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The map label for this gene is prk [H]

Identifier: 17229842

GI number: 17229842

Start: 2832938

End: 2833879

Strand: Direct

Name: prk [H]

Synonym: alr2350

Alternate gene names: 17229842

Gene position: 2832938-2833879 (Clockwise)

Preceding gene: 17229840

Following gene: 17229843

Centisome position: 44.17

GC content: 44.16

Gene sequence:

>942_bases
ATGATGAGCCGTCCAATAATTCTTGGTATTGTTGGTGATAGTGCTGCTGGCAAAACTACACTAACTAGGGGCATTGCTCA
GGTACTGGGGCCAGAAAATGTCACACTCATCTGCACAGATGATTATCATCGGTACGATCGCCAACAACGTGCAGAAATAG
GAATTACCGCTCTCCACCCCGATTGTAACCATTTGGATATTATGCAGCAGCATCTATCGCTGCTACGCACAGGACAACCA
ATTCTTAAACCAGTTTATAGTCACAAAACCGGAAGTTTTGAGCCGCCCCAATATATAAAACCCAACAAATTCGTTATTAT
CGAGGGATTACTTGGTTATTCTACTCGCGCCGCCCGTGACTGTTACGATGTGAAAGTTTACCTCGCTCCTCCAGAGAACC
TCCGTGCTAAATGGAAAGTTAAACGCGACACGCAAAAACGCGGCTACACTCCCGAACAAGTTTTAGCAGAACTAGAGAAG
CGCGAACCAGATTCAGAACAATTTATTCGTCCCCAAAGACAATGGTCTGATATTGTTGTCAGTTTCTATCCACCTCATGA
GGATGGAGATGAAACCAACGGACATCTCAACGTGCGTTTAGTATTGCGTCCTACTATTCCCCACCCAGACTTTACTTCCA
TTATTAATTTGACTAATGGTAGTTCTGTGTCAGCTATTCGCCTGGGATTGGACAGAGATATGAGTAAACCAGTTGATGTG
TTAGAAGTTGACGGTCACGCCACCTTAGAACAGGTAAACAAATTAGAGCATATTCTCTGTTCTGATATGCCTTACTTGAG
TAGTGTATGCGATCGCGAAAGTAACCCAGAACTCGGCAAGATTGCTGGGACAACTGGCGAAACACTACAAAGTTACCCCC
TTGCCCTGACTCAGTTAATCATCACCTACCATATGCTCAAGGCAACGCAAATTTATCAATAA

Upstream 100 bases:

>100_bases
GCACAAATGTGTGCAATTAAATGACTTGACACAATCCCTTCTAAAATAAAAAAACATTCTCTGCAAAATTTATTACTATA
GTTACTTGTATCGGGGGGAT

Downstream 100 bases:

>100_bases
AAATCTTTGATTTTCATGGTTGACTGTTCACAGTTCGCGGTCAACAACTTTAAAAGACAAAAAGGAAAAGCAAAAATTAA
AAATTTTCTCAAGCTAGGGC

Product: phosphoribulokinase

Products: NA

Alternate protein names: PRK; PRKase; Phosphopentokinase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MMSRPIILGIVGDSAAGKTTLTRGIAQVLGPENVTLICTDDYHRYDRQQRAEIGITALHPDCNHLDIMQQHLSLLRTGQP
ILKPVYSHKTGSFEPPQYIKPNKFVIIEGLLGYSTRAARDCYDVKVYLAPPENLRAKWKVKRDTQKRGYTPEQVLAELEK
REPDSEQFIRPQRQWSDIVVSFYPPHEDGDETNGHLNVRLVLRPTIPHPDFTSIINLTNGSSVSAIRLGLDRDMSKPVDV
LEVDGHATLEQVNKLEHILCSDMPYLSSVCDRESNPELGKIAGTTGETLQSYPLALTQLIITYHMLKATQIYQ

Sequences:

