAATACCCGCATCCCGACTGGGGAAGTGGAAATCTACGCTGATAAAATTGAACTACTCAATGGGGTGCG
GAAACAGTTACCATTCCAAGTTTCTACCGCCGACACTGAGACAGTTAGGGAAGACTTGCGGCTAAAATATCGTTACTTGG
ACTTGCGGCGCGATCGCATGGCGCGTAACATACAACTACGTCATCAAGTGGTGAAAGCGATGCGTCGTTATTTGGAAGAC
GTAGAAGGTTTCATCGAAGTGGAAACCCCAATCCTCACCCGTTCCACCCCCGAAGGCGCGCGGGATTATGTGCTACCTAG
CCGCGTCAATCCTGGGGAATGGTTTGCTTTACCCCAATCACCACAACTATTCAAACAGATCCTCATGGTATCTGGGTTAG
ATAGATATTATCAAATCGCTCGATGCTTCCGTGATGAGGACTTACGTGCAGATAGACAGCCAGAATTTACTCAGTTAGAC
ATGGAAATGAGTTTCATGTCTGAGGAGGAAATTATTGAACTTAACGAAAAGTTAGTTAGTTATATCTTCAAAACCGTTAA
AGGGGTTGAGTTACCGCTTCCGTTCCCCCGTCTCACCTACGCCGAAGCAATGGAACGCTACGGTTGTGATAAACCAGATA
CCCGCTACGATTTACAACTAGTTAACGTTTCCGATGTCATGAAAGACTCTGGTTTCAAAGTCTTTCGGGATGCTGTCGCC
AATGGTGGTATCGTCAAAATTCTGCCCATACCCAATGGTAACGAGCAAATCTCTAATGTGCGGATTAAACCAGGTGGGGA
TTTATTTAGAGAAGCCAGCGAAGCCGGTGCAAAAGGTTTAGCTTATATCCGGGTGCGTGAAGATGGTGAAATTGACACCA
TCGGCGCGATTAAAGATAACCTTTCAGAAGAACAGAAACAGGAAATCTTGCAGCGCACAGGTGCAAAACCCGGACATCTG
TTATTGTTTGGTGCTGGTGATGCAGTTACCGTGAATAAAACCTTGGATAGATTGCGGCAGGCGATCGCCAAAGAATTTGG
TTTAATTGATCCAGATAAAATCAACTTGCTTTGGGTTGTTGATTTCCCCATGTTTGAGTGGAATGCAGATGAGAAGCGCC
TAGAAGCACTACACCACCCATTTACCGCACCCCACCCTGATGATTTGCATGACTTAAAAACAGCCCGCGCTCAAGCCTAT
GATTTAGTATTCAATGGTTTTGAAGTGGGTGGCGGTAGTCGGCGGATTTATCAACGGGAAGTCCAAGAACAAGTGTTTGA
AACCATTGGTTTATCCCCGGAAGAAGCACAAAATAAATTTGGCTTTTTGTTAGAAGCATTTGAATATGGTACACCGCCGC
ATGGTGGTATCGCCTACGGTTTAGATCGGTTGGTGATGTTATTTGCTGGCGAAGAATCAATTCGAGATGTTATTGCTTTT
CCGAAGACACAGCAAGCACGTTGTTTGTTGACAGATGCACCTTCTGGGGTAGATGTCAAGCAGTTGAAGGAATTACACGT
TGCTTCGACTTATAAGCCGAAGTCTTAG

Upstream 100 bases:

>100_bases
TTATGCCAACTGTTCTTCAATTAGATACGATTGATGCTAGATAATGGGAAGGCTTTGGCATTCACTAGCAAATCTAGCCC
GGAAGAACAGATTAACAACT

Downstream 100 bases:

>100_bases
GGATGAGAAATAAGATACCTGGATTTTTGAGAATGCGGGTATCTTATTTTTAACGCAGAGGGGGCAGAGGTTAGCGCAGA
GGTATGCGGAGGGTAAGAGT

Product: aspartyl-tRNA synthetase

Products: NA

Alternate protein names: Aspartate--tRNA ligase; AspRS [H]

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MRTHYCGELRQKDIGETVTLYGWVDRRRDHGGVIFLDLRDRSGIVQVVSDPQRTPDSYELANSLRNEYVVEITGRVTQRP
EESLNTRIPTGEVEIYADKIELLNGVRKQLPFQVSTADTETVREDLRLKYRYLDLRRDRMARNIQLRHQVVKAMRRYLED
VEGFIEVETPILTRSTPEGARDYVLPSRVNPGEWFALPQSPQLFKQILMVSGLDRYYQIARCFRDEDLRADRQPEFTQLD
MEMSFMSEEEIIELNEKLVSYIFKTVKGVELPLPFPRLTYAEAMERYGCDKPDTRYDLQLVNVSDVMKDSGFKVFRDAVA
NGGIVKILPIPNGNEQISNVRIKPGGDLFREASEAGAKGLAYIRVREDGEIDTIGAIKDNLSEEQKQEILQRTGAKPGHL
LLFGAGDAVTVNKTLDRLRQAIAKEFGLIDPDKINLLWVVDFPMFEWNADEKRLEALHHPFTAPHPDDLHDLKTARAQAY
DLVFNGFEVGGGSRRIYQREVQEQVFETIGLSPEEAQNKFGFLLEAFEYGTPPHGGIAYGLDRLVMLFAGEESIRDVIAF
PKTQQARCLLTDAPSGVDVKQLKELHVASTYKPKS

Sequences:

>Translated_595_residues
MRTHYCGELRQKDIGETVTLYGWVDRRRDHGGVIFLDLRDRSGIVQVVSDPQRTPDSYELANSLRNEYVVEITGRVTQRP
EESLNTRIPTGEVEIYADKIELLNGVRKQLPFQVSTADTETVREDLRLKYRYLDLRRDRMARNIQLRHQVVKAMRRYLED
VEGFIEVETPILTRSTPEGARDYVLPSRVNPGEWFALPQSPQLFKQILMVSGLDRYYQIARCFRDEDLRADRQPEFTQLD
MEMSFMSEEEIIELNEKLVSYIFKTVKGVELPLPFPRLTYAEAMERYGCDKPDTRYDLQLVNVSDVMKDSGFKVFRDAVA
NGGIVKILPIPNGNEQISNVRIKPGGDLFREASEAGAKGLAYIRVREDGEIDTIGAIKDNLSEEQKQEILQRTGAKPGHL
LLFGAGDAVTVNKTLDRLRQAIAKEFGLIDPDKINLLWVVDFPMFEWNADEKRLEALHHPFTAPHPDDLHDLKTARAQAY
DLVFNGFEVGGGSRRIYQREVQEQVFETIGLSPEEAQNKFGFLLEAFEYGTPPHGGIAYGLDRLVMLFAGEESIRDVIAF
PKTQQARCLLTDAPSGVDVKQLKELHVASTYKPKS
>Mature_595_residues
MRTHYCGELRQKDIGETVTLYGWVDRRRDHGGVIFLDLRDRSGIVQVVSDPQRTPDSYELANSLRNEYVVEITGRVTQRP
EESLNTRIPTGEVEIYADKIELLNGVRKQLPFQVSTADTETVREDLRLKYRYLDLRRDRMARNIQLRHQVVKAMRRYLED
VEGFIEVETPILTRSTPEGARDYVLPSRVNPGEWFALPQSPQLFKQILMVSGLDRYYQIARCFRDEDLRADRQPEFTQLD
MEMSFMSEEEIIELNEKLVSYIFKTVKGVELPLPFPRLTYAEAMERYGCDKPDTRYDLQLVNVSDVMKDSGFKVFRDAVA
NGGIVKILPIPNGNEQISNVRIKPGGDLFREASEAGAKGLAYIRVREDGEIDTIGAIKDNLSEEQKQEILQRTGAKPGHL
LLFGAGDAVTVNKTLDRLRQAIAKEFGLIDPDKINLLWVVDFPMFEWNADEKRLEALHHPFTAPHPDDLHDLKTARAQAY
DLVFNGFEVGGGSRRIYQREVQEQVFETIGLSPEEAQNKFGFLLEAFEYGTPPHGGIAYGLDRLVMLFAGEESIRDVIAF
PKTQQARCLLTDAPSGVDVKQLKELHVASTYKPKS

Specific function: Unknown

COG id: COG0173

COG function: function code J; Aspartyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI40789249, Length=603, Percent_Identity=41.2935323383085, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI5031815, Length=303, Percent_Identity=27.0627062706271, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI194272210, Length=303, Percent_Identity=27.0627062706271, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI45439306, Length=271, Percent_Identity=26.5682656826568, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1788173, Length=602, Percent_Identity=48.1727574750831, Blast_Score=554, Evalue=1e-159,
Organism=Escherichia coli, GI1789256, Length=289, Percent_Identity=25.9515570934256, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1790571, Length=289, Percent_Identity=26.2975778546713, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1787161, Length=275, Percent_Identity=28.3636363636364, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32566633, Length=612, Percent_Identity=34.8039215686275, Blast_Score=329, Evalue=3e-90,
Organism=Caenorhabditis elegans, GI17535925, Length=316, Percent_Identity=26.2658227848101, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71994340, Length=316, Percent_Identity=26.2658227848101, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17535927, Length=273, Percent_Identity=27.1062271062271, Blast_Score=107, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17551876, Length=282, Percent_Identity=25.531914893617, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6325153, Length=657, Percent_Identity=31.9634703196347, Blast_Score=267, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6320242, Length=260, Percent_Identity=28.4615384615385, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6323011, Length=281, Percent_Identity=29.5373665480427, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6321807, Length=295, Percent_Identity=28.4745762711864, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324256, Length=191, Percent_Identity=25.130890052356, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24584738, Length=599, Percent_Identity=40.0667779632721, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24640849, Length=273, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24640851, Length=273, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17136276, Length=268, Percent_Identity=26.865671641791, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19922416, Length=293, Percent_Identity=25.2559726962457, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI19921528, Length=232, Percent_Identity=28.448275862069, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR020564
- InterPro:   IPR004524
- InterPro:   IPR018153
- InterPro:   IPR002312
- InterPro:   IPR004115
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02938 GAD; PF00152 tRNA-synt_2; PF01336 tRNA_anti [H]

