Click here to switch to the map view.

The map label for this gene is pyrC [H]

Identifier: 17229795

GI number: 17229795

Start: 2773257

End: 2774576

Strand: Reverse

Name: pyrC [H]

Synonym: all2303

Alternate gene names: 17229795

Gene position: 2774576-2773257 (Counterclockwise)

Preceding gene: 17229806

Following gene: 17229794

Centisome position: 43.26

GC content: 47.73

Gene sequence:

>1320_bases
ATGTCATCTCCACAAAGTTTGCTAATTCGCGGCGCTCGCATCATTTTACCGAATGGTGAATTTTTGGTGGGGGATGTGTT
GACACGCGATCGCCATATCGTTGAAGTAGGGACAGAAATAGTCAACACTACACCAGCTACAGAGATTGACGCGAAAGGGT
TGACTTTGTTGCCAGGAGTCATAGACCCCCAGGTGCATTTCCGCGAACCTGGGCTAGAACATAAAGAAGATTTGTTTACA
GCCAGCTGCGCCTGTGCCAAAGGTGGGGTAACTTCTTTTTTAGAAATGCCCAACACGCGCCCCCTGACAACTACCCAGCA
AGCGCTAGATGATAAGTTACAACGGGCTGCTAGTAAGTGTTTGGTGAATTATGGTTTTTTCATCGGGGCAACAGGGGATA
ACACACCAGAATTATTAGCCGCACACCCAACACCAGGCATTAAGATTTTCATGGGGTCAATGCACGGTCAGTTGTTGGTT
GATCAAGAGGCTGCACTAGAATCGATATTTGCTCAAGGTCAACGCCTAATTGCTGTTCATGCGGAAGACCAAGCCAGAAT
TAACCAGCGCCGTCAAGAATTTGCGGGGATTCAAGACCCAGCAATTCACTCCCAAATTCAAGACAATCAAGCGGCACTGT
TAGCAACACAATTGGCATTAAAACTTTCTAAAAAATATCAGCGTCGGTTACATATTCTGCATATGTCCACAGCCGACGAA
GCCGAATTGTTGCGCCAAGACAAACCCAGTTGGGTAACAGCCGAGGTCACACCACAACATTTGGTGATGAATACTGGTGA
TTATCAGCGTATTGGCACATTAGCACAAATGAATCCGCCCTTGCGATCGCCCCACGATAACGAAGTTTTATGGCAAGCGT
TGCGGGATGGTGTGATAGATTTCATCGCCACAGACCACGCTCCCCACACCTTAGAAGAAAAAGCTCAACCCTATCCCAAT
AGTCCTTCTGGGATGCCTGGGGTAGAAACATCCTTGGCTGTCATGTTGACGGCGGCGATGGAGGGGAAATGTACCATTGC
CCAAGTAGCCAACTGGATGTCCAAAGCTGTCGCTGTAGCTTATGGTATCCCCAATAAAGGAGCGATCGCCCCTGGTTACG
ATGCTGATTTAGTGCTTGTTGATTTGAATACATACCGCCCCGTCCTCCGAGAAGAAACCTTAACCAAATGTCACTGGAGT
CCCTTTGAAGGTTGGAACCTCACAGGATGGGCTGACACAACTATAGTTGGTGGTCAGATTGTCTACCACAAAGGCAAGTT
AAACACAGAAGTGCGCGGTCAAGCTTTAAGCTTTGTGTAG

Upstream 100 bases:

>100_bases
AAATAACTGCAAAAAATTATTACAAAAAGTACTGTTAAGATTGACCTAAAAGGATAGTTTTTTATAGTCTATAACTCCTG
TATTGAAAATTGTTAGCATC

Downstream 100 bases:

>100_bases
CAAATAATATTCTCTGATTACGTAGATTACAACTGTAAAACAGATTTAGGCGACAGAAATTATTCTTCCCTGATCCCCAG
CCCCTAATCTACCAAGGAGA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MSSPQSLLIRGARIILPNGEFLVGDVLTRDRHIVEVGTEIVNTTPATEIDAKGLTLLPGVIDPQVHFREPGLEHKEDLFT
ASCACAKGGVTSFLEMPNTRPLTTTQQALDDKLQRAASKCLVNYGFFIGATGDNTPELLAAHPTPGIKIFMGSMHGQLLV
DQEAALESIFAQGQRLIAVHAEDQARINQRRQEFAGIQDPAIHSQIQDNQAALLATQLALKLSKKYQRRLHILHMSTADE
AELLRQDKPSWVTAEVTPQHLVMNTGDYQRIGTLAQMNPPLRSPHDNEVLWQALRDGVIDFIATDHAPHTLEEKAQPYPN
SPSGMPGVETSLAVMLTAAMEGKCTIAQVANWMSKAVAVAYGIPNKGAIAPGYDADLVLVDLNTYRPVLREETLTKCHWS
PFEGWNLTGWADTTIVGGQIVYHKGKLNTEVRGQALSFV

Sequences:

>Translated_439_residues
MSSPQSLLIRGARIILPNGEFLVGDVLTRDRHIVEVGTEIVNTTPATEIDAKGLTLLPGVIDPQVHFREPGLEHKEDLFT
ASCACAKGGVTSFLEMPNTRPLTTTQQALDDKLQRAASKCLVNYGFFIGATGDNTPELLAAHPTPGIKIFMGSMHGQLLV
DQEAALESIFAQGQRLIAVHAEDQARINQRRQEFAGIQDPAIHSQIQDNQAALLATQLALKLSKKYQRRLHILHMSTADE
AELLRQDKPSWVTAEVTPQHLVMNTGDYQRIGTLAQMNPPLRSPHDNEVLWQALRDGVIDFIATDHAPHTLEEKAQPYPN
SPSGMPGVETSLAVMLTAAMEGKCTIAQVANWMSKAVAVAYGIPNKGAIAPGYDADLVLVDLNTYRPVLREETLTKCHWS
PFEGWNLTGWADTTIVGGQIVYHKGKLNTEVRGQALSFV
>Mature_438_residues
SSPQSLLIRGARIILPNGEFLVGDVLTRDRHIVEVGTEIVNTTPATEIDAKGLTLLPGVIDPQVHFREPGLEHKEDLFTA
SCACAKGGVTSFLEMPNTRPLTTTQQALDDKLQRAASKCLVNYGFFIGATGDNTPELLAAHPTPGIKIFMGSMHGQLLVD
QEAALESIFAQGQRLIAVHAEDQARINQRRQEFAGIQDPAIHSQIQDNQAALLATQLALKLSKKYQRRLHILHMSTADEA
ELLRQDKPSWVTAEVTPQHLVMNTGDYQRIGTLAQMNPPLRSPHDNEVLWQALRDGVIDFIATDHAPHTLEEKAQPYPNS
PSGMPGVETSLAVMLTAAMEGKCTIAQVANWMSKAVAVAYGIPNKGAIAPGYDADLVLVDLNTYRPVLREETLTKCHWSP
FEGWNLTGWADTTIVGGQIVYHKGKLNTEVRGQALSFV

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=385, Percent_Identity=30.9090909090909, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI4503051, Length=446, Percent_Identity=24.4394618834081, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI62422571, Length=446, Percent_Identity=24.4394618834081, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI4503379, Length=445, Percent_Identity=24.9438202247191, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI4503377, Length=454, Percent_Identity=23.7885462555066, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4503375, Length=456, Percent_Identity=25.4385964912281, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI19923821, Length=450, Percent_Identity=23.1111111111111, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI190194363, Length=446, Percent_Identity=23.9910313901345, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1786722, Length=434, Percent_Identity=27.4193548387097, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI87082175, Length=456, Percent_Identity=26.0964912280702, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI193204318, Length=425, Percent_Identity=30.8235294117647, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71989490, Length=455, Percent_Identity=26.5934065934066, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17539558, Length=452, Percent_Identity=25.8849557522124, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322218, Length=435, Percent_Identity=28.0459770114943, Blast_Score=139, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24642586, Length=386, Percent_Identity=30.0518134715026, Blast_Score=178, Evalue=8e-45,
Organism=Drosophila melanogaster, GI18859883, Length=450, Percent_Identity=30.4444444444444, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17137462, Length=451, Percent_Identity=25.0554323725055, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48036; Mature: 47905

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPQSLLIRGARIILPNGEFLVGDVLTRDRHIVEVGTEIVNTTPATEIDAKGLTLLPGV
CCCCHHHHEECCEEEECCCCEEEEHHHHCCCEEEEHHHHHHCCCCCCCCCCCCCEECCCC
IDPQVHFREPGLEHKEDLFTASCACAKGGVTSFLEMPNTRPLTTTQQALDDKLQRAASKC
CCCCCEECCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
LVNYGFFIGATGDNTPELLAAHPTPGIKIFMGSMHGQLLVDQEAALESIFAQGQRLIAVH
HHHCCEEEECCCCCCCCEEEECCCCCEEEEEECCCCEEEECHHHHHHHHHHCCCEEEEEE
AEDQARINQRRQEFAGIQDPAIHSQIQDNQAALLATQLALKLSKKYQRRLHILHMSTADE
CCHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCH
AELLRQDKPSWVTAEVTPQHLVMNTGDYQRIGTLAQMNPPLRSPHDNEVLWQALRDGVID
HHHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHE
FIATDHAPHTLEEKAQPYPNSPSGMPGVETSLAVMLTAAMEGKCTIAQVANWMSKAVAVA
EHCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEE
YGIPNKGAIAPGYDADLVLVDLNTYRPVLREETLTKCHWSPFEGWNLTGWADTTIVGGQI
ECCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCEE
VYHKGKLNTEVRGQALSFV
EEECCCCCCCCCCCEECCC
>Mature Secondary Structure 
SSPQSLLIRGARIILPNGEFLVGDVLTRDRHIVEVGTEIVNTTPATEIDAKGLTLLPGV
CCCHHHHEECCEEEECCCCEEEEHHHHCCCEEEEHHHHHHCCCCCCCCCCCCCEECCCC
IDPQVHFREPGLEHKEDLFTASCACAKGGVTSFLEMPNTRPLTTTQQALDDKLQRAASKC
CCCCCEECCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
LVNYGFFIGATGDNTPELLAAHPTPGIKIFMGSMHGQLLVDQEAALESIFAQGQRLIAVH
HHHCCEEEECCCCCCCCEEEECCCCCEEEEEECCCCEEEECHHHHHHHHHHCCCEEEEEE
AEDQARINQRRQEFAGIQDPAIHSQIQDNQAALLATQLALKLSKKYQRRLHILHMSTADE
CCHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCH
AELLRQDKPSWVTAEVTPQHLVMNTGDYQRIGTLAQMNPPLRSPHDNEVLWQALRDGVID
HHHHHCCCCCEEEEECCCCEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHE
FIATDHAPHTLEEKAQPYPNSPSGMPGVETSLAVMLTAAMEGKCTIAQVANWMSKAVAVA
EHCCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEE
YGIPNKGAIAPGYDADLVLVDLNTYRPVLREETLTKCHWSPFEGWNLTGWADTTIVGGQI
ECCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCEE
VYHKGKLNTEVRGQALSFV
EEECCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]