>Translated_313_residues
MMSRPIILGIVGDSAAGKTTLTRGIAQVLGPENVTLICTDDYHRYDRQQRAEIGITALHPDCNHLDIMQQHLSLLRTGQP
ILKPVYSHKTGSFEPPQYIKPNKFVIIEGLLGYSTRAARDCYDVKVYLAPPENLRAKWKVKRDTQKRGYTPEQVLAELEK
REPDSEQFIRPQRQWSDIVVSFYPPHEDGDETNGHLNVRLVLRPTIPHPDFTSIINLTNGSSVSAIRLGLDRDMSKPVDV
LEVDGHATLEQVNKLEHILCSDMPYLSSVCDRESNPELGKIAGTTGETLQSYPLALTQLIITYHMLKATQIYQ
>Mature_313_residues
MMSRPIILGIVGDSAAGKTTLTRGIAQVLGPENVTLICTDDYHRYDRQQRAEIGITALHPDCNHLDIMQQHLSLLRTGQP
ILKPVYSHKTGSFEPPQYIKPNKFVIIEGLLGYSTRAARDCYDVKVYLAPPENLRAKWKVKRDTQKRGYTPEQVLAELEK
REPDSEQFIRPQRQWSDIVVSFYPPHEDGDETNGHLNVRLVLRPTIPHPDFTSIINLTNGSSVSAIRLGLDRDMSKPVDV
LEVDGHATLEQVNKLEHILCSDMPYLSSVCDRESNPELGKIAGTTGETLQSYPLALTQLIITYHMLKATQIYQ

Specific function: Pyrimidine salvage pathway. [C]

COG id: COG0572

COG function: function code F; Uridine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoribulokinase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=179, Percent_Identity=26.8156424581006, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI57863312, Length=179, Percent_Identity=26.8156424581006, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI18699734, Length=189, Percent_Identity=24.8677248677249, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI13899253, Length=192, Percent_Identity=27.0833333333333, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87082034, Length=183, Percent_Identity=29.5081967213115, Blast_Score=85, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17539892, Length=189, Percent_Identity=25.3968253968254, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17539894, Length=189, Percent_Identity=25.3968253968254, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221458995, Length=190, Percent_Identity=25.7894736842105, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24649624, Length=190, Percent_Identity=25.7894736842105, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573516, Length=182, Percent_Identity=26.3736263736264, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28573514, Length=182, Percent_Identity=26.3736263736264, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28573512, Length=182, Percent_Identity=26.3736263736264, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45550449, Length=182, Percent_Identity=26.3736263736264, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006082
- InterPro:   IPR006083 [H]

Pfam domain/function: PF00485 PRK [H]

EC number: =2.7.1.19 [H]

Molecular weight: Translated: 35281; Mature: 35281

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00567 PHOSPHORIBULOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSRPIILGIVGDSAAGKTTLTRGIAQVLGPENVTLICTDDYHRYDRQQRAEIGITALHP
CCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCEEEECC
DCNHLDIMQQHLSLLRTGQPILKPVYSHKTGSFEPPQYIKPNKFVIIEGLLGYSTRAARD
CCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHCCC
CYDVKVYLAPPENLRAKWKVKRDTQKRGYTPEQVLAELEKREPDSEQFIRPQRQWSDIVV
EEEEEEEEECCCCCCEEEEECCCHHHCCCCHHHHHHHHHHCCCCHHHHCCCHHCCCCEEE
SFYPPHEDGDETNGHLNVRLVLRPTIPHPDFTSIINLTNGSSVSAIRLGLDRDMSKPVDV
EEECCCCCCCCCCCEEEEEEEEECCCCCCCHHHEEEECCCCCEEEEEECCCCCCCCCCCE
LEVDGHATLEQVNKLEHILCSDMPYLSSVCDRESNPELGKIAGTTGETLQSYPLALTQLI
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHH
ITYHMLKATQIYQ
HHHHHHHHHHHCC
>Mature Secondary Structure
MMSRPIILGIVGDSAAGKTTLTRGIAQVLGPENVTLICTDDYHRYDRQQRAEIGITALHP
CCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCEEEECC
DCNHLDIMQQHLSLLRTGQPILKPVYSHKTGSFEPPQYIKPNKFVIIEGLLGYSTRAARD
CCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCHHCCC
CYDVKVYLAPPENLRAKWKVKRDTQKRGYTPEQVLAELEKREPDSEQFIRPQRQWSDIVV
EEEEEEEEECCCCCCEEEEECCCHHHCCCCHHHHHHHHHHCCCCHHHHCCCHHCCCCEEE
SFYPPHEDGDETNGHLNVRLVLRPTIPHPDFTSIINLTNGSSVSAIRLGLDRDMSKPVDV
EEECCCCCCCCCCCEEEEEEEEECCCCCCCHHHEEEECCCCCEEEEEECCCCCCCCCCCE
LEVDGHATLEQVNKLEHILCSDMPYLSSVCDRESNPELGKIAGTTGETLQSYPLALTQLI
EEECCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHH
ITYHMLKATQIYQ
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1660882; 8905231 [H]