EC number: =6.1.1.12 [H]

Molecular weight: Translated: 67906; Mature: 67906

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTHYCGELRQKDIGETVTLYGWVDRRRDHGGVIFLDLRDRSGIVQVVSDPQRTPDSYEL
CCCCCCHHHHHHHCCCEEEEEEEHHCCCCCCCEEEEEECCCCCEEEEECCCCCCCCHHHH
ANSLRNEYVVEITGRVTQRPEESLNTRIPTGEVEIYADKIELLNGVRKQLPFQVSTADTE
HHHHCCCEEEEEECCHHCCCHHHHCCCCCCCCEEEEHHHHHHHHHHHHHCCEEEECCCHH
TVREDLRLKYRYLDLRRDRMARNIQLRHQVVKAMRRYLEDVEGFIEVETPILTRSTPEGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEECCCCCCC
RDYVLPSRVNPGEWFALPQSPQLFKQILMVSGLDRYYQIARCFRDEDLRADRQPEFTQLD
CCCCCCCCCCCCCEEECCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCEEEC
MEMSFMSEEEIIELNEKLVSYIFKTVKGVELPLPFPRLTYAEAMERYGCDKPDTRYDLQL
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEE
VNVSDVMKDSGFKVFRDAVANGGIVKILPIPNGNEQISNVRIKPGGDLFREASEAGAKGL
ECHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHHHHCCCCCE
AYIRVREDGEIDTIGAIKDNLSEEQKQEILQRTGAKPGHLLLFGAGDAVTVNKTLDRLRQ
EEEEEECCCCEEEEHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCEEEHHHHHHHHHH
AIAKEFGLIDPDKINLLWVVDFPMFEWNADEKRLEALHHPFTAPHPDDLHDLKTARAQAY
HHHHHHCCCCCCCEEEEEEEECCCEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
DLVFNGFEVGGGSRRIYQREVQEQVFETIGLSPEEAQNKFGFLLEAFEYGTPPHGGIAYG
HHEEECEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LDRLVMLFAGEESIRDVIAFPKTQQARCLLTDAPSGVDVKQLKELHVASTYKPKS
HHHHHHHHCCCHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRTHYCGELRQKDIGETVTLYGWVDRRRDHGGVIFLDLRDRSGIVQVVSDPQRTPDSYEL
CCCCCCHHHHHHHCCCEEEEEEEHHCCCCCCCEEEEEECCCCCEEEEECCCCCCCCHHHH
ANSLRNEYVVEITGRVTQRPEESLNTRIPTGEVEIYADKIELLNGVRKQLPFQVSTADTE
HHHHCCCEEEEEECCHHCCCHHHHCCCCCCCCEEEEHHHHHHHHHHHHHCCEEEECCCHH
TVREDLRLKYRYLDLRRDRMARNIQLRHQVVKAMRRYLEDVEGFIEVETPILTRSTPEGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEECCCCCCC
RDYVLPSRVNPGEWFALPQSPQLFKQILMVSGLDRYYQIARCFRDEDLRADRQPEFTQLD
CCCCCCCCCCCCCEEECCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCEEEC
MEMSFMSEEEIIELNEKLVSYIFKTVKGVELPLPFPRLTYAEAMERYGCDKPDTRYDLQL
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEE
VNVSDVMKDSGFKVFRDAVANGGIVKILPIPNGNEQISNVRIKPGGDLFREASEAGAKGL
ECHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHHHHCCCCCE
AYIRVREDGEIDTIGAIKDNLSEEQKQEILQRTGAKPGHLLLFGAGDAVTVNKTLDRLRQ
EEEEEECCCCEEEEHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCEEEHHHHHHHHHH
AIAKEFGLIDPDKINLLWVVDFPMFEWNADEKRLEALHHPFTAPHPDDLHDLKTARAQAY
HHHHHHCCCCCCCEEEEEEEECCCEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
DLVFNGFEVGGGSRRIYQREVQEQVFETIGLSPEEAQNKFGFLLEAFEYGTPPHGGIAYG
HHEEECEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LDRLVMLFAGEESIRDVIAFPKTQQARCLLTDAPSGVDVKQLKELHVASTYKPKS
HHHHHHHHCCCHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA