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The map label for this gene is mprA [H]

Identifier: 17229772

GI number: 17229772

Start: 2746186

End: 2747451

Strand: Direct

Name: mprA [H]

Synonym: alr2280

Alternate gene names: 17229772

Gene position: 2746186-2747451 (Clockwise)

Preceding gene: 17229771

Following gene: 17229786

Centisome position: 42.82

GC content: 39.89

Gene sequence:

>1266_bases
ATGAAAGAAAATACATTTTCCTCAGTCCCCAATCTGAATTACCCCTCATCCTCAGAATGGTCGCCACCTTACCCAGCCCC
CCAGCCTCCATCTCCACCCACTAAAGTCAAAATCTTAGTAATTGATGATGATCGCATCATCCAATTAATTCTCAAACAGG
CATTGCAAGAACAAGGCTATGAAGTCATTCTCGCCACCAATGGTTTACAAGGAATCGAGCAAGCCGATAAACACCACCCA
GCACTGATAATTTGTGATTGGCAAATGGATGAAATGGATGGTTTAGAAGTGTGCCGCAAAATTAAATCAGAGCCAACCCT
ATCTACGACTTTTTTTATTCTCTTAACCTCACGGCGAGCTGTAGAAGACCGAGTGGAAGGCTTAGATACGGGGGCAGATG
ATTTTTTAAGCAAACCAATTGACGTAAATGAACTCAAAGCCCGTGTACGCTCTGGCTTGAGGCTATATCAAACAAATCAA
GAACTGCAAAGATTAGCGCAAGATTTACAACTCCAAAAACAGCTTTTAGAAACAGAGTTGAATGAAGCGGCTGATTATGT
CAAATCGATTCTTCCCCAACCTTTATCGGGATTAATCAACATCAATTCTCAATTTTTGCCCTCTAGTCAATTAGGTGGTG
ATTGTTTTGATTACTACTGGCTTGATGATGATCATTTAGTTATCTACCTGCTGGATGTTTCTGGACATGGATTGGCAGCA
GCATTACCATCAATTTCCATACATAATCTACTGCGATCGCGTTCTCTTCCTCAAGCTGATCTATACGATCCCGCACAAGT
TCTCCGAGACTTAAATCTTTTCTTTCAAATGGATCAGCAAAATTGTCAATACTTTACGATGTGGTACGGAGTTTTTAAGC
GGAGTTCTCAGCAGCTCACTTATGCTAGCGCCGGTCATCCTCCAGCTTTACTACTTTCTCCTTCCACTGACTCTCAATTA
GATATCCAAAAGTTAGCCACTCGCAGTCTGCCAATTGGAGCATTTACAGAAGCAAAATATTGCAATGCTATCTGTAATAT
CCAAAGCGGTAGTAAACTCTATGTATTTAGTGATGGAGTTTATGAAGTGGAAAAATCTGATGGTAATATGTGGAATTTTG
AAAGCTTCATTAAGGTAATAGCTATGTGCAATCAACCACTCGAAGAAGGGTTAAGTGAGATTTTAGAAGCCATAAAAACT
ACCACTGGTAGTCAAATATTCAACGATGACTGCTCTTTAATAGAAATAAATTTTGTTCTTAAGTAA

Upstream 100 bases:

>100_bases
TAATCAACTCAACAACGAATATCAAAATGTTGTAGCGGCACTTAAAACCCTTATTTTTTAAAATAAATAGCATTTTTCTC
TTAGCTCAAATTAAAAAAAT

Downstream 100 bases:

>100_bases
CTCAAATTTTTGGATGTAATCAAATTAATAATTTAGCTGAAAATCAGCAGATTTATTGTAATTTTCATCATGCTTTGTTC
ATGGTTGATTAGTTTTATCT

Product: two-component response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MKENTFSSVPNLNYPSSSEWSPPYPAPQPPSPPTKVKILVIDDDRIIQLILKQALQEQGYEVILATNGLQGIEQADKHHP
ALIICDWQMDEMDGLEVCRKIKSEPTLSTTFFILLTSRRAVEDRVEGLDTGADDFLSKPIDVNELKARVRSGLRLYQTNQ
ELQRLAQDLQLQKQLLETELNEAADYVKSILPQPLSGLININSQFLPSSQLGGDCFDYYWLDDDHLVIYLLDVSGHGLAA
ALPSISIHNLLRSRSLPQADLYDPAQVLRDLNLFFQMDQQNCQYFTMWYGVFKRSSQQLTYASAGHPPALLLSPSTDSQL
DIQKLATRSLPIGAFTEAKYCNAICNIQSGSKLYVFSDGVYEVEKSDGNMWNFESFIKVIAMCNQPLEEGLSEILEAIKT
TTGSQIFNDDCSLIEINFVLK

Sequences:

>Translated_421_residues
MKENTFSSVPNLNYPSSSEWSPPYPAPQPPSPPTKVKILVIDDDRIIQLILKQALQEQGYEVILATNGLQGIEQADKHHP
ALIICDWQMDEMDGLEVCRKIKSEPTLSTTFFILLTSRRAVEDRVEGLDTGADDFLSKPIDVNELKARVRSGLRLYQTNQ
ELQRLAQDLQLQKQLLETELNEAADYVKSILPQPLSGLININSQFLPSSQLGGDCFDYYWLDDDHLVIYLLDVSGHGLAA
ALPSISIHNLLRSRSLPQADLYDPAQVLRDLNLFFQMDQQNCQYFTMWYGVFKRSSQQLTYASAGHPPALLLSPSTDSQL
DIQKLATRSLPIGAFTEAKYCNAICNIQSGSKLYVFSDGVYEVEKSDGNMWNFESFIKVIAMCNQPLEEGLSEILEAIKT
TTGSQIFNDDCSLIEINFVLK
>Mature_421_residues
MKENTFSSVPNLNYPSSSEWSPPYPAPQPPSPPTKVKILVIDDDRIIQLILKQALQEQGYEVILATNGLQGIEQADKHHP
ALIICDWQMDEMDGLEVCRKIKSEPTLSTTFFILLTSRRAVEDRVEGLDTGADDFLSKPIDVNELKARVRSGLRLYQTNQ
ELQRLAQDLQLQKQLLETELNEAADYVKSILPQPLSGLININSQFLPSSQLGGDCFDYYWLDDDHLVIYLLDVSGHGLAA
ALPSISIHNLLRSRSLPQADLYDPAQVLRDLNLFFQMDQQNCQYFTMWYGVFKRSSQQLTYASAGHPPALLLSPSTDSQL
DIQKLATRSLPIGAFTEAKYCNAICNIQSGSKLYVFSDGVYEVEKSDGNMWNFESFIKVIAMCNQPLEEGLSEILEAIKT
TTGSQIFNDDCSLIEINFVLK

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG2208

COG function: function code TK; Serine phosphatase RsbU, regulator of sigma subunit

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=122, Percent_Identity=40.9836065573771, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788550, Length=133, Percent_Identity=34.5864661654135, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786911, Length=119, Percent_Identity=35.2941176470588, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789809, Length=124, Percent_Identity=35.4838709677419, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790437, Length=119, Percent_Identity=38.655462184874, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786599, Length=118, Percent_Identity=32.2033898305085, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786784, Length=119, Percent_Identity=37.8151260504202, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790552, Length=136, Percent_Identity=31.6176470588235, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790860, Length=118, Percent_Identity=34.7457627118644, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI2367329, Length=120, Percent_Identity=37.5, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789402, Length=128, Percent_Identity=36.71875, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787375, Length=119, Percent_Identity=29.4117647058824, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788394, Length=127, Percent_Identity=31.496062992126, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788713, Length=162, Percent_Identity=31.4814814814815, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1790863, Length=114, Percent_Identity=29.8245614035088, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787487, Length=325, Percent_Identity=25.5384615384615, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1787229, Length=116, Percent_Identity=31.0344827586207, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 47311; Mature: 47311

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKENTFSSVPNLNYPSSSEWSPPYPAPQPPSPPTKVKILVIDDDRIIQLILKQALQEQGY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCC
EVILATNGLQGIEQADKHHPALIICDWQMDEMDGLEVCRKIKSEPTLSTTFFILLTSRRA
EEEEEECCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEEEEECCHH
VEDRVEGLDTGADDFLSKPIDVNELKARVRSGLRLYQTNQELQRLAQDLQLQKQLLETEL
HHHHHHCCCCCHHHHHCCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
NEAADYVKSILPQPLSGLININSQFLPSSQLGGDCFDYYWLDDDHLVIYLLDVSGHGLAA
HHHHHHHHHHCCCCHHHHEECCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCHHH
ALPSISIHNLLRSRSLPQADLYDPAQVLRDLNLFFQMDQQNCQYFTMWYGVFKRSSQQLT
HCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHEEECCCCCCEEHHHHHHHHCCCCCEE
YASAGHPPALLLSPSTDSQLDIQKLATRSLPIGAFTEAKYCNAICNIQSGSKLYVFSDGV
EECCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHEECCCCCEEEEEECCE
YEVEKSDGNMWNFESFIKVIAMCNQPLEEGLSEILEAIKTTTGSQIFNDDCSLIEINFVL
EEEECCCCCEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEEE
K
C
>Mature Secondary Structure
MKENTFSSVPNLNYPSSSEWSPPYPAPQPPSPPTKVKILVIDDDRIIQLILKQALQEQGY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCC
EVILATNGLQGIEQADKHHPALIICDWQMDEMDGLEVCRKIKSEPTLSTTFFILLTSRRA
EEEEEECCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCEEEEEEEECCHH
VEDRVEGLDTGADDFLSKPIDVNELKARVRSGLRLYQTNQELQRLAQDLQLQKQLLETEL
HHHHHHCCCCCHHHHHCCCCCHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
NEAADYVKSILPQPLSGLININSQFLPSSQLGGDCFDYYWLDDDHLVIYLLDVSGHGLAA
HHHHHHHHHHCCCCHHHHEECCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCHHH
ALPSISIHNLLRSRSLPQADLYDPAQVLRDLNLFFQMDQQNCQYFTMWYGVFKRSSQQLT
HCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHEEECCCCCCEEHHHHHHHHCCCCCEE
YASAGHPPALLLSPSTDSQLDIQKLATRSLPIGAFTEAKYCNAICNIQSGSKLYVFSDGV
EECCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHEECCCCCEEEEEECCE
YEVEKSDGNMWNFESFIKVIAMCNQPLEEGLSEILEAIKTTTGSQIFNDDCSLIEINFVL
EEEECCCCCEECHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEEE
